| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
proline
proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.. Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons. | 2.13 | 1 | 0 | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
paraherquamide
paraherquamide: structure very similar to marcfortine A; RN given refers to the (1'alpha,5'abeta,7'beta,8'abeta,9'abeta)-isomer; RN for cpd without isomeric designation not avail 6/90 | 3.51 | 2 | 0 | | |
vm 55599
VM 55599: from Penicillium strain IMI 332995; structure given in first source | 1.99 | 1 | 0 | | |
asperparaline a
asperparaline A : An alkaloid isolated from Aspergillus aculeatus.. aspergillimide: isolated from Aspergillus; structure in first source | 3.11 | 1 | 0 | alkaloid;
azaspiro compound;
dicarboximide | Aspergillus metabolite |
curdlan
D-hexose : A hexose that has D-configuration at position 5. | 2.06 | 1 | 0 | hexose | |
anthranilic acid
anthranilic acid: RN given refers to parent cpd; structure in Negwer, 5th ed, #565. anthranilic acid : An aminobenzoic acid that is benzoic acid having a single amino substituent located at position 2. It is a metabolite produced in L-tryptophan-kynurenine pathway in the central nervous system. | 3.18 | 1 | 0 | aminobenzoic acid | human metabolite;
mouse metabolite |
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group. | 2.02 | 1 | 0 | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid | algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite |
chloroform
Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines. | 1.95 | 1 | 0 | chloromethanes;
one-carbon compound | carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant |
gliotoxin
gliotoxin : A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.. Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent. | 3.18 | 1 | 0 | dipeptide;
organic disulfide;
organic heterotetracyclic compound;
pyrazinoindole | antifungal agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
immunosuppressive agent;
mycotoxin;
proteasome inhibitor |
xanthomegnin
xanthomegnin: pigment isolated from pathogenic fungus, Microsporum cookei; also Penicillium viridicatum; structure | 6.98 | 1 | 0 | | |
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts. | 7.41 | 1 | 0 | copper group element atom;
elemental gold | |
isocoumarins
isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.. Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule. | 2.06 | 1 | 0 | isocoumarins | |
tryptoquivaline
tryptoquivaline: tremor-producing metabolite from Aspergillus clavatus; tetrapeptide derived from tryptophan, anthranilic acid, valine, & methylalanine; structure & N1 names previously assigned to tryptoquivaline C & tryptoquivaline D found to be incorrect & are revised in third source; see also record for tryptoquivalone; structure in third source | 3.18 | 1 | 0 | | |
paraherquamide
paraherquamide: structure very similar to marcfortine A; RN given refers to the (1'alpha,5'abeta,7'beta,8'abeta,9'abeta)-isomer; RN for cpd without isomeric designation not avail 6/90 | 3.11 | 1 | 0 | | |
asperphenamate
asperphenamate: isolated from culture filtrate & mycelium of Aspergillus flavipes ATCC 11013; structure. asperphenamate : A carboxylic ester resulting from the formal condensation of the carboxy group of N-benzoyl-L-phenylalanine with the hydroxy group of N-benzoyl-L-phenylalaninol. A metabolite found in several Pencillium and Aspergillus species, as well as in plants as a product of endophytic fungi. | 2.02 | 1 | 0 | benzamides;
carboxylic ester;
L-phenylalanine derivative | antineoplastic agent |
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring. | 2.06 | 1 | 0 | | |
epiglucan
epiglucan: a highly side-chain/branched alkali-insoluble cell wall glucan from fungus such as Epicoccum nigrum, Botrytis cinerea, ascomycetes & basidiomycetes; also isolated S-4001 from Lei Wan (polyporus mylitiae), HA-beta-glucan from mushroom Pleutotus ostreatus (Fr.) Quel., and translam from seaweed Laminaria cichorioides; with commercially important functional properties including emulsification and friction reduction. | 2.06 | 1 | 0 | | |
ergosterol
[no description available] | 6.98 | 1 | 0 | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | fungal metabolite;
Saccharomyces cerevisiae metabolite |
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. | 2.42 | 2 | 0 | 2-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols | anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic |
viomellein
viomellein: metabolite of Penicillium viridicatum causing hepatic lesions in mice | 6.98 | 1 | 0 | | |
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups. | 1.98 | 1 | 0 | | |
sterigmatocystin
[no description available] | 2.06 | 1 | 0 | sterigmatocystins | metabolite |
roquefortine
roquefortine: metabolite of Penicillium roqueforti; structure | 2.02 | 1 | 0 | pyrroloindole | |
neoechinulin a
neoechinulin A: from the marine-derived fungus Aspergillus sp.; structure in first source | 2.06 | 1 | 0 | | |
cladosporin
cladosporin: antifungal metabolite from Cladosporium cladosporioides; toxic, minor metabolite of Aspersillus flavus; inhibits tRNA synthetase in Plasmodium falciparum | 2.06 | 1 | 0 | | |
asperparaline a
asperparaline A : An alkaloid isolated from Aspergillus aculeatus.. aspergillimide: isolated from Aspergillus; structure in first source | 3.11 | 1 | 0 | alkaloid;
azaspiro compound;
dicarboximide | Aspergillus metabolite |
neoechinulin
neoechinulin: structure | 2.06 | 1 | 0 | | |