isocoumarins has been researched along with 3,4-dichloroisocoumarin in 77 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (2.60) | 18.7374 |
1990's | 51 (66.23) | 18.2507 |
2000's | 14 (18.18) | 29.6817 |
2010's | 9 (11.69) | 24.3611 |
2020's | 1 (1.30) | 2.80 |
Authors | Studies |
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Hecker, M; Kaw, S; Southan, GJ; Vane, JR; Warner, TD | 1 |
Baumeister, W; Dahlmann, B; Grziwa, A; Kuehn, L; Zwickl, P | 1 |
Djaballah, H; Harness, JA; Rivett, AJ; Savory, PJ | 1 |
Cardozo, C; Hidalgo, MC; Michaud, C; Orlowski, M; Vinitsky, A | 1 |
Margolis, JW; Nguyen, T; Pereira, ME; Wagner, BJ; Wilk, S; Yu, B | 1 |
Djaballah, H; Rivett, AJ | 1 |
Aebersold, R; Greenberg, AH; Kraut, RP; Shi, L | 1 |
Mason, RW | 1 |
Beynon, RJ; Rusbridge, NM | 1 |
Michaud, C; Orlowski, M | 1 |
Harper, JW; Hemmi, K; Powers, JC | 1 |
Enghild, JJ; Pizzo, SV; Thøgersen, IB; Valnickova, Z | 1 |
Clemmons, DR; Gockerman, A | 1 |
Chow, SC; Eriksson, JE; Holmström, TH; Kass, GE; Orrenius, S; Weis, M | 1 |
Anees, M; Steven, FS | 1 |
Cardozo, C; Eleuteri, AM; Orlowski, M | 1 |
Guesdon, F; Haskill, S; Ikebe, T; Saklatvala, J; Stylianou, E; Warwick-Davies, J | 1 |
Baumeister, W; Huber, R; Löwe, J; Lupas, A; Seemüller, E; Stock, D | 1 |
Atkinson, EA; Bleackley, RC; Helgason, CD; Pinkoski, MJ | 1 |
Christensen, S; Enghild, JJ; Nielsen, HR; Pizzo, SV; Roepstorff, P; Thøgersen, IB; Valnickova, Z | 1 |
Parent, D; Remold-O'Donnell, E | 1 |
Bast, RC; Becherer, JD; Boyer, CM; Champion, B; Connolly, KM; Conway, JG; Furdon, P; Karp, S; Kidao, S; McGeehan, GM | 1 |
Bochan, MR; Brahmi, Z; Froelich, CJ; Hanna, WL; Su, B | 1 |
Strobl, B; Vlasak, R | 1 |
Cardozo, C; Michaud, C; Orlowski, M | 2 |
Megyeri, P; Pabst, KM; Pabst, MJ | 1 |
Busse, R; Hecker, M; Preiss, C; Schini-Kerth, VB | 1 |
Fagan, JM; Strack, PR; Waxman, L | 1 |
Schnellmann, RG; Yang, X | 1 |
Ito, K; Kabashima, T; Kitano, A; Kitazono, A; Yoshimoto, T | 1 |
Lu, Q; Mellgren, RL | 1 |
Colas, B; Durand, P; Roy, P | 1 |
Brodsky, JL; McCracken, AA; Werner, ED | 1 |
Björk, I; Olson, ST; Patston, PA; Swanson, R | 1 |
Bettaïeb, A; Jaffrézou, JP; Laurent, G; Levade, T; Mansat, V | 1 |
Bisogni, R; Bonelli, P; Cerra, M; Ferrone, S; Lamberti, A; Petrella, A; Romano, MF; Sun, SC; Turco, MC; Venuta, S | 1 |
Pommier, Y; Shimizu, T | 1 |
Bochan, MR; Brahmi, Z; Froelich, CJ; Goebel, WS; Hommel-Berrey, GA; Montel, AH | 1 |
Cardozo, C; Eleuteri, AM; Kam, CM; Kohanski, R; Orlowski, M; Powers, JC | 1 |
Cao, CX; Pommier, Y; Shao, RG; Shimizu, T | 1 |
Hintze, TH; Nasjletti, A; Xu, X; Zhang, X | 1 |
Barczak, AK; Coyle, JT; Luthi-Carter, R; Speno, H | 1 |
Elia, G; Rossi, A; Santoro, MG | 1 |
Deeg, M; Dick, TP; Groll, M; Heinemeyer, W; Huber, R; Keilholz, W; Nussbaum, AK; Rammensee, HG; Schild, H; Schirle, M; Stevanović, S; Wolf, DH | 1 |
Babu, YS; Jing, H; Kilpatrick, JM; Liu, XY; Moore, D; Narayana, SV; Volanakis, JE | 1 |
Babu, YS; Chu, N; Cole, LB; Kilpatrick, JM | 1 |
Aslam, U; Hameed, A; Ying, AJ | 1 |
Honda, T; Mercken, M; Murayama, M; Murayama, O; Nihonmatsu, N; Omori, A; Saido, TC; Sato, K; Takahashi, H; Takashima, A; Tsubuki, S; Yasutake, K | 1 |
Conseil, V; Dubremetz, JF; Soête, M | 1 |
Alexanian, AR; Bamburg, JR | 1 |
Deutschländer, N; Fink, E; Heitsch, H; Rudolphi, K; Wiemer, G; Wirth, KJ | 1 |
Angeletti, M; Bini, L; Eleuteri, AM; Fioretti, E; Lupidi, G; Tacconi, R | 1 |
Addonizio, L; Gersony, WM; Hintze, TH; Loke, KE; Mital, S; Slater, JP | 1 |
Altschuller-Felberg, C; Cardozo, C; Loukissa, A; Nelson, JE | 1 |
Bogyo, M; Lemberg, MK; Martoglio, B; Ploegh, HL; Weihofen, A | 1 |
Hasegawa, N; Kimura, Y; Komatsu, N; Muramatsu, T; Oda, T | 1 |
Bruno, AP; d'Orgeix, AT; Laurent, G; Lautier, D; Quillet-Mary, A | 1 |
Faden, AI; Fan, L; Movsesyan, VA; Yakovlev, AG | 1 |
Albrecht, RF; Balyasnikova, IV; Danilov, SM; Karran, EH | 1 |
Reboud-Ravaux, M | 1 |
Fujimura, S; Hirai, K; Shibata, Y | 1 |
Bucheli, P; Gysler, C; Laloi, M; McCarthy, J; Morandi, O | 1 |
Hirasawa, A; Shiojima, S; Tsujimoto, G; Yamada, M | 1 |
Berchtold, S; Brand, V; Huber, SM; Lang, F; Lang, KS; Lang, PA; Myssina, S; Sandu, C; Wieder, T | 1 |
Finke, J; Grüllich, C; McGoldrick, S; Zeiser, R | 1 |
Berge, KE; Kulseth, MA; Leren, TP; Ranheim, T; Tveten, K | 1 |
Chow, WA; Fousek, K; Guan, M; Guo, S; Jiang, C; Shih, CC; Synold, T; Xi, B | 1 |
Chang, BI; Chen, WS; Cheng, TL; Hsu, FC; Lai, CH; Lin, HY; Liu, SK; Shi, GY; Wu, HL; Wu, YT | 1 |
Ašler, IL; Luić, M; Pigac, J; Štefanić, Z; Vujaklija, D | 1 |
Ha, Y; Xue, Y | 1 |
Boivin, WA; Granville, DJ; Hackett, TL; Knight, DA; Shackleford, M; Vanden Hoek, A; Zhao, H | 1 |
Biran, A; Krizhanovsky, V; Lowe, SW; Sagiv, A; Simon, J; Yon, M | 1 |
Allmaier, G; Ašler, IL; Kojić-Prodić, B; Kovačić, F; Marchetti-Deschmann, M; Stefanić, Z | 1 |
Verhelst, SH; Wolf, EV; Zeissler, A | 1 |
Huang, N; Tian, Y; Wang, J; Xiang, P; Xu, JH; Zhang, M; Zhang, Y | 1 |
Temesvari, LA; Walters, HA; Welter, BH | 1 |
1 review(s) available for isocoumarins and 3,4-dichloroisocoumarin
Article | Year |
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Proteasome inhibitors.
Topics: Acetylcysteine; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Hydrolysis; Inflammation; Isocoumarins; Macromolecular Substances; Molecular Weight; Multienzyme Complexes; Neoplasms; Peptides; Proteasome Endopeptidase Complex; Substrate Specificity | 2002 |
76 other study(ies) available for isocoumarins and 3,4-dichloroisocoumarin
Article | Year |
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Characterization of serine protease-derived metabolites of big endothelin in the cytosolic fraction from human polymorphonuclear leukocytes.
Topics: Cathepsin G; Cathepsins; Chromatography, High Pressure Liquid; Coumarins; Cytosol; Endothelin-1; Endothelins; Glycine; Humans; Isocoumarins; Leukocyte Elastase; Mass Spectrometry; Neutrophils; Pancreatic Elastase; Protein Precursors; Serine Endopeptidases; Sulfonamides | 1992 |
Biochemical properties of the proteasome from Thermoplasma acidophilum.
Topics: Amino Acid Sequence; Cations, Divalent; Cations, Monovalent; Coumarins; Cysteine Endopeptidases; Enzyme Activation; Hydrogen-Ion Concentration; Isocoumarins; Isoelectric Point; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Serpins; Temperature; Thermoplasma | 1992 |
Use of serine-protease inhibitors as probes for the different proteolytic activities of the rat liver multicatalytic proteinase complex.
Topics: Amino Acid Sequence; Animals; Coumarins; Cysteine Endopeptidases; Isocoumarins; Isoflurophate; Kinetics; Liver; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Substrate Specificity; Trypsin | 1992 |
A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex.
Topics: Amino Acid Sequence; Animals; Cattle; Coumarins; Cysteine Endopeptidases; Drug Resistance; Isocoumarins; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Pituitary Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Substrate Specificity | 1992 |
3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex.
Topics: Amino Acid Sequence; Animals; Binding Sites; Caseins; Catalysis; Cattle; Chromatography, Gel; Coumarins; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Hydrolysis; Isocoumarins; Molecular Sequence Data; Multienzyme Complexes; Phosphorylation; Pituitary Gland; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors | 1992 |
Peptidylglutamyl-peptide hydrolase activity of the multicatalytic proteinase complex: evidence for a new high-affinity site, analysis of cooperative kinetics, and the effect of manganese ions.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cations, Divalent; Coumarins; Cysteine Endopeptidases; Enzyme Stability; Hot Temperature; Hydrogen-Ion Concentration; Isocoumarins; Liver; Metals; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Potassium Chloride; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Rats, Inbred Strains | 1992 |
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
Topics: Amino Acid Sequence; Animals; Calcium; Cell Death; Chromatography, Gel; Coumarins; Deoxyribonucleases; DNA Damage; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Granzymes; Isocoumarins; Killer Cells, Natural; Molecular Sequence Data; Rats; Rats, Inbred F344; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Tumor Cells, Cultured | 1992 |
Characterization of the active site of human multicatalytic proteinase.
Topics: Amino Acid Sequence; Binding Sites; Chromatography, Ion Exchange; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diazomethane; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Isocoumarins; Isoflurophate; Kinetics; Liver; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Sulfhydryl Reagents | 1990 |
3,4-Dichloroisocoumarin, a serine protease inhibitor, inactivates glycogen phosphorylase b.
Topics: Animals; Coumarins; In Vitro Techniques; Isocoumarins; Muscles; Phosphorylases; Rabbits; Serine Proteinase Inhibitors | 1990 |
Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity.
Topics: Amino Acid Sequence; Animals; Cattle; Chymotrypsin; Coumarins; Cysteine Endopeptidases; Endopeptidases; Enzyme Activation; Fatty Acids; Heparin; Immune Sera; Isocoumarins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Phosphorylation; Pituitary Gland; Proteasome Endopeptidase Complex; Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Sodium Dodecyl Sulfate; Substrate Specificity; Trypsin | 1989 |
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
Topics: Animals; Blood Coagulation Factors; Cattle; Coumarins; Humans; Isocoumarins; Kinetics; Leukocytes; Mast Cells; Models, Chemical; Pancreatic Elastase; Protease Inhibitors; Rats; Serine Endopeptidases; Structure-Activity Relationship; Swine | 1985 |
Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors.
Topics: alpha-2-Antiplasmin; Amino Acid Sequence; Animals; Chymotrypsin; Coumarins; Endopeptidases; Enzyme Stability; Humans; Isocoumarins; Leukocyte Elastase; Mice; Molecular Sequence Data; Pancreatic Elastase; Protein Conformation; Receptors, Cell Surface; Serpins; Thermodynamics | 1994 |
Porcine aortic smooth muscle cells secrete a serine protease for insulin-like growth factor binding protein-2.
Topics: Animals; Aorta; Aprotinin; Arteriosclerosis; Carrier Proteins; Cells, Cultured; Chromatography; Coumarins; Culture Media; Edetic Acid; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isocoumarins; Muscle, Smooth, Vascular; Peptide Hydrolases; Serine Endopeptidases; Serine Proteinase Inhibitors; Somatomedins; Swine | 1995 |
Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes.
Topics: Antigens, Surface; Apoptosis; Caspase 1; Cell Line; Cell Nucleus; Cell-Free System; Coumarins; Cysteine Endopeptidases; Endopeptidases; fas Receptor; Humans; Isocoumarins; T-Lymphocytes; Tosylphenylalanyl Chloromethyl Ketone | 1995 |
Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine-isethionate and guanidino derivatives.
Topics: Benzoates; Binding, Competitive; Carboxylic Ester Hydrolases; Carcinoma, Squamous Cell; Cell Membrane; Coumarins; Dexamethasone; Endopeptidases; Guanidines; Humans; Isocoumarins; Kinetics; Lung Neoplasms; Medroxyprogesterone; Microscopy, Fluorescence; Pentamidine; Protease Inhibitors; Sodium Dodecyl Sulfate; Sulfaguanidine | 1994 |
Differences in catalytic activities and subunit pattern of multicatalytic proteinase complexes (proteasomes) isolated from bovine pituitary, lung, and liver. Changes in LMP7 and the component necessary for expression of the chymotrypsin-like activity.
Topics: Amino Acid Sequence; Animals; Catalysis; Cattle; Chymotrypsin; Coumarins; Cysteine Endopeptidases; Isocoumarins; Liver; Lung; Molecular Sequence Data; Multienzyme Complexes; Pituitary Gland; Proteasome Endopeptidase Complex; Proteins | 1995 |
Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor kappa B of HeLa cells. Interference in signalling by the proteinase inhibitors 3,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone.
Topics: Base Sequence; Chromatography, Ion Exchange; Coumarins; DNA-Binding Proteins; Heat-Shock Proteins; HeLa Cells; Humans; I-kappa B Proteins; Interleukin-1; Isocoumarins; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Serine Proteinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Transcription Factor RelB; Transcription Factors | 1995 |
Proteasome from Thermoplasma acidophilum: a threonine protease.
Topics: Amino Acid Sequence; Archaeal Proteins; Binding Sites; Coumarins; Endopeptidases; Hydrogen-Ion Concentration; Isocoumarins; Molecular Sequence Data; Mutagenesis; Protein Folding; Sequence Alignment; Serine Proteinase Inhibitors; Thermoplasma | 1995 |
Proteinases are involved in both DNA fragmentation and membrane damage during CTL-mediated target cell killing.
Topics: Animals; Arginine; Aurintricarboxylic Acid; Cells, Cultured; Coumarins; Cytotoxicity, Immunologic; DNA; Endopeptidases; Isocoumarins; Kinetics; Mast-Cell Sarcoma; Mice; Mice, Inbred BALB C; Protease Inhibitors; Substrate Specificity; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Tyrosine | 1995 |
Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop.
Topics: Animals; Binding Sites; Coumarins; Electrophoresis, Polyacrylamide Gel; Isocoumarins; Kinetics; Protein Binding; Protein Structure, Secondary; Serine; Serine Proteinase Inhibitors; Serpins; Sodium Dodecyl Sulfate; Swine; Trypsin | 1995 |
Downregulation of neutrophil CD43 by opsonized zymosan.
Topics: Antigens, CD; Coumarins; Down-Regulation; Endopeptidases; Humans; Isocoumarins; Isoflurophate; Leukosialin; Neutrophils; Opsonin Proteins; Respiratory Burst; Sialoglycoproteins; Sulfones; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1995 |
Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor.
Topics: Animals; Cell Line; Coumarins; Female; Humans; Interleukins; Isocoumarins; Macrophages; Metalloendopeptidases; Mice; Mice, Inbred C3H; Monocytes; Phenylalanine; Protein Processing, Post-Translational; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Human granzyme B is essential for DNA fragmentation of susceptible target cells.
Topics: Animals; Aurintricarboxylic Acid; Blotting, Northern; Blotting, Western; Cell Survival; Chymases; Coumarins; Cytoplasmic Granules; Cytotoxicity, Immunologic; DNA; Egtazic Acid; Granzymes; Humans; Isocoumarins; Killer Cells, Natural; Mice; Serine Endopeptidases; Sulfones; Tumor Cells, Cultured | 1994 |
The receptor-destroying enzyme of influenza C virus is required for entry into target cells.
Topics: Acetylesterase; Animals; Blotting, Northern; Cell Line; Coumarins; Dogs; Gammainfluenzavirus; Hemagglutinins, Viral; Hemolysis; Humans; Influenza A virus; Isocoumarins; Isoflurophate; Kidney; Kinetics; RNA, Viral; Serine Proteinase Inhibitors; Viral Fusion Proteins; Viral Proteins | 1993 |
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.
Topics: Amino Acid Sequence; Animals; Calcium; Cattle; Chymotrypsin; Coumarins; Cysteine Endopeptidases; Isocoumarins; Kinetics; Lauric Acids; Magnesium; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Pituitary Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Sodium Dodecyl Sulfate; Substrate Specificity; Trypsin | 1993 |
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide.
Topics: Cell Culture Techniques; Coumarins; Dose-Response Relationship, Drug; Humans; Isocoumarins; Kinetics; Lipopolysaccharides; Monocytes; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Superoxides; Tumor Necrosis Factor-alpha | 1995 |
Antioxidants differentially affect nuclear factor kappa B-mediated nitric oxide synthase expression in vascular smooth muscle cells.
Topics: Animals; Antioxidants; Aorta, Thoracic; Base Sequence; Cells, Cultured; Chromonar; Coumarins; DNA; Flavonoids; Gene Expression; Isocoumarins; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide Synthase; Rats; Rats, Wistar; Serotonin | 1996 |
Activation of the multicatalytic endopeptidase by oxidants. Effects on enzyme structure.
Topics: Amino Acid Sequence; Animals; Chickens; Chloromercuribenzoates; Coumarins; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; Hydrogen Peroxide; Hydrolysis; Iron; Isocoumarins; Male; Molecular Sequence Data; Multienzyme Complexes; Oxidants; p-Chloromercuribenzoic Acid; Peptides; Proteasome Endopeptidase Complex; Protein Conformation; Proteins; Serine Proteinase Inhibitors | 1996 |
Proteinases in renal cell death.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antipain; Carboxypeptidases; Cathepsin A; Cathepsin B; Cell Death; Coumarins; Cysteine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Hydrocarbons, Fluorinated; Hydroquinones; Isocoumarins; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Membrane Potentials; Pepstatins; Peroxides; Rabbits; Reactive Oxygen Species; Serine Proteinase Inhibitors; tert-Butylhydroperoxide; Tosyllysine Chloromethyl Ketone | 1996 |
Prolyl aminopeptidase is also present in Enterobacteriaceae: cloning and sequencing of the Hafnia alvei enzyme-gene and characterization of the expressed enzyme.
Topics: Aeromonas; Amino Acid Sequence; Aminopeptidases; Bacillus; Base Sequence; Chloromercuribenzoates; Cloning, Molecular; Coumarins; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Enterobacteriaceae; Gene Expression Regulation, Enzymologic; Isocoumarins; Lactobacillus; Molecular Sequence Data; Neisseria; Open Reading Frames; p-Chloromercuribenzoic Acid; Restriction Mapping; Substrate Specificity | 1996 |
Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells.
Topics: Apoptosis; Calpain; Coumarins; Cycloheximide; Cysteine Proteinase Inhibitors; Diazomethane; HL-60 Cells; Humans; Isocoumarins; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors | 1996 |
Purification, kinetical and molecular characterizations of a serine collagenolytic protease from greenshore crag (Carcinus maenas) digestive gland.
Topics: alpha 1-Antitrypsin; Amino Acid Sequence; Animals; Brachyura; Coumarins; Digestive System; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Isocoumarins; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Oligopeptides; Serine Proteinase Inhibitors; Tosyl Compounds; Trypsin Inhibitor, Bowman-Birk Soybean | 1996 |
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate.
Topics: Acetylcysteine; Adenosine Triphosphate; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Fungal Proteins; Genes, Fungal; Isocoumarins; Kinetics; Microsomes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity | 1996 |
Apparent formation of sodium dodecyl sulfate-stable complexes between serpins and 3,4-dichloroisocoumarin-inactivated proteinases is due to regeneration of active proteinase from the inactivated enzyme.
Topics: Animals; Cattle; Coumarins; Endopeptidases; Enzyme Activation; Humans; Isocoumarins; Serine Proteinase Inhibitors; Serpins; Sodium Dodecyl Sulfate | 1997 |
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
Topics: Antibiotics, Antineoplastic; Antipain; Apoptosis; Ceramides; Coumarins; Daunorubicin; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Hydrolysis; Isocoumarins; Leupeptins; NF-kappa B; Pepstatins; Protease Inhibitors; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured | 1997 |
Induction of nuclear factor kappa B/Rel nuclear activity in human peripheral blood T lymphocytes by anti-HLA class I monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; COS Cells; Coumarins; Gene Expression Regulation; Histocompatibility Antigens Class I; Humans; Isocoumarins; Kinetics; NF-kappa B; NF-kappa B p50 Subunit; Nuclear Proteins; Rabbits; Serine Proteinase Inhibitors; T-Lymphocytes; Transcription Factor RelA | 1997 |
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Nucleus; Cell-Free System; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Gene Deletion; Genes, p53; HL-60 Cells; Humans; Isocoumarins; Lamin Type B; Lamins; Nuclear Proteins; Poly Adenosine Diphosphate Ribose; Prodrugs; Serine Endopeptidases; Serine Proteinase Inhibitors; Tumor Suppressor Protein p53 | 1997 |
Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
Topics: Apoptosis; Cells, Cultured; Coumarins; Cytotoxicity, Immunologic; DNA Damage; Granzymes; Humans; Isocoumarins; Killer Cells, Lymphokine-Activated; Membrane Glycoproteins; Perforin; Pore Forming Cytotoxic Proteins; RNA, Messenger; RNA, Viral; Serine Endopeptidases; Serine Proteinase Inhibitors; Vesicular stomatitis Indiana virus; Virus Cultivation | 1997 |
Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes).
Topics: Animals; Carbon Radioisotopes; Catalysis; Cattle; Coumarins; Cysteine Endopeptidases; Isocoumarins; Multienzyme Complexes; Pituitary Gland; Proteasome Endopeptidase Complex; Proteins; Serine Proteinase Inhibitors; Spleen; Viral Matrix Proteins | 1997 |
Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells.
Topics: Amino Acid Sequence; Apoptosis; Camptothecin; Cell Nucleus; Coumarins; Cytosol; DNA Fragmentation; HL-60 Cells; Humans; Isocoumarins; Isoenzymes; Kinetics; Lamin Type B; Lamins; Molecular Sequence Data; Nuclear Proteins; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Structure, Secondary; Serine Proteinase Inhibitors; Time Factors; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53 | 1998 |
Neutral endopeptidase and angiotensin-converting enzyme inhibitors increase nitric oxide production in isolated canine coronary microvessels by a kinin-dependent mechanism.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Coronary Vessels; Coumarins; Dogs; Drug Interactions; Glycopeptides; In Vitro Techniques; Isocoumarins; Neprilysin; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Protease Inhibitors; Ramipril; Serine Proteinase Inhibitors; Thiorphan | 1998 |
Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.
Topics: Animals; Antigens, Surface; Binding, Competitive; Carboxypeptidases; Chelating Agents; Cloning, Molecular; Cobalt; Coumarins; Dipeptides; Edetic Acid; Folic Acid; Glutamate Carboxypeptidase II; Histamine H1 Antagonists; Humans; Hydrolysis; Isocoumarins; Kinetics; Leucine; Male; Neuropeptides; Pepstatins; Phenanthrolines; Prostatic Neoplasms; Protease Inhibitors; Rats; Serine Proteinase Inhibitors; Substrate Specificity; Synaptic Transmission; Tumor Cells, Cultured | 1998 |
Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition.
Topics: Coumarins; DNA; DNA-Binding Proteins; Down-Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Humans; Isocoumarins; Jurkat Cells; NF-kappa B; Serine Proteinase Inhibitors; Transcription Factors | 1998 |
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Coumarins; Cysteine Endopeptidases; Fluorescence; Fungal Proteins; Histocompatibility Antigens Class I; Isocoumarins; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Vertebrates | 1998 |
Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
Topics: Binding Sites; Complement Factor D; Coumarins; Crystallography, X-Ray; Enzyme Inhibitors; Histidine; Isocoumarins; Models, Molecular; Oxazines; Protein Conformation; Serine Endopeptidases; Serine Proteinase Inhibitors; Water | 1998 |
Structure of 3,4-dichloroisocoumarin-inhibited factor D.
Topics: Animals; Benzoxazines; Carbamates; Complement Factor D; Complement Pathway, Alternative; Coumarins; Crystallization; Crystallography, X-Ray; Humans; Isocoumarins; Models, Molecular; Molecular Sequence Data; Oxazines; Pancreatic Elastase; Protein Conformation; Serine Proteinase Inhibitors; Swine | 1998 |
3,4-Dichloroisocoumarin serine protease inhibitor induces DNA fragmentation and apoptosis in susceptible target cells.
Topics: 3T3 Cells; Animals; Apoptosis; Coumarins; DNA Damage; Humans; Isocoumarins; Killer Cells, Lymphokine-Activated; Mice; Microscopy, Electron; Serine Proteinase Inhibitors | 1998 |
Dual roles of proteasome in the metabolism of presenilin 1.
Topics: Acetylcysteine; Alzheimer Disease; Amino Acid Sequence; Brain Chemistry; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glycoproteins; Humans; Isocoumarins; Kidney; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Mutation; Neuroblastoma; Peptide Fragments; Precipitin Tests; Presenilin-1; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Sulfones; Trypsin Inhibitors; Tumor Cells, Cultured | 1999 |
Serine protease inhibitors block invasion of host cells by Toxoplasma gondii.
Topics: Animals; Chlorocebus aethiops; Coumarins; Isocoumarins; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfones; Toxoplasma; Vero Cells | 1999 |
Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Cattle; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Hydrolysis; Insulin; Isocoumarins; Kinetics; Lactams; Molecular Sequence Data; Multienzyme Complexes; Pituitary Gland; Proteasome Endopeptidase Complex | 1999 |
Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB.
Topics: Animals; Antioxidants; Brain Chemistry; Calcineurin Inhibitors; Calcium-Binding Proteins; Cattle; Cell Nucleus; Cell Survival; Cells, Cultured; Chick Embryo; Coumarins; Cyclosporine; Dexamethasone; Dimerization; Immunophilins; Immunosuppressive Agents; Isocoumarins; Macromolecular Substances; Nerve Growth Factors; Neurons; NF-kappa B; Prosencephalon; Pyrethrins; Pyrrolidines; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serine Proteinase Inhibitors; Sirolimus; Tacrolimus; Thiocarbamates | 1999 |
Amyloid beta-(1-40) stimulates cyclic GMP production via release of kinins in primary cultured endothelial cells.
Topics: Amyloid beta-Peptides; Animals; Aorta; Bradykinin; Bradykinin Receptor Antagonists; Cattle; Cells, Cultured; Coronary Vessels; Coumarins; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Isocoumarins; Kallikreins; Kinins; Microcirculation; Microscopy, Electron; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Rats; Serine Proteinase Inhibitors | 1999 |
Isolation and characterization of bovine thymus multicatalytic proteinase complex.
Topics: Animals; Blotting, Western; Cattle; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Gel, Two-Dimensional; Isocoumarins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Spleen; Thymus Gland | 2000 |
Synergy of amlodipine and angiotensin-converting enzyme inhibitors in regulating myocardial oxygen consumption in normal canine and failing human hearts.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Calcium Channel Blockers; Child; Coumarins; Dogs; Drug Synergism; Drug Therapy, Combination; Female; Heart Failure; Humans; Isocoumarins; Male; Middle Aged; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxygen Consumption; Penicillamine; Ramipril; Serine Proteinase Inhibitors | 1999 |
Proteasome from cytokine-treated human cells shows stimulated BrAAP activity and depressed PGPH activity.
Topics: Amino Acids, Branched-Chain; Cells, Cultured; Coumarins; Cysteine Endopeptidases; Endopeptidases; Endothelium, Vascular; Humans; Interferon-gamma; Interleukin-1; Interleukin-6; Isocoumarins; Lipopolysaccharides; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; Serine Proteinase Inhibitors; Tumor Necrosis Factor-alpha; Umbilical Veins | 2000 |
Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding, Competitive; Calcium; Calmodulin; Cell Line; Coumarins; Cysteine Proteinase Inhibitors; Cytosol; Dipeptides; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Endoplasmic Reticulum; Humans; Inhibitory Concentration 50; Intracellular Membranes; Isocoumarins; Ketones; Mice; Molecular Sequence Data; Plasmids; Protein Binding; Protein Biosynthesis; Protein Sorting Signals; Protein Synthesis Inhibitors; Puromycin; Serine Proteinase Inhibitors; Substrate Specificity; Time Factors; Transcription, Genetic | 2000 |
Isolated ricin B-chain-mediated apoptosis in U937 cells.
Topics: Apoptosis; Aspartic Acid; Brefeldin A; Cell Nucleus; Coumarins; Cycloheximide; Cysteine Proteinase Inhibitors; DNA Fragmentation; Humans; Isocoumarins; Oligopeptides; Protein Biosynthesis; Protein Synthesis Inhibitors; Ricin; Serine Proteinase Inhibitors; U937 Cells | 2000 |
Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: implication of granzyme B and perforin.
Topics: Antigens, CD34; Antineoplastic Agents; Cell Survival; Coumarins; Cytarabine; Cytotoxicity Tests, Immunologic; Daunorubicin; DNA, Antisense; Edetic Acid; Etoposide; Flow Cytometry; Granzymes; HeLa Cells; Humans; Isocoumarins; Jurkat Cells; K562 Cells; Leukemia, Myeloid, Acute; Magnesium Chloride; Membrane Glycoproteins; Perforin; Pore Forming Cytotoxic Proteins; Serine Endopeptidases; Tumor Cells, Cultured; U937 Cells | 2000 |
Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis.
Topics: Animals; Apoptosis; Behavior, Animal; Brain Injuries; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Coumarins; Culture Media, Serum-Free; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Isocoumarins; Male; Motor Activity; Neurons; Nucleic Acid Synthesis Inhibitors; Potassium; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Serine Proteinase Inhibitors; Spatial Behavior; Staurosporine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Wounds, Nonpenetrating | 2001 |
Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Membrane; Cells, Cultured; CHO Cells; Coumarins; Cricetinae; Endopeptidases; Endothelium, Vascular; Epitopes; Humans; Isocoumarins; Kinetics; Peptidyl-Dipeptidase A; Recombinant Proteins; Serine Proteinase Inhibitors; Transfection; Umbilical Veins | 2002 |
Dipeptidyl peptidase with strict substrate specificity of an anaerobic periodontopathogen Porphyromonas gingivalis.
Topics: Alanine; Anaerobiosis; Bacterial Proteins; Cations, Divalent; Coumarins; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Inhibitors; Hydrogen-Ion Concentration; Isocoumarins; Isoelectric Point; Isoflurophate; Molecular Weight; Porphyromonas gingivalis; Prevotella; Prevotella intermedia; Serine Proteinase Inhibitors; Species Specificity; Substrate Specificity | 2002 |
Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.
Topics: Amino Acid Sequence; Aspartic Acid Endopeptidases; Cacao; Cloning, Molecular; Coumarins; DNA, Complementary; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydrogen-Ion Concentration; Isocoumarins; Isoenzymes; Leucine; Molecular Sequence Data; Pepstatins; Phylogeny; Plant Proteins; RNA, Messenger; Seeds; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Yarrowia | 2002 |
Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells.
Topics: Antineoplastic Agents, Hormonal; Apoptosis; Coumarins; Dexamethasone; Gene Expression Profiling; Genes, bcl-2; Glucocorticoids; Granzymes; Humans; Isocoumarins; Leukemia, B-Cell; Models, Biological; RNA, Messenger; Serine Endopeptidases; Serine Proteinase Inhibitors; Transfection; Tumor Cells, Cultured | 2003 |
Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes.
Topics: Animals; Annexins; Calcium; Caspases; Cell Death; Cell Size; Ceramides; Coumarins; Erythrocytes; Fumonisins; Humans; Ionomycin; Isocoumarins; Mice; Mice, Knockout; Osmotic Pressure; Protein Binding; Sphingomyelin Phosphodiesterase; Sphingomyelins | 2004 |
The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability.
Topics: Apoptosis; Caspase Inhibitors; Cell Line, Transformed; Coumarins; Cysteine Proteinase Inhibitors; Cytotoxicity Tests, Immunologic; fas Receptor; Humans; Intracellular Membranes; Isocoumarins; Macrolides; Mitochondria; Oligopeptides; Permeability; Receptors, Tumor Necrosis Factor; Signal Transduction; T-Lymphocytes, Cytotoxic | 2005 |
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.
Topics: Animals; Biotinylation; CHO Cells; Coumarins; Cricetinae; Cricetulus; Enzyme Inhibitors; Humans; Immunohistochemistry; Isocoumarins; Macrolides; Mutation; Plasmids; Protease Inhibitors; Receptors, LDL; Sulfones; Transfection | 2009 |
Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.
Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Apoptosis; Caspase 6; Caspase 9; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Coumarins; Endoplasmic Reticulum; Enzyme Activation; Fatty Acid Synthase, Type I; Female; Humans; Isocoumarins; Liposarcoma; Metalloendopeptidases; Mice; Mice, SCID; Nelfinavir; Neoplasm Transplantation; Phenanthrolines; Proprotein Convertases; Protease Inhibitors; Protein Transport; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Serine Endopeptidases; Sterol Regulatory Element Binding Protein 1; Transcription, Genetic; Transplantation, Heterologous; Tumor Burden | 2011 |
Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing.
Topics: Animals; Antibodies, Blocking; Cell Line; Coumarins; Culture Media, Conditioned; Endopeptidases; Humans; Isocoumarins; Keratinocytes; Mice; Mice, Inbred C57BL; Recombinant Proteins; RNA, Small Interfering; Serine Endopeptidases; Serine Proteases; Serine Proteinase Inhibitors; Skin; Thrombomodulin; Wound Healing | 2011 |
Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3,4-dichloroisocoumarin.
Topics: Coumarins; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Extracellular Space; Isocoumarins; Lipase; Streptomyces | 2011 |
Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate.
Topics: Bacterial Proteins; Coumarins; Crystallography, X-Ray; Isocoumarins; Isoflurophate; Models, Molecular; Peptide Hydrolases; Protease Inhibitors; Protein Structure, Secondary; Protein Structure, Tertiary; Providencia | 2012 |
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.
Topics: Biglycan; Biocatalysis; Blotting, Western; Cells, Cultured; Coumarins; Decorin; Extracellular Matrix; Extracellular Space; Granzymes; Humans; Isocoumarins; Kinetics; Muscle, Smooth, Vascular; Phosphorylation; Proteoglycans; Receptors, Transforming Growth Factor beta; Serine Proteinase Inhibitors; Smad3 Protein; Solubility; Substrate Specificity; Transforming Growth Factor beta1 | 2012 |
Granule exocytosis mediates immune surveillance of senescent cells.
Topics: Animals; Apoptosis; beta-Galactosidase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cellular Senescence; Coumarins; Cytoplasmic Granules; Enzyme Inhibitors; Exocytosis; Extracellular Matrix Proteins; Hepatic Stellate Cells; Humans; Immunologic Surveillance; Isocoumarins; Killer Cells, Natural; Liver; Liver Cirrhosis; Macrolides; Mice; Mice, Inbred C57BL; Mice, Knockout; Perforin; RNA Interference; RNA, Small Interfering; Serine Proteinase Inhibitors; Tumor Necrosis Factor Decoy Receptors | 2013 |
Inhibition of extracellular lipase from Streptomyces rimosus with 3,4-dichloroisocoumarin.
Topics: Coumarins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Isocoumarins; Lipase; Molecular Structure; Streptomyces; Structure-Activity Relationship | 2013 |
Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing.
Topics: Bacterial Proteins; Coumarins; Escherichia coli Proteins; Inhibitory Concentration 50; Isocoumarins; Models, Biological; Models, Molecular; Protease Inhibitors; Protein Array Analysis; Small Molecule Libraries; Substrate Specificity | 2015 |
A metal-free one-pot synthesis of benzo[c]chromen-6-ones from 3,4-dichlorocoumarins and butadienes using tandem photo-thermal-photo reactions.
Topics: Benzopyrans; Butadienes; Chemistry Techniques, Synthetic; Coumarins; Isocoumarins; Photochemical Processes; Temperature | 2016 |
Reduced expression of a rhomboid protease, EhROM1, correlates with changes in the submembrane distribution and size of the Gal/GalNAc lectin subunits in the human protozoan parasite, Entamoeba histolytica.
Topics: Acetylgalactosamine; Entamoeba histolytica; Galactose; Gene Expression Regulation; Host-Parasite Interactions; Isocoumarins; Lectins; Membrane Microdomains; Peptide Hydrolases; Protein Multimerization; Protein Subunits; Protozoan Proteins; RNA Interference | 2020 |