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isocoumarins and 3,4-dichloroisocoumarin

isocoumarins has been researched along with 3,4-dichloroisocoumarin in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.60)18.7374
1990's51 (66.23)18.2507
2000's14 (18.18)29.6817
2010's9 (11.69)24.3611
2020's1 (1.30)2.80

Authors

AuthorsStudies
Hecker, M; Kaw, S; Southan, GJ; Vane, JR; Warner, TD1
Baumeister, W; Dahlmann, B; Grziwa, A; Kuehn, L; Zwickl, P1
Djaballah, H; Harness, JA; Rivett, AJ; Savory, PJ1
Cardozo, C; Hidalgo, MC; Michaud, C; Orlowski, M; Vinitsky, A1
Margolis, JW; Nguyen, T; Pereira, ME; Wagner, BJ; Wilk, S; Yu, B1
Djaballah, H; Rivett, AJ1
Aebersold, R; Greenberg, AH; Kraut, RP; Shi, L1
Mason, RW1
Beynon, RJ; Rusbridge, NM1
Michaud, C; Orlowski, M1
Harper, JW; Hemmi, K; Powers, JC1
Enghild, JJ; Pizzo, SV; Thøgersen, IB; Valnickova, Z1
Clemmons, DR; Gockerman, A1
Chow, SC; Eriksson, JE; Holmström, TH; Kass, GE; Orrenius, S; Weis, M1
Anees, M; Steven, FS1
Cardozo, C; Eleuteri, AM; Orlowski, M1
Guesdon, F; Haskill, S; Ikebe, T; Saklatvala, J; Stylianou, E; Warwick-Davies, J1
Baumeister, W; Huber, R; Löwe, J; Lupas, A; Seemüller, E; Stock, D1
Atkinson, EA; Bleackley, RC; Helgason, CD; Pinkoski, MJ1
Christensen, S; Enghild, JJ; Nielsen, HR; Pizzo, SV; Roepstorff, P; Thøgersen, IB; Valnickova, Z1
Parent, D; Remold-O'Donnell, E1
Bast, RC; Becherer, JD; Boyer, CM; Champion, B; Connolly, KM; Conway, JG; Furdon, P; Karp, S; Kidao, S; McGeehan, GM1
Bochan, MR; Brahmi, Z; Froelich, CJ; Hanna, WL; Su, B1
Strobl, B; Vlasak, R1
Cardozo, C; Michaud, C; Orlowski, M2
Megyeri, P; Pabst, KM; Pabst, MJ1
Busse, R; Hecker, M; Preiss, C; Schini-Kerth, VB1
Fagan, JM; Strack, PR; Waxman, L1
Schnellmann, RG; Yang, X1
Ito, K; Kabashima, T; Kitano, A; Kitazono, A; Yoshimoto, T1
Lu, Q; Mellgren, RL1
Colas, B; Durand, P; Roy, P1
Brodsky, JL; McCracken, AA; Werner, ED1
Björk, I; Olson, ST; Patston, PA; Swanson, R1
Bettaïeb, A; Jaffrézou, JP; Laurent, G; Levade, T; Mansat, V1
Bisogni, R; Bonelli, P; Cerra, M; Ferrone, S; Lamberti, A; Petrella, A; Romano, MF; Sun, SC; Turco, MC; Venuta, S1
Pommier, Y; Shimizu, T1
Bochan, MR; Brahmi, Z; Froelich, CJ; Goebel, WS; Hommel-Berrey, GA; Montel, AH1
Cardozo, C; Eleuteri, AM; Kam, CM; Kohanski, R; Orlowski, M; Powers, JC1
Cao, CX; Pommier, Y; Shao, RG; Shimizu, T1
Hintze, TH; Nasjletti, A; Xu, X; Zhang, X1
Barczak, AK; Coyle, JT; Luthi-Carter, R; Speno, H1
Elia, G; Rossi, A; Santoro, MG1
Deeg, M; Dick, TP; Groll, M; Heinemeyer, W; Huber, R; Keilholz, W; Nussbaum, AK; Rammensee, HG; Schild, H; Schirle, M; Stevanović, S; Wolf, DH1
Babu, YS; Jing, H; Kilpatrick, JM; Liu, XY; Moore, D; Narayana, SV; Volanakis, JE1
Babu, YS; Chu, N; Cole, LB; Kilpatrick, JM1
Aslam, U; Hameed, A; Ying, AJ1
Honda, T; Mercken, M; Murayama, M; Murayama, O; Nihonmatsu, N; Omori, A; Saido, TC; Sato, K; Takahashi, H; Takashima, A; Tsubuki, S; Yasutake, K1
Conseil, V; Dubremetz, JF; Soête, M1
Alexanian, AR; Bamburg, JR1
Deutschländer, N; Fink, E; Heitsch, H; Rudolphi, K; Wiemer, G; Wirth, KJ1
Angeletti, M; Bini, L; Eleuteri, AM; Fioretti, E; Lupidi, G; Tacconi, R1
Addonizio, L; Gersony, WM; Hintze, TH; Loke, KE; Mital, S; Slater, JP1
Altschuller-Felberg, C; Cardozo, C; Loukissa, A; Nelson, JE1
Bogyo, M; Lemberg, MK; Martoglio, B; Ploegh, HL; Weihofen, A1
Hasegawa, N; Kimura, Y; Komatsu, N; Muramatsu, T; Oda, T1
Bruno, AP; d'Orgeix, AT; Laurent, G; Lautier, D; Quillet-Mary, A1
Faden, AI; Fan, L; Movsesyan, VA; Yakovlev, AG1
Albrecht, RF; Balyasnikova, IV; Danilov, SM; Karran, EH1
Reboud-Ravaux, M1
Fujimura, S; Hirai, K; Shibata, Y1
Bucheli, P; Gysler, C; Laloi, M; McCarthy, J; Morandi, O1
Hirasawa, A; Shiojima, S; Tsujimoto, G; Yamada, M1
Berchtold, S; Brand, V; Huber, SM; Lang, F; Lang, KS; Lang, PA; Myssina, S; Sandu, C; Wieder, T1
Finke, J; Grüllich, C; McGoldrick, S; Zeiser, R1
Berge, KE; Kulseth, MA; Leren, TP; Ranheim, T; Tveten, K1
Chow, WA; Fousek, K; Guan, M; Guo, S; Jiang, C; Shih, CC; Synold, T; Xi, B1
Chang, BI; Chen, WS; Cheng, TL; Hsu, FC; Lai, CH; Lin, HY; Liu, SK; Shi, GY; Wu, HL; Wu, YT1
Ašler, IL; Luić, M; Pigac, J; Štefanić, Z; Vujaklija, D1
Ha, Y; Xue, Y1
Boivin, WA; Granville, DJ; Hackett, TL; Knight, DA; Shackleford, M; Vanden Hoek, A; Zhao, H1
Biran, A; Krizhanovsky, V; Lowe, SW; Sagiv, A; Simon, J; Yon, M1
Allmaier, G; Ašler, IL; Kojić-Prodić, B; Kovačić, F; Marchetti-Deschmann, M; Stefanić, Z1
Verhelst, SH; Wolf, EV; Zeissler, A1
Huang, N; Tian, Y; Wang, J; Xiang, P; Xu, JH; Zhang, M; Zhang, Y1
Temesvari, LA; Walters, HA; Welter, BH1

Reviews

1 review(s) available for isocoumarins and 3,4-dichloroisocoumarin

ArticleYear
Proteasome inhibitors.
    Progress in molecular and subcellular biology, 2002, Volume: 29

    Topics: Acetylcysteine; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Hydrolysis; Inflammation; Isocoumarins; Macromolecular Substances; Molecular Weight; Multienzyme Complexes; Neoplasms; Peptides; Proteasome Endopeptidase Complex; Substrate Specificity

2002

Other Studies

76 other study(ies) available for isocoumarins and 3,4-dichloroisocoumarin

ArticleYear
Characterization of serine protease-derived metabolites of big endothelin in the cytosolic fraction from human polymorphonuclear leukocytes.
    Journal of cardiovascular pharmacology, 1992, Volume: 20 Suppl 12

    Topics: Cathepsin G; Cathepsins; Chromatography, High Pressure Liquid; Coumarins; Cytosol; Endothelin-1; Endothelins; Glycine; Humans; Isocoumarins; Leukocyte Elastase; Mass Spectrometry; Neutrophils; Pancreatic Elastase; Protein Precursors; Serine Endopeptidases; Sulfonamides

1992
Biochemical properties of the proteasome from Thermoplasma acidophilum.
    European journal of biochemistry, 1992, Sep-15, Volume: 208, Issue:3

    Topics: Amino Acid Sequence; Cations, Divalent; Cations, Monovalent; Coumarins; Cysteine Endopeptidases; Enzyme Activation; Hydrogen-Ion Concentration; Isocoumarins; Isoelectric Point; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Serpins; Temperature; Thermoplasma

1992
Use of serine-protease inhibitors as probes for the different proteolytic activities of the rat liver multicatalytic proteinase complex.
    European journal of biochemistry, 1992, Oct-15, Volume: 209, Issue:2

    Topics: Amino Acid Sequence; Animals; Coumarins; Cysteine Endopeptidases; Isocoumarins; Isoflurophate; Kinetics; Liver; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Substrate Specificity; Trypsin

1992
A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex.
    Biochemistry, 1992, Aug-18, Volume: 31, Issue:32

    Topics: Amino Acid Sequence; Animals; Cattle; Coumarins; Cysteine Endopeptidases; Drug Resistance; Isocoumarins; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Pituitary Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Substrate Specificity

1992
3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex.
    The Journal of biological chemistry, 1992, Apr-15, Volume: 267, Issue:11

    Topics: Amino Acid Sequence; Animals; Binding Sites; Caseins; Catalysis; Cattle; Chromatography, Gel; Coumarins; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Hydrolysis; Isocoumarins; Molecular Sequence Data; Multienzyme Complexes; Phosphorylation; Pituitary Gland; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors

1992
Peptidylglutamyl-peptide hydrolase activity of the multicatalytic proteinase complex: evidence for a new high-affinity site, analysis of cooperative kinetics, and the effect of manganese ions.
    Biochemistry, 1992, Apr-28, Volume: 31, Issue:16

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cations, Divalent; Coumarins; Cysteine Endopeptidases; Enzyme Stability; Hot Temperature; Hydrogen-Ion Concentration; Isocoumarins; Liver; Metals; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Potassium Chloride; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Rats, Inbred Strains

1992
A natural killer cell granule protein that induces DNA fragmentation and apoptosis.
    The Journal of experimental medicine, 1992, Feb-01, Volume: 175, Issue:2

    Topics: Amino Acid Sequence; Animals; Calcium; Cell Death; Chromatography, Gel; Coumarins; Deoxyribonucleases; DNA Damage; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Granzymes; Isocoumarins; Killer Cells, Natural; Molecular Sequence Data; Rats; Rats, Inbred F344; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Tumor Cells, Cultured

1992
Characterization of the active site of human multicatalytic proteinase.
    The Biochemical journal, 1990, Jan-15, Volume: 265, Issue:2

    Topics: Amino Acid Sequence; Binding Sites; Chromatography, Ion Exchange; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diazomethane; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Isocoumarins; Isoflurophate; Kinetics; Liver; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Sulfhydryl Reagents

1990
3,4-Dichloroisocoumarin, a serine protease inhibitor, inactivates glycogen phosphorylase b.
    FEBS letters, 1990, Jul-30, Volume: 268, Issue:1

    Topics: Animals; Coumarins; In Vitro Techniques; Isocoumarins; Muscles; Phosphorylases; Rabbits; Serine Proteinase Inhibitors

1990
Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity.
    Biochemistry, 1989, Nov-28, Volume: 28, Issue:24

    Topics: Amino Acid Sequence; Animals; Cattle; Chymotrypsin; Coumarins; Cysteine Endopeptidases; Endopeptidases; Enzyme Activation; Fatty Acids; Heparin; Immune Sera; Isocoumarins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Phosphorylation; Pituitary Gland; Proteasome Endopeptidase Complex; Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Sodium Dodecyl Sulfate; Substrate Specificity; Trypsin

1989
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
    Biochemistry, 1985, Apr-09, Volume: 24, Issue:8

    Topics: Animals; Blood Coagulation Factors; Cattle; Coumarins; Humans; Isocoumarins; Kinetics; Leukocytes; Mast Cells; Models, Chemical; Pancreatic Elastase; Protease Inhibitors; Rats; Serine Endopeptidases; Structure-Activity Relationship; Swine

1985
Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors.
    The Journal of biological chemistry, 1994, Aug-05, Volume: 269, Issue:31

    Topics: alpha-2-Antiplasmin; Amino Acid Sequence; Animals; Chymotrypsin; Coumarins; Endopeptidases; Enzyme Stability; Humans; Isocoumarins; Leukocyte Elastase; Mice; Molecular Sequence Data; Pancreatic Elastase; Protein Conformation; Receptors, Cell Surface; Serpins; Thermodynamics

1994
Porcine aortic smooth muscle cells secrete a serine protease for insulin-like growth factor binding protein-2.
    Circulation research, 1995, Volume: 76, Issue:4

    Topics: Animals; Aorta; Aprotinin; Arteriosclerosis; Carrier Proteins; Cells, Cultured; Chromatography; Coumarins; Culture Media; Edetic Acid; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isocoumarins; Muscle, Smooth, Vascular; Peptide Hydrolases; Serine Endopeptidases; Serine Proteinase Inhibitors; Somatomedins; Swine

1995
Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes.
    FEBS letters, 1995, May-08, Volume: 364, Issue:2

    Topics: Antigens, Surface; Apoptosis; Caspase 1; Cell Line; Cell Nucleus; Cell-Free System; Coumarins; Cysteine Endopeptidases; Endopeptidases; fas Receptor; Humans; Isocoumarins; T-Lymphocytes; Tosylphenylalanyl Chloromethyl Ketone

1995
Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine-isethionate and guanidino derivatives.
    Journal of enzyme inhibition, 1994, Volume: 8, Issue:3

    Topics: Benzoates; Binding, Competitive; Carboxylic Ester Hydrolases; Carcinoma, Squamous Cell; Cell Membrane; Coumarins; Dexamethasone; Endopeptidases; Guanidines; Humans; Isocoumarins; Kinetics; Lung Neoplasms; Medroxyprogesterone; Microscopy, Fluorescence; Pentamidine; Protease Inhibitors; Sodium Dodecyl Sulfate; Sulfaguanidine

1994
Differences in catalytic activities and subunit pattern of multicatalytic proteinase complexes (proteasomes) isolated from bovine pituitary, lung, and liver. Changes in LMP7 and the component necessary for expression of the chymotrypsin-like activity.
    The Journal of biological chemistry, 1995, Sep-22, Volume: 270, Issue:38

    Topics: Amino Acid Sequence; Animals; Catalysis; Cattle; Chymotrypsin; Coumarins; Cysteine Endopeptidases; Isocoumarins; Liver; Lung; Molecular Sequence Data; Multienzyme Complexes; Pituitary Gland; Proteasome Endopeptidase Complex; Proteins

1995
Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor kappa B of HeLa cells. Interference in signalling by the proteinase inhibitors 3,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone.
    The Biochemical journal, 1995, Apr-01, Volume: 307 ( Pt 1)

    Topics: Base Sequence; Chromatography, Ion Exchange; Coumarins; DNA-Binding Proteins; Heat-Shock Proteins; HeLa Cells; Humans; I-kappa B Proteins; Interleukin-1; Isocoumarins; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Serine Proteinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Transcription Factor RelB; Transcription Factors

1995
Proteasome from Thermoplasma acidophilum: a threonine protease.
    Science (New York, N.Y.), 1995, Apr-28, Volume: 268, Issue:5210

    Topics: Amino Acid Sequence; Archaeal Proteins; Binding Sites; Coumarins; Endopeptidases; Hydrogen-Ion Concentration; Isocoumarins; Molecular Sequence Data; Mutagenesis; Protein Folding; Sequence Alignment; Serine Proteinase Inhibitors; Thermoplasma

1995
Proteinases are involved in both DNA fragmentation and membrane damage during CTL-mediated target cell killing.
    Experimental cell research, 1995, Volume: 218, Issue:1

    Topics: Animals; Arginine; Aurintricarboxylic Acid; Cells, Cultured; Coumarins; Cytotoxicity, Immunologic; DNA; Endopeptidases; Isocoumarins; Kinetics; Mast-Cell Sarcoma; Mice; Mice, Inbred BALB C; Protease Inhibitors; Substrate Specificity; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Tyrosine

1995
Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop.
    The Journal of biological chemistry, 1995, Jun-23, Volume: 270, Issue:25

    Topics: Animals; Binding Sites; Coumarins; Electrophoresis, Polyacrylamide Gel; Isocoumarins; Kinetics; Protein Binding; Protein Structure, Secondary; Serine; Serine Proteinase Inhibitors; Serpins; Sodium Dodecyl Sulfate; Swine; Trypsin

1995
Downregulation of neutrophil CD43 by opsonized zymosan.
    Blood, 1995, Jan-15, Volume: 85, Issue:2

    Topics: Antigens, CD; Coumarins; Down-Regulation; Endopeptidases; Humans; Isocoumarins; Isoflurophate; Leukosialin; Neutrophils; Opsonin Proteins; Respiratory Burst; Sialoglycoproteins; Sulfones; Superoxides; Tetradecanoylphorbol Acetate; Zymosan

1995
Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor.
    Nature, 1994, Aug-18, Volume: 370, Issue:6490

    Topics: Animals; Cell Line; Coumarins; Female; Humans; Interleukins; Isocoumarins; Macrophages; Metalloendopeptidases; Mice; Mice, Inbred C3H; Monocytes; Phenylalanine; Protein Processing, Post-Translational; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1994
Human granzyme B is essential for DNA fragmentation of susceptible target cells.
    European journal of immunology, 1994, Volume: 24, Issue:9

    Topics: Animals; Aurintricarboxylic Acid; Blotting, Northern; Blotting, Western; Cell Survival; Chymases; Coumarins; Cytoplasmic Granules; Cytotoxicity, Immunologic; DNA; Egtazic Acid; Granzymes; Humans; Isocoumarins; Killer Cells, Natural; Mice; Serine Endopeptidases; Sulfones; Tumor Cells, Cultured

1994
The receptor-destroying enzyme of influenza C virus is required for entry into target cells.
    Virology, 1993, Volume: 192, Issue:2

    Topics: Acetylesterase; Animals; Blotting, Northern; Cell Line; Coumarins; Dogs; Gammainfluenzavirus; Hemagglutinins, Viral; Hemolysis; Humans; Influenza A virus; Isocoumarins; Isoflurophate; Kidney; Kinetics; RNA, Viral; Serine Proteinase Inhibitors; Viral Fusion Proteins; Viral Proteins

1993
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.
    Biochemistry, 1993, Feb-16, Volume: 32, Issue:6

    Topics: Amino Acid Sequence; Animals; Calcium; Cattle; Chymotrypsin; Coumarins; Cysteine Endopeptidases; Isocoumarins; Kinetics; Lauric Acids; Magnesium; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Pituitary Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Sodium Dodecyl Sulfate; Substrate Specificity; Trypsin

1993
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide.
    Immunology, 1995, Volume: 86, Issue:4

    Topics: Cell Culture Techniques; Coumarins; Dose-Response Relationship, Drug; Humans; Isocoumarins; Kinetics; Lipopolysaccharides; Monocytes; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Superoxides; Tumor Necrosis Factor-alpha

1995
Antioxidants differentially affect nuclear factor kappa B-mediated nitric oxide synthase expression in vascular smooth muscle cells.
    FEBS letters, 1996, Feb-19, Volume: 380, Issue:3

    Topics: Animals; Antioxidants; Aorta, Thoracic; Base Sequence; Cells, Cultured; Chromonar; Coumarins; DNA; Flavonoids; Gene Expression; Isocoumarins; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide Synthase; Rats; Rats, Wistar; Serotonin

1996
Activation of the multicatalytic endopeptidase by oxidants. Effects on enzyme structure.
    Biochemistry, 1996, Jun-04, Volume: 35, Issue:22

    Topics: Amino Acid Sequence; Animals; Chickens; Chloromercuribenzoates; Coumarins; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; Hydrogen Peroxide; Hydrolysis; Iron; Isocoumarins; Male; Molecular Sequence Data; Multienzyme Complexes; Oxidants; p-Chloromercuribenzoic Acid; Peptides; Proteasome Endopeptidase Complex; Protein Conformation; Proteins; Serine Proteinase Inhibitors

1996
Proteinases in renal cell death.
    Journal of toxicology and environmental health, 1996, Volume: 48, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antipain; Carboxypeptidases; Cathepsin A; Cathepsin B; Cell Death; Coumarins; Cysteine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Hydrocarbons, Fluorinated; Hydroquinones; Isocoumarins; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Membrane Potentials; Pepstatins; Peroxides; Rabbits; Reactive Oxygen Species; Serine Proteinase Inhibitors; tert-Butylhydroperoxide; Tosyllysine Chloromethyl Ketone

1996
Prolyl aminopeptidase is also present in Enterobacteriaceae: cloning and sequencing of the Hafnia alvei enzyme-gene and characterization of the expressed enzyme.
    Journal of biochemistry, 1996, Volume: 119, Issue:3

    Topics: Aeromonas; Amino Acid Sequence; Aminopeptidases; Bacillus; Base Sequence; Chloromercuribenzoates; Cloning, Molecular; Coumarins; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Enterobacteriaceae; Gene Expression Regulation, Enzymologic; Isocoumarins; Lactobacillus; Molecular Sequence Data; Neisseria; Open Reading Frames; p-Chloromercuribenzoic Acid; Restriction Mapping; Substrate Specificity

1996
Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells.
    Archives of biochemistry and biophysics, 1996, Oct-01, Volume: 334, Issue:1

    Topics: Apoptosis; Calpain; Coumarins; Cycloheximide; Cysteine Proteinase Inhibitors; Diazomethane; HL-60 Cells; Humans; Isocoumarins; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors

1996
Purification, kinetical and molecular characterizations of a serine collagenolytic protease from greenshore crag (Carcinus maenas) digestive gland.
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 1996, Volume: 115, Issue:1

    Topics: alpha 1-Antitrypsin; Amino Acid Sequence; Animals; Brachyura; Coumarins; Digestive System; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Isocoumarins; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Oligopeptides; Serine Proteinase Inhibitors; Tosyl Compounds; Trypsin Inhibitor, Bowman-Birk Soybean

1996
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Nov-26, Volume: 93, Issue:24

    Topics: Acetylcysteine; Adenosine Triphosphate; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Fungal Proteins; Genes, Fungal; Isocoumarins; Kinetics; Microsomes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity

1996
Apparent formation of sodium dodecyl sulfate-stable complexes between serpins and 3,4-dichloroisocoumarin-inactivated proteinases is due to regeneration of active proteinase from the inactivated enzyme.
    The Journal of biological chemistry, 1997, May-16, Volume: 272, Issue:20

    Topics: Animals; Cattle; Coumarins; Endopeptidases; Enzyme Activation; Humans; Isocoumarins; Serine Proteinase Inhibitors; Serpins; Sodium Dodecyl Sulfate

1997
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1997, Volume: 11, Issue:8

    Topics: Antibiotics, Antineoplastic; Antipain; Apoptosis; Ceramides; Coumarins; Daunorubicin; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Hydrolysis; Isocoumarins; Leupeptins; NF-kappa B; Pepstatins; Protease Inhibitors; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tosylphenylalanyl Chloromethyl Ketone; Tumor Cells, Cultured

1997
Induction of nuclear factor kappa B/Rel nuclear activity in human peripheral blood T lymphocytes by anti-HLA class I monoclonal antibodies.
    Tissue antigens, 1997, Volume: 50, Issue:1

    Topics: Animals; Antibodies, Monoclonal; COS Cells; Coumarins; Gene Expression Regulation; Histocompatibility Antigens Class I; Humans; Isocoumarins; Kinetics; NF-kappa B; NF-kappa B p50 Subunit; Nuclear Proteins; Rabbits; Serine Proteinase Inhibitors; T-Lymphocytes; Transcription Factor RelA

1997
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases.
    Leukemia, 1997, Volume: 11, Issue:8

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Camptothecin; Caspase 3; Caspases; Cell Nucleus; Cell-Free System; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Gene Deletion; Genes, p53; HL-60 Cells; Humans; Isocoumarins; Lamin Type B; Lamins; Nuclear Proteins; Poly Adenosine Diphosphate Ribose; Prodrugs; Serine Endopeptidases; Serine Proteinase Inhibitors; Tumor Suppressor Protein p53

1997
Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
    Cellular immunology, 1997, Aug-25, Volume: 180, Issue:1

    Topics: Apoptosis; Cells, Cultured; Coumarins; Cytotoxicity, Immunologic; DNA Damage; Granzymes; Humans; Isocoumarins; Killer Cells, Lymphokine-Activated; Membrane Glycoproteins; Perforin; Pore Forming Cytotoxic Proteins; RNA, Messenger; RNA, Viral; Serine Endopeptidases; Serine Proteinase Inhibitors; Vesicular stomatitis Indiana virus; Virus Cultivation

1997
Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes).
    Biochemistry, 1997, Nov-11, Volume: 36, Issue:45

    Topics: Animals; Carbon Radioisotopes; Catalysis; Cattle; Coumarins; Cysteine Endopeptidases; Isocoumarins; Multienzyme Complexes; Pituitary Gland; Proteasome Endopeptidase Complex; Proteins; Serine Proteinase Inhibitors; Spleen; Viral Matrix Proteins

1997
Lamin B phosphorylation by protein kinase calpha and proteolysis during apoptosis in human leukemia HL60 cells.
    The Journal of biological chemistry, 1998, Apr-10, Volume: 273, Issue:15

    Topics: Amino Acid Sequence; Apoptosis; Camptothecin; Cell Nucleus; Coumarins; Cytosol; DNA Fragmentation; HL-60 Cells; Humans; Isocoumarins; Isoenzymes; Kinetics; Lamin Type B; Lamins; Molecular Sequence Data; Nuclear Proteins; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Structure, Secondary; Serine Proteinase Inhibitors; Time Factors; Topoisomerase I Inhibitors; Tumor Suppressor Protein p53

1998
Neutral endopeptidase and angiotensin-converting enzyme inhibitors increase nitric oxide production in isolated canine coronary microvessels by a kinin-dependent mechanism.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:4

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Coronary Vessels; Coumarins; Dogs; Drug Interactions; Glycopeptides; In Vitro Techniques; Isocoumarins; Neprilysin; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Protease Inhibitors; Ramipril; Serine Proteinase Inhibitors; Thiorphan

1998
Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.
    Brain research, 1998, Jun-08, Volume: 795, Issue:1-2

    Topics: Animals; Antigens, Surface; Binding, Competitive; Carboxypeptidases; Chelating Agents; Cloning, Molecular; Cobalt; Coumarins; Dipeptides; Edetic Acid; Folic Acid; Glutamate Carboxypeptidase II; Histamine H1 Antagonists; Humans; Hydrolysis; Isocoumarins; Kinetics; Leucine; Male; Neuropeptides; Pepstatins; Phenanthrolines; Prostatic Neoplasms; Protease Inhibitors; Rats; Serine Proteinase Inhibitors; Substrate Specificity; Synaptic Transmission; Tumor Cells, Cultured

1998
Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition.
    The Journal of biological chemistry, 1998, Jun-26, Volume: 273, Issue:26

    Topics: Coumarins; DNA; DNA-Binding Proteins; Down-Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Humans; Isocoumarins; Jurkat Cells; NF-kappa B; Serine Proteinase Inhibitors; Transcription Factors

1998
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants.
    The Journal of biological chemistry, 1998, Oct-02, Volume: 273, Issue:40

    Topics: Acetylcysteine; Amino Acid Sequence; Animals; Coumarins; Cysteine Endopeptidases; Fluorescence; Fungal Proteins; Histocompatibility Antigens Class I; Isocoumarins; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Vertebrates

1998
Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
    Journal of molecular biology, 1998, Oct-09, Volume: 282, Issue:5

    Topics: Binding Sites; Complement Factor D; Coumarins; Crystallography, X-Ray; Enzyme Inhibitors; Histidine; Isocoumarins; Models, Molecular; Oxazines; Protein Conformation; Serine Endopeptidases; Serine Proteinase Inhibitors; Water

1998
Structure of 3,4-dichloroisocoumarin-inhibited factor D.
    Acta crystallographica. Section D, Biological crystallography, 1998, Sep-01, Volume: 54, Issue:Pt 5

    Topics: Animals; Benzoxazines; Carbamates; Complement Factor D; Complement Pathway, Alternative; Coumarins; Crystallization; Crystallography, X-Ray; Humans; Isocoumarins; Models, Molecular; Molecular Sequence Data; Oxazines; Pancreatic Elastase; Protein Conformation; Serine Proteinase Inhibitors; Swine

1998
3,4-Dichloroisocoumarin serine protease inhibitor induces DNA fragmentation and apoptosis in susceptible target cells.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1998, Volume: 219, Issue:2

    Topics: 3T3 Cells; Animals; Apoptosis; Coumarins; DNA Damage; Humans; Isocoumarins; Killer Cells, Lymphokine-Activated; Mice; Microscopy, Electron; Serine Proteinase Inhibitors

1998
Dual roles of proteasome in the metabolism of presenilin 1.
    Journal of neurochemistry, 1999, Volume: 72, Issue:1

    Topics: Acetylcysteine; Alzheimer Disease; Amino Acid Sequence; Brain Chemistry; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glycoproteins; Humans; Isocoumarins; Kidney; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Mutation; Neuroblastoma; Peptide Fragments; Precipitin Tests; Presenilin-1; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Sulfones; Trypsin Inhibitors; Tumor Cells, Cultured

1999
Serine protease inhibitors block invasion of host cells by Toxoplasma gondii.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:6

    Topics: Animals; Chlorocebus aethiops; Coumarins; Isocoumarins; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfones; Toxoplasma; Vero Cells

1999
Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues.
    Biochemistry, 1999, Jul-27, Volume: 38, Issue:30

    Topics: Acetylcysteine; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Cattle; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Hydrolysis; Insulin; Isocoumarins; Kinetics; Lactams; Molecular Sequence Data; Multienzyme Complexes; Pituitary Gland; Proteasome Endopeptidase Complex

1999
Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:12

    Topics: Animals; Antioxidants; Brain Chemistry; Calcineurin Inhibitors; Calcium-Binding Proteins; Cattle; Cell Nucleus; Cell Survival; Cells, Cultured; Chick Embryo; Coumarins; Cyclosporine; Dexamethasone; Dimerization; Immunophilins; Immunosuppressive Agents; Isocoumarins; Macromolecular Substances; Nerve Growth Factors; Neurons; NF-kappa B; Prosencephalon; Pyrethrins; Pyrrolidines; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serine Proteinase Inhibitors; Sirolimus; Tacrolimus; Thiocarbamates

1999
Amyloid beta-(1-40) stimulates cyclic GMP production via release of kinins in primary cultured endothelial cells.
    European journal of pharmacology, 1999, Oct-01, Volume: 382, Issue:1

    Topics: Amyloid beta-Peptides; Animals; Aorta; Bradykinin; Bradykinin Receptor Antagonists; Cattle; Cells, Cultured; Coronary Vessels; Coumarins; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Isocoumarins; Kallikreins; Kinins; Microcirculation; Microscopy, Electron; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Rats; Serine Proteinase Inhibitors

1999
Isolation and characterization of bovine thymus multicatalytic proteinase complex.
    Protein expression and purification, 2000, Volume: 18, Issue:2

    Topics: Animals; Blotting, Western; Cattle; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Gel, Two-Dimensional; Isocoumarins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Spleen; Thymus Gland

2000
Synergy of amlodipine and angiotensin-converting enzyme inhibitors in regulating myocardial oxygen consumption in normal canine and failing human hearts.
    The American journal of cardiology, 1999, Jun-17, Volume: 83, Issue:12A

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Calcium Channel Blockers; Child; Coumarins; Dogs; Drug Synergism; Drug Therapy, Combination; Female; Heart Failure; Humans; Isocoumarins; Male; Middle Aged; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxygen Consumption; Penicillamine; Ramipril; Serine Proteinase Inhibitors

1999
Proteasome from cytokine-treated human cells shows stimulated BrAAP activity and depressed PGPH activity.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2000, Volume: 78, Issue:2

    Topics: Amino Acids, Branched-Chain; Cells, Cultured; Coumarins; Cysteine Endopeptidases; Endopeptidases; Endothelium, Vascular; Humans; Interferon-gamma; Interleukin-1; Interleukin-6; Isocoumarins; Lipopolysaccharides; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; Serine Proteinase Inhibitors; Tumor Necrosis Factor-alpha; Umbilical Veins

2000
Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.
    The Journal of biological chemistry, 2000, Oct-06, Volume: 275, Issue:40

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Binding, Competitive; Calcium; Calmodulin; Cell Line; Coumarins; Cysteine Proteinase Inhibitors; Cytosol; Dipeptides; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Endoplasmic Reticulum; Humans; Inhibitory Concentration 50; Intracellular Membranes; Isocoumarins; Ketones; Mice; Molecular Sequence Data; Plasmids; Protein Binding; Protein Biosynthesis; Protein Sorting Signals; Protein Synthesis Inhibitors; Puromycin; Serine Proteinase Inhibitors; Substrate Specificity; Time Factors; Transcription, Genetic

2000
Isolated ricin B-chain-mediated apoptosis in U937 cells.
    Bioscience, biotechnology, and biochemistry, 2000, Volume: 64, Issue:7

    Topics: Apoptosis; Aspartic Acid; Brefeldin A; Cell Nucleus; Coumarins; Cycloheximide; Cysteine Proteinase Inhibitors; DNA Fragmentation; Humans; Isocoumarins; Oligopeptides; Protein Biosynthesis; Protein Synthesis Inhibitors; Ricin; Serine Proteinase Inhibitors; U937 Cells

2000
Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: implication of granzyme B and perforin.
    Blood, 2000, Sep-01, Volume: 96, Issue:5

    Topics: Antigens, CD34; Antineoplastic Agents; Cell Survival; Coumarins; Cytarabine; Cytotoxicity Tests, Immunologic; Daunorubicin; DNA, Antisense; Edetic Acid; Etoposide; Flow Cytometry; Granzymes; HeLa Cells; Humans; Isocoumarins; Jurkat Cells; K562 Cells; Leukemia, Myeloid, Acute; Magnesium Chloride; Membrane Glycoproteins; Perforin; Pore Forming Cytotoxic Proteins; Serine Endopeptidases; Tumor Cells, Cultured; U937 Cells

2000
Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis.
    Experimental neurology, 2001, Volume: 167, Issue:2

    Topics: Animals; Apoptosis; Behavior, Animal; Brain Injuries; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Coumarins; Culture Media, Serum-Free; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Isocoumarins; Male; Motor Activity; Neurons; Nucleic Acid Synthesis Inhibitors; Potassium; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Serine Proteinase Inhibitors; Spatial Behavior; Staurosporine; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Wounds, Nonpenetrating

2001
Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface.
    The Biochemical journal, 2002, Mar-15, Volume: 362, Issue:Pt 3

    Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Membrane; Cells, Cultured; CHO Cells; Coumarins; Cricetinae; Endopeptidases; Endothelium, Vascular; Epitopes; Humans; Isocoumarins; Kinetics; Peptidyl-Dipeptidase A; Recombinant Proteins; Serine Proteinase Inhibitors; Transfection; Umbilical Veins

2002
Dipeptidyl peptidase with strict substrate specificity of an anaerobic periodontopathogen Porphyromonas gingivalis.
    FEMS microbiology letters, 2002, Mar-19, Volume: 209, Issue:1

    Topics: Alanine; Anaerobiosis; Bacterial Proteins; Cations, Divalent; Coumarins; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Inhibitors; Hydrogen-Ion Concentration; Isocoumarins; Isoelectric Point; Isoflurophate; Molecular Weight; Porphyromonas gingivalis; Prevotella; Prevotella intermedia; Serine Proteinase Inhibitors; Species Specificity; Substrate Specificity

2002
Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.
    Planta, 2002, Volume: 215, Issue:5

    Topics: Amino Acid Sequence; Aspartic Acid Endopeptidases; Cacao; Cloning, Molecular; Coumarins; DNA, Complementary; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydrogen-Ion Concentration; Isocoumarins; Isoenzymes; Leucine; Molecular Sequence Data; Pepstatins; Phylogeny; Plant Proteins; RNA, Messenger; Seeds; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Yarrowia

2002
Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:12

    Topics: Antineoplastic Agents, Hormonal; Apoptosis; Coumarins; Dexamethasone; Gene Expression Profiling; Genes, bcl-2; Glucocorticoids; Granzymes; Humans; Isocoumarins; Leukemia, B-Cell; Models, Biological; RNA, Messenger; Serine Endopeptidases; Serine Proteinase Inhibitors; Transfection; Tumor Cells, Cultured

2003
Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes.
    Cell death and differentiation, 2004, Volume: 11, Issue:2

    Topics: Animals; Annexins; Calcium; Caspases; Cell Death; Cell Size; Ceramides; Coumarins; Erythrocytes; Fumonisins; Humans; Ionomycin; Isocoumarins; Mice; Mice, Knockout; Osmotic Pressure; Protein Binding; Sphingomyelin Phosphodiesterase; Sphingomyelins

2004
The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability.
    Leukemia & lymphoma, 2005, Volume: 46, Issue:8

    Topics: Apoptosis; Caspase Inhibitors; Cell Line, Transformed; Coumarins; Cysteine Proteinase Inhibitors; Cytotoxicity Tests, Immunologic; fas Receptor; Humans; Intracellular Membranes; Isocoumarins; Macrolides; Mitochondria; Oligopeptides; Permeability; Receptors, Tumor Necrosis Factor; Signal Transduction; T-Lymphocytes, Cytotoxic

2005
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.
    Acta biochimica et biophysica Sinica, 2009, Volume: 41, Issue:3

    Topics: Animals; Biotinylation; CHO Cells; Coumarins; Cricetinae; Cricetulus; Enzyme Inhibitors; Humans; Immunohistochemistry; Isocoumarins; Macrolides; Mutation; Plasmids; Protease Inhibitors; Receptors, LDL; Sulfones; Transfection

2009
Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-01, Volume: 17, Issue:7

    Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Apoptosis; Caspase 6; Caspase 9; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Coumarins; Endoplasmic Reticulum; Enzyme Activation; Fatty Acid Synthase, Type I; Female; Humans; Isocoumarins; Liposarcoma; Metalloendopeptidases; Mice; Mice, SCID; Nelfinavir; Neoplasm Transplantation; Phenanthrolines; Proprotein Convertases; Protease Inhibitors; Protein Transport; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Serine Endopeptidases; Sterol Regulatory Element Binding Protein 1; Transcription, Genetic; Transplantation, Heterologous; Tumor Burden

2011
Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing.
    The Journal of investigative dermatology, 2011, Volume: 131, Issue:12

    Topics: Animals; Antibodies, Blocking; Cell Line; Coumarins; Culture Media, Conditioned; Endopeptidases; Humans; Isocoumarins; Keratinocytes; Mice; Mice, Inbred C57BL; Recombinant Proteins; RNA, Small Interfering; Serine Endopeptidases; Serine Proteases; Serine Proteinase Inhibitors; Skin; Thrombomodulin; Wound Healing

2011
Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3,4-dichloroisocoumarin.
    Acta crystallographica. Section F, Structural biology and crystallization communications, 2011, Nov-01, Volume: 67, Issue:Pt 11

    Topics: Coumarins; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Extracellular Space; Isocoumarins; Lipase; Streptomyces

2011
Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate.
    The Journal of biological chemistry, 2012, Jan-27, Volume: 287, Issue:5

    Topics: Bacterial Proteins; Coumarins; Crystallography, X-Ray; Isocoumarins; Isoflurophate; Models, Molecular; Peptide Hydrolases; Protease Inhibitors; Protein Structure, Secondary; Protein Structure, Tertiary; Providencia

2012
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Biglycan; Biocatalysis; Blotting, Western; Cells, Cultured; Coumarins; Decorin; Extracellular Matrix; Extracellular Space; Granzymes; Humans; Isocoumarins; Kinetics; Muscle, Smooth, Vascular; Phosphorylation; Proteoglycans; Receptors, Transforming Growth Factor beta; Serine Proteinase Inhibitors; Smad3 Protein; Solubility; Substrate Specificity; Transforming Growth Factor beta1

2012
Granule exocytosis mediates immune surveillance of senescent cells.
    Oncogene, 2013, Apr-11, Volume: 32, Issue:15

    Topics: Animals; Apoptosis; beta-Galactosidase; Cell Cycle Checkpoints; Cell Proliferation; Cells, Cultured; Cellular Senescence; Coumarins; Cytoplasmic Granules; Enzyme Inhibitors; Exocytosis; Extracellular Matrix Proteins; Hepatic Stellate Cells; Humans; Immunologic Surveillance; Isocoumarins; Killer Cells, Natural; Liver; Liver Cirrhosis; Macrolides; Mice; Mice, Inbred C57BL; Mice, Knockout; Perforin; RNA Interference; RNA, Small Interfering; Serine Proteinase Inhibitors; Tumor Necrosis Factor Decoy Receptors

2013
Inhibition of extracellular lipase from Streptomyces rimosus with 3,4-dichloroisocoumarin.
    Journal of enzyme inhibition and medicinal chemistry, 2013, Volume: 28, Issue:5

    Topics: Coumarins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Isocoumarins; Lipase; Molecular Structure; Streptomyces; Structure-Activity Relationship

2013
Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing.
    ACS chemical biology, 2015, Oct-16, Volume: 10, Issue:10

    Topics: Bacterial Proteins; Coumarins; Escherichia coli Proteins; Inhibitory Concentration 50; Isocoumarins; Models, Biological; Models, Molecular; Protease Inhibitors; Protein Array Analysis; Small Molecule Libraries; Substrate Specificity

2015
A metal-free one-pot synthesis of benzo[c]chromen-6-ones from 3,4-dichlorocoumarins and butadienes using tandem photo-thermal-photo reactions.
    Organic & biomolecular chemistry, 2016, Oct-18, Volume: 14, Issue:41

    Topics: Benzopyrans; Butadienes; Chemistry Techniques, Synthetic; Coumarins; Isocoumarins; Photochemical Processes; Temperature

2016
Reduced expression of a rhomboid protease, EhROM1, correlates with changes in the submembrane distribution and size of the Gal/GalNAc lectin subunits in the human protozoan parasite, Entamoeba histolytica.
    PloS one, 2020, Volume: 15, Issue:3

    Topics: Acetylgalactosamine; Entamoeba histolytica; Galactose; Gene Expression Regulation; Host-Parasite Interactions; Isocoumarins; Lectins; Membrane Microdomains; Peptide Hydrolases; Protein Multimerization; Protein Subunits; Protozoan Proteins; RNA Interference

2020