Compounds > icd 1578
Page last updated: 2024-12-09

icd 1578

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-N-phenylcarbamoylamino-4-chloro-3-propyloxyisocoumarin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID577033
CHEMBL ID140958
SCHEMBL ID7311335
MeSH IDM0292560

Synonyms (13)

Synonym
7-phenylureido-4-chloro-3-propyloxyisocoumarin
CHEMBL140958
00541o72ry ,
icd-1578
140653-02-7
urea, n-(4-chloro-1-oxo-3-propoxy-1h-2-benzopyran-7-yl)-n'-phenyl-
unii-00541o72ry
SCHEMBL7311335
NTIRQLXQCVZDJU-UHFFFAOYSA-N
4-chloro-7-(3-phenylureido)-3-(propyloxy)-1h-2-benzopyran-1-one
n-(4-chloro-1-oxo-3-propoxy-1h-isochromen-7-yl)-n'-phenylurea #
7-n-phenylcarbamoylamino-4-chloro-3-propyloxyisocoumarin
Q27231318
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID52459The second order inactivation rate constant was expressed as inhibition of chymotrypsin (ChT). Inhibitor concentrations were 3.4-70 uM1995Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency.
AID155080The second order inactivation rate constant was expressed as inhibition of porcine pancreatic elastase (PPE). Inhibitor concentrations were 34-56 uM1995Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency.
AID67482Inhibition of human leukocyte elastase(HLE) at 0.7-1.7 uM1995Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency.
AID42661In vitro inhibitory potency was tested against botulinum neurotoxin/B (BoNT/B) expressed as Ki2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Development of potent inhibitors of botulinum neurotoxin type B.
AID23826Rate of deacylation in porcine pancreatic elastase (PPE).1995Journal of medicinal chemistry, Feb-03, Volume: 38, Issue:3
Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bis(5-amidino-2-benzimidazolyl)methane
bis(5-amidino-2-benzimidazolyl)methane: aromatic diamidine which has a significant suppressive effect on the cytopathology & yield of respiratory synctial (RS) virus; RN given refers to parent cpd		2.0110
7-amino-4-chloro-3-methoxy-2-benzopyran-1-one
[no description available]		1.9810isocoumarins
captopril
Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.		1.9910alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
isocoumarins
Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.. isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.		3.8430isocoumarins
7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin
7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin: RN & structure given in first source		1.9810
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.8430benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Factitious Disorders
Disorders characterized by physical or psychological symptoms that are not real, genuine, or natural.		02.0810