Compounds > diaporthin
Page last updated: 2024-12-11

diaporthin

Description

diaporthin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5323561
CHEMBL ID4163739
MeSH IDM0402545

Synonyms (16)

Synonym
6512-79-4
diaporthin
8-hydroxy-3-[(2s)-2-hydroxypropyl]-6-methoxyisochromen-1-one
(s)-8-hydroxy-3-(2-hydroxypropyl)-6-methoxy-1h-2-benzopyran-1-one
348g93mx9z ,
unii-348g93mx9z
10532-39-5
1h-2-benzopyran-1-one, 8-hydroxy-3-(2-hydroxypropyl)-6-methoxy-, (s)-
isocoumarin, 8-hydroxy-3-(2-hydroxypropyl)-6-methoxy-, (+)-
8-hydroxy-3-(2-hydroxy-propyl)-6-methoxy-isochromen-1-one, (+)-
8-hydroxy-3-(2-hydroxy-propyl)-6-methoxy-isochromen-1-one, (s)-
ncgc00384779-01!8-hydroxy-3-[(2s)-2-hydroxypropyl]-6-methoxyisochromen-1-one
Q27256349
DTXSID60909444
8-hydroxy-3-(2-hydroxypropyl)-6-methoxy-1h-2-benzopyran-1-one
CHEMBL4163739

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1354809Cytotoxicity against human MCF7 cells by MTT assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Peniisocoumarins A-J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel.
AID1354806Cytotoxicity against human A549 cells by MTT assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Peniisocoumarins A-J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel.
AID1354807Cytotoxicity against human HepG2 cells by MTT assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Peniisocoumarins A-J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel.
AID1354810Cytotoxicity against human HEK293T cells by MTT assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Peniisocoumarins A-J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel.
AID1354808Cytotoxicity against human HeLa cells by MTT assay2018Journal of natural products, 06-22, Volume: 81, Issue:6
Peniisocoumarins A-J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel.
AID1354802Inhibition of Saccharomyces cerevisiae alpha-glucosidase at 200 uM using p-nitrophenyl-glycoside as substrate incubated for 20 mins followed by substrate addition measured immediately relative to control2018Journal of natural products, 06-22, Volume: 81, Issue:6
Peniisocoumarins A-J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel.
AID1354805Inhibition of Mycobacterium tuberculosis H37Ra PTPB expressed in Escherichia coli BL21 (DE3) at 50 uM using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by spectrophotometric analysis2018Journal of natural products, 06-22, Volume: 81, Issue:6
Peniisocoumarins A-J: Isocoumarins from Penicillium commune QQF-3, an Endophytic Fungus of the Mangrove Plant Kandelia candel.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxyphenyllactic acid
4-hydroxyphenyllactic acid: tyrosing metabolite; RN given refers to cpd without isomeric designation. 3-(4-hydroxyphenyl)lactic acid : A 2-hydroxy carboxylic acid that is lactic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.		2.01102-hydroxy carboxylic acid;
phenols		bacterial metabolite;
human metabolite
oleanolic acid
[no description available]		2.1710hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
ochratoxin b
ochratoxin B: structure given in first source. ochratoxin B : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations.		210isochromanes;
monocarboxylic acid;
N-acyl-L-phenylalanine;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
mycotoxin;
Penicillium metabolite
ethionine
L-ethionine : An S-ethylhomocysteine that has S-configuration at the chiral centre.		210S-ethylhomocysteineantimetabolite;
carcinogenic agent
ochracin
ochracin: produced by Aspergillus alutaceus; structure in first source		210isochromanes
acarbose
[no description available]		2.1710tetrasaccharide derivativeEC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent
isocoumarins
Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.. isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.		2.4620isocoumarins
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.0110
ochratoxin a
ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.		210isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent
ConditionIndicatedRelationship StrengthStudiesTrials
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