bupivacaine has been researched along with Labor Pain in 50 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Labor Pain: Pain associated with OBSTETRIC LABOR in CHILDBIRTH. It is caused primarily by UTERINE CONTRACTION as well as pressure on the CERVIX; BLADDER; and the GASTROINTESTINAL TRACT. Labor pain mostly occurs in the ABDOMEN; the GROIN; and the BACK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0625% bupivacaine could provide dose-dependent analgesic effects on early-stage labor pain." | 9.14 | Optimizing epidural fentanyl loading dose for early labor pain. ( Chen, LK; Chen, SS; Huang, CH; Lin, CJ; Tsai, FF; Wu, GJ, 2009) |
| "The study compares the effectiveness of bupivacaine and fentanyl (BUPI-FEN) and ropivacaine and fentanyl (ROPI-EFN) in epidural analgesia for labor pain through a meta-analysis of relevant randomized clinical trials." | 8.91 | Epidural analgesia with amide local anesthetics, bupivacaine, and ropivacaine in combination with fentanyl for labor pain relief: a meta-analysis. ( Fan, Y; Hu, C; Li, Y; Wang, H; Xu, H, 2015) |
| "Effective labour analgesia lasting up to 120 minutes was observed in the fentanyl-bupivacaine group but with high incidence of breakthrough pain." | 5.17 | A COMPARATIVE STUDY ON THE EFFICACY OF TWO REGIMENS OF SINGLE- SHOT SPINAL BLOCK FOR PAIN RELIEF IN WOMEN PRESENTING IN ESTABLISHED LABOUR. ( Chokwe, TM; Ogutu, O; Olang, PO; Tshibuyl, PN, 2013) |
| "0625% bupivacaine could provide dose-dependent analgesic effects on early-stage labor pain." | 5.14 | Optimizing epidural fentanyl loading dose for early labor pain. ( Chen, LK; Chen, SS; Huang, CH; Lin, CJ; Tsai, FF; Wu, GJ, 2009) |
| "The addition of clonidine to epidural levobupivacaine and sufentanil for patient-controlled epidural analgesia in labour improved analgesia, reduced the supplementation rate and reduced pruritus without improvement in maternal satisfaction." | 5.14 | Effects of a continuous low-dose clonidine epidural regimen on pain, satisfaction and adverse events during labour: a randomized, double-blind, placebo-controlled trial. ( Aubrun, F; Bouret, C; Broisin, F; Charpiat, B; Clement, HJ; Derre, E; Huissoud, C; Lopez, F; Pignal, C; Schoeffler, M; Viale, JP; Wallet, F, 2010) |
| "The addition of small dose of morphine to the spinal component of the CSE technique improved the effectiveness of epidural labour analgesia and reduced the need for pain medications over 24 h, but resulted in a small increase in nausea." | 5.12 | Intrathecal morphine reduces breakthrough pain during labour epidural analgesia. ( Hess, PE; Sarge, TW; Snowman, CE; Sundar, S; Vasudevan, A, 2007) |
| "The objective of the study was to evaluate and compare the safety of levobupivacaine and racemic bupivacaine for paracervical block (PCB) in the first stage of labor after uncomplicated pregnancy." | 5.11 | A comparative study of the safety of 0.25% levobupivacaine and 0.25% racemic bupivacaine for paracervical block in the first stage of labor. ( Huhtala, H; Kirkinen, P; Palomäki, O, 2005) |
| "The study compares the effectiveness of bupivacaine and fentanyl (BUPI-FEN) and ropivacaine and fentanyl (ROPI-EFN) in epidural analgesia for labor pain through a meta-analysis of relevant randomized clinical trials." | 4.91 | Epidural analgesia with amide local anesthetics, bupivacaine, and ropivacaine in combination with fentanyl for labor pain relief: a meta-analysis. ( Fan, Y; Hu, C; Li, Y; Wang, H; Xu, H, 2015) |
| " Dose-response curves for individual drugs were fitted to a hyperbolic dose-response model using nonlinear regression." | 2.79 | Synergistic interaction between fentanyl and bupivacaine given intrathecally for labor analgesia. ( Khaw, KS; Lee, A; Ng, FF; Ng, KK; Ngan Kee, WD; So, R, 2014) |
| "The labor pain is one of the most severe pains that a woman could ever be suffered." | 2.77 | [Comparison of bupivacaine and levobupivacaine with epidural technique for labor analgesia]. ( Arslantaş, MK; Arslantaş, R; Ozyuvaci, E, 2012) |
| "The primary long-term outcome was backache occurring within 3 months of the birth persisting for longer than 6 weeks." | 2.76 | Long-term effects of epidural analgesia in labor: a randomized controlled trial comparing high dose with two mobile techniques. ( Lancashire, RJ; MacArthur, C; Moore, PA; Shennan, A; Wilson, MJ, 2011) |
| "This is the first dose-finding study specifically designed to estimate the ED95 of intrathecal bupivacaine combined with a fixed amount of fentanyl for analgesia in active labor." | 2.73 | Determination of the ED95 for intrathecal plain bupivacaine combined with fentanyl in active labor. ( Carvalho, JC; Goldszmidt, E; Parkes, RK; Whitty, R, 2007) |
| " The purpose of this systematic review and meta-analysis is to compare the efficacy and safety of bupivacaine with ropivacaine and levobupivacaine in combination with sufentanil (BUPI-, ROPI-, and LBUPI-SUF respectively) in epidural analgesia for labor." | 2.50 | Efficacy and safety of local anesthetics bupivacaine, ropivacaine and levobupivacaine in combination with sufentanil in epidural anesthesia for labor and delivery: a meta-analysis. ( Fang, F; Lv, BS; Mi, WD; Wang, JH; Wang, W; Wang, XW; Wang, ZQ, 2014) |
| "Describing the relationship between magnitude of response, probability of response, dose and time is difficult using traditional two-dimensional dose-response curves." | 1.39 | Multi-dimensional response-probability-dose curves for bupivacaine and ropivacaine epidural labour analgesia. ( Lee, A; Ngan Kee, WD, 2013) |
| "Horner's syndrome is a rare complication of epidural analgesia for labor." | 1.34 | Trigeminal nerve palsy and Horner's syndrome following epidural analgesia for labor: a subdural block? ( Avellanal, M; Baticón, P; De la Gala, F; González-Zarco, LM; Reyes, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (42.00) | 29.6817 |
| 2010's | 26 (52.00) | 24.3611 |
| 2020's | 3 (6.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mazda, Y | 1 |
| Arzola, C | 1 |
| Downey, K | 1 |
| Ye, XY | 1 |
| Carvalho, JCA | 1 |
| Liu, X | 2 |
| Zhang, H | 2 |
| Guo, M | 1 |
| Gao, Y | 1 |
| Du, C | 1 |
| Aslan, B | 1 |
| Moraloğlu, Ö | 1 |
| Ferrer, LE | 1 |
| Romero, DJ | 1 |
| Vásquez, OI | 1 |
| Matute, EC | 1 |
| Van de Velde, M | 1 |
| Katz, D | 1 |
| Hamburger, J | 1 |
| Gutman, D | 1 |
| Wang, R | 1 |
| Lin, HM | 1 |
| Marotta, M | 1 |
| Zahn, J | 2 |
| Beilin, Y | 3 |
| Lange, EMS | 1 |
| Wong, CA | 2 |
| Fitzgerald, PC | 1 |
| Davila, WF | 1 |
| Rao, S | 1 |
| McCarthy, RJ | 2 |
| Toledo, P | 1 |
| Genç Moralar, D | 1 |
| Aygen Türkmen, U | 1 |
| Altan, A | 1 |
| Arısoy, R | 1 |
| Tahaoğlu, E | 1 |
| Ozakın, E | 1 |
| Punshi, GD | 1 |
| Afshan, G | 1 |
| Mhyre, JM | 1 |
| Hong, RW | 1 |
| Greenfield, ML | 1 |
| Pace, NL | 1 |
| Polley, LS | 1 |
| Ngan Kee, WD | 2 |
| Khaw, KS | 1 |
| Ng, FF | 1 |
| Ng, KK | 1 |
| So, R | 1 |
| Lee, A | 2 |
| Lv, BS | 1 |
| Wang, W | 1 |
| Wang, ZQ | 1 |
| Wang, XW | 1 |
| Wang, JH | 1 |
| Fang, F | 1 |
| Mi, WD | 1 |
| Craig, MG | 1 |
| Grant, EN | 1 |
| Tao, W | 1 |
| McIntire, DD | 1 |
| Leveno, KJ | 1 |
| Li, Y | 1 |
| Hu, C | 1 |
| Fan, Y | 1 |
| Wang, H | 1 |
| Xu, H | 1 |
| Ye, Y | 1 |
| Song, X | 1 |
| Liu, L | 1 |
| Shi, SQ | 1 |
| Garfield, RE | 1 |
| Zhang, G | 1 |
| Liu, H | 1 |
| Tshibuyl, PN | 1 |
| Olang, PO | 1 |
| Ogutu, O | 1 |
| Chokwe, TM | 1 |
| Mitra, S | 1 |
| Arora, J | 1 |
| Ahuja, V | 1 |
| Takkar, N | 1 |
| Arabin, B | 1 |
| Kuizenga, K | 1 |
| van Zoeren, D | 1 |
| Zveren, DV | 1 |
| Eyck, JV | 1 |
| Goodman, SR | 1 |
| Smiley, RM | 1 |
| Negron, MA | 1 |
| Freedman, PA | 1 |
| Landau, R | 1 |
| Weissman, A | 1 |
| Torkhov, O | 1 |
| Weissman, AI | 1 |
| Drugan, A | 1 |
| Mebazaa, MS | 1 |
| Tanoubi, I | 1 |
| Mestiri, T | 1 |
| Gara, MF | 1 |
| Ben Ammar, MS | 1 |
| Tsai, FF | 1 |
| Wu, GJ | 1 |
| Lin, CJ | 1 |
| Huang, CH | 1 |
| Chen, SS | 1 |
| Chen, LK | 1 |
| Wang, LZ | 1 |
| Chang, XY | 1 |
| Hu, XX | 1 |
| Tang, BL | 1 |
| Okutomi, T | 1 |
| Wallet, F | 1 |
| Clement, HJ | 1 |
| Bouret, C | 1 |
| Lopez, F | 1 |
| Broisin, F | 1 |
| Pignal, C | 1 |
| Schoeffler, M | 1 |
| Derre, E | 1 |
| Charpiat, B | 1 |
| Huissoud, C | 1 |
| Aubrun, F | 1 |
| Viale, JP | 1 |
| El-Kerdawy, H | 1 |
| Farouk, A | 1 |
| Shafer, SL | 1 |
| Lemmer, B | 1 |
| Boselli, E | 1 |
| Boiste, F | 1 |
| Bouvet, L | 1 |
| Allaouchiche, B | 1 |
| Chassard, D | 1 |
| Halpern, S | 1 |
| Wilson, MJ | 1 |
| Moore, PA | 1 |
| Shennan, A | 1 |
| Lancashire, RJ | 1 |
| MacArthur, C | 1 |
| Capogna, G | 1 |
| Camorcia, M | 1 |
| Stirparo, S | 1 |
| Farcomeni, A | 1 |
| Cutura, N | 1 |
| Soldo, V | 1 |
| Milovanović, SR | 1 |
| Orescanin-Dusić, Z | 1 |
| Curković, A | 1 |
| Tomović, B | 1 |
| Janković-Raznatović, S | 1 |
| Arslantaş, R | 1 |
| Arslantaş, MK | 1 |
| Ozyuvaci, E | 1 |
| Bauchat, JR | 1 |
| Koski, TR | 1 |
| Cambic, CR | 1 |
| Lee, AI | 1 |
| Margarido, CB | 1 |
| Dlacic, A | 1 |
| Balki, M | 1 |
| Furtado, L | 1 |
| Carvalho, JC | 2 |
| Supandji, M | 1 |
| Sia, AT | 1 |
| Ocampo, CE | 1 |
| Pace, MC | 1 |
| Aurilio, C | 1 |
| Bulletti, C | 1 |
| Iannotti, M | 1 |
| Passavanti, MB | 1 |
| Palagiano, A | 1 |
| Palomäki, O | 2 |
| Huhtala, H | 2 |
| Kirkinen, P | 2 |
| Orbach-Zinger, S | 1 |
| Friedman, L | 1 |
| Avramovich, A | 1 |
| Ilgiaeva, N | 1 |
| Orvieto, R | 1 |
| Sulkes, J | 1 |
| Eidelman, LA | 1 |
| Vasudevan, A | 1 |
| Snowman, CE | 1 |
| Sundar, S | 1 |
| Sarge, TW | 1 |
| Hess, PE | 1 |
| De la Gala, F | 1 |
| Reyes, A | 1 |
| Avellanal, M | 1 |
| Baticón, P | 1 |
| González-Zarco, LM | 1 |
| Chandra, S | 2 |
| Kuczkowski, KM | 3 |
| Whitty, R | 1 |
| Goldszmidt, E | 1 |
| Parkes, RK | 1 |
| Ngamprasertwong, P | 1 |
| Kumwilaisakmd, K | 1 |
| Indrambarya, T | 1 |
| Supbornsug, K | 1 |
| Ngarmukos, S | 1 |
| Guinn, NR | 1 |
| Bernstein, HH | 1 |
| Hossain, S | 1 |
| Bodian, CA | 1 |
| Volmanen, P | 1 |
| Sarvela, J | 1 |
| Akural, EI | 1 |
| Raudaskoski, T | 1 |
| Korttila, K | 1 |
| Alahuhta, S | 1 |
| Meuser, T | 1 |
| Wiese, R | 1 |
| Molitor, D | 1 |
| Grond, S | 1 |
| Stamer, UM | 1 |
| Atiénzar, MC | 1 |
| Palanca, JM | 1 |
| Torres, F | 1 |
| Borràs, R | 1 |
| Gil, S | 1 |
| Esteve, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: a RCT Comparing 125 mL/h Versus 250 mL/h Bolus Delivery Flow[NCT03236298] | 90 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| Does the Addition of Epinephrine Increase the Duration of Intrathecal Hyperbaric Bupivacaine for Repeat Cesarean Section?[NCT02369510] | Phase 4 | 68 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| A Randomized Double-blinded Trial of the Effects of Bupivacaine Induced Motor Blockade on the Second Stage of Labor[NCT01621230] | Phase 4 | 481 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| The Effect of Epidural Analgesia on Labour and Neonatal and Maternal Outcomes in 1, 2a, 3, and 4a Robson's Classes: a Propensity Score-matched Analysis[NCT05579808] | 21,808 participants (Actual) | Observational | 2021-06-01 | Completed | |||
| A Double-blind, Randomized, Controlled, Pilot Study Comparing Three Different Anesthesic Techniques for Pregnant Women in Labour: Dural Puncture Epidural, Epidural and Combined Spinal Epidural. Evaluation of the Pain Control and the Hypotension Incidence [NCT05196256] | Phase 3 | 90 participants (Anticipated) | Interventional | 2022-06-30 | Not yet recruiting | ||
| A Randomized Double Blind Clinical Trial Comparing Programed Intermittent Epidural Boluses (PIEB) Versus Patient Controlled Epidural Analgesia (PCEA) With Epidural or Combined Spinal-epidural (CSE) Technique[NCT02768272] | Phase 4 | 240 participants (Actual) | Interventional | 2016-03-01 | Completed | ||
| Epidural Analgesia During Labour. Impact of Clonidine Addition to Levobupivacaine and Sufentanil[NCT00437996] | Phase 3 | 85 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Pain Management During Labor: Use of Intermittent Drug Delivery Devices for Obstetric and Neonatal Outcome Improvement and Health-care Burden Reduction[NCT02710877] | 671 participants (Actual) | Interventional | 2014-12-23 | Terminated (stopped due to Stopped funding by Regional Healthcare System.) | |||
| Epidural Analgesia During Labour Randomized Clinical Trial Comparing Patient Controlled Epidural Analgesia Versus Patient Intermittent Epidural Boluses With Levobupivacaine[NCT03133091] | Phase 3 | 200 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Programmed Intermittent Epidural Bolus Versus Continuous Infusion When Added to Patient-controlled Epidural Analgesia on Bupivacaine Consumption in Labour Analgesia: a Randomized Controlled Trial[NCT03730753] | 200 participants (Anticipated) | Interventional | 2019-06-01 | Recruiting | |||
| Comparison of Programmed Intermittent Epidural Boluses With Continuous Epidural Infusion for Maintenance of Labor Analgesia[NCT02949271] | Phase 4 | 179 participants (Actual) | Interventional | 2016-11-08 | Completed | ||
| Effect of the Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy[NCT05930405] | 252 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | |||
| Programmed Intermittent Epidural Bolus vs. Continuous Epidural Infusion: a Multicenter, Pragmatic, Cluster-randomized Trial[NCT05255263] | 0 participants (Actual) | Interventional | 2022-06-01 | Withdrawn (stopped due to Study is currently on hold, pending further evaluation and coordination.) | |||
| Effect of Epidural Infusion Bolus Delivery Rate on the Duration of Labor Analgesia[NCT02340806] | 220 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization During General Anesthesia: A Randomized Controlled Double Blinded Study[NCT02368054] | Phase 4 | 34 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Comparative Study of the Combination of Different Modes of Administration of Local Anesthetics in Labor Analgesia[NCT03839056] | 151 participants (Actual) | Observational | 2015-08-02 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
As measured by pinprick sensation and/or patient discomfort as measured by verbal pain score on a scale of 0=no pain to 10=worst imaginable pain, obtained within 3 hours of receiving anesthesia. (NCT02369510)
Timeframe: up to 3 hrs
| Intervention | units on a scale (Median) |
|---|---|
| Low-dose Epinephrine | 0 |
| High-dose Epinephrine | 0 |
| No Epinephrine | 0 |
Time to a onset of T4 level of anesthesia or the highest level achieved in 15min (NCT02369510)
Timeframe: up to 15 min
| Intervention | minutes (Median) |
|---|---|
| Low-dose Epinephrine | 6 |
| High-dose Epinephrine | 8 |
| No Epinephrine | 8 |
Time to Bromage 3 motor recovery (NCT02369510)
Timeframe: up to 4 hours
| Intervention | minutes (Median) |
|---|---|
| Low-dose Epinephrine | 150 |
| High-dose Epinephrine | 172 |
| No Epinephrine | 120 |
"Patient satisfaction score was elicited upon arrival to the recovery room on a 1-5 Likert scale. Number of participants selecting the highest score of 5 or completely satisfied." (NCT02369510)
Timeframe: up to 3 hours
| Intervention | percentage of participants (Number) |
|---|---|
| Low-dose Epinephrine | 90 |
| High-dose Epinephrine | 85 |
| No Epinephrine | 87 |
Time to T10 sensory recovery as measured by pinprick sensation (NCT02369510)
Timeframe: up to 3 hours
| Intervention | minutes (Median) |
|---|---|
| Low-dose Epinephrine | 135 |
| High-dose Epinephrine | 165 |
| No Epinephrine | 120 |
(NCT02369510)
Timeframe: up to 3 hours
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| 2 minutes | 25 minutes | |
| High-dose Epinephrine | 0 | 6 |
| Low-dose Epinephrine | 2 | 3 |
| No Epinephrine | 4 | 1 |
Incidence of hypotension as measured by participants needing vasopressor agents (NCT02369510)
Timeframe: at 2 minutes and at 25 minutes
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| 2 minutes | 25 minutes | |
| High-dose Epinephrine | 2 | 9 |
| Low-dose Epinephrine | 5 | 3 |
| No Epinephrine | 8 | 3 |
Number of participants whose newborns received an APGAR score of <=3 at 1 min. A lower APGAR score represents poor health or a worsening in the Outcome, (NCT01621230)
Timeframe: At the time of Delivery, up to 3 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Epidural Fentanyl | 14 |
| Epidural Bupivacaine Plus Fentanyl (Bupivacaine) | 11 |
Number of participants whose newborns received an APGAR score of <=3 at 5 minutes. A lower APGAR score represents poor health or a worsening in the Outcome (NCT01621230)
Timeframe: At the time of Delivery, up to 3 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Epidural Fentanyl | 2 |
| Epidural Bupivacaine Plus Fentanyl (Bupivacaine) | 1 |
The length of the second stage of labor (measured as minutes a parturient spends in Stage II) in nulliparous women received a epidural bupivacaine plus fentanyl or fentanyl alone. (NCT01621230)
Timeframe: Duration of second stage of labor approximately 30 minutes to 150 minutes
| Intervention | minutes (Median) |
|---|---|
| Group I (Bupivacaine) | 75 |
| Group II (No Bupivacaine) | 73 |
(NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | minutes (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 44 |
| Continuous Epidural Infusion | 63 |
Measured using a verbal analog pain scale of 1-10, where 0=no pain and 10=worst possible pain. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | score on a scale (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 3 |
| Continuous Epidural Infusion | 2 |
Determined by the number of times subject activates the PCEA pump (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | attempts (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 0.75 |
| Continuous Epidural Infusion | 0.63 |
Number of patients who needed a vasopressor medication to treat a drop in blood pressure (NCT02949271)
Timeframe: duration of labor, up to 24 hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Programmed Intermittent Epidural Bolus | 8 |
| Continuous Epidural Infusion | 3 |
Ratio generated by the number of times subjects activates PCEA and receives additional anesthetic compared with times subject activates PCEA and does not receive additional anesthetic. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | ratio of attempts (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 0.17 |
| Continuous Epidural Infusion | 0.12 |
The volume of local anesthetic that the patient received through activation of the patient-controlled epidural analgesia system per hour. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | milliliters per hour (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 4.03 |
| Continuous Epidural Infusion | 4.52 |
The total volume of local anesthetic that the patient received from the CAPP pump per hour. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | milliliters per hour (Median) |
|---|---|
| Programmed Intermittent Epidural Bolus | 11.49 |
| Continuous Epidural Infusion | 12.38 |
The Modified Bromage Score ranges from 1-5. 1 = complete block, 2 = almost complete block, 3 = partial block, 4 = detectable weakness of hip flexion, and 5 = no detectable weakness of hip flexion while supine. (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| Score of 5 | Score of 4 | Score of 3 | Score of 2 | Score of 1 | |
| Continuous Epidural Infusion | 26 | 20 | 3 | 2 | 1 |
| Programmed Intermittent Epidural Bolus | 37 | 9 | 4 | 1 | 0 |
"Determined using a 5-point scale where 1=very dissatisfied, 2=dissatisfied, 3=neutral, 4=satisfied, 5=very satisfied. Subjects were considered satisfied if selected very satisfied or satisfied on the patient questionnaire." (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Very satisfied | Satisfied | |
| Continuous Epidural Infusion | 39 | 3 |
| Programmed Intermittent Epidural Bolus | 35 | 9 |
Modes of delivery: spontaneous vaginal delivery (SVD), assisted vaginal delivery (AVD), and caesarean delivery (CD) (NCT02949271)
Timeframe: duration of labor, up to 24hrs
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| SVD | AVD | CD | |
| Continuous Epidural Infusion | 37 | 5 | 17 |
| Programmed Intermittent Epidural Bolus | 41 | 5 | 15 |
Weighted mean pain score (measured by the area under the VAS (Visual Analog Scale)-time curve calculated using the trapezoidal integration divided by the duration of labor analgesia).Visual Analog Scale is a 100 millimeter scale where 0 is no pain and 100 is worst pain imaginable. (NCT02340806)
Timeframe: epidural placement to delivery, up to 36 hours.
| Intervention | units on a scale (Mean) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 9 |
| Low Rate Bolus (CADD-Solis Pump) | 6.9 |
Number of participants who experienced breakthrough pain requiring a provider administered bolus by the anesthesia providers. (NCT02340806)
Timeframe: epidural placement to delivery, up to 36 hours.
| Intervention | Participants (Count of Participants) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 37 |
| Low Rate Bolus (CADD-Solis Pump) | 43 |
Patient satisfaction of labor anesthesia using a score of 0 low satisfaction to 100 high satisfaction on a 100 millimeter scale. (NCT02340806)
Timeframe: Up to 24 hours after delivery of baby
| Intervention | score on a scale (0 poor 100 good) (Median) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 98 |
| Low Rate Bolus (CADD-Solis Pump) | 98 |
The ratio of the total number of PCEA (Patient Controlled Epidural Anesthesia) bolus's requested and PCEA doses delivered. (NCT02340806)
Timeframe: epidural placement to delivery, up to 36 hours.
| Intervention | Ratio (Median) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 1.4 |
| Low Rate Bolus (CADD-Solis Pump) | 1.5 |
Patients overall satisfaction with pain management. The scale 0= poor satisfaction and 100= good satisfaction with pain management. (NCT02340806)
Timeframe: up to 24 hours after delivery
| Intervention | score on a scale (0 poor 100 good) (Median) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 98 |
| Low Rate Bolus (CADD-Solis Pump) | 98 |
Time to provider administered supplemental boluses measured in minutes (NCT02340806)
Timeframe: epidural to first request of redose up to 10 hours
| Intervention | Minutes (Median) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 357 |
| Low Rate Bolus (CADD-Solis Pump) | 302 |
Total bupivacaine amount (milligrams/hour mg/h) via pump and provider administered supplemental boluses (NCT02340806)
Timeframe: epidural placement to delivery, up to 36 hours.
| Intervention | milligrams per hour (Median) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 9.9 |
| Low Rate Bolus (CADD-Solis Pump) | 10.8 |
Total number of PCEA (Patient Controlled Epidural Anesthesia) bolus's delivered. (NCT02340806)
Timeframe: epidural placement to delivery, up to 36 hours.
| Intervention | Doses (Median) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 9 |
| Low Rate Bolus (CADD-Solis Pump) | 10 |
Number of PCEA (Patient Controlled Epidural Anesthesia) bolus doses delivered (NCT02340806)
Timeframe: epidural placement to delivery, up to 36 hours.
| Intervention | Doses (Median) |
|---|---|
| High Rate Bolus (CADD-Solis Pump) | 14 |
| Low Rate Bolus (CADD-Solis Pump) | 17 |
Total number of patients requiring epidural re-doses given by the provider. (NCT02340806)
Timeframe: epidural placement to delivery, up to 36 hours.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| No- redoses | 1 re-dose | 2 re-doses | 3 re-doses | |
| High Rate Bolus (CADD-Solis Pump) | 59 | 31 | 6 | 6 |
| Low Rate Bolus (CADD-Solis Pump) | 71 | 27 | 5 | 5 |
The stage of labor ( first or second) at the time of re-dose request. (NCT02340806)
Timeframe: Through 2 stages of labor up to 24 hours
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| First stage of labor | Second stage of labor | |
| High Rate Bolus (CADD-Solis Pump) | 34 | 3 |
| Low Rate Bolus (CADD-Solis Pump) | 40 | 3 |
5 reviews available for bupivacaine and Labor Pain
| Article | Year |
|---|---|
Intermittent epidural bolus versus continuous epidural infusions for labor analgesia: A meta-analysis of randomized controlled trials.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics; Bupivacaine; Delivery, Obstetric; Dr | 2020 |
Efficacy and safety of local anesthetics bupivacaine, ropivacaine and levobupivacaine in combination with sufentanil in epidural anesthesia for labor and delivery: a meta-analysis.
Topics: Amides; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Drug Therapy, Com | 2014 |
Epidural analgesia with amide local anesthetics, bupivacaine, and ropivacaine in combination with fentanyl for labor pain relief: a meta-analysis.
Topics: Adult; Amides; Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Drug Therapy, Combination; Fema | 2015 |
[From balanced analgesia to epidural analgesia or combined spinal-epidural analgesia for relief of labor pain].
Topics: Amides; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opio | 2010 |
Focused review: ropivacaine versus bupivacaine for epidural labor analgesia.
Topics: Amides; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Animals; Bupivacaine; Consu | 2010 |
32 trials available for bupivacaine and Labor Pain
13 other studies available for bupivacaine and Labor Pain
| Article | Year |
|---|---|
Effect of programmed intermittent epidural boluses and continuous epidural infusion on labor analgesia and obstetric outcomes: a randomized controlled trial.
Topics: Adolescent; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anest | 2017 |
Effects of Patient-Controlled Epidural Analgesia on Uterine Electromyography During Spontaneous Onset of Labor in Term Nulliparous Women.
Topics: Administration, Intravenous; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient- | 2015 |
Long-term epidural block treatment in patients with early threatening preterm delivery and vaginal fetal engagement.
Topics: Adjuvants, Anesthesia; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Apgar Scor | 2008 |
Pitfalls in chronobiology: a suggested analysis using intrathecal bupivacaine analgesia as an example.
Topics: Adult; Analgesia, Epidural; Bupivacaine; Chronobiology Phenomena; Drug Chronotherapy; Female; Humans | 2010 |
Optimal dose of an anesthetic in epidural anesthesia and its effect on labor duration and administration of vacuum extractor and forceps.
Topics: Adult; Anesthesia, Epidural; Anesthetics, Local; Body Mass Index; Bupivacaine; Case-Control Studies; | 2011 |
Prior lumbar discectomy surgery does not alter the efficacy of neuraxial labor analgesia.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthetics, Local; Bupivacaine; Case- | 2012 |
Multi-dimensional response-probability-dose curves for bupivacaine and ropivacaine epidural labour analgesia.
Topics: Amides; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Bupivacaine; Dose-Response | 2013 |
The epidural electric stimulation test does not predict local anesthetic spread or consumption in labour epidural analgesia.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthetics, Loca | 2013 |
Risk factors for failure to extend labor epidural analgesia to epidural anesthesia for Cesarean section.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Epidural; Anesth | 2006 |
Trigeminal nerve palsy and Horner's syndrome following epidural analgesia for labor: a subdural block?
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Intravenous; Anesthetics, Local; Bu | 2007 |
Levobupivacaine for labor pain: appear good from afar, but far too expensive (?).
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Cost-Benefit Analysis; Female; Humans; Lab | 2007 |
[A survey of labour pain management in Germany].
Topics: Amides; Analgesics; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Local; Anesthesia, Obstetr | 2008 |
Maternal satisfaction with single-dose spinal analgesia for labor pain in Indonesia: a landmark study.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics; Anesthesia, Spinal; Benchmarking; Bupivacaine | 2008 |