Page last updated: 2024-09-27

CADASIL

A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)

Synonyms(1)

Synonym
CADASIL

Research Excerpts

Overview

ExcerptReference
"CADASIL is an inherited small-vessel disease responsible for lacunar strokes and cognitive impairment."( Domenga, V; Dubroca, C; Henrion, D; Joutel, A; Lacombe, P; Levy, B; Maciazek, J; Tournier-Lasserve, E, 2005)
"CADASIL is associated with mutations in the Notch3 gene but the causal mechanisms of the disorder remain unclear."( Kalaria, RN; Low, WC; Santa, Y; Tabira, T; Takahashi, K, 2006)
"CADASIL is a monogenic form of SVD caused by mutations in the Notch3 gene."( Dichgans, M; Freilinger, T; Opherk, C; Peters, N; Pfefferkorn, T, 2007)
"CADASIL is an autosomal dominant arteriopathy characterised by diffuse white matter lesions and small subcortical infarcts on neuroimaging and a variable combination of recurrent cerebral ischaemic episodes, cognitive deficits, migraine with aura and psychiatric symptoms."( Cacchiò, G; Cavallaro, T; Fabrizi, GM; Ragno, M; Scarcella, M; Silvaggio, F; Taioli, F; Trojano, L, 2007)
"CADASIL is associated with mutations within NOCT3 gene, mainly clustered in exons 3 and 4."( Azan, G; Doriguzzi, C; Mauro, A; Pradotto, L; Valentini, C, 2008)
"CADASIL is due to NOTCH3 gene mutations."( Battisti, C; Di Maio, G; Di Stefano, A; Dotti, MT; Federico, A; Formichi, P; Leonini, A; Radi, E; Tarquini, E, 2009)
"CADASIL is a hereditary arteriopathy causing recurrent strokes and cognitive decline."( Amberla, K; Bronge, L; Junna, M; Kääriäinen, H; Kalimo, H; Mykkänen, K; Pöyhönen, M; Viitanen, M, 2009)
"CADASIL is a generalized angiopathy caused by mutations in NOTCH 3 gene leading to degeneration and loss of vascular smooth muscle cells (VSMC) in small arteries and arterioles."( Dziewulska, D; Lewandowska, E, 2012)
"CADASIL is the most prominent inherited form of vascular dementia."( Bernardi, L; Bianchi, S; Bruni, AC; D'Eramo, C; Di Donato, I; Dotti, MT; Federico, A; Gallus, GN; Maletta, R; Puccio, G, 2013)
"CADASIL is an inherited systemic small vessel disease, the affected status of brain vessels leading to subcortical vascular dementia."( Baumann, M; Kääriäinen, H; Mykkänen, K; Pescini, F; Pöyhönen, M; Rovio, S; Siitonen, M; Viitanen, M, 2015)
"CADASIL is caused by NOTCH3 mutations that influence vascular smooth muscle cell (VSMC) function through unknown processes."( Alves-Lopes, R; Delles, C; Harvey, AP; Joutel, A; Montezano, AC; Moreton, F; Muir, K; Neves, KB; Nguyen Dinh Cat, A; Rios, FJ; Rocchicciolli, P; Touyz, RM, 2019)
"CADASIL is an inherited small blood vessel disease caused by mutations in the gene encoding the neurogenic locus notch homolog protein 3 (NOTCH3)."( Huang, L; Li, W; Li, Y; Song, C; Sun, X; Wang, H; Wang, P, 2020)
"CADASIL is a vascular protein aggregation disorder caused by cysteine-altering NOTCH3 variants, leading to mid-adult-onset stroke and dementia."( Aartsma-Rus, A; Baas, F; Brouwer, G; Dauwerse, JG; Gravesteijn, G; Hegeman, I; Jost, CR; Kruit, MC; Lesnik Oberstein, SAJ; Mulder, AA; Overzier, M; Rutten, JW; Terwindt, GM; van Duinen, SG, 2020)
"CADASIL is characterised by vascular dysfunction and granular osmiophilic material (GOM) accumulation in cerebral small vessels."( Alves-Lopes, R; Delles, C; Montezano, AC; Moreton, F; Morris, HE; Muir, KW; Neves, KB; Touyz, RM, 2021)

Context

ExcerptReference
"CADASIL has been linked to nucleotide substitutions and deletions in the Notch3 gene."( Bono, F; Caracciolo, M; Cenacchi, G; Conforti, FL; Fera, F; Gabriele, AL; Gallo, O; Lanza, PL; Lupo, MR; Magariello, A; Mazzei, R; Muglia, M; Patitucci, A; Quattrone, A; Santoro, G; Sprovieri, T; Valentino, P, 2004)

Research

Studies (137)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's39 (28.47)18.1394
2010's65 (47.45)28.8240
2020's33 (24.09)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
choline0low10
n(g),n(g')-dimethyl-l-arginine0low10
creatine0low20
lactic acid0low20
glycine0low30
inositol0low10
nitrites0low10
cgp 524110low10
acetaminophen0low10
acetazolamide0low50
aspirin0low60
azathioprine0low10
bupivacaine0low20
verapamil0low10
valproic acid0low20
donepezil0medium21
fentanyl0low10
staurosporine aglycone0low10
lomerizine0low20
lorazepam0low10
losartan0low10
memantine0low10
methyclothiazide0low10
nitroglycerin0low10
potassium chloride0low10
ticlopidine0low10
aspartic acid0low20
glutamine0low10
phenylephrine0low10
levodopa0low20
tyrosine0low10
leucine0low10
mannitol0low10
tryptophan0low20
arginine0medium141
methylprednisolone0low10
pyrroles0low10
uranyl acetate0low10
maleimide0low10
isobutyl nitrite0low10
amiloride0low10
fucose0low20
osmium tetroxide0low10
glutamic acid0low10
atorvastatin0low20
n-acetylaspartic acid0low20
fluorodeoxyglucose f180low10
dipropylacetamide0low10
fibrinogen0low20
homocysteine0low40
levobupivacaine0low10
n,n-dimethylarginine0low10
4-iodoamphetamine0low10
omega-n-methylarginine0low10
aspartyl-proline0low10
3-nitrotyrosine0low10
glycogen0low10
cysteinylglycine0low10
capsaicin0low10
tamoxifen0low10
cystine0low20
codeine0low10
sirolimus0low10
deoxyribose0low10
cysteine0low440
ribose0low10
melitten0low10
angiotensinogen0low10
cardiovascular agents0low10
piperidines0medium21
epidermal growth factor0low50
transforming growth factor beta0low20
technetium tc-99m tetrofosmin0low10
exudates0low10
cyclic gmp0low10
sapropterin0medium11

Protein Targets (1,180)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A4004
phosphopantetheinyl transferase100010
bromodomain adjacent to zinc finger domain 2B5005
euchromatic histone-lysine N-methyltransferase 2220022
pyruvate kinase PKM isoform a1001
geminin170017
Glycoprotein hormones alpha chain1001
Guanine nucleotide-binding protein G1001
Tubulin--tyrosine ligase0202
RAR-related orphan receptor gamma7007
ATAD5 protein, partial5005
GLS protein9009
Microtubule-associated protein tau6006
Smad34004
aldehyde dehydrogenase 1 family, member A19009
thyroid stimulating hormone receptor9009
nuclear receptor subfamily 1, group I, member 3100010
progesterone receptor7007
EWS/FLI fusion protein7007
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha150015
estrogen nuclear receptor alpha210021
peroxisome proliferator activated receptor gamma110011
aryl hydrocarbon receptor3003
chromobox protein homolog 18008
thyroid hormone receptor beta isoform 2100010
peripheral myelin protein 22100010
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi83011
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Solute carrier family 22 member 60303
Carbonic anhydrase 120319
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0606
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump017017
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 107118
Carbonic anhydrase 207117
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20203
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30319
Cytochrome P450 3A40708
Cytochrome P450 2D60505
Cytochrome P450 2C9 0606
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-183011
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta83011
Gamma-aminobutyric acid receptor subunit gamma-283112
UDP-glucuronosyltransferase 1-60002
Glutamate receptor 26219
Gamma-aminobutyric acid receptor subunit alpha-583011
Gamma-aminobutyric acid receptor subunit alpha-383011
Arachidonate 5-lipoxygenase-activating protein0202
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 405110
Prostaglandin G/H synthase 10505
Carbonic anhydrase 60318
Gamma-aminobutyric acid receptor subunit gamma-183011
Gamma-aminobutyric acid receptor subunit alpha-283011
Gamma-aminobutyric acid receptor subunit alpha-483011
Gamma-aminobutyric acid receptor subunit gamma-383011
Gamma-aminobutyric acid receptor subunit alpha-683011
Carbonic anhydrase 5A, mitochondrial04110
Prostaglandin G/H synthase 20304
Carbonic anhydrase 70318
Nuclear receptor ROR-gamma6006
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-184113
Gamma-aminobutyric acid receptor subunit beta-383011
Gamma-aminobutyric acid receptor subunit beta-283112
Carbonic anhydrase 904110
GABA theta subunit83011
Canalicular multispecific organic anion transporter 1010010
Carbonic anhydrase 150307
Carbonic anhydrase 130306
Gamma-aminobutyric acid receptor subunit epsilon83011
Carbonic anhydrase 140319
Carbonic anhydrase 5B, mitochondrial0319
toxin B0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase3003
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase170017
GALC protein2002
GLI family zinc finger 3130013
cytochrome P450 family 3 subfamily A polypeptide 49009
glucocorticoid receptor [Homo sapiens]160016
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A110011
Carbonic anhydrase0101
Bloom syndrome protein isoform 1100010
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 1120012
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 13003
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 20202
Cathepsin B0101
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0213
Polyunsaturated fatty acid 5-lipoxygenase0303
Cytochrome P450 2C80303
Cytochrome P450 2A60303
5-hydroxytryptamine receptor 2A0213
Androgen receptor0505
Translocator protein0101
Cannabinoid receptor 10101
Cytochrome P450 2B60404
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10204
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Endochitinase0101
Adenosine receptor A2a0305
5-hydroxytryptamine receptor 2B0213
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0707
Cytochrome P450 2C190404
Delta-type opioid receptor0303
Mu-type opioid receptor0415
Carbonic anhydrase0205
Kappa-type opioid receptor0606
Carbonic anhydrase0101
D(1A) dopamine receptor1102
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0104
D(2) dopamine receptor0213
Cholinesterase0606
Carbonic anhydrase 0101
Mu-type opioid receptor0303
Fatty-acid amide hydrolase 10202
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B08213
Squalene synthase0202
Neuronal acetylcholine receptor subunit alpha-70202
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0104
Carbonic anhydrase 30101
Carbonic anhydrase0105
Carbonic anhydrase0105
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10606
Renin0101
Carbonic anhydrase 0104
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
Carbonic anhydrase 40203
Acidic mammalian chitinase0101
Carbonic anhydrase 70101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, 2-oxoglutarate Oxygenase5005
acid sphingomyelinase1001
acetylcholinesterase7007
TDP1 protein160016
AR protein200020
regulator of G-protein signaling 47007
glucocerebrosidase5005
alpha-galactosidase3003
cytochrome P450 2D6 isoform 14004
lysosomal alpha-glucosidase preproprotein2002
cytochrome P450 2C19 precursor6006
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
huntingtin isoform 24004
lamin isoform A-delta10150015
Membrane primary amine oxidase 0101
Solute carrier family 22 member 1 0607
Prothrombin0112
Coagulation factor X0101
Plasminogen0101
Urokinase-type plasminogen activator0202
Tissue-type plasminogen activator0202
Cationic trypsin0101
Coagulation factor XI0101
Plasma kallikrein0104
Vitamin K-dependent protein C0101
Cellular tumor antigen p538008
Urokinase-type plasminogen activator0202
Trypsin-10101
Trypsin-20101
Sodium/hydrogen exchanger 10101
Amine oxidase [flavin-containing] A0303
Sodium/hydrogen exchanger 10202
Sodium/hydrogen exchanger 30202
Adenosine receptor A2a0303
Trypsin-30101
Amiloride-sensitive sodium channel subunit alpha0101
5-hydroxytryptamine receptor 70303
Sodium/hydrogen exchanger 20202
Acid-sensing ion channel 10101
Potassium voltage-gated channel subfamily H member 20808
Sodium channel protein type 5 subunit alpha0202
Sodium/hydrogen exchanger 50202
Solute carrier family 22 member 10203
Solute carrier family 22 member 20203
Acid-sensing ion channel 30101
Sodium/hydrogen exchanger0101
Solute carrier family 22 member 30101
Phenylethanolamine N-methyltransferase0202
Substance-P receptor0101
5-hydroxytryptamine receptor 1A0819
Cytochrome P450 2A50101
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 1B0516
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 60011
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
Beta-2 adrenergic receptor0101
5-hydroxytryptamine receptor 3B0011
Sigma non-opioid intracellular receptor 10213
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
NFKB1 protein, partial4004
flap endonuclease 15005
DNA polymerase iota isoform a (long)9009
muscarinic acetylcholine receptor M16006
lethal factor (plasmid)4004
Nitric oxide synthase, endothelial0103
Nitric oxide synthase, brain0315
Nitric oxide synthase, brain 0304
Nitric oxide synthase, inducible0102
Nitric oxide synthase, inducible0215
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase8008
Chain A, Ferritin light chain5005
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 07212
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 07212
Glutamate receptor ionotropic, NMDA 2C07212
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0006
Glutamate receptor ionotropic, NMDA 2D07212
Glutamate receptor ionotropic, NMDA 3B07212
Glutamate receptor ionotropic, NMDA 3A07212
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
hypothetical protein, conserved1001
cytochrome P450 2D63003
peroxisome proliferator-activated receptor delta7007
Rac1 protein0011
IDH15005
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
DNA polymerase kappa isoform 14004
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0516
Fatty acid-binding protein, liver0202
Integrin beta-32114
Myeloperoxidase0202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2114
Glutathione hydrolase 1 proenzyme0101
Substance-P receptor0202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10718
Chain A, Cruzipain3003
SMAD family member 24004
SMAD family member 34004
caspase 7, apoptosis-related cysteine protease3003
estrogen receptor 2 (ER beta)6006
pregnane X nuclear receptor9009
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-33003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
Caspase-72002
vitamin D3 receptor isoform VDRA6006
caspase-32002
Solute carrier organic anion transporter family member 2B1 0001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
ATP-dependent translocase ABCB108218
Insulin receptor 0101
Dipeptidyl peptidase 40101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Histone deacetylase 10404
Histone deacetylase 20404
Solute carrier organic anion transporter family member 1B30203
Histone deacetylase 60404
Broad substrate specificity ATP-binding cassette transporter ABCG20415
Solute carrier organic anion transporter family member 1B10607
Fumarate hydratase3003
thioredoxin glutathione reductase3003
farnesoid X nuclear receptor4004
G5005
polyprotein3003
P531001
thyroid stimulating hormone receptor7007
activating transcription factor 65005
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x3003
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
heat shock protein beta-14004
M-phase phosphoprotein 85005
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 5005
Inositol hexakisphosphate kinase 15005
ATPase family AAA domain-containing protein 55005
Ataxin-27007
Protein-arginine deiminase type-40101
cytochrome P450 2C9, partial5005
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
15-lipoxygenase, partial3003
67.9K protein6006
mitogen-activated protein kinase 12002
nuclear receptor ROR-gamma isoform 13003
transient receptor potential cation channel subfamily V member 11001
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0101
NADH-ubiquinone oxidoreductase chain 10101
Cannabinoid receptor 10101
Acetylcholinesterase07311
Cannabinoid receptor 2 0101
Spike glycoprotein5016
Inositol monophosphatase 12002
Potassium voltage-gated channel subfamily A member 10101
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
Transient receptor potential cation channel subfamily V member 40011
Transient receptor potential cation channel subfamily V member 20011
endonuclease IV1001
RGS121001
USP1 protein, partial4004
Thrombopoietin1001
DNA polymerase III, partial2002
nonstructural protein 12002
potassium voltage-gated channel subfamily H member 2 isoform d8008
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
neuropeptide S receptor isoform A2002
Serine/threonine-protein kinase D30314
Tyrosine-protein kinase ABL10112
Amyloid-beta precursor protein0303
Protein kinase C gamma type0303
Platelet-derived growth factor receptor beta0101
Protein kinase C beta type0314
Potassium-transporting ATPase alpha chain 10101
Proto-oncogene tyrosine-protein kinase Src0112
Protein kinase C alpha type0314
Potassium-transporting ATPase subunit beta0101
Protein kinase C eta type0303
Platelet-derived growth factor receptor alpha 0101
Protein kinase C iota type0314
Tyrosine-protein kinase ABL20112
Protein kinase C epsilon type0303
Protein kinase C theta type0314
Protein kinase C zeta type0314
Protein kinase C delta type0314
Serine/threonine-protein kinase D10303
cAMP-dependent protein kinase 0101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20002
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-50101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0102
Neuronal acetylcholine receptor subunit alpha-60202
Neuronal acetylcholine receptor subunit alpha-90101
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
UDP-glucuronosyltransferase 2B70103
Kappa-type opioid receptor0101
Mu-type opioid receptor0628
Delta-type opioid receptor0606
Kappa-type opioid receptor0606
Mu-type opioid receptor0202
Cytochrome P450 2D40101
Mas-related G-protein coupled receptor member X20011
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10405
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
Glutamate receptor 10314
Glutamate receptor 20314
Glutamate receptor 30213
Glutamate receptor ionotropic, kainate 30303
Solute carrier family 15 member 10202
Glutamate receptor 40314
Solute carrier family 15 member 20101
Chain A, limonene-1,2-epoxide hydrolase0101
Chain A, Epoxide hydrolase0101
Acetylcholinesterase0505
Voltage-dependent L-type calcium channel subunit alpha-1F0202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Acetylcholinesterase0303
Cholinesterase0404
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0202
Liver carboxylesterase 10202
Acetylcholinesterase 0303
Amine oxidase [flavin-containing] B0202
Sodium-dependent serotonin transporter0505
Acetylcholinesterase0202
Glycogen synthase kinase-3 beta0213
Beta-secretase 10101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Cholinesterase0101
Acetylcholine receptor subunit epsilon0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Cytochrome P450 1B10101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0404
Histamine H3 receptor0101
Luciferase6006
Nuclear receptor subfamily 1 group I member 20033
D(2) dopamine receptor0303
D(4) dopamine receptor0303
Kappa-type opioid receptor0101
Histamine H1 receptor0101
D(3) dopamine receptor0505
Fucose-binding lectin PA-IIL0101
CD209 antigen0202
Chain A, ACETYLCHOLINESTERASE0101
Chain A, Acetylcholinesterase0101
Vascular endothelial growth factor receptor 1 0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Prolyl endopeptidase0101
Small conductance calcium-activated potassium channel protein 30101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
D(1A) dopamine receptor3003
transcriptional regulator ERG isoform 33003
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
histone acetyltransferase KAT2A isoform 13003
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 433003
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0124
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial4004
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Metabotropic glutamate receptor 80011
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10303
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0303
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0202
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10505
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10305
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Sodium/myo-inositol cotransporter 20101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Phospholipase A-2-activating protein0202
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
dopamine D1 receptor2002
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA12002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
snurportin-12002
DNA polymerase eta isoform 11001
Polyphenol oxidase 20002
Tyrosine-protein kinase Lck0213
Tyrosine-protein kinase Fyn0213
Tyrosinase0101
SLC16A10 protein0003
Monocarboxylate transporter 100003
phosphoglycerate kinase1001
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Prostaglandin D2 receptor 20101
Translocator protein0101
Neprilysin0101
Angiotensin-converting enzyme 0101
Atrial natriuretic peptide receptor 30101
Thromboxane A2 receptor 0102
Type-1A angiotensin II receptor 0213
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0215
Type-1 angiotensin II receptor0112
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
Multidrug and toxin extrusion protein 10101
Type-1 angiotensin II receptor0112
hypoxia-inducible factor 1 alpha subunit3003
LacZ protein (plasmid)0101
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
[tau protein] kinase 0101
C-C chemokine receptor type 60101
serine/threonine-protein kinase PLK11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
Glycogen synthase kinase-3 alpha0112
lethal(3)malignant brain tumor-like protein 1 isoform I1001
serine/threonine-protein kinase mTOR isoform 12002
ClpP1001
nuclear factor erythroid 2-related factor 2 isoform 24004
PPM1D protein2002
nuclear receptor subfamily 1, group I, member 21001
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nuclear receptor subfamily 1 group I member 20011
Rap guanine nucleotide exchange factor 41001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
Neutrophil elastase0101
Proteinase-activated receptor 10101
Nitric oxide synthase, endothelial0202
Collagenase 30101
Nitric oxide synthase, brain0101
Alpha-1B adrenergic receptor 0011
ras-related protein Rab-9A2002
Beta-2 adrenergic receptor0011
Beta-1 adrenergic receptor0213
Alpha-2A adrenergic receptor0718
Beta-3 adrenergic receptor0213
POU domain, class 2, transcription factor 10001
Alpha-1B adrenergic receptor0303
Alpha-2B adrenergic receptor0505
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0314
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Alpha-2B adrenergic receptor0001
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Alpha-1A adrenergic receptor0303
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Taste receptor type 2 member 310011
Taste receptor type 2 member 600011
Sodium/potassium/calcium exchanger 40112
Taste receptor type 2 member 140012
Taste receptor type 2 member 130011
Taste receptor type 2 member 90011
Taste receptor type 2 member 40011
Sodium/potassium/calcium exchanger 20112
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Insulin receptor0011
Cyclin-dependent kinase 10011
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
DNA topoisomerase 2-alpha0011
Cyclin-dependent kinase 40112
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Tyrosine-protein kinase Fer0011
cAMP-dependent protein kinase catalytic subunit alpha0112
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0112
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Cyclin-dependent kinase 20112
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Alpha-synuclein2002
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Exosome RNA helicase MTR40011
Serine/threonine-protein kinase mTOR0112
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
DNA topoisomerase 2-beta0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Tyrosine-protein kinase BTK0011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0112
Calcium/calmodulin-dependent protein kinase type II subunit delta0112
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110112
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
eyes absent homolog 2 isoform a1001
B2 bradykinin receptor0101
G1/S-specific cyclin-E20101
cAMP-dependent protein kinase catalytic subunit alpha0101
Beta-lactamase0101
Zinc finger protein GLI10101
Zinc finger protein GLI20101
Malate dehydrogenase0101
Chymotrypsinogen B0101
cAMP-dependent protein kinase catalytic subunit gamma0101
G1/S-specific cyclin-D10101
G1/S-specific cyclin-E10101
Tyrosine-protein kinase JAK30101
Mitogen-activated protein kinase kinase kinase 90101
Mitogen-activated protein kinase kinase kinase 100101
C-terminal-binding protein 11001
Calcium/calmodulin-dependent protein kinase type II subunit beta0101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Chain A, CES1 protein0101
thyrotropin-releasing hormone receptor1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
ubiquitin-conjugating enzyme E2 N0101
streptokinase A precursor0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40404
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C alpha type0101
Estrogen receptor0012
Progesterone receptor0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10303
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Muscarinic acetylcholine receptor M30202
Substance-K receptor0202
D(1A) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
5-hydroxytryptamine receptor 2B0404
Melanocortin receptor 30202
Histamine H2 receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Disintegrin and metalloproteinase domain-containing protein 171001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Stromelysin-10101
Indoleamine 2,3-dioxygenase 10102
Tryptophan 2,3-dioxygenase0102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
pregnane X receptor1001
Cocaine esterase0101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Albumin0011
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10102
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Multidrug resistance-associated protein 1 0214
Chloroquine resistance transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]