donepezil has been researched along with CADASIL in 2 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
CADASIL: A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil had no effect on the primary endpoint, the V-ADAS-cog score in CADASIL patients with cognitive impairment." | 9.13 | Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. ( Chabriat, HS; Dichgans, M; Markus, HS; Moline, M; Posner, H; Salloway, S; Verkkoniemi, A; Wang, Q, 2008) |
| "Donepezil had no effect on the primary endpoint, the V-ADAS-cog score in CADASIL patients with cognitive impairment." | 5.13 | Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. ( Chabriat, HS; Dichgans, M; Markus, HS; Moline, M; Posner, H; Salloway, S; Verkkoniemi, A; Wang, Q, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schneider, LS | 1 |
| Dichgans, M | 1 |
| Markus, HS | 1 |
| Salloway, S | 1 |
| Verkkoniemi, A | 1 |
| Moline, M | 1 |
| Wang, Q | 1 |
| Posner, H | 1 |
| Chabriat, HS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An 18-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment[NCT00103948] | Phase 2 | 165 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for donepezil and CADASIL
| Article | Year |
|---|---|
Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL.
Topics: Adult; Aged; CADASIL; Cognition Disorders; Confidence Intervals; Donepezil; Double-Blind Method; Fem | 2008 |
1 other study available for donepezil and CADASIL
| Article | Year |
|---|---|
Does donepezil improve executive function in patients with CADASIL?
Topics: CADASIL; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Problem Solving | 2008 |