aspirin has been researched along with CADASIL in 6 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
CADASIL: A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although intracerebral hemorrhage (ICH) has been described in patients with CADASIL, the cause of such ICH is still unknown." | 5.35 | Aspirin-associated intracerebral hemorrhage in a patient with CADASIL. ( Choi, JC; Kang, JH; Kang, SY; Lee, JS; Oh, JH, 2008) |
| " I have selected 4 translations in the field of vascular neurology in which I have been involved in different respects: (1) the translation of results from men to women, taking the example of aspirin which, in primary prevention, decreases the risk of myocardial infarction in men and the risk of cerebral infarction in women, the reason for this sex difference being so far unknown; (2) the 'inverse translational research', from bedside to bench, taking the example of the disease we have identified--CADASIL--and showing how the study of one patient and his family led to the identification of a gene, Notch3, so far unknown in humans and to the discovery of its key role in the physiology of vascular smooth muscle cells; (3) the translation from individual case reports to multidisciplinary trials taking the example of hemicraniectomy in malignant cerebral infarction and emphasizing the interest in such rare and severe conditions of pooling and reporting the results of randomized clinical trials before the results of individual trials, and (4) the translation from research to practice, emphasizing not the well-known 'evidence to practice gap' but the slippery slope of 'lack of evidence to overpractice', taking the example of patent foramen ovale closure in migraine." | 4.84 | Some translations in vascular neurology. The Johann Jacob Wepfer Award 2008. ( Bousser, MG, 2008) |
| "Although intracerebral hemorrhage (ICH) has been described in patients with CADASIL, the cause of such ICH is still unknown." | 1.35 | Aspirin-associated intracerebral hemorrhage in a patient with CADASIL. ( Choi, JC; Kang, JH; Kang, SY; Lee, JS; Oh, JH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Trifan, G | 1 |
| Hillmann, M | 1 |
| Testai, FD | 1 |
| Zhang, C | 1 |
| Zhang, Z | 1 |
| Lamberg, JJ | 1 |
| Cherian, VT | 1 |
| Bousser, MG | 1 |
| Nannucci, S | 1 |
| Pescini, F | 1 |
| Valenti, R | 1 |
| Ciolli, L | 1 |
| Bianchi, S | 1 |
| Dotti, MT | 1 |
| Inzitari, D | 1 |
| Pantoni, L | 1 |
| Oh, JH | 1 |
| Lee, JS | 1 |
| Kang, SY | 1 |
| Kang, JH | 1 |
| Choi, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II, Randomized, Crossover, Single Blind, Safety Trial of DABIGATRAN Versus ASA for Preventing Ischaemic Brain Lesions in Patients Affected by CADASIL[NCT01361763] | Phase 2 | 50 participants (Anticipated) | Interventional | 2011-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for aspirin and CADASIL
| Article | Year |
|---|---|
Some translations in vascular neurology. The Johann Jacob Wepfer Award 2008.
Topics: Aspirin; Awards and Prizes; Biomedical Research; CADASIL; Cardiovascular Agents; Cardiovascular Dise | 2008 |
5 other studies available for aspirin and CADASIL
| Article | Year |
|---|---|
Acute Stroke as the Presenting Symptom of SARS-CoV-2 Infection in a Young Patient with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.
Topics: Adult; Aspirin; Betacoronavirus; CADASIL; Coronavirus Infections; COVID-19; Female; Host-Pathogen In | 2020 |
CADASIL with Large Intracranial Arterial Atherosclerotic Stenosis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atorvastatin; CADASIL; Humans; Hydroxymethy | 2019 |
Neuraxial anesthesia in CADASIL syndrome.
Topics: Anesthesia, Epidural; Anesthesia, Spinal; Aspirin; CADASIL; Female; Hemorrhoids; Humans; Intraoperat | 2013 |
Stroke recurrence in an elderly CADASIL patient on aspirin discontinuation due to severe auto-immune thrombocytopenia.
Topics: Aged, 80 and over; Aspirin; Autoimmune Diseases; CADASIL; Exons; Humans; Male; Receptor, Notch3; Rec | 2010 |
Aspirin-associated intracerebral hemorrhage in a patient with CADASIL.
Topics: Acute Disease; Adult; Aspirin; CADASIL; Cerebral Hemorrhage; Diffusion Magnetic Resonance Imaging; F | 2008 |