valproic acid has been researched along with CADASIL in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
CADASIL: A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a woman with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) followed for 15 years, we observed magnetic resonance imaging white matter hyperintensities that vanished in the anterior temporal poles while the brain volume decreased unexpectedly." | 1.56 | Vanishing White Matter Hyperintensities in CADASIL: A Case Report with Insight into Disease Mechanisms. ( Alili, N; Chabriat, H; Hervé, D; Jouvent, E, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jouvent, E | 1 |
| Alili, N | 1 |
| Hervé, D | 1 |
| Chabriat, H | 1 |
| Martikainen, MH | 1 |
| Roine, S | 1 |
1 review available for valproic acid and CADASIL
| Article | Year |
|---|---|
Rapid improvement of a complex migrainous episode with sodium valproate in a patient with CADASIL.
Topics: Adult; CADASIL; GABA Agents; Humans; Male; Migraine Disorders; Valproic Acid | 2012 |
1 other study available for valproic acid and CADASIL
| Article | Year |
|---|---|
Vanishing White Matter Hyperintensities in CADASIL: A Case Report with Insight into Disease Mechanisms.
Topics: Antimanic Agents; Bipolar Disorder; Brain; CADASIL; Disease Progression; Drug Substitution; Female; | 2020 |