technetium-tc-99m-medronate and Bone-Cysts

Single photon emission computed tomography (SPECT) images provide many details of the anatomical structure. Also about bone scintigraphy, there are many reports of the improvement of diagnosis by SPECT images. Although SPECT is useful, it requires much time. So to perform SPECT for all cases is difficult in the clinical situation. Recently, due to technical improvements in gamma cameras, we can get SPECT images in a short time. We examined diagnosis of solitary hot spots of thoracic spine in cancer patients using short-time SPECT. And we considered whether short-time SPECT contributes to the precise diagnosis of the lesion.. We performed bone scintigraphy image acquisition and both planar and short-time SPECT of the chest. Short-time SPECT was acquired in 6 minutes. We selected 36 cases with malignancy, whose bone scintigraphy demonstrated a solitary accumulation hot spot in the thoracic spine. Three experienced radiologists in nuclear medicine and 4 beginners diagnosed the images. They interpreted planar, short-time SPECT and maximum intensity projection (MIP) view of the chest of each case. The observers' response data were analyzed with receiver operating characteristic (ROC) curve analysis.. Of the three types of images, the Az (the area under ROC curve) values of short-time SPECT were the highest in all the observers except for only one beginner. Compared with experienced observers, beginners scored lower Az values of short-time SPECT. MIP images were constructed using SPECT data, but the Az values of MIP images were not higher than those of planar images. As to diagnosis, beginners tended to interprete most of the accumulations as metastatic lesions.. Short-time SPECT can be helpful to some degree, but to provide greater benefit, the observers require considerable exercise and experience.

Topics: Adult; Aged; Aged, 80 and over; Bone Cysts; Female; Humans; Image Enhancement; Male; Middle Aged; Observer Variation; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Spinal Neoplasms; Technetium Tc 99m Medronate; Thoracic Vertebrae; Time Factors; Tomography, Emission-Computed, Single-Photon

Topics: Biopsy; Bone Cysts; Diagnostic Imaging; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Periosteum; Radius; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

We describe a simple bone cyst in a patient who had an osteoblastic lesion which had been discovered 1 1/2 years earlier. Curettage and drilling proved effective treatment. We suggest that increased regional blood flow, in association with bone formation, produces a hydrodynamic disorder followed by venous obstruction leading to the formation of a bone cyst.

Topics: Biopsy; Bone Cysts; Bone Screws; Child; Curettage; Female; Femoral Neoplasms; Femur; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Osteoblastoma; Regional Blood Flow; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Glucose phosphate (GP) labelled with 99mTc was used to obtain scintigraphic images of bone lesions in one group of patients (n = 28) and of lung tumors in another (n = 35). All bone lesions detected by 99mTc-MDP were also demonstrated by 99mTc-GP; all lung tumors except 4 were detected by 99mTc-GP, the failure rate being about the same as that for 67Ga. The use of 99mTc-GP is preferable to that of 99mTc-MDP because the former does not accumulate in normal bone; the advantage of 99mTc-GP over 67Ga lies in its better physical characteristics and in the fact that the result of the study is available within a few hours rather than three days.

Topics: Adolescent; Adult; Aged; Bone Cysts; Bone Diseases; Bone Neoplasms; Child; Child, Preschool; Female; Glucosephosphates; Humans; Hyperparathyroidism; Lung Neoplasms; Male; Middle Aged; Organotechnetium Compounds; Osteitis Deformans; Prostatic Neoplasms; Radionuclide Imaging; Technetium Tc 99m Medronate

Aneurysmal bone cyst is rarely found in the mandible, and roentgenographic diagnosis of this condition is not easily made. In this report, the diagnostic value of bone scintigraphy and radionuclide angiography and CT imaging in two cases of aneurysmal bone cyst of the mandible are discussed. Bone scintigraphy with Tc-99m MDP demonstrated ring-like or doughnut-pattern accumulation of radioactivity, which corresponded to the expansile character of the bony lesion. The accumulation of radioactivity was intensive in the peripheral region despite the fact that the lesion was benign. Furthermore, the central rarefaction showed that the lesion was cystic. Radionuclide angiography with Tc-99m HSA, including blood pool scan, did not detect radioactive concentration. Thus bone scintigraphy and radionuclide angiography were found to be essential in the differential diagnosis of aneurysmal bone cyst from other forms of tumor, especially hypervascularized tumor and central hemangioma of the mandible.

Topics: Angiography; Bone Cysts; Child; Female; Humans; Male; Mandibular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Bone scintigrams of 25 aneurysmal bone cysts showed abnormal activity in every case. In 22 cases, the activity was correlated with the true pathologic extent of the lesions; only three exhibited a false-positive extended pattern of uptake beyond the true tumor margins. Sixteen scintigrams (64%) revealed increased uptake, chiefly around the periphery of the lesions, with less activity in their centers. This feature could not be explained simply by the cystic nature of the lesions, since aneurysmal bone cysts may contain considerable fibrous tissue septa containing trabeculae of reactive new bone. However, there was no correlation between any specific anatomic or histologic pattern and the intensity and pattern of abnormal scintigraphic activity.

Topics: Adolescent; Adult; Bone Cysts; Child; Child, Preschool; Diphosphates; Diphosphonates; Female; Femoral Neoplasms; Fibula; Humans; Male; Radionuclide Imaging; Scapula; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Pyrophosphate; Ulna

Intraosseous ganglia are benign cystic lesions of bone located in close relationship to the articular cartilage. The typical location and roentgenographic appearance of this lesion should permit a diagnosis of this entity which should be considered in the differential diagnosis of benign lesions of bone. Appearance of this lesion on a bone scan is shown in this case report.

Topics: Bone Cysts; Diagnosis, Differential; Diphosphonates; Humans; Male; Middle Aged; Radionuclide Imaging; Synovial Cyst; Technetium; Technetium Tc 99m Medronate