bromochloroacetic-acid and Bone-Cysts

Paragangliomas are derived from neurosecretory cells believed to be of neural crest origin. A spinal location of paraganglioma is rare and usually presents as an intradural mass.. A primary intraosseous paraganglioma of sacrum is extremely unusual, and only 6 cases were reported. In this study, we report a rare case of a 44-year-old man with the complaint of low back pain and lower extremity weakness. Imaging workup, including computerized tomography (CT), and magnetic resonance imaging (MRI) presented an intraosseous sacral lesion with invasion of sacrum in the S1-S3 vertebrae, and extension to L4-L5 spinal canal. The patient underwent subtotal tumor resection, followed by radiation therapy.. The morphological and immunohistochemical studies revealed a composite tumor of paraganglioma and ganglioneuroma components, with immunopositivity for cytokeratin.. To the best of our knowledge, this is the first report in the literature demonstrating an intraosseous sacral paraganglioma with these 2 pathological features.

Topics: Adult; Bone Cysts; Ganglioneuroma; Humans; Keratins; Male; Paraganglioma; Sacrum; Spinal Neoplasms

Adamantinoma of the long bones is a rare primary bone tumor of uncertain embryogenesis. It tends to involve the tibia almost exclusively. We report on adamantinomas occurring in a 16-year-old male patient, with synchronous tibial and fibular lesions. Histologically, there were characteristic clusters of epithelial cells in a fibrous background, forming a keratin cyst. Immunohistochemically, these cells were strongly positive for cytokeratin. This keratin cyst formation is quite an unusual finding in classic adamantinoma.

Topics: Adamantinoma; Adolescent; Bone Cysts; Bone Neoplasms; Diagnosis, Differential; Fibula; Humans; Keratins; Magnetic Resonance Imaging; Male; Neoplasms, Multiple Primary; Tibia

Tubulopapillary hidradenoma is a benign sweat gland tumor that appears as a well-defined, superficially located dermal nodule. It combines ductal as well as apocrine and eccrine glandular differentiation. Microscopically, the tumor is composed of tubular structures that characteristically show intraluminal non-villous papillary projections and a peripheral myoepithelial cell layer. A tumor that is histologically and immunohistochemically identical to tubulopapillary hidradenoma occurred in the mandible of a 73-year-old man and resulted in considerable diagnostic difficulty. The neoplasm developed in a mandibular cyst and recurred 5 years after initial enucleation. This is the first report of a central (intraosseous) sweat gland adenoma of the mandible. The differential diagnosis and possible histogenesis are discussed.

Topics: Actins; Adenoma, Sweat Gland; Aged; Apocrine Glands; Bone Cysts; Cell Nucleolus; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Diagnosis, Differential; Eccrine Glands; Epithelial Cells; Follow-Up Studies; Humans; Keratins; Male; Mandibular Neoplasms; Muscle, Smooth; Neoplasm Recurrence, Local; Vimentin

Large cholesterol cysts were found in revision surgery in six patients with previous ear surgery one to 28 years ago. The cysts mimicked brain herniation in open cavities, filled the mastoid and ear canal in closed cavities, or caused postauricular swelling. Bone around the cysts was soft and granulomatous. Secretory cells were scarce in the epithelial lining of the lumen, but subepithelial glands were frequent. Cholesterol granulomas and hemosiderin-laden macrophages were present inside the wall. The cyst lining and the glands under it showed cytokeratin staining typical for simple and glandular epithelia. Antiprekeratin antibodies showed no decoration of the lining but reacted positively with the meatal skin. These findings prove that respiratory-type epithelium separated from an aerated middle ear does not undergo changes into keratin-forming epithelium.

Topics: Adult; Aged; Bone Cysts; Cholesterol; Epithelium; Female; Granuloma; Hemosiderin; Humans; Keratins; Macrophages; Male; Mastoid; Middle Aged

The technique for registration of fluid pressure in jaw cysts by means of pressure transducer and cannulation of the cyst cavity or cementation of a two-way valve into a tooth communicating with the cyst is described. Twenty-six closed cysts were subjected to registration of intracystic pressure. Subsequent histologic examination showed that all cysts were non-keratinized. Initial pressure values in apical periodontal cysts averaged +47 mmHg, in follicular cysts +44 mmHg, and in residual cysts +38 mmHg. A median palatine cyst exhibited a pressure of +81 mmHg. Most cysts showed intracystic pulsation corresponding to the number of heart beats on electrocardiograms obtained simultaneously. The intracystic pulsation disappeared when the intracystic pressure was experimentally increased and reappeared when it was lowered. In three cases in which registration of pressure was performed 7-14 days after the aspiration of the cyst fluid, an intracystic pressure in the same range as the initial one was found. The findings indicate deficient lymphatic drainage of non-keratinizing jaw cysts.

Topics: Bone Cysts; Humans; Jaw Diseases; Keratins; Lymphatic System; Mouth Diseases; Odontogenic Cysts; Periodontal Cyst; Pressure

Topics: Bone Cysts; Cysts; Dentigerous Cyst; Humans; Keratins; Mouth Diseases; Nonodontogenic Cysts; Odontogenic Cysts; Radicular Cyst; Radiography

Topics: Bone Cysts; Dentigerous Cyst; Humans; Jaw Diseases; Jaw Neoplasms; Keratins; Lymphatic System; Methods; Nonodontogenic Cysts; Odontogenic Cysts; Osmosis; Recurrence

Topics: Adult; Bone Cysts; Carcinoma, Basal Cell; Diagnosis, Differential; Epidermal Cyst; Humans; Jaw Diseases; Keratins; Male; Ribs; Skin; Skin Neoplasms; Syndrome

Topics: Adolescent; Adult; Age Factors; Aged; Bone Cysts; Child; Chondroma; Curettage; Diagnosis, Differential; Female; Fingers; Humans; Keratins; Male; Middle Aged; Postoperative Complications; Radiography; Sex Factors