Compounds > dcb 3503
Page last updated: 2024-11-08

dcb 3503

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Cross-References

ID SourceID
PubMed CID402628
CHEMBL ID399454
SCHEMBL ID12389871
MeSH IDM0496880

Synonyms (17)

Synonym
nsc716802
NCI60_040362
dibenzo[f,2-b]isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (13as-trans)-
nsc-716802
CHEMBL399454 ,
dcb-3503
(13as,14s)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizin-14-ol
bdbm50213933
(12as,13s)-2,3,6,7-tetramethoxy-9,10,11,12,12a,13-hexahydro-9a-aza-cyclopenta[b]triphenylen-13-ol
unii-txf835u41k
dibenzo(f,h)pyrrolo(1,2-b)isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (13as,14s)-
87302-58-7
dibenzo(f,h)pyrrolo(1,2-b)isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-2,3,6,7-tetramethoxy-, (13as-trans)-
txf835u41k ,
SCHEMBL12389871
Q27290473
AKOS040748221
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Transcription factor AP-1Homo sapiens (human)IC50 (µMol)1.06700.00790.39202.0300AID308180
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (21)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IITranscription factor AP-1Homo sapiens (human)
regulation of transcription by RNA polymerase IITranscription factor AP-1Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayTranscription factor AP-1Homo sapiens (human)
release from viral latencyTranscription factor AP-1Homo sapiens (human)
cellular response to reactive oxygen speciesTranscription factor AP-1Homo sapiens (human)
response to endoplasmic reticulum stressTranscription factor AP-1Homo sapiens (human)
positive regulation of apoptotic processTranscription factor AP-1Homo sapiens (human)
negative regulation of DNA bindingTranscription factor AP-1Homo sapiens (human)
negative regulation by host of viral transcriptionTranscription factor AP-1Homo sapiens (human)
positive regulation by host of viral transcriptionTranscription factor AP-1Homo sapiens (human)
negative regulation of DNA-templated transcriptionTranscription factor AP-1Homo sapiens (human)
positive regulation of DNA-templated transcriptionTranscription factor AP-1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IITranscription factor AP-1Homo sapiens (human)
SMAD protein signal transductionTranscription factor AP-1Homo sapiens (human)
cellular response to cadmium ionTranscription factor AP-1Homo sapiens (human)
integrated stress response signalingTranscription factor AP-1Homo sapiens (human)
positive regulation of miRNA transcriptionTranscription factor AP-1Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferationTranscription factor AP-1Homo sapiens (human)
positive regulation of DNA-templated transcription initiationTranscription factor AP-1Homo sapiens (human)
regulation of cell population proliferationTranscription factor AP-1Homo sapiens (human)
regulation of cell cycleTranscription factor AP-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (20)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingTranscription factor AP-1Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTranscription factor AP-1Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificTranscription factor AP-1Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificTranscription factor AP-1Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificTranscription factor AP-1Homo sapiens (human)
DNA bindingTranscription factor AP-1Homo sapiens (human)
DNA-binding transcription factor activityTranscription factor AP-1Homo sapiens (human)
RNA bindingTranscription factor AP-1Homo sapiens (human)
GTPase activator activityTranscription factor AP-1Homo sapiens (human)
protein bindingTranscription factor AP-1Homo sapiens (human)
enzyme bindingTranscription factor AP-1Homo sapiens (human)
ubiquitin protein ligase bindingTranscription factor AP-1Homo sapiens (human)
cAMP response element bindingTranscription factor AP-1Homo sapiens (human)
identical protein bindingTranscription factor AP-1Homo sapiens (human)
ubiquitin-like protein ligase bindingTranscription factor AP-1Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingTranscription factor AP-1Homo sapiens (human)
R-SMAD bindingTranscription factor AP-1Homo sapiens (human)
general transcription initiation factor bindingTranscription factor AP-1Homo sapiens (human)
sequence-specific double-stranded DNA bindingTranscription factor AP-1Homo sapiens (human)
transcription factor bindingTranscription factor AP-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
nuclear chromosomeTranscription factor AP-1Homo sapiens (human)
nucleusTranscription factor AP-1Homo sapiens (human)
nucleoplasmTranscription factor AP-1Homo sapiens (human)
transcription factor AP-1 complexTranscription factor AP-1Homo sapiens (human)
RNA polymerase II transcription regulator complexTranscription factor AP-1Homo sapiens (human)
chromatinTranscription factor AP-1Homo sapiens (human)
euchromatinTranscription factor AP-1Homo sapiens (human)
transcription regulator complexTranscription factor AP-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (98)

Assay IDTitleYearJournalArticle
AID1481801Inhibition of DNA synthesis in human Bel7402 cells assessed as BrdU incorporation at 1 uM preincubated for 1 hr followed by BrdU addition for 30 mins by FITC/propidium iodide staining based flow cytometry (Rvb = 35.5%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID648632Antiproliferative activity against human A549 cells after 72 hrs by MTT assay2012European journal of medicinal chemistry, May, Volume: 51Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.
AID1481780Antiproliferative activity against human KB cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481814Induction of apoptosis in human Bel7402 cells assessed as viable cells at 0.1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 92.4%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481850Growth inhibition of human KB-HU-R cells after 8 days by methylene blue-staining based spectrophotometry2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481785Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481788Antiproliferative activity against human Bel7402 cells assessed as reduction in cell viability at 0.012 to 1 uM up to 10 days by fluorescence-based cell imaging method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481812Induction of DNA damage in human Bel7402 cells assessed as increase in CHK2 phosphorylation at Thr68 residue at 0.1 to 10 uM after 1 hr by Western blot analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1092197In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated left side of Nicotiana tabacum L. leaves assessed as inactivation effect at 100 ug/mL co-incubated with virus measured after 3 to 4 days2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID648635Antiproliferative activity against human A549 cells at 10'-7 mol/L after 72 hrs by MTT assay2012European journal of medicinal chemistry, May, Volume: 51Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.
AID1481815Induction of apoptosis in human Bel7402 cells assessed as early apoptotic cells at 0.1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 3.66%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1092196In vivo antiviral activity against Tobacco mosaic virus (TMV) pre-inoculated Nicotiana tabacum L. leaves assessed as curative effect at 500 ug/mL measured after 3 to 4 days2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID648629Antiproliferative activity against human HL60 cells at 10'-8 mol/L after 72 hrs by SRB assay2012European journal of medicinal chemistry, May, Volume: 51Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.
AID1481841Effect on P-gp expression in human K562/ADR cells up to 10 uM after 24 hrs by Western blot analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481818Induction of apoptosis in human Bel7402 cells assessed as viable cells at 1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 92.4%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481790Inhibition of colony formation in human Bel7402 cells at 0.01 to 10 uM after 24 hrs by SRB staining-based plate colony formation assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1164337Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
AID1481808Induction of DNA damage in human Bel7402 cells assessed as increase in gamma-H2AX levels at 0.1 to 10 uM after 1 hr by Western blot analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481774Antiproliferative activity against human SMMC7721 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481835Antiproliferative activity against human K562/ADR cells after 72 hrs by MTT assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481763Antiproliferative activity against human MDA-MB-157 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481810Induction of DNA damage in human Bel7402 cells assessed as increase in CHK1 phosphorylation at Ser345 residue at 0.1 to 10 uM after 1 hr by Western blot analysis2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1388907Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral DNA level after 6 days by Southern blot analysis2018Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents.
AID1092198In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated left side of Nicotiana tabacum L. leaves assessed as inactivation effect at 500 ug/mL co-incubated with virus measured after 3 to 4 days2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID1481847Growth inhibition of human KBV1 cells after 8 days by methylene blue-staining based spectrophotometry2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481796Cell cycle arrest in human Bel7402 cells assessed as delay in progression of S-phase to G2-phase at 0.1 to 1 uM pre-treated with aphidicolin for 16 hrs followed by compound addition measured up to 24 hrs by propidium iodide staining-based flow cytometric 2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481821Induction of apoptosis in human Bel7402 cells assessed as necrotic cells at 1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 0.38%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481823Induction of apoptosis in human Bel7402 cells assessed as early apoptotic cells at 10 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 3.66%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1164338Cytotoxicity against mouse RAW264.7 cells assessed as cell death at 1 uM after 48 hrs by MTT assay2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
AID1481765Antiproliferative activity against human T47D cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481816Induction of apoptosis in human Bel7402 cells assessed as late apoptotic cells at 0.1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 3.6%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481838Resistance factor, ratio of IC50 for human HL60/MX2 cells to IC50 for human HL60 cells2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481782Antiproliferative activity against human 786-O cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID308180Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.
AID1481819Induction of apoptosis in human Bel7402 cells assessed as early apoptotic cells at 1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 3.66%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID308177Reduction of body weight in HepG2 xenografted nude mouse at 9 mg/kg, ip after 10 days2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.
AID1481751Antiproliferative activity against human Bel7402 cells assessed as reduction in viability after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481836Resistance factor, ratio of IC50 for human K562/ADR cells to IC50 for human K562 cells2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481766Antiproliferative activity against human MKN45 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1164331Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
AID1481772Antiproliferative activity against human HuH7 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481762Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1164329Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
AID1388904Antiviral activity against HCV genotype 1b con1 infected in human Huh-luc/neo-ET cells assessed as inhibition of viral replication after 72 hrs2018Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents.
AID1481786Antiproliferative activity against human Rh30 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1092194In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated right side of Nicotiana tabacum L. leaves assessed as protection effect at 500 ug/mL preincubated 12 hr before viral challenge measured after 3 to 4 days2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID1481768Antiproliferative activity against human SGC7901 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481839Antiproliferative activity against human KB/VCR cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481799Inhibition of DNA synthesis in human Bel7402 cells assessed as reduction in BrdU incorporation preincubated for 1 hr followed by BrdU addition for 30 mins by FITC/propidium iodide staining based flow cytometry2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1388906Therapeutic index, ratio of IC50 for human Huh-luc/neo-ET cells to EC50 for HCV genotype 1b con12018Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents.
AID1481770Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481802Inhibition of DNA synthesis in human Bel7402 cells assessed as BrdU incorporation at 10 uM preincubated for 1 hr followed by BrdU addition for 30 mins by FITC/propidium iodide staining based flow cytometry (Rvb = 35.5%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481825Induction of apoptosis in human Bel7402 cells assessed as necrotic cells at 10 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 0.38%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1673353Antiproliferative activity against human Bel-7402 cells after 72 hrs by SRB assay2019Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14
Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents.
AID1481778Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481750Antiproliferative activity against human A549 cells assessed as reduction in viability after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481777Antiproliferative activity against human COLO205 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1164335Induction of Foxp3 expression in B6 Foxp3-GFP mouse CD4-positive T cells at 100 nM after 3 days by flow cytometry in presence of 5 ng/ml TGF-beta (Rvb = 37.15 %)2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
AID1481767Antiproliferative activity against human KATO III cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481817Induction of apoptosis in human Bel7402 cells assessed as necrotic cells at 0.1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 0.38%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481771Antiproliferative activity against human Hep3B cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481773Antiproliferative activity against human SKHEP1 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID648631Antiproliferative activity against human HL60 cells at 10'-6 mol/L after 72 hrs by SRB assay2012European journal of medicinal chemistry, May, Volume: 51Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.
AID1481761Antiproliferative activity against human K562 cells after 72 hrs by MTT assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481820Induction of apoptosis in human Bel7402 cells assessed as late apoptotic cells at 1 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 3.6%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481781Antiproliferative activity against human Detroit 562 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1673354Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay2019Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14
Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents.
AID1481793Cell cycle arrest in human Bel7402 cells assessed as accumulation in S-phase at 0.012 to 1 uM after 24 hrs by propidium iodide staining-based flow cytometry2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1092193In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated right side of Nicotiana tabacum L. leaves assessed as protection effect at 100 ug/mL preincubated 12 hr before viral challenge measured after 3 to 4 days2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID1481764Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481779Antiproliferative activity against human SUDHL6 cells after 72 hrs by MTT assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481840Resistance factor, ratio of IC50 for human KB/VCR cells to IC50 for human KB cells2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481824Induction of apoptosis in human Bel7402 cells assessed as late apoptotic cells at 10 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 3.6%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1388905Cytotoxicity against human Huh-luc/neo-ET cells assessed as cell growth inhibition2018Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents.
AID1481783Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481759Antiproliferative activity against human U118MG cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1092195In vivo antiviral activity against Tobacco mosaic virus (TMV) pre-inoculated Nicotiana tabacum L. leaves assessed as curative effect at 100 ug/mL measured after 3 to 4 days2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID1481800Inhibition of DNA synthesis in human Bel7402 cells assessed as BrdU incorporation at 0.1 uM preincubated for 1 hr followed by BrdU addition for 30 mins by FITC/propidium iodide staining based flow cytometry (Rvb = 35.5%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481776Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481775Antiproliferative activity against human Zip-177 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481784Antiproliferative activity against human SKOV3 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481837Antiproliferative activity against human HL60/MX2 cells after 72 hrs by MTT assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1481849Growth inhibition of human KB-7d cells after 8 days by methylene blue-staining based spectrophotometry2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID648630Antiproliferative activity against human HL60 cells at 10'-7 mol/L after 72 hrs by SRB assay2012European journal of medicinal chemistry, May, Volume: 51Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.
AID648634Antiproliferative activity against human A549 cells at 10'-8 mol/L after 72 hrs by MTT assay2012European journal of medicinal chemistry, May, Volume: 51Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.
AID1164340Solubility of the compound in DMSO2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
AID1092200Antiviral activity against Tobacco mosaic virus (TMV) inoculated in 5-6 growth stage leaf assessed as inhibition effect at 500 ug/mL at 25 degC after 72 hr by half-leaf method2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID308179Inhibition of CRE-mediated gene transcription in HepG2 cells by luciferase reporter gene assay2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.
AID308176Reduction of body weight in HepG2 xenografted nude mouse at 9 mg/kg, ip after 9 days2007Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15
Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.
AID1481769Antiproliferative activity against human Bel7404 cells after 72 hrs by SRB assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1388908Cytotoxicity against human HepG2(2.2.15) cells assessed as cell growth inhibition2018Bioorganic & medicinal chemistry, 02-01, Volume: 26, Issue:3
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents.
AID1481848Growth inhibition of human KB-MDR cells after 8 days by methylene blue-staining based spectrophotometry2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1092199Antiviral activity against Tobacco mosaic virus (TMV) inoculated in 5-6 growth stage leaf assessed as inhibition effect at 100 ug/mL at 25 degC after 72 hr by half-leaf method2012Journal of agricultural and food chemistry, Oct-17, Volume: 60, Issue:41
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
AID1481822Induction of apoptosis in human Bel7402 cells assessed as viable cells at 10 uM after 72 hrs by Annexin V/propidium iodide staining based flow cytometric analysis (Rvb = 92.4%)2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID1164330Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
AID1481760Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
AID648633Antiproliferative activity against human A549 cells at 10'-6 mol/L after 72 hrs by MTT assay2012European journal of medicinal chemistry, May, Volume: 51Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.
AID1164326Induction of Foxp3 expression in B6 Foxp3-GFP mouse CD4-positive T cells assessed as increase in iTregs at 100 nM after 3 days by flow cytometry2014ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
vincristine
[no description available]		2.1510acetate ester;
formamides;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid		antineoplastic agent;
drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.1510delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
dioxohexahydrotriazine
[no description available]		2.0710
ribavirin
Rebetron: Rebetron is tradename		2.07101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
mitoxantrone hydrochloride
[no description available]		2.1510hydrochlorideantineoplastic agent
tylophorine
tylophorine: phenanthroindolizidine alkaloid		2.9840organic heteropentacyclic compound;
organonitrogen heterocyclic compound
cryptopleurine
cryptopleurine: plant bark alkaloid shown to inhibit protein synthesis; RN given refers to (R)-isomer; structure. cryptopleurine : An organic heteropentacyclic compound that is (14aR)-11,12,13,14,14a,15-hexahydro-9H-dibenzo[f,h]pyrido[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups.		2.5220alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound		antineoplastic agent;
antiviral agent;
protein synthesis inhibitor
tylophorinidine
tylophorinidine: antileukemic agent from T. indica		2.0310
doxorubicin hydrochloride
[no description available]		2.5820anthracycline
antofine
antofine: structure in first source. (-)-antofine : An organic heteropentacyclic compound that is (13aR)-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups. It is an alkaloid produced by relatives of the milkweed family and exhibits antiviral, anti-inflammatory, antiadipogenic and antitumorigenic activities.		2.4820alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound		angiogenesis inhibitor;
anti-inflammatory agent;
antimicrobial agent;
antineoplastic agent;
antiviral agent;
phytotoxin;
plant metabolite
ningnanmycin
ningnanmycin: isolated from Strepcomces noursei		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.1510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1510