Page last updated: 2024-12-07

hei 712

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID Source	ID
PubMed CID	85184
CHEMBL ID	5220089
CHEBI ID	194805
SCHEMBL ID	3906125
MeSH ID	M0404952

Synonyms (46)

Synonym
KUC100220 ,
6-fluoro-2-methyl-quinolin-4-ol
BB 0222195
OPREA1_074210
KUC100220N
6-fluoro-2-methyl-4-quinolinol
AP-906/42846205
6-fluoro-4-hydroxy-2-methylquinoline, 97%
NCGC00159982-01
6-fluoro-4-hydroxy-2-methylquinoline
15912-68-2
MAYBRIDGE1_000260
HMS1624G01
HMS542D18
AKOS002258360
6-luoro-2-methyl-1h-quinolin-4-one
6-fluoro-2-methylquinolin-4-ol
CHEBI:194805
6-fluoro-2-methyl-1h-quinolin-4-one
A810000
AKOS009158521
6-fluoro-2-methylquinolin-4(1h)-one
389635-71-6
einecs 240-054-4
FT-0621125
SCHEMBL3906125
4-quinolinol, 6-fluoro-2-methyl-
6-fluoro-2-methyl-4-quinolinol #
J-650152
BTB 01148
F0997
DTXSID60166590
mfcd00041442
mfcd11053891
AS-60915
CS-0084709
F19996
AMY18017
A873740
SB67603
SB67670
6-fluoranyl-2-methyl-quinolin-4-ol
VBW ,
SY049833
bdbm50607320
CHEMBL5220089 ,

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
quinolone
organofluorine compound	An organofluorine compound is a compound containing at least one carbon-fluorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Kelch-like ECH-associated protein 1	Homo sapiens (human)	Ki	2,600.0000	0.5600	0.5600	0.5600	AID1918093
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Kelch-like ECH-associated protein 1	Homo sapiens (human)	Kd	1,800.0000	1.0000	1.7667	2.4000	AID1918095
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (53)

Process	via Protein(s)	Taxonomy
in utero embryonic development	Kelch-like ECH-associated protein 1	Homo sapiens (human)
ubiquitin-dependent protein catabolic process	Kelch-like ECH-associated protein 1	Homo sapiens (human)
regulation of autophagy	Kelch-like ECH-associated protein 1	Homo sapiens (human)
protein ubiquitination	Kelch-like ECH-associated protein 1	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cellular response to oxidative stress	Kelch-like ECH-associated protein 1	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Kelch-like ECH-associated protein 1	Homo sapiens (human)
regulation of epidermal cell differentiation	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cellular response to interleukin-4	Kelch-like ECH-associated protein 1	Homo sapiens (human)
negative regulation of response to oxidative stress	Kelch-like ECH-associated protein 1	Homo sapiens (human)
response to ischemia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
inflammatory response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
proteasomal ubiquitin-independent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of gene expression	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of cardiac muscle cell apoptotic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of neuron projection development	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein ubiquitination	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of blood coagulation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
endoplasmic reticulum unfolded protein response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
PERK-mediated unfolded protein response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to glucose starvation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of innate immune response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cell redox homeostasis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of angiogenesis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of embryonic development	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
aflatoxin catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of glucose import	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to hydrogen peroxide	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to copper ion	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to tumor necrosis factor	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to hypoxia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to xenobiotic stimulus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to fluid shear stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to laminar fluid shear stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of ferroptosis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
integrated stress response signaling	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of cellular response to hypoxia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of cellular response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of hematopoietic stem cell differentiation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of glutathione biosynthetic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of ERAD pathway	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to angiotensin	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell migration	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of ubiquitin-dependent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of removal of superoxide radicals	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (17)

Process	via Protein(s)	Taxonomy
protein binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
identical protein binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
disordered domain specific binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
ubiquitin-like ligase-substrate adaptor activity	Kelch-like ECH-associated protein 1	Homo sapiens (human)
transcription factor binding	Kelch-like ECH-associated protein 1	Homo sapiens (human)
transcription cis-regulatory region binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
transcription coregulator binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein domain specific binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
ubiquitin protein ligase binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
sequence-specific DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
molecular condensate scaffold activity	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (18)

Process	via Protein(s)	Taxonomy
nucleoplasm	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cytoplasm	Kelch-like ECH-associated protein 1	Homo sapiens (human)
endoplasmic reticulum	Kelch-like ECH-associated protein 1	Homo sapiens (human)
cytosol	Kelch-like ECH-associated protein 1	Homo sapiens (human)
actin filament	Kelch-like ECH-associated protein 1	Homo sapiens (human)
inclusion body	Kelch-like ECH-associated protein 1	Homo sapiens (human)
midbody	Kelch-like ECH-associated protein 1	Homo sapiens (human)
centriolar satellite	Kelch-like ECH-associated protein 1	Homo sapiens (human)
Cul3-RING ubiquitin ligase complex	Kelch-like ECH-associated protein 1	Homo sapiens (human)
mediator complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
non-membrane-bounded organelle	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleoplasm	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cytoplasm	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
Golgi apparatus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
centrosome	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cytosol	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
plasma membrane	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
chromatin	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein-DNA complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1918093	Inhibition of recombinant human His-tagged Keap1 kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3) cells to Cy5-Nrf2 (unknown origin) protein-protein interaction incubated for 10 to 15 mins by fluorescence polarization assay	2022	Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21	Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
AID1918095	Binding affinity to Keap1 kelch domain (unknown origin) by surface plasmon resonance assay	2022	Journal of medicinal chemistry, 11-10, Volume: 65, Issue:21	Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	2 (40.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes
3-morpholinopropylamine 3-morpholinopropylamine : A member of the class of morpholines that is morpholine substituted by a 3-aminopropyl group a the N atom.	2.41	1	morpholines; primary amino compound
2,4'-bisphenol f 2,4'-bisphenol F: contact allergen; structure given in first source	2.41	1
2-(5-Chlorobenzo[b]thiophen-3-yl)acetic acid [no description available]	2.41	1	1-benzothiophenes

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1

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hei 712

Cross-References

Synonyms (46)

Drug Classes (2)

Protein Targets (2)

Inhibition Measurements

Activation Measurements

Biological Processes (53)

Molecular Functions (17)

Ceullar Components (18)

Bioassays (6)

Research

Studies (5)

Study Types

Related Drugs (3)

Related Conditions (4)