| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347387 | Cytotoxicity qHTS for assessment of Hepg2 cells membrane integrity screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347401 | Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347379 | qHTS for Inflammasome Signaling Inhibitors: IL-1-beta AlphaLISA screen against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347345 | OV-KATE Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347376 | 10-beta competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347373 | qHTS for Constitutive Androstane Receptor (CAR) Agonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347347 | UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347368 | G06 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347375 | qHTS for Hypoxia signaling pathway (HIF-1) agonists against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347356 | HPAF-II 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347358 | HPAF-II 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347372 | qHTS for Constitutive Androstane Receptor (CAR) Antagonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347396 | qHTS for inhibitors of Wild type Zika virus screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347402 | qHTS for inhibitors of Rabies Virus screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347389 | qHTS assay for small molecule disruptors of mitochondrial membrane potential screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347361 | HEK293 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347349 | Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347362 | Diaphorse counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347348 | OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347352 | COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347394 | Vero-766 cells viability qHTS against the NCATS CANVASS Library: Counterscreen for Zika virus inhibition assay | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347400 | Viability qHTS for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347363 | Firefly luciferase counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347374 | qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347390 | Secretion counterscreen for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347365 | SDT Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347353 | A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347367 | qHTS for ATAD5 Agonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347381 | Inflammasome Signaling qHTS Counterscreen: IL-1-beta AlphaLISA counterscreen against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347371 | J3T Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347393 | qHTS for inhibitors of ER calcium dysfunction: SERCaMP assay screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347357 | HEK293 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347377 | DH5-alpha competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347364 | KB-8-5-11 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347370 | qHTS for ATAD5 Antagonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347359 | HEK293 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347366 | KB-3-1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347392 | qHTS for activators of dead-cell proteases activity screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347354 | UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347346 | HPAF-II Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347378 | qHTS for H2AX Agonists against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347388 | qHTS for Activators of p53 Stress Response Pathway screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347355 | HEK-293 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347350 | SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347391 | qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347351 | U-118MG Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347369 | MCF7 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347360 | HPAF-II 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1347380 | qHTS for Antimalaria activity screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12
| Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
| AID1605773 | Toxicity in C57BL/6 mouse assessed as induction of organ damage at <=25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605778 | Induction of PXR-dependent CYP3A11 protein expression in C57BL/6 mouse intestine at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605765 | Agonist activity at PXR in human HT29 cells assessed as increase in CYP3A4 protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605750 | Agonist activity at PXR in human HepG2 cells assessed as increase in CYP3A4 protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605759 | Agonist activity at PXR in human HepaRG cells assessed as reversion of PXR antagonist sulforaphane-induced suppression of PXR expression at 10 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605743 | Agonist activity at His-tagged PXR-LBD/SRC-1p (unknown origin) expressed in Escherichia coli BL21(DE3) by coactivator recruitment based Alpha-screen assay relative to T0901317 | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1777222 | Inhibition of 5-LOX in human PMNL assessed as reduction in 5-LOX product formation preincubated for 10 mins before addition of AA and A23187 and measured after 10 mins by RP-HPLC method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. |
| AID1703353 | Inhibition of 5-LO in human PMNL cells assessed as reduction in LTB4, 5-H(P)ETE, 12-HETE and 15-HETE products formation using arachidonic acid as substrate preincubated for 10 mins followed by addition of substrate and measured after 10 mins by RP-HPLC me | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. |
| AID1605758 | Agonist activity at PXR in human HepaRG cells assessed as reversion of PXR binding at 10 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605763 | Agonist activity at PXR in human HepG2 cells assessed as stimulation of CYP450-mediated alpha-tocopherol metabolites efflux at 25 uM | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605769 | Toxicity in C57BL/6 mouse assessed as mortality at 50 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605762 | Agonist activity at PXR in human HepG2 cells assessed as stimulation of CYP450-mediated alpha-tocopherol metabolites production at 25 uM | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1696173 | Antibacterial activity against Streptococcus sobrinus 6715 assessed as reduction in bacterial growth incubated for 24 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7
| Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| AID1605772 | Toxicity in C57BL/6 mouse assessed as induction of liver damage at <=25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605767 | Agonist activity at PXR in human HT29-MTX cells assessed as increase in CYP3A4 protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605760 | Agonist activity at PXR in human HepaRG cells assessed as reversion of PXR antagonist sulforaphane-induced suppression of CYP3A4 expression at 10 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605776 | Induction of PXR mRNA expression in C57BL/6 mouse intestine at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605741 | Agonist activity at His-tagged PXR-LBD/SRC-1p (unknown origin) expressed in Escherichia coli BL21(DE3) at 10 uM by coactivator recruitment based Alpha-screen assay | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605768 | Toxicity in C57BL/6 mouse assessed as mortality at 100 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605753 | Agonist activity at PXR in human HepG2 cells assessed as increase recombinant human Pgp in a cell membrane fraction by Pgp-Glo assay | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605752 | Agonist activity at PXR in human HepG2 cells assessed as increase in MDR1 mRNA expression at 1 to 50 uM incubated for 24 hrs | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605749 | Agonist activity at PXR in human HepG2 cells assessed as increase in PXR protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605751 | Agonist activity at PXR in human HepG2 cells assessed as increase in CYP3A4 mRNA expression at 1 to 50 uM incubated for 24 hrs | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605770 | Toxicity in C57BL/6 mouse assessed as effect on gross appearance at <=25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605785 | Induction of PXR protein expression in C57BL/6 mouse intestine assessed as induction of localization of PXR protein at brush border of enterocytes at 10 mg dosed as oral gavage as single bolus and measured after 24 hrs by IHC analysis relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605754 | Agonist activity at PXR in human HepaRG cells assessed as increase in PXR protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1703351 | Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21(DE3) assessed as reduction in LTB4 and 5-H(P)ETE formation using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 1 | 2020 | European journal of medicinal chemistry, Sep-15, Volume: 202 | Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. |
| AID1605774 | Induction of PXR protein expression in C57BL/6 mouse liver at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605781 | Induction of PXR protein expression in C57BL/6 mouse hepatic parenchyma assessed as induction of localization of PXR protein at hepatocytes around centro-lobular veins at 25 mg dosed as oral gavage as single bolus and measured after 24 hrs by IHC analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1777221 | Inhibition of recombinant human 5-LOX expressed in Escherichia coli BL21 (DE3) cells assessed as residual activity at 1 uM preincubated for 10 mins followed by arachidonic acid addition and measured after 10 mins by RP-HPLC method relative to control | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. |
| AID1605744 | Agonist activity at LXR-beta (unknown origin) at 10 uM by coactivator recruitment based Alpha-screen assay | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605777 | Induction of PXR protein expression in C57BL/6 mouse intestine at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605764 | Agonist activity at PXR in human HT29 cells assessed as increase in PXR protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605780 | Induction of PXR protein expression in C57BL/6 mouse hepatic parenchyma assessed as induction of localization of PXR protein at sinusoidal endothelial cells at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs by IHC analysis relat | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1696172 | Bactericidal activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in bacterial growth incubated for 48 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7
| Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| AID1696171 | Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in bacterial growth incubated for 24 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7
| Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| AID1605745 | Agonist activity at PXR in human HepG2 cells transfected with PXR siRNA at 10 to 50 uM incubated for 24 hrs | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605779 | Induction of PXR-dependent CYP3A11 protein expression in C57BL/6 mouse liver at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605782 | Induction of PXR protein expression in C57BL/6 mouse hepatic parenchyma assessed as induction of localization of PXR protein at hepatocytes around lobular midzonal area at 25 mg dosed as oral gavage as single bolus and measured after 24 hrs by IHC analysi | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605775 | Induction of PXR mRNA expression in C57BL/6 mouse liver at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605747 | Binding affinity to His-tagged PXR-LBD (unknown origin) expressed in Escherichia coli BL21 Gold by ITC analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1777223 | Inhibition of 5-LOX in human PMNL assessed as residual activity by measuring reduction in 5-LOX product formation at 3 uM preincubated for 10 mins before addition of AA and A23187 and measured after 10 mins by RP-HPLC method relative to control | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. |
| AID1777220 | Inhibition of recombinant human 5-LOX expressed in Escherichia coli BL21 (DE3) cells preincubated for 10 mins followed by arachidonic acid addition and measured after 10 mins by RP-HPLC method | 2021 | Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15
| Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. |
| AID1605761 | Effect on alpha-tocopherol level in human HepG2 cells at 25 uM | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605742 | Agonist activity at His-tagged PXR-LBD/SRC-1p (unknown origin) expressed in Escherichia coli BL21(DE3) by coactivator recruitment based Alpha-screen assay | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605746 | Agonist activity at PXR in human HepG2 cells transfected with PXR siRNA assessed as induction of CYP3A4 expression at 10 to 50 uM incubated for 24 hrs | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605784 | Induction of PXR protein expression in C57BL/6 mouse intestine assessed as induction of localization of PXR protein at glandular epithelium of crypts at base of mucosa epithelium at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605766 | Agonist activity at PXR in human HT29-MTX cells assessed as increase in PXR protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605771 | Toxicity in C57BL/6 mouse assessed as effect on animal behavior at <=25 mg dosed as oral gavage as single bolus and measured after 24 hrs relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1696174 | Bactericidal activity against Streptococcus sobrinus 6715 assessed as reduction in bacterial growth incubated for 48 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7
| Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| AID1605755 | Agonist activity at PXR in human HepaRG cells assessed as increase in CYP3A4 protein expression at 1 to 25 uM incubated for 24 hrs by immunoblot analysis | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1605783 | Induction of PXR protein expression in C57BL/6 mouse intestine assessed as induction of localization of PXR protein at villous epithelium at 5 to 25 mg dosed as oral gavage as single bolus and measured after 24 hrs by IHC analysis relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. |
| AID1347164 | 384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347158 | ZIKV-mCherry secondary qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347157 | Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347163 | 384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347156 | DAPI mCherry counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |