| Assay ID | Title | Year | Journal | Article |
|---|
| AID509545 | Agonist activity at hedgehog receptor | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Modulators of the hedgehog signaling pathway. |
| AID1066851 | Modulation of LXR in human myotubes assessed as decrease of T0901317-induced SCD1 mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID1066836 | Modulation of LXR in human HepG2 cells assessed as reduction of T0901317-induced lipogenesis using [1-14C]acetate at 1 uM after 4 days by scintillation counting | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID1066852 | Modulation of LXR in human myotubes assessed as increase of ABCA1 mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID1066850 | Modulation of LXR in human myotubes assessed as decrease of T0901317-induced FAS mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID695017 | Agonist activity at Hh receptor in mouse C3H10T1/2 cells assessed as fold increase in Gli1 expression at 5 uM by RT-PCR analysis relative to control | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. |
| AID695019 | Selectivity ratio of agonist activity at Hh receptor over agonist activity at LXR in mouse C3H10T1/2 cells | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. |
| AID1066844 | Modulation of LXR in human HepG2 cells assessed as decrease of T0901317-induced SCD1 mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID1066843 | Modulation of LXR in human HepG2 cells assessed as decrease of T0901317-induced FAS mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID768317 | Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane at 10 uM after 24 hrs by fluorescence microscopic analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect. |
| AID1066849 | Modulation of LXR in human myotubes assessed as decrease of T0901317-induced ABCA1 mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID1060432 | Induction of lipogenesis in human myotubes at 10 uM after 4 days by scintillation counting analysis in presence of [1-14C]acetate relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol. |
| AID1066842 | Modulation of LXR in human HepG2 cells assessed as decrease of T0901317-induced ABCA1 mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID101845 | Tested for its ability to activate Liver X receptor-alpha expressed as Relative efficacy determined by maximal increase in relative fluorescence in LiSA by 100 uM | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. |
| AID695018 | Agonist activity at LXR in mouse C3H10T1/2 cells assessed as fold increase in ABCA1 expression at 5 uM by RT-PCR analysis relative to control | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. |
| AID1066838 | Modulation of LXR in human myotubes assessed as reduction of T0901317-induced lipogenesis using [1-14C]acetate at 1 uM after 4 days by scintillation counting | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID1179742 | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein. |
| AID101839 | Binding affinity towards LXR alpha receptor was determined in LiSA | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. |
| AID1060433 | Antagonist activity at LXR in human myotubes assessed as downregulation of SCD1 expression at 10 uM after 4 days by qPCR analysis | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol. |
| AID768321 | Binding affinity to NPC1 (unknown origin) | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect. |
| AID1066845 | Modulation of LXR in human HepG2 cells assessed as increase of ABCA1 mRNA expression at 10 uM after 4 days by qPCR analysis | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models. |
| AID1060431 | Inhibition of tularic-induced lipogenesis in human myotubes at 10 uM after 4 days by scintillation counting analysis in presence of [1-14C]acetate relative to control | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |