Assay ID | Title | Year | Journal | Article |
AID379156 | Cytotoxicity against human HT-29 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10
| Cytotoxic hypothemycin analogues from Hypomyces subiculosus. |
AID1870096 | Inhibition of recombinant human N-terminal GST-tagged TAK1 (1 to 303 residues)/TAB1 (437 to end residues) expressed in baculovirus infected Sf9 insect cells using myelin basic protein as substrate preincubated for 10 mins followed by ATP addition and meas | 2022 | Journal of natural products, 08-26, Volume: 85, Issue:8
| Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol. |
AID1763944 | Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assay | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID379154 | Cytotoxicity against human SKOV3 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10
| Cytotoxic hypothemycin analogues from Hypomyces subiculosus. |
AID1602315 | Toxicity in zebrafish embryo assessed as mortality at 10 uM measured 120 hpf by fluorescence microscopy | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID1378627 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID1602304 | Cytotoxicity in human THP1 cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID1602362 | Inhibition of covalent binding of 50 uM (Z)-N-(2-(2-(4-(2,8-Diethyl-5,5-difluoro-1,3,7,9-tetramethyl-5H-4lambda4,5lambda4-dipyrrolo[1,2-c:2',1'-f ][1,3,2]diazaborinin-10-yl)phenoxy)-acetamido)ethyl)-2,4-dimethyl-5-((2-oxo-5-(vinylsulfon-amido)-indolin-3-y | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID1378629 | Antifungal activity against Fusarium verticillioides after 8 hrs by conidial germination assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID1870098 | Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability measured after 72 hrs by celltiter-blue cell viability assay | 2022 | Journal of natural products, 08-26, Volume: 85, Issue:8
| Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol. |
AID1602301 | Irreversible inhibition of recombinant human FLT3 D835Y mutant (571 to 993 residues) expressed in baculovirus expression system at 1 uM preincubated for 5 to 30 mins followed by myelobasic protein addition and measured after 120 mins in presence of ATP by | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID379155 | Cytotoxicity against human COLO829 cells | 2006 | Journal of natural products, Oct, Volume: 69, Issue:10
| Cytotoxic hypothemycin analogues from Hypomyces subiculosus. |
AID1763935 | Reversible inhibition of recombinant human GSK-3beta at 20 uM preincubated for 3 hrs followed by diluted with substrate and ATP master mix solution measured upto 1.5 hrs by jump dilution assays | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID1763942 | Reversible inhibition of recombinant human GSK-3beta at 100 nM incubated with substrate and ATP master mix solution by jump dilution assays | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID1254043 | Inhibition of TAK1 (unknown origin) | 2015 | Bioorganic & medicinal chemistry, Nov-01, Volume: 23, Issue:21
| Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues. |
AID1763943 | Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID606022 | Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5
| Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. |
AID606023 | Cytotoxicity against human H460 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5
| Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. |
AID1763934 | Reversible inhibition of recombinant human GSK-3beta at 70 uM preincubated for 3 hrs followed by diluted with substrate and ATP master mix solution measured upto 1.5 hrs by jump dilution assays | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID1602298 | Cytotoxicity in human MV4-11 cells assessed as inhibition of cellular viability incubated for 72 hrs by CellTiter-Blue assay | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID606024 | Cytotoxicity against human SF268 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5
| Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. |
AID1602303 | Irreversible inhibition of recombinant human FLT3 ITD mutant (571 to 993 residues) expressed in baculovirus expression system at 0.1 uM preincubated for 5 to 30 mins followed by myelobasic protein addition measured after 120 mins in presence of ATP by ADP | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID1763947 | Inhibition of human GSK-3beta at 10 uM in presence of 2 mM GSH by kinase-profiling analysis | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID606025 | Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5
| Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. |
AID1378625 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID1602302 | Irreversible inhibition of recombinant human FLT3 D835Y mutant (571 to 993 residues) expressed in baculovirus expression system at 0.1 uM preincubated for 5 to 30 mins followed by myelobasic protein addition measured after 120 mins in presence of ATP by A | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID1602305 | Cytotoxicity in human Jurkat cells assessed as inhibition of cellular viability after 72 hrs by CellTiter-Glo luminescent assay | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID1763941 | Reversible inhibition of recombinant human GSK-3beta at 200 nM incubated with substrate and ATP master mix solution by jump dilution assays | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID1763946 | Inhibition of human GSK-3beta at 10 uM in presence of 2 mM TCEP by kinase-profiling analysis | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID1602306 | Half life of the compound in potassium phosphate buffer at 10 uM in presence of 100 fold excess reduced glutathione by HPLC analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
AID606021 | Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5
| Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. |
AID1378628 | Antifungal activity against Peronophythora litchii after 8 hrs by conidial germination assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID652589 | Inhibition of MAP | 2011 | ACS medicinal chemistry letters, Sep-08, Volume: 2, Issue:9
| Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets. |
AID1763945 | Inhibition of human GSK-3beta at 10 uM in presence of 2 mM DTT by kinase-profiling analysis | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID1763940 | Reversible inhibition of recombinant human GSK-3beta at 700 nM incubated with substrate and ATP master mix solution by jump dilution assays | 2021 | Bioorganic & medicinal chemistry, 06-15, Volume: 40 | A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism. |
AID1378626 | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. |
AID1870097 | Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability measured after 72 hrs by celltiter-blue cell viability assay | 2022 | Journal of natural products, 08-26, Volume: 85, Issue:8
| Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol. |
AID1602321 | Binding affinity to wild type FLT3 (unknown origin) assessed as covalent modification at Cys828 residue by MALDI-TOF spectrometric analysis | 2019 | Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
| Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |