| Assay ID | Title | Year | Journal | Article |
|---|
| AID1585872 | Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. |
| AID1585888 | Inhibition of Hedgehog signaling pathway in VDR-deficient mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. |
| AID1353236 | Antifibrotic activity against TGFbeta1 stimulated rat LTC-14 cells assessed as inhibition of collagen 1 level at 500 nM after 24 hrs by Western blot | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. |
| AID254447 | Binding affinity to androgen receptor by incubation with GST-hARLBD and [3H]testosterone; ND = not detected | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19
| Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities. |
| AID730427 | Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID730430 | Agonist activity at VDR (unknown origin) by reporter gene assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID721295 | Agonist activity at VDR in human MG-63 cells assessed as osteocalcin production compound incubated for 8 hrs measured after 4 days by EIA relative to 1,25(OH)2D3 | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Effects of fluorines on nonsecosteroidal vitamin D receptor agonists. |
| AID730421 | Agonist activity at human androgen receptor expressed in HEK293 cells assessed as increase in transcriptional activity in presence of 0.3 nM testosterone by luciferase and beta-galactosidase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID730429 | Growth inhibition of human LNCAP cells | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID1353235 | Antifibrotic activity against TGFbeta1 stimulated rat LTC-14 cells assessed as inhibition of collagen 1 synthesis at 0.5 uM after 24 hrs by ELISA relative to calcipotriol | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. |
| AID741579 | Agonist activity at VDR in human MG-63 cells expressing VDRE assessed as induction of osteocalcin production after 4 days relative to 1,25(OH)2D3 | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| A series of nonsecosteroidal vitamin D receptor agonists for osteoporosis therapy. |
| AID730425 | Selectivity index, ratio of agonist PC50 for CMX-GAL4 tagged human VDR to antagonist IC50 for human androgen receptor | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID730428 | Induction of monocytic cell differentiation in human HL60 cells | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID255706 | Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19
| Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities. |
| AID1353237 | Antifibrotic activity against TGFbeta1 stimulated rat LTC-14 cells assessed as inhibition of alpha-SMA level at 500 nM after 24 hrs by Western blot | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. |
| AID1585884 | Inhibition of Hedgehog signaling pathway in VDR-deficient mouse C3H10T1/2 cells assessed as change in CYP24A1 mRNA expression at 1 uM after 24 hrs by q-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. |
| AID730431 | Agonist activity at CMX-GAL4 tagged human VDR expressed in HEK293 cells assessed as increase in transcriptional activity by luciferase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID1353232 | Inhibition of fluoromone VDR red binding to human VDR LBD expressed in insect cells at 1 uM by fluorescent polarization assay relative to 1,25(OH)2D3 | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. |
| AID1585871 | Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression at 1 uM after 48 hrs by q-PCR analysis relative to control | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. |
| AID1585867 | Activation of VDR in mouse C3H10T1/2 cells assessed as change in Cyp24A1 mRNA expression at 2.5 uM after 24 hrs by q-PCR analysis relative to control | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. |
| AID741581 | Agonist activity at VDR in human MG-63 cells expressing VDRE after 3 days by luciferase reporter gene based luminescence assay relative to 1,25(OH)2D3 | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| A series of nonsecosteroidal vitamin D receptor agonists for osteoporosis therapy. |
| AID1353234 | Transactivation of VDR (unknown origin) expressed in HEK293 cells harboring pENTER-CMV-human RXRalpha at 10'-8M to 10'-6M after 24 hrs by luciferase reporter gene assay | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. |
| AID1824244 | Selectivity index, ratio of IC50 for Inhibition of hedgehog signalling in mouse VDR-KO MEF cells to IC50 for inhibition of hedgehog signalling in mouse ASZ001 cells | 2022 | European journal of medicinal chemistry, Jan-15, Volume: 228 | Affinity-based protein profiling identifies vitamin D3 as a heat shock protein 70 antagonist that regulates hedgehog transduction in murine basal cell carcinoma. |
| AID1353238 | Antifibrotic activity against TGFbeta1 stimulated rat LTC-14 cells assessed as inhibition of collagen 1 alpha 1 mRNA expression at 500 nM after 24 hrs by RT-qPCR analysis | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. |
| AID256061 | Activity ratio of effective dose against vitamin D3 and inhibitory activity against androgen antagonistic activity | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19
| Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities. |
| AID255943 | Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation | 2005 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 15, Issue:19
| Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities. |
| AID1585868 | Inhibition of Hedgehog signaling pathway in mouse ASZ001 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 48 hrs by q-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. |
| AID730426 | Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity at 10 uM by luciferase and beta-galactosidase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
| Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange. |
| AID721296 | Agonist activity at VDR in human MG-63 cells assessed as transcriptional activation of osteopontin gene after 3 days by luciferase reporter gene assay relative to 1,25(OH)2D3 | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Effects of fluorines on nonsecosteroidal vitamin D receptor agonists. |
| AID670418 | Agonist activity at VDR expressed in human MG63 cells assessed as stimulation of VDRE-mediated luciferase reporter gene activity after 3 days by luminescence analysis relative to 1,25(OH)2D3 | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
| Systematic SAR study of the side chain of nonsecosteroidal vitamin D₃ analogs. |
| AID721294 | Induction of human HL60 cell differentiation after 4 days by WST-8 assay relative to 1.25-OH2 D3 | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Effects of fluorines on nonsecosteroidal vitamin D receptor agonists. |
| AID1585865 | Inhibition of Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. |
| AID1353239 | Antifibrotic activity against TGFbeta1 stimulated rat LTC-14 cells assessed as inhibition of alpha-SMA mRNA expression at 500 nM after 24 hrs by RT-qPCR analysis | 2018 | European journal of medicinal chemistry, Feb-25, Volume: 146 | Design, synthesis and biological evaluation of non-secosteriodal vitamin D receptor ligand bearing double side chain for the treatment of chronic pancreatitis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |