| Assay ID | Title | Year | Journal | Article |
|---|
| AID717488 | Solubility of the compound in 5:95 MeOH-d4:D2O solution at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID717489 | Solubility of the compound in 10:90 DMSO-d6:D2O solution at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583542 | Inhibition of human A2B adenosine receptor incubated for 60 mins by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID306128 | Inhibition of tobacco hornworm midgut vacuolar ATPase V1/V0 holoenzyme | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor. |
| AID1583535 | Displacement of [3H]PSB-11 from human A3 adenosine receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583539 | Inhibition of Calcium channel (unknown origin) at 10 uM relative to control | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583536 | Inhibition of human leukocyte elastase assessed as reduction in pNA release using chromogenic MeO-Suc-Ala-Ala-Pro-Val-pNA substrate measured over 10 mins by spectrophotometry | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717484 | Solubility of the compound in 10:90 MeOH-d4:D2O solution at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583541 | Inhibition of human A2A adenosine receptor incubated for 60 mins by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583531 | Inhibition of human P2X1 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by calcium 5 dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717480 | Solubility in 4 mM LDAO at 1 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583548 | Inhibition of human P2Y12 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583553 | Inhibition of human P2X7 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583549 | Inhibition of human P2Y14 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583532 | Growth inhibition of human 1321N1 cells incubated for 72 hrs by MTT assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583552 | Inhibition of human P2X4 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID601539 | Inhibition of Manduca sexta V-ATPase V1/Vo holoenzyme activity assessed as inorganic phosphate production pretreated for 5 mins | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5
| Archazolid A-15-O-β-D-glucopyranoside and iso-archazolid B: potent V-ATPase inhibitory polyketides from the myxobacteria Cystobacter violaceus and Archangium gephyra. |
| AID1583533 | Inhibition of Manduca sexta V-type proton ATPase assessed as reduction in inorganic phosphate production pre-inucubated for 5 mins before Tris-ATP addition and measured after 2 mins | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583560 | Inhibition of chymotrypsin (unknown origin) assessed as reduction in pNA release using chromogenic Suc-Ala-Ala-Pro-Phe-pNA substrate measured over 12.5 mins by spectrophotometry | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717479 | Solubility in 3 mM DPC at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583557 | Inhibition of trypsin (unknown origin) assessed as reduction in pNA release using chromogenic Suc-Ala-Ala-Pro-Arg-pNA substrate measured over 10 mins by spectrophotometry | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583550 | Inhibition of human GPR17 at 10 uM by Oregon-green BAPTA-1/AM dye based calcium mobilization assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID601540 | Antiproliferative activity against mouse L929 cells assessed as growth inhibition after 5 days by MTT assay | 2011 | Journal of natural products, May-27, Volume: 74, Issue:5
| Archazolid A-15-O-β-D-glucopyranoside and iso-archazolid B: potent V-ATPase inhibitory polyketides from the myxobacteria Cystobacter violaceus and Archangium gephyra. |
| AID1583546 | Inhibition of human P2Y6 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583538 | Inhibition of human PPARgamma at 10 uM relative to control | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583558 | Inhibition of cathepsin B (unknown origin) assessed as reduction in pNA release using chromogenic Z-Arg-Arg-pNA substrate measured over 1 hr by spectrophotometry | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717490 | Solubility of the compound in 50:50 DMSO-d6:D2O solution at 1 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583544 | Inhibition of human P2Y2 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717487 | Solubility of the compound in 5:95 EtOH-d6:D2O solution at 1 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID717482 | Solubility of the compound in 42:9:49 EtOH-d6:CNCD3:D2O solution at <0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID717486 | Solubility of the compound in 5:95 CNCD3-d6:D2O solution at 1 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583551 | Inhibition of human P2X2 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583537 | Ratio of IC50 for inhibition of Manduca sexta V-type proton ATPase assessed as reduction in inorganic phosphate production pre-inucubated for 5 mins before Tris-ATP addition and measured after 2 mins to IC50 for inhibition of human 1321N1 cells incubated | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID306129 | Growth inhibition of mouse L929 cells by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor. |
| AID1583559 | Inhibition of cathepsin L (unknown origin) assessed as reduction in pNA release using chromogenic Z-Phe-Arg-pNA substrate measured over 1 hr by spectrophotometry | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717481 | Solubility in 17 mM DHPC at 1 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID717485 | Solubility of the compound in 5:95 EtOH-d6:D2O solution at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583547 | Inhibition of human P2Y11 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717477 | Solubility in 50 mM OG at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1305701 | Agonist activity at farnesoid x receptor(unknown origin) | 2016 | Bioorganic & medicinal chemistry, Aug-01, Volume: 24, Issue:15
| Novel approaches to map small molecule-target interactions. |
| AID717478 | Solubility in 2 mM LMPC at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583534 | Inhibition of human P2X3 assessed as reduction in agonist-induced intracellular Ca2+ concentration pre-incubated for 30 mins before agonist addition by calcium 5 dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717483 | Solubility of the compound in 40:40:1 CDCl3:MeOH-d4:D2O at 1 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583554 | Non-competitive inhibition of human P2X3 expressed in human 1321N1 cells assessed as reduction in maximal effect of ATP-induced intracellular Ca2+ concentration pre-incubated for 30 mins before agonist addition by calcium 5 dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID717476 | Solubility in 0.4 mM OG at 0.5 mM by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID717475 | Binding affinity to tobacco hornworm V-ATPase c subunit in 4:4:1 CDCl3:MeOH-d4:D2O by NMR analysis | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid. |
| AID1583543 | Inhibition of human P2Y1 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583540 | Inhibition of human A1 adenosine receptor incubated for 60 mins by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| AID1583545 | Inhibition of human P2Y4 assessed as reduction in agonist-induced intracellular Ca2+ concentration at 10 uM pre-incubated for 30 mins before agonist addition by FLUO-4 AM dye based fluorescence assay | 2020 | Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4
| Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |