Tetrachloronitrobenzene (TCNB) is a highly chlorinated aromatic compound that exists in six isomers. It is primarily produced as a byproduct of the synthesis of other chlorinated aromatic compounds, such as hexachlorobenzene. TCNB has been studied for its potential environmental impact, as it is a persistent organic pollutant that can bioaccumulate in the food chain. Studies have focused on its toxicity to aquatic organisms and its effects on human health. Research into the synthesis of TCNB is limited, but it is known to be synthesized via chlorination of nitrobenzene. Its importance lies in understanding the potential environmental risks associated with its production and release. TCNB is studied to evaluate its fate and transport in the environment, its bioaccumulation potential, and its toxicity to various organisms.'
ID Source | ID |
---|---|
PubMed CID | 13428 |
CHEMBL ID | 1418603 |
SCHEMBL ID | 3650611 |
MeSH ID | M0072110 |
Synonym |
---|
benzene, tetrachloronitro- |
28804-67-3 |
MLS002152855 |
smr001224479 |
db-905 |
benzene,2,3,4-tetrachloro- |
nsc-5577 |
nsc5577 |
879-39-0 |
2,4,5-tetrachloronitrobenzene |
2,4,5-tetrachloro-1-nitrobenzene |
benzene,2,3,4-tetrachloro-5-nitro- |
wln: wnr bg cg dg eg |
1-nitro-2,4,5-tetrachlorobenzene |
tcbn |
folosan db-905 fumite |
1,3,4-tetrachloro-5-nitrobenzene |
1-nitro-2,3,4,5-tetrachlorobenzene |
1,2,3,4-tetrachloro-5-nitro-benzene |
benzene, 1,2,3,4-tetrachloro-5-nitro- |
nsc57752 |
nsc-57752 |
2,3,4,5-tetrachloronitrobenzene |
NCGC00090838-01 |
nsc 57752 |
benzene, 5-nitro-1,2,3,4-tetrachloro- |
2,3,4,5-tetrachloro-1-nitrobenzene |
ai3-23025 |
brn 2273256 |
hsdb 4286 |
nsc 5577 |
ccris 5938 |
einecs 212-906-5 |
NCIOPEN2_002406 |
1,2,3,4-tetrachloro-5-nitrobenzene |
mtbytwzdrvombr-uhfffaoysa- |
inchi=1/c6hcl4no2/c7-2-1-3(11(12)13)5(9)6(10)4(2)8/h1h |
T1128 |
NCGC00090838-02 |
NCGC00090838-03 |
HMS3039I09 |
n2wu0k04eh , |
unii-n2wu0k04eh |
tox21_200893 |
dtxsid5026097 , |
dtxcid106097 |
cas-879-39-0 |
NCGC00258447-01 |
FT-0633066 |
AKOS015850053 |
2,3,4,5-tetrachloronitrobenzene [hsdb] |
SCHEMBL3650611 |
2,3,4,5-tetrachloro-1-nitro-benzene |
CHEMBL1418603 |
1,2,3,4-tetrachloro-5-nitrobenzene, pestanal(r), analytical standard |
mfcd00007064 |
Q27284440 |
T73027 |
CS-0157885 |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
interleukin 8 | Homo sapiens (human) | Potency | 84.1267 | 0.0473 | 49.4806 | 74.9780 | AID651758 |
acetylcholinesterase | Homo sapiens (human) | Potency | 79.3809 | 0.0025 | 41.7960 | 15,848.9004 | AID1347395 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 2.5119 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 54.2611 | 0.0060 | 38.0041 | 19,952.5996 | AID1159523 |
SMAD family member 2 | Homo sapiens (human) | Potency | 51.7757 | 0.1737 | 34.3047 | 61.8120 | AID1346859; AID1346924 |
SMAD family member 3 | Homo sapiens (human) | Potency | 51.7757 | 0.1737 | 34.3047 | 61.8120 | AID1346859; AID1346924 |
TDP1 protein | Homo sapiens (human) | Potency | 2.5929 | 0.0008 | 11.3822 | 44.6684 | AID686978 |
GLI family zinc finger 3 | Homo sapiens (human) | Potency | 31.9504 | 0.0007 | 14.5928 | 83.7951 | AID1259368; AID1259392 |
AR protein | Homo sapiens (human) | Potency | 33.0413 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID743036; AID743042; AID743053 |
thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 56.2341 | 0.1000 | 22.9075 | 100.0000 | AID485364 |
nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 7.4749 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224893 |
glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 27.7965 | 0.0002 | 14.3764 | 60.0339 | AID588533; AID720692 |
retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 51.9916 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159555 |
retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 30.9160 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531 |
estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 70.6211 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224848; AID1224849; AID1259403 |
farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 61.4337 | 0.3758 | 27.4851 | 61.6524 | AID743217 |
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 60.8820 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 52.1001 | 0.0002 | 29.3054 | 16,493.5996 | AID1259244; AID743080; AID743091 |
bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 35.4813 | 0.7079 | 36.9043 | 89.1251 | AID504333 |
peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 36.0336 | 0.0010 | 24.5048 | 61.6448 | AID743212; AID743215 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 68.9297 | 0.0237 | 23.2282 | 63.5986 | AID743222 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 54.2611 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
activating transcription factor 6 | Homo sapiens (human) | Potency | 54.7528 | 0.1434 | 27.6121 | 59.8106 | AID1159516 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 61.4337 | 19.7391 | 45.9784 | 64.9432 | AID1159509 |
v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 46.1451 | 0.0578 | 21.1097 | 61.2679 | AID1159526; AID1159528 |
Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 97.5998 | 0.0391 | 47.5451 | 146.8240 | AID1224845; AID1224896 |
potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 7.0795 | 0.0178 | 9.6374 | 44.6684 | AID588834 |
thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 59.1791 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
heat shock protein beta-1 | Homo sapiens (human) | Potency | 68.9297 | 0.0420 | 27.3789 | 61.6448 | AID743210 |
nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 18.5364 | 0.0006 | 27.2152 | 1,122.0200 | AID651741; AID720636; AID743202; AID743219 |
Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 68.3107 | 0.0015 | 57.7890 | 15,848.9004 | AID1259244 |
Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 19.2526 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 68.3107 | 0.0015 | 51.7393 | 15,848.9004 | AID1259244 |
Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 0.0266 | 22.4482 | 66.8242 | AID651802 |
ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 68.3107 | 0.0119 | 17.9420 | 71.5630 | AID651632; AID720516 |
Ataxin-2 | Homo sapiens (human) | Potency | 68.3107 | 0.0119 | 12.2221 | 68.7989 | AID651632 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (28.37) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |