Dioctyldimethyl ammonium chloride (DODMAC) is a quaternary ammonium compound commonly used as a cationic surfactant. It is synthesized by reacting dimethylamine with octyl chloride, followed by further alkylation with octyl chloride. DODMAC exhibits strong antimicrobial activity against a wide range of microorganisms, including bacteria, fungi, and viruses. Its effectiveness stems from its ability to disrupt cell membranes and cause cell lysis. Due to its biocidal properties, DODMAC finds application in various industrial and consumer products, such as disinfectants, sanitizers, textile softeners, and antistatic agents. Research on DODMAC focuses on understanding its efficacy against specific microorganisms, exploring its potential toxicity and environmental impact, and developing alternative formulations to minimize potential drawbacks. The study of DODMAC remains crucial due to its widespread use and the ongoing need for effective and safe antimicrobial agents.'
| ID Source | ID |
|---|---|
| PubMed CID | 62581 |
| CHEMBL ID | 2357351 |
| CHEBI ID | 183784 |
| SCHEMBL ID | 33353 |
| MeSH ID | M0449170 |
| Synonym |
|---|
| AC-129 |
| dioctyl dimethyl ammonium chloride |
| rc 5626 |
| hoe-s 2617 |
| ammonium, dimethyldioctyl-, chloride |
| epa pesticide chemical code 069166 |
| dodigen 2617 |
| n,n-dimethyl-n-octyl-1-octanaminium chloride |
| querton 28cl |
| 1-octanaminium, n,n-dimethyl-n-octyl-, chloride |
| caswell no. 392h |
| dioctyldimethylammonium chloride |
| dimethyldioctylammonium chloride |
| einecs 226-901-0 |
| FT-0660874 |
| CHEBI:183784 |
| 5538-94-3 |
| dimethyl(dioctyl)azanium;chloride |
| NCGC00182056-02 |
| NCGC00182056-03 |
| bisoctyl dimethyl ammonium chloride |
| tox21_112930 |
| dtxsid6035491 , |
| dtxcid4015491 |
| tox21_113024 |
| cas-5538-94-3 |
| 0x0rl40y6h , |
| dimethyl dioctyl ammonium chloride |
| 1-octanaminium, n,n-dimethyl-n-octyl-, chloride (1:1) |
| dioctyldimonium chloride |
| unii-0x0rl40y6h |
| dioctyldimethyl ammonium chloride |
| AKOS015901426 |
| bardac lf 80 |
| swanol ca 3080 |
| dicaprylyldimonium chloride |
| dimethyl-n-octyl-1-octanaminium chloride, n,n- |
| pentonium do 50 |
| SCHEMBL33353 |
| n,n-dimethyl-n-octyloctan-1-aminium chloride |
| FARBQUXLIQOIDY-UHFFFAOYSA-M |
| disoctyl dimethyl ammonium chloride |
| W-110045 |
| CHEMBL2357351 |
| bardac lf |
| 4-(5-octyl-2-pyrimidinyl)phenyldecanoate |
| AMY22492 |
| Q27231207 |
| aq 208 |
| CS-0453547 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| Class | Description |
|---|---|
| quaternary ammonium salt | Derivatives of ammonium compounds, (NH4(+))Y(-), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| TDP1 protein | Homo sapiens (human) | Potency | 1.3376 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| AR protein | Homo sapiens (human) | Potency | 17.7637 | 0.0002 | 21.2231 | 8,912.5098 | AID743035; AID743042; AID743054; AID743063 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 15.0916 | 0.0123 | 7.9835 | 43.2770 | AID1645841 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 25.8598 | 0.0002 | 14.3764 | 60.0339 | AID720691; AID720692 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.7531 | 0.0002 | 29.3054 | 16,493.5996 | AID743069; AID743075; AID743078; AID743079; AID743080; AID743091 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 0.6741 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 28.2263 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 12.6857 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743066; AID743067 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 22.4209 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 5.6319 | 0.0119 | 17.9420 | 71.5630 | AID651632; AID720516 |
| Ataxin-2 | Homo sapiens (human) | Potency | 5.3080 | 0.0119 | 12.2221 | 68.7989 | AID651632 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.21) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||