Compounds > r 6597
Page last updated: 2024-12-06

r 6597

Description

2-nitronaphtho(2,1-b)furan: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID50354
CHEMBL ID7174
SCHEMBL ID11095673
MeSH IDM0151556

Synonyms (20)

Synonym
nsc329124
69267-51-2
nsc-329124
nsc 329124
r 6597
brn 1376274
2-nitronaphtho(2,1-b)furan
naphtho(2,1-b)furan, 2-nitro-
r6597 ,
2-nitronaphtho[2,1-b]furan
CHEMBL7174 ,
bdbm50304340
2-nitro-naphtho[2,1-b]furan
5-17-02-00234 (beilstein handbook reference)
r-6597
DTXSID00219332
SCHEMBL11095673
2-nitronaphthofuran
nitro-naphtho(2,1-b)furan, 2-
AZD85CW5YA
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Hepatocyte nuclear factor 4-alphaHomo sapiens (human)EC50 (µMol)2.09002.09002.33002.5700AID455458
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
positive regulation of transcription by RNA polymerase IIHepatocyte nuclear factor 4-alphaHomo sapiens (human)
regulation of transcription by RNA polymerase IIHepatocyte nuclear factor 4-alphaHomo sapiens (human)
transcription by RNA polymerase IIHepatocyte nuclear factor 4-alphaHomo sapiens (human)
ornithine metabolic processHepatocyte nuclear factor 4-alphaHomo sapiens (human)
lipid metabolic processHepatocyte nuclear factor 4-alphaHomo sapiens (human)
xenobiotic metabolic processHepatocyte nuclear factor 4-alphaHomo sapiens (human)
sex differentiationHepatocyte nuclear factor 4-alphaHomo sapiens (human)
blood coagulationHepatocyte nuclear factor 4-alphaHomo sapiens (human)
negative regulation of cell population proliferationHepatocyte nuclear factor 4-alphaHomo sapiens (human)
response to glucoseHepatocyte nuclear factor 4-alphaHomo sapiens (human)
regulation of gastrulationHepatocyte nuclear factor 4-alphaHomo sapiens (human)
regulation of lipid metabolic processHepatocyte nuclear factor 4-alphaHomo sapiens (human)
signal transduction involved in regulation of gene expressionHepatocyte nuclear factor 4-alphaHomo sapiens (human)
negative regulation of cell growthHepatocyte nuclear factor 4-alphaHomo sapiens (human)
intracellular receptor signaling pathwayHepatocyte nuclear factor 4-alphaHomo sapiens (human)
glucose homeostasisHepatocyte nuclear factor 4-alphaHomo sapiens (human)
cholesterol homeostasisHepatocyte nuclear factor 4-alphaHomo sapiens (human)
regulation of circadian rhythmHepatocyte nuclear factor 4-alphaHomo sapiens (human)
negative regulation of DNA-templated transcriptionHepatocyte nuclear factor 4-alphaHomo sapiens (human)
positive regulation of DNA-templated transcriptionHepatocyte nuclear factor 4-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIHepatocyte nuclear factor 4-alphaHomo sapiens (human)
rhythmic processHepatocyte nuclear factor 4-alphaHomo sapiens (human)
regulation of insulin secretionHepatocyte nuclear factor 4-alphaHomo sapiens (human)
lipid homeostasisHepatocyte nuclear factor 4-alphaHomo sapiens (human)
phospholipid homeostasisHepatocyte nuclear factor 4-alphaHomo sapiens (human)
triglyceride homeostasisHepatocyte nuclear factor 4-alphaHomo sapiens (human)
anatomical structure developmentHepatocyte nuclear factor 4-alphaHomo sapiens (human)
cell differentiationHepatocyte nuclear factor 4-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (15)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificHepatocyte nuclear factor 4-alphaHomo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificHepatocyte nuclear factor 4-alphaHomo sapiens (human)
DNA bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
chromatin bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
DNA-binding transcription factor activityHepatocyte nuclear factor 4-alphaHomo sapiens (human)
signaling receptor bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
fatty acid bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
protein bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
zinc ion bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
protein homodimerization activityHepatocyte nuclear factor 4-alphaHomo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
sequence-specific double-stranded DNA bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingHepatocyte nuclear factor 4-alphaHomo sapiens (human)
nuclear receptor activityHepatocyte nuclear factor 4-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
nucleusHepatocyte nuclear factor 4-alphaHomo sapiens (human)
nucleoplasmHepatocyte nuclear factor 4-alphaHomo sapiens (human)
cytoplasmHepatocyte nuclear factor 4-alphaHomo sapiens (human)
chromatinHepatocyte nuclear factor 4-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID70453Genotoxicity (SOSIP) on Escherichia coli PQ37 (SOS induction potential data, as a measure of genotoxicity)1993Journal of medicinal chemistry, Apr-16, Volume: 36, Issue:8
Mechanistic interpretation of the genotoxicity of nitrofurans (antibacterial agents) using quantitative structure-activity relationships and comparative molecular field analysis.
AID455692Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity at 12.5 uM by beta-galactosidase one hybrid assay relative to control2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.
AID201367Mutagenicity inSalmonella Typhimurium TA100 was determined1993Journal of medicinal chemistry, Apr-16, Volume: 36, Issue:8
Mechanistic interpretation of the genotoxicity of nitrofurans (antibacterial agents) using quantitative structure-activity relationships and comparative molecular field analysis.
AID455696Cytotoxicity against human HepG2/C3A cells after 48 hrs by MTT assay2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.
AID23231Calculated partition coefficient (clogP)1993Journal of medicinal chemistry, Apr-16, Volume: 36, Issue:8
Mechanistic interpretation of the genotoxicity of nitrofurans (antibacterial agents) using quantitative structure-activity relationships and comparative molecular field analysis.
AID455458Agonist activity at human full length HNF4alpha nuclear receptor expressed in human HepG2/C3A cells co-transfected with LexADBD assessed as increase in transcriptional activity after 16 hrs by beta-galactosidase one hybrid assay2009Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds.
AID201369Mutagenicity inSalmonella Typhimurium TA98 was determined1993Journal of medicinal chemistry, Apr-16, Volume: 36, Issue:8
Mechanistic interpretation of the genotoxicity of nitrofurans (antibacterial agents) using quantitative structure-activity relationships and comparative molecular field analysis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		1.9710ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		1.9710naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9710acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
2-nitrobenzofuran
[no description available]		2.3820
2-nitro-7-methoxynaphtho(2-1b)furan
2-nitro-7-methoxynaphtho(2-1b)furan: structure given in first source		2.6830
2-nitro-8-methoxynaphtho(2,1-b)furan
[no description available]		2.6830
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		1.9810
nadp
[no description available]		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Fibrosarcoma
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)		01.9710
Cancer of Skin
[description not available]		01.9710
Cocarcinogenesis
The combination of two or more different factors in the production of cancer.		01.9710
Skin Neoplasms
Tumors or cancer of the SKIN.		01.9710
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