2,4-dibromophenyl 2,4,5-tribromophenyl ether : A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, 5, 2', and 4' positions have been replaced by bromines. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 36159 |
| CHEMBL ID | 374400 |
| CHEBI ID | 81582 |
| SCHEMBL ID | 14938654 |
| MeSH ID | M0484000 |
| Synonym |
|---|
| benzene,1,2,4-tribromo-5-(2,4-dibromophenoxy)- |
| pentabromodiphenyl oxide (technical) (de 71) |
| 2,2',4,4',5-pentabromodiphenyl ether |
| 60348-60-9 |
| NCGC00091436-01 |
| NCGC00091436-02 |
| NCGC00091436-03 |
| pbde 99 |
| de 71 |
| de-71 , |
| 1,2,4-tribromo-5-(2,4-dibromophenoxy)benzene |
| benzene, 1,1'-oxybis-, pentabromo deriv. |
| pentabromodiphenyl oxide repackaged |
| pentabromodiphenyl oxide (technical) |
| bde 99 |
| bde-99 |
| pbde-99 |
| MLS001065585 |
| smr000568490 |
| chebi:81582 , |
| CHEMBL374400 |
| 2,2',4,4',5 pentabromodiphenyl ether |
| C18203 |
| NCGC00091436-04 |
| NCGC00091436-05 |
| HMS3039F12 |
| tox21_201143 |
| dtxsid9030048 , |
| NCGC00258695-01 |
| dsstox_gsid_24246 |
| NCGC00257710-01 |
| cas-32534-81-9 |
| cas-60348-60-9 |
| dsstox_rid_77340 |
| dtxcid404246 |
| dsstox_cid_4246 |
| tox21_200156 |
| benzene, 1,2,4-tribromo-5-(2,4-dibromophenoxy)- |
| unii-d3a2t91i1e |
| d3a2t91i1e , |
| 2,2',4,4',5-pentabromodiphenyl oxide |
| tardex 50l |
| tardex 50 |
| 2,4-dibromophenyl 2,4,5-tribromophenyl ether |
| SCHEMBL14938654 |
| 2,2',4,4',5,-penabromodiphenyl ether |
| bde no 99, analytical standard |
| 1-[2,4-bis(bromanyl)phenoxy]-2,4,5-tris(bromanyl)benzene |
| 2,2,4,4,5-pentabromodiphenyl ether |
| Q412017 |
| bde no 99 |
| 2,2',4,4',5-pentabromdiphenylether, bde 99 |
| mfcd04112998 |
| YSCK0279 |
| pbde no. 99 |
| 2,2',4,4',5-pentabromodiphenyl ether (>80per cent)(contains ~10per cent 2,2',4,4',5,5'-hexabromomdip |
| pbde 99 50 microg/ml in nonane |
| E89249 |
| Class | Description |
|---|---|
| polybromodiphenyl ether | An aromatic ether that is diphenyl ether carrying between 2 and 10 bromo substituents attached to the two benzene rings. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 19.9526 | 0.6310 | 35.7641 | 100.0000 | AID504339 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 19.9526 | 0.0020 | 14.6779 | 39.8107 | AID1476 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 14.2780 | 0.0072 | 15.7588 | 89.3584 | AID1224835 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 0.0473 | 49.4806 | 74.9780 | AID651758 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 50.4513 | 0.0251 | 27.9203 | 501.1870 | AID651751 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 36.4132 | 0.0060 | 38.0041 | 19,952.5996 | AID1159523 |
| TDP1 protein | Homo sapiens (human) | Potency | 29.0929 | 0.0008 | 11.3822 | 44.6684 | AID686978 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 29.2585 | 0.0007 | 14.5928 | 83.7951 | AID1259369; AID1259392 |
| AR protein | Homo sapiens (human) | Potency | 15.7453 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID1259381; AID743035; AID743040; AID743063 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.6228 | 0.0013 | 18.0743 | 39.8107 | AID926; AID938 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 31.2648 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
| progesterone receptor | Homo sapiens (human) | Potency | 35.9172 | 0.0004 | 17.9460 | 75.1148 | AID1346795 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 33.6305 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159553; AID1159555 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 32.7969 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531; AID588544 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 37.1048 | 0.0015 | 30.6073 | 15,848.9004 | AID1224849; AID1259403 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.0328 | 0.3758 | 27.4851 | 61.6524 | AID588526; AID588527; AID743217; AID743220 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 31.9266 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982; AID720659 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 40.7955 | 0.0002 | 29.3054 | 16,493.5996 | AID588514; AID743069; AID743075; AID743079; AID743080 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 31.6228 | 0.7079 | 36.9043 | 89.1251 | AID504333 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 35.4813 | 0.0010 | 24.5048 | 61.6448 | AID588535 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 43.6073 | 0.0010 | 19.4141 | 70.9645 | AID588536; AID588537; AID743094 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 18.7609 | 0.0007 | 23.0674 | 1,258.9301 | AID743085; AID743122 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 17.3517 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 46.1194 | 0.0016 | 28.0151 | 77.1139 | AID1224895; AID1259385; AID1259395 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 69.6916 | 19.7391 | 45.9784 | 64.9432 | AID1159509 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 27.7447 | 0.0578 | 21.1097 | 61.2679 | AID1159526 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 17.7828 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 21.4509 | 0.0100 | 39.5371 | 1,122.0200 | AID588545; AID588547 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 39.8107 | 0.0178 | 9.6374 | 44.6684 | AID588834 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 39.0198 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.7831 | 0.0398 | 16.7842 | 39.8107 | AID995 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 43.2676 | 0.0006 | 27.2152 | 1,122.0200 | AID651741; AID720636 |
| geminin | Homo sapiens (human) | Potency | 26.1011 | 0.0046 | 11.3741 | 33.4983 | AID624296; AID624297 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 1.3948 | 0.0200 | 10.7869 | 31.6228 | AID912 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 20.1865 | 0.0023 | 19.5956 | 74.0614 | AID651743 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 54.2347 | 0.0266 | 22.4482 | 66.8242 | AID651802 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 11.2202 | 3.9811 | 46.7448 | 112.2020 | AID720708 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID289348 | Biomagnification factors in human | 2007 | Science (New York, N.Y.), Jul-13, Volume: 317, Issue:5835 | Food web-specific biomagnification of persistent organic pollutants. |
| AID289347 | Biomagnification factors in Diporeia | 2007 | Science (New York, N.Y.), Jul-13, Volume: 317, Issue:5835 | Food web-specific biomagnification of persistent organic pollutants. |
| AID289345 | Octanol-water partition coefficient, log KOW of the compound | 2007 | Science (New York, N.Y.), Jul-13, Volume: 317, Issue:5835 | Food web-specific biomagnification of persistent organic pollutants. |
| AID289346 | Octanol-air partition coefficient, log KOA of the compound | 2007 | Science (New York, N.Y.), Jul-13, Volume: 317, Issue:5835 | Food web-specific biomagnification of persistent organic pollutants. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.71) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||