Pencycuron is a synthetic fungicide that inhibits the biosynthesis of ergosterol, a crucial component of fungal cell membranes. This disruption in ergosterol production leads to impaired fungal growth and development. Pencycuron is primarily used to control diseases caused by fungi in a wide range of crops, including wheat, barley, and fruit trees. The compound is applied as a seed treatment or as a foliar spray. Its effectiveness has been shown to be influenced by various factors, including the specific fungal species, environmental conditions, and application techniques. The research on pencycuron focuses on understanding its mode of action, its efficacy against different fungal pathogens, its environmental fate and potential risks, and its impact on beneficial organisms. Ongoing studies are investigating the development of new pencycuron formulations and alternative fungicides with improved efficacy and reduced environmental impact.'
pencycuron: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
pencycuron : A member of the class of phenylureas that is urea which is substituted by p-chlorobenzyl and cyclopentyl groups at position 1 and a phenyl group at position 3. A fungicide used to control diseases caused by Rhizoctonia solani and Pellicularia spp. It is not highly toxic to mammals but is moderately toxic to birds, most aquatic organisms, honeybees and earthworms. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 91692 |
| CHEMBL ID | 2229452 |
| CHEBI ID | 7957 |
| SCHEMBL ID | 22525 |
| MeSH ID | M0111762 |
| Synonym |
|---|
| urea, n-[(4-chlorophenyl)methyl]-n-cyclopentyl-n'-phenyl- |
| pencycuron |
| 66063-05-6 |
| monceren |
| brn 2154416 |
| einecs 266-096-3 |
| caswell no. 638a |
| 1-(p-chlorobenzyl)-1-cyclopentyl-3-phenylurea |
| urea, n-((4-chlorophenyl)methyl)-n-cyclopentyl-n'-phenyl- |
| pencycuron [bsi:iso] |
| n-((4-chlorophenyl)methyl)-n-cyclopentyl-n'-phenylurea |
| 1-((4-chlorophenyl)methyl)-1-cyclopentyl-3-phenylurea |
| ntn 19701 |
| epa pesticide chemical code 128823 |
| bay ntn 19701 |
| 1-(4-chlorobenzyl)-1-cyclopentyl-3-phenylurea |
| 1-[(4-chlorophenyl)methyl]-1-cyclopentyl-3-phenylurea |
| tox21_301255 |
| dtxcid1022261 |
| NCGC00255755-01 |
| dtxsid3042261 , |
| cas-66063-05-6 |
| gch2g449hp , |
| unii-gch2g449hp |
| FT-0630759 |
| AKOS015902852 |
| chebi:7957 , |
| CHEMBL2229452 |
| monceraen 250sc |
| pencycuron [mi] |
| pencycuron [iso] |
| ntn-19701 |
| SCHEMBL22525 |
| 1-[(4-chlorophenyl)methyl]-1-cyclopentyl-3-phenyl-urea |
| n-4-chlorobenzyl-n-cyclopentyl-n'-phenylurea |
| [(chlorophenyl)-methyl]-n-cyclopentyl-n'-phenylurea |
| n-(4-chlorobenzyl)-n-cyclopentyl-n'-phenylurea # |
| trotis |
| pencycuron, pestanal(r), analytical standard |
| Q4989650 |
| pencycuron 50 microg/ml in acetonitrile |
Pencycuron is a non-systemic protective fungicide for controlling sheath blight of rice.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Pencycuron is a non-systemic protective fungicide for controlling sheath blight of rice. " | ( Dissipation of pencycuron in rice plant. Chakrabarti, K; Chakraborty, A; Chowdhury, A; Pal, R, 2005) | 2.12 |
| Role | Description |
|---|---|
| antifungal agrochemical | Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| monochlorobenzenes | Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine. |
| phenylureas | Any member of the class of ureas in which at least one of the nitrogens of the urea moiety is substituted by a phenyl or substituted phenyl group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 61.1306 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 68.5896 | 0.0007 | 14.5928 | 83.7951 | AID1259369; AID1259392 |
| AR protein | Homo sapiens (human) | Potency | 41.9804 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID743035; AID743054; AID743063 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 24.3365 | 0.0006 | 57.9133 | 22,387.1992 | AID1259378 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 40.2308 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
| progesterone receptor | Homo sapiens (human) | Potency | 15.3553 | 0.0004 | 17.9460 | 75.1148 | AID1346795 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 12.2998 | 0.0002 | 14.3764 | 60.0339 | AID720692 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 61.1306 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159555 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.9485 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 57.9497 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224848; AID1224849; AID1259401; AID1259403 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 54.9410 | 0.3758 | 27.4851 | 61.6524 | AID743217 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 6.1131 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 51.9536 | 0.0002 | 29.3054 | 16,493.5996 | AID743069; AID743078 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 28.9507 | 0.0010 | 19.4141 | 70.9645 | AID743140; AID743191 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 46.5268 | 0.0007 | 23.0674 | 1,258.9301 | AID743085; AID743122 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 48.5577 | 0.0016 | 28.0151 | 77.1139 | AID1224843; AID1224895 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.8848 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 62.7583 | 0.0006 | 27.2152 | 1,122.0200 | AID743202; AID743219 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.5896 | 0.0023 | 19.5956 | 74.0614 | AID651631; AID720552 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 48.5577 | 0.0119 | 17.9420 | 71.5630 | AID651632 |
| Ataxin-2 | Homo sapiens (human) | Potency | 48.5577 | 0.0119 | 12.2221 | 68.7989 | AID651632 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1081595 | Antifungal activity against Rhizoctonia solani AG-4 assessed as inhibition of colony size at 250 ppm at 27 degC measured after 48 hr | 2010 | Journal of agricultural and food chemistry, Aug-11, Volume: 58, Issue:15 | Bioactive saponin from tea seed pomace with inhibitory effects against Rhizoctonia solani. |
| AID1081593 | Antifungal activity against Rhizoctonia solani AG-4 assessed as inhibition of colony size at 2.5 ppm at 27 degC measured after 48 hr | 2010 | Journal of agricultural and food chemistry, Aug-11, Volume: 58, Issue:15 | Bioactive saponin from tea seed pomace with inhibitory effects against Rhizoctonia solani. |
| AID1081592 | Antifungal activity against Rhizoctonia solani AG-4 assessed as inhibition of colony size at 0.25 ppm at 27 degC measured after 48 hr | 2010 | Journal of agricultural and food chemistry, Aug-11, Volume: 58, Issue:15 | Bioactive saponin from tea seed pomace with inhibitory effects against Rhizoctonia solani. |
| AID1081591 | Antifungal activity against Rhizoctonia solani AG-4 assessed as inhibition of mycelial growth at 27 degC measured after 48 hr | 2010 | Journal of agricultural and food chemistry, Aug-11, Volume: 58, Issue:15 | Bioactive saponin from tea seed pomace with inhibitory effects against Rhizoctonia solani. |
| AID1081594 | Antifungal activity against Rhizoctonia solani AG-4 assessed as inhibition of colony size at 25 ppm at 27 degC measured after 48 hr | 2010 | Journal of agricultural and food chemistry, Aug-11, Volume: 58, Issue:15 | Bioactive saponin from tea seed pomace with inhibitory effects against Rhizoctonia solani. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (27.04) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||