SR 11217: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 3035780 |
| CHEMBL ID | 24966 |
| SCHEMBL ID | 7412191 |
| MeSH ID | M0233815 |
| Synonym |
|---|
| 4-[2-methyl-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid |
| bdbm50033080 |
| sr 11217 |
| CHEMBL24966 , |
| sr-11217 |
| 4-(2-methyl-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl)benzoic acid |
| sr11217 |
| 146670-35-1 |
| benzoic acid, 4-(2-methyl-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)- |
| SCHEMBL7412191 |
| 4-[1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-methyl-1-propenyl]benzoic acid |
| XYIWGTYPSQVWKX-UHFFFAOYSA-N |
| 4-[1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-methyl-l-propenyl]benzoic acid |
| DTXSID90163431 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 (µMol) | 0.0860 | 0.0001 | 0.3427 | 9.1000 | AID199632 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | EC50 (µMol) | 0.9800 | 0.0008 | 0.5254 | 5.2000 | AID199801 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor alpha | Homo sapiens (human) | AC50 | 1.0000 | 0.0190 | 0.1095 | 0.2000 | AID197904 |
| Retinoic acid receptor beta | Homo sapiens (human) | AC50 | 1.0000 | 0.0020 | 0.0253 | 0.0520 | AID198359 |
| Retinoic acid receptor gamma | Homo sapiens (human) | AC50 | 1.0000 | 0.0030 | 0.0323 | 0.0680 | AID198882 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | AC50 | 0.1600 | 0.0070 | 0.0835 | 0.1600 | AID167586 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID199801 | Effective concentrations against Retinoic acid receptor RXR-beta | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17 | Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
| AID197918 | Relative activity against Retinoic acid receptor alpha at 10e-6 M with respect to 10e-6 M of trans-RA | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17 | Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
| AID198895 | Relative activity against Retinoic acid receptor gamma at 10e-6 M with respect to 10e-6 M of trans-RA | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17 | Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
| AID198063 | Percent transcriptional activation of Retinoic acid receptor RAR alpha at 1 uM compared to 1 uM trans-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID199625 | Relative activity against Retinoic acid receptor RXR-alpha at 10e-6 M retinoid relative to 10e-6 M of 9-cis-RA. | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17 | Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
| AID167586 | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR-alpha | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID199063 | Percent transcriptional activation of Retinoic acid receptor RAR gamma receptor at 1 uM compared to 1 uM trans-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID198552 | Percent transcriptional activation of Retinoic acid receptor beta at 1 uM compared to 1 uM trans-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID198359 | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID199632 | Effective concentration against Retinoic acid receptor RXR-alpha | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17 | Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
| AID197904 | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID167590 | Percent transcriptional activation of Retinoic acid receptor RXR-alpha at 1 uM compared to 1 uM 9-cis-retinoic acid | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID198882 | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | 2000 | Bioorganic & medicinal chemistry letters, Jun-19, Volume: 10, Issue:12 | sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity. |
| AID198372 | Relative activity against Retinoic acid receptor beta at 10e-6 M with respect to 10e-6 M of trans-RA | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17 | Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.86) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||