| Assay ID | Title | Year | Journal | Article |
|---|
| AID272963 | Anabolic activity in orchidectomized rat at 3.0 mg/kg, po measured as increase in levator ani muscle weight to eugonadal level | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID1872308 | Modulation of Androgen receptor (unknown origin) | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998-2021). |
| AID290227 | Agonist activity at human androgen receptor expressed in CV1 cells | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones. |
| AID375617 | Agonist activity at androgen receptor | 2009 | Journal of medicinal chemistry, Jun-25, Volume: 52, Issue:12
| Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. |
| AID272962 | Antagonist activity against human ERalpha in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID298545 | Agonist activity at human androgen receptor by luciferase reporter gene assay | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID1872310 | Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constant | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998-2021). |
| AID272967 | Anabolic activity in orchidectomized rat measured as increase in levator ani muscle weight relative to intact rat | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID293943 | Antagonist activity at human AR | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. |
| AID272946 | Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID375642 | Myotropic activity in rat assessed as ventral prostate weight at 100 mg/kg by Hershberger assay | 2009 | Journal of medicinal chemistry, Jun-25, Volume: 52, Issue:12
| Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. |
| AID298558 | Bioavailability in Sprague-Dawley rat at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID375644 | Suppression of hyphalamic-pituitary-gonadal axis in rat at 3 mg/kg | 2009 | Journal of medicinal chemistry, Jun-25, Volume: 52, Issue:12
| Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. |
| AID272948 | Antagonist activity against human androgen receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID272953 | Binding affinity to mineralocorticoid receptor | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID298549 | Binding affinity to human AR | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID290231 | Binding affinity to human androgen receptor expressed in CV1 cells | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones. |
| AID272961 | Agonist activity at human ERalpha in CV1 cells measured as stimulation of luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID272947 | Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity with relative to DHT by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID298547 | Antagonist activity at human androgen receptor by luciferase reporter gene assay | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID272956 | Antagonist activity against human progesterone receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID298546 | Agonist efficacy at human androgen receptor by luciferase reporter gene assay relative to DHT | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID272951 | Binding affinity to progesterone receptor | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID293941 | Agonist activity at human AR | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. |
| AID290228 | Agonist activity at human androgen receptor expressed in CV1 cells relative to DHT | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones. |
| AID1885023 | Agonist activity at human Androgen receptor | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Therapeutic Strategies to Target the Androgen Receptor. |
| AID272958 | Antagonist activity against human glucocorticoid receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID375626 | Myotropic activity in rat assessed as levator ani muscle weight by Hershberger assay relative to intact tissue | 2009 | Journal of medicinal chemistry, Jun-25, Volume: 52, Issue:12
| Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. |
| AID272950 | Antagonist activity against human androgen receptor in CV1 cells measured as percent of maximal inhibition of DHT-stimulated luciferase reporter gene activity by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID293942 | Agonist activity at human AR relative to DHT | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. |
| AID272966 | Androgenic activity in orchidectomized rat at 100 mg/kg, po measured as increase in ventral prostate weight to intact level | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID298548 | Antagonist efficacy at human androgen receptor assessed as inhibition of DHT activity by luciferase reporter gene assay | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID272952 | Binding affinity to glucocorticoid receptor | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID272954 | Binding affinity to estrogen receptor | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID272955 | Agonist activity at human progesterone receptor in CV1 cells measured as stimulation of luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID1885021 | Binding affinity to human Androgen receptor | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Therapeutic Strategies to Target the Androgen Receptor. |
| AID272957 | Agonist activity at human glucocorticoid receptor in CV1 cells measured as stimulation of luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID298557 | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID272949 | Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID272959 | Agonist activity at human mineralocorticoid receptor in CV1 cells measured as stimulation of luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID298554 | Half life in Sprague-Dawley rat at 2.5 mg/kg, iv | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| AID1885024 | Agonist activity at human Androgen receptor relative to control | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Therapeutic Strategies to Target the Androgen Receptor. |
| AID293944 | Antagonist activity at human AR assessed as inhibition of DHT-induced response | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. |
| AID272960 | Antagonist activity against human mineralocorticoid receptor in CV1 cells measured as inhibition of DHT-stimulated luciferase reporter gene activity upto 10 uM by cotransfection assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID293945 | Binding affinity to human AR | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
| Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. |
| AID1797738 | AR Transcriptional Activation Assay and MDA Whole-Cell Binding Assay from Article 10.1021/jm070231h: \\Substituted 6-(1-Pyrrolidine)quinolin-2(1H)-ones as Novel Selective Androgen Receptor Modulators.\\ | 2007 | Journal of medicinal chemistry, Oct-18, Volume: 50, Issue:21
| Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |