Page last updated: 2024-12-08

davidigenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

davidigenin: has antispasmodic activity; isolated from Mascarenhasia arborescens; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

davidigenin : A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', and 4' respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Mascarenhasiagenus[no description available]ApocynaceaeThe dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH]

Cross-References

ID SourceID
PubMed CID442342
CHEMBL ID192877
CHEBI ID27655
SCHEMBL ID750182
MeSH IDM0551348

Synonyms (22)

Synonym
23130-26-9
davidigenin
4,2',4'-trihydroxydihydrochalcone
C09618
LMPK12120452
CHEMBL192877
chebi:27655 ,
1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
2',4,4'-trihydroxydihydrochalcone
2',4'-dihydroxy-3-(p-hydroxyphenyl)-propiophenone
SCHEMBL750182
UDGKKUWYNITJRX-UHFFFAOYSA-N
1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone
1-propanone, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-
DTXSID60331802
AKOS027379512
compound np-007307
FT-0711281
Q27103244
unii-oml9b432g4
isoliquiritigenin metabolite m5
oml9b432g4 ,
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
anti-allergic agentA drug used to treat allergic reactions.
anti-asthmatic agentAny compound that has anti-asthmatic effects.
antioxidantA substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
dihydrochalconesAny ketone that is 1,3-diphenylpropanone and its derivatives obtained by substitution.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Estrogen receptorHomo sapiens (human)IC50 (µMol)1,000.00000.00000.723732.7000AID241876
Mu-type opioid receptorCavia porcellus (domestic guinea pig)IC50 (µMol)1,000.00000.00020.660310.0000AID241850
Estrogen receptor betaHomo sapiens (human)IC50 (µMol)1,000.00000.00010.529432.7000AID241850
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (44)

Processvia Protein(s)Taxonomy
positive regulation of transcription by RNA polymerase IIEstrogen receptorHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIEstrogen receptorHomo sapiens (human)
antral ovarian follicle growthEstrogen receptorHomo sapiens (human)
epithelial cell developmentEstrogen receptorHomo sapiens (human)
chromatin remodelingEstrogen receptorHomo sapiens (human)
regulation of DNA-templated transcriptionEstrogen receptorHomo sapiens (human)
signal transductionEstrogen receptorHomo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathwayEstrogen receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationEstrogen receptorHomo sapiens (human)
androgen metabolic processEstrogen receptorHomo sapiens (human)
male gonad developmentEstrogen receptorHomo sapiens (human)
negative regulation of gene expressionEstrogen receptorHomo sapiens (human)
positive regulation of phospholipase C activityEstrogen receptorHomo sapiens (human)
intracellular steroid hormone receptor signaling pathwayEstrogen receptorHomo sapiens (human)
intracellular estrogen receptor signaling pathwayEstrogen receptorHomo sapiens (human)
response to estradiolEstrogen receptorHomo sapiens (human)
regulation of toll-like receptor signaling pathwayEstrogen receptorHomo sapiens (human)
negative regulation of smooth muscle cell apoptotic processEstrogen receptorHomo sapiens (human)
negative regulation of canonical NF-kappaB signal transductionEstrogen receptorHomo sapiens (human)
negative regulation of DNA-binding transcription factor activityEstrogen receptorHomo sapiens (human)
response to estrogenEstrogen receptorHomo sapiens (human)
positive regulation of DNA-templated transcriptionEstrogen receptorHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIEstrogen receptorHomo sapiens (human)
fibroblast proliferationEstrogen receptorHomo sapiens (human)
positive regulation of fibroblast proliferationEstrogen receptorHomo sapiens (human)
stem cell differentiationEstrogen receptorHomo sapiens (human)
regulation of inflammatory responseEstrogen receptorHomo sapiens (human)
positive regulation of DNA-binding transcription factor activityEstrogen receptorHomo sapiens (human)
RNA polymerase II preinitiation complex assemblyEstrogen receptorHomo sapiens (human)
uterus developmentEstrogen receptorHomo sapiens (human)
vagina developmentEstrogen receptorHomo sapiens (human)
prostate epithelial cord elongationEstrogen receptorHomo sapiens (human)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisEstrogen receptorHomo sapiens (human)
regulation of branching involved in prostate gland morphogenesisEstrogen receptorHomo sapiens (human)
mammary gland branching involved in pregnancyEstrogen receptorHomo sapiens (human)
mammary gland alveolus developmentEstrogen receptorHomo sapiens (human)
epithelial cell proliferation involved in mammary gland duct elongationEstrogen receptorHomo sapiens (human)
protein localization to chromatinEstrogen receptorHomo sapiens (human)
cellular response to estradiol stimulusEstrogen receptorHomo sapiens (human)
negative regulation of miRNA transcriptionEstrogen receptorHomo sapiens (human)
regulation of epithelial cell apoptotic processEstrogen receptorHomo sapiens (human)
regulation of transcription by RNA polymerase IIEstrogen receptorHomo sapiens (human)
cellular response to estrogen stimulusEstrogen receptorHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIEstrogen receptor betaHomo sapiens (human)
regulation of DNA-templated transcriptionEstrogen receptor betaHomo sapiens (human)
signal transductionEstrogen receptor betaHomo sapiens (human)
cell-cell signalingEstrogen receptor betaHomo sapiens (human)
negative regulation of cell growthEstrogen receptor betaHomo sapiens (human)
intracellular estrogen receptor signaling pathwayEstrogen receptor betaHomo sapiens (human)
positive regulation of DNA-templated transcriptionEstrogen receptor betaHomo sapiens (human)
positive regulation of DNA-binding transcription factor activityEstrogen receptor betaHomo sapiens (human)
cellular response to estradiol stimulusEstrogen receptor betaHomo sapiens (human)
regulation of transcription by RNA polymerase IIEstrogen receptor betaHomo sapiens (human)
cellular response to estrogen stimulusEstrogen receptor betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (29)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingEstrogen receptorHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificEstrogen receptorHomo sapiens (human)
TFIIB-class transcription factor bindingEstrogen receptorHomo sapiens (human)
transcription coregulator bindingEstrogen receptorHomo sapiens (human)
transcription corepressor bindingEstrogen receptorHomo sapiens (human)
transcription coactivator bindingEstrogen receptorHomo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificEstrogen receptorHomo sapiens (human)
chromatin bindingEstrogen receptorHomo sapiens (human)
DNA-binding transcription factor activityEstrogen receptorHomo sapiens (human)
nuclear receptor activityEstrogen receptorHomo sapiens (human)
steroid bindingEstrogen receptorHomo sapiens (human)
protein bindingEstrogen receptorHomo sapiens (human)
calmodulin bindingEstrogen receptorHomo sapiens (human)
beta-catenin bindingEstrogen receptorHomo sapiens (human)
zinc ion bindingEstrogen receptorHomo sapiens (human)
TBP-class protein bindingEstrogen receptorHomo sapiens (human)
enzyme bindingEstrogen receptorHomo sapiens (human)
protein kinase bindingEstrogen receptorHomo sapiens (human)
nitric-oxide synthase regulator activityEstrogen receptorHomo sapiens (human)
nuclear estrogen receptor activityEstrogen receptorHomo sapiens (human)
nuclear estrogen receptor bindingEstrogen receptorHomo sapiens (human)
estrogen response element bindingEstrogen receptorHomo sapiens (human)
identical protein bindingEstrogen receptorHomo sapiens (human)
ATPase bindingEstrogen receptorHomo sapiens (human)
14-3-3 protein bindingEstrogen receptorHomo sapiens (human)
sequence-specific double-stranded DNA bindingEstrogen receptorHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingEstrogen receptor betaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificEstrogen receptor betaHomo sapiens (human)
DNA bindingEstrogen receptor betaHomo sapiens (human)
nuclear steroid receptor activityEstrogen receptor betaHomo sapiens (human)
nuclear receptor activityEstrogen receptor betaHomo sapiens (human)
steroid bindingEstrogen receptor betaHomo sapiens (human)
protein bindingEstrogen receptor betaHomo sapiens (human)
zinc ion bindingEstrogen receptor betaHomo sapiens (human)
enzyme bindingEstrogen receptor betaHomo sapiens (human)
nuclear estrogen receptor activityEstrogen receptor betaHomo sapiens (human)
estrogen response element bindingEstrogen receptor betaHomo sapiens (human)
receptor antagonist activityEstrogen receptor betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (13)

Processvia Protein(s)Taxonomy
nucleusEstrogen receptorHomo sapiens (human)
nucleoplasmEstrogen receptorHomo sapiens (human)
transcription regulator complexEstrogen receptorHomo sapiens (human)
cytoplasmEstrogen receptorHomo sapiens (human)
Golgi apparatusEstrogen receptorHomo sapiens (human)
cytosolEstrogen receptorHomo sapiens (human)
plasma membraneEstrogen receptorHomo sapiens (human)
membraneEstrogen receptorHomo sapiens (human)
chromatinEstrogen receptorHomo sapiens (human)
euchromatinEstrogen receptorHomo sapiens (human)
protein-containing complexEstrogen receptorHomo sapiens (human)
nucleusEstrogen receptorHomo sapiens (human)
nucleusEstrogen receptor betaHomo sapiens (human)
nucleoplasmEstrogen receptor betaHomo sapiens (human)
mitochondrionEstrogen receptor betaHomo sapiens (human)
intracellular membrane-bounded organelleEstrogen receptor betaHomo sapiens (human)
chromatinEstrogen receptor betaHomo sapiens (human)
nucleusEstrogen receptor betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (48)

Assay IDTitleYearJournalArticle
AID465642Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 after 24 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467653Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as decrease in LDH release treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467633Proliferative activity against human Hep3B cells assessed as cell viability after 4 days by cell counting method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467644Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID381256Cytotoxicity against human 9KB cells assessed as cell survival at 100 ug/ml relative to control
AID1467645Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465641Antibacterial activity against Bacillus spizizenii ATCC 6633 after 24 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467632Proliferative activity against human Hep3B cells assessed as cell viability at 100 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467651Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465648Antibacterial activity against Bacillus spizizenii ATCC 6633 after 48 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467647Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465652Antifungal activity against Aspergillus niger ATCC 16404 after 5 days by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1286193Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives.
AID1286194Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives.
AID1467637Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467641Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465643Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID465639Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467649Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467650Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465646Antibacterial activity against Staphylococcus aureus ATCC 6538 after 48 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467634Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465638Antioxidant activity assessed as DPPH radical scavenging activity after 10 mins2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467635Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467638Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467631Proliferative activity against human Hep3B cells assessed as cell viability at 10 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467629Proliferative activity against human Hep3B cells assessed as cell viability at 0.1 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465640Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 24 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID465650Antibacterial activity against Escherichia coli ATCC 8739 after 48 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID241876Binding affinity for human Estrogen receptor Alpha; NC= Nonconvergence with an IC50>1 mM2005Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases.
AID241850Binding affinity for human Estrogen receptor beta; NC= Nonconvergence with an IC50>1 mM2005Journal of medicinal chemistry, May-19, Volume: 48, Issue:10
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases.
AID1467655Cytotoxicity against human Hep3B cells assessed as effect on cell morphology at 0.1 to 100 uM measured every day during 4 days incubation period by microscopic method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465647Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 48 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467646Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467643Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as increase in cell survival treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467642Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465649Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 after 48 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID381257Cytotoxicity against human 9KB cells assessed as cell survival at 10 ug/ml relative to control
AID1467630Proliferative activity against human Hep3B cells assessed as cell viability at 1 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465651Antifungal activity against Candida albicans ATCC 10231 after 5 days by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467636Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467652Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID465644Antifungal activity against Candida albicans ATCC 10231 after 24 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID465645Antifungal activity against Aspergillus niger ATCC 16404 after 24 hrs by broth microdilution method2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Saponins and polyphenols from Fadogia ancylantha (makoni tea).
AID1467640Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467639Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as increase in cell survival treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467648Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as decrease in LDH release treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467654Cytotoxicity against human Hep3B cells assessed as effect on cell attachment at 0.1 to 100 uM measured every day during 4 days incubation period by microscopic method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's7 (77.78)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]