Substance | Relationship Strength | Studies | Trials | Classes | Roles |
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions. | 3.15 | 1 | 0 | alkaloid; colchicine | anti-inflammatory agent; gout suppressant; mutagen |
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA. | 3.15 | 1 | 0 | furonaphthodioxole; lignan; organic heterotetracyclic compound | antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator |
thiocholchicine thiocholchicine: RN refers to (S)-isomer | 3.15 | 1 | 0 | | |
helenalin helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure. helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. | 3.82 | 3 | 0 | cyclic ketone; gamma-lactone; organic heterotricyclic compound; secondary alcohol; sesquiterpene lactone | anti-inflammatory agent; antineoplastic agent; metabolite; plant metabolite |
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. | 3.15 | 1 | 0 | azide; pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor |
etoposide [no description available] | 3.15 | 1 | 0 | beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound | antineoplastic agent; DNA synthesis inhibitor |
betulinic acid [no description available] | 3.15 | 1 | 0 | hydroxy monocarboxylic acid; pentacyclic triterpenoid | anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite |
suksdorfin suksdorfin: from the fruit of Lomatium sukdorfi; structure given in first source | 3.15 | 1 | 0 | | |
heraclenol heraclenol: isolated from the herb Huanghuaren | 3.15 | 1 | 0 | | |
dehydroleucodine dehydroleucodine: has antimicrobial activity; RN given refers to (3aS-(3aalpha,9aalpha,9bbeta))-isomer | 2.43 | 2 | 0 | | |
Mexicanin I [no description available] | 2.43 | 2 | 0 | sesquiterpene lactone | |
parthenolide [no description available] | 2.03 | 1 | 0 | germacranolide | |
npf-etoposide NPF-etoposide: RN given refers to (5R-(5alpha,5abeta,8aalpha,9beta))-isomer; structure in first source | 3.15 | 1 | 0 | | |
gl 331 GL 331: structure in first source | 3.15 | 1 | 0 | | |
arnicolide d arnicolide D: cytotoxic; from Centipeda minima L.; structure in first source | 2.43 | 2 | 0 | sesquiterpene lactone | |
santamarine santamarine: sesquiterpene derivative of costunolide. santamarin : A sesquiterpene lactone of the eudesmanolide group. | 2.43 | 2 | 0 | sesquiterpene lactone | |
11alpha,13-dihydrohelenalin [no description available] | 3.82 | 3 | 0 | sesquiterpene lactone | |
bevirimat bevirimat: an HIV inhibitor; disrupts late step in processing HIV Major Core Protein p24, preventing the capsid precursor p25 from being converted to mature capsid p24. bevirimat : A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems. | 3.15 | 1 | 0 | dicarboxylic acid monoester; monocarboxylic acid; pentacyclic triterpenoid | HIV-1 maturation inhibitor; metabolite |
ic9564 IC9564: betulinic acid derivative; structure in first source | 3.15 | 1 | 0 | | |
moronic acid moronic acid: from root bark extract of Ozoroa mucronata; RN & N1 from 9th CI. moronic acid : A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group. | 3.15 | 1 | 0 | pentacyclic triterpenoid | anti-HIV agent; anti-HSV-1 agent; metabolite |
sesquiterpenes [no description available] | 2.36 | 2 | 0 | | |
costunolide [no description available] | 2.03 | 1 | 0 | germacranolide; heterobicyclic compound | anthelminthic drug; antiinfective agent; antineoplastic agent; antiparasitic agent; antiviral drug; metabolite |
furanoheliangolide furanoheliangolide: structure in first source | 2.43 | 2 | 0 | | |
daurichromenic acid daurichromenic acid: structure in first source | 3.15 | 1 | 0 | | |
desmosdumotin c desmosdumotin C: an antitumor agent; structure in first source | 3.15 | 1 | 0 | olefinic compound | |
tirotundin tirotundin: structure in first source | 2.03 | 1 | 0 | | |
cumambrin b cumambrin B: RN given for (3aR-(3aalpha,4alpha,6alpha,6aalpha,9aalpha,9bbeta))-isomer; isolated from Chrysanthemum boreale; structure in first source | 2.43 | 2 | 0 | | |
chamissonolide chamissonolide: structure given in first source | 2.03 | 1 | 0 | | |
gomisin-g [no description available] | 3.15 | 1 | 0 | | |
achalensolide achalensolide: structure in first source | 2.43 | 2 | 0 | | |
centratherin centratherin: from Eremanthus eriopus (Asteraceae); structure in first source | 2.03 | 1 | 0 | | |