altersolanol a profile

altersolanol A: isolated from fermentation product of fungus Alternaria porri(Ellis) Ciferri;RN given refers to (1R-(1alpha,2beta,3beta,4alpha))-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	89644
CHEMBL ID	512054
CHEBI ID	2615
SCHEMBL ID	2793105
MeSH ID	M0163869

Synonym
22268-16-2
altersolanol a
chebi:2615 ,
CHEMBL512054
AC1L3IB0 ,
(1s,2r,3s,4r)-1,2,3,4,8-pentahydroxy-6-methoxy-3-methyl-2,4-dihydro-1h-anthracene-9,10-dione
(1s,2r,3s,4r)-6-methoxy-3-methyl-1,2,3,4,8-pentakis(oxidanyl)-2,4-dihydro-1h-anthracene-9,10-dione
A831436
as-a 2
9,10-anthracenedione, 1,2,3,4-tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-, (1r-(1alpha,2beta,3beta,4alpha))-
unii-zs3lu23be3
nsc 173943
zs3lu23be3 ,
AC1Q6I5J ,
SCHEMBL2793105
HB3756
bdbm50480485
J-014615
DTXSID10891800
Q27105737
(1r-(1alpha,2beta,3beta,4alpha))-1,2,3,4-tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
(1r,2s,3r,4s)-1,2,3,4-tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
9,10-anthracenedione, 1,2,3,4-tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-, (1r,2s,3r,4s)-
rel-(1r,2s,3r,4s)-1,2,3,4-tetrahydro-1,2,3,4,5- pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
DTXSID701043575
116948-40-4

Class	Description
pentahydroxyanthraquinone	An anthraquinone in which the anthraquinone moiety is substituted by a five hydroxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)	IC50 (µMol)	0.8000	0.0001	1.9731	8.0000	AID1142307
Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)	IC50 (µMol)	0.8000	0.0001	1.8088	8.0000	AID1142307
Transcription factor p65	Homo sapiens (human)	IC50 (µMol)	0.8000	0.0001	1.8981	8.8000	AID1142307
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to lipopolysaccharide	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
apoptotic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
inflammatory response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
JNK cascade	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of gene expression	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of macrophage derived foam cell differentiation	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of lipid storage	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of calcidiol 1-monooxygenase activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of vitamin D biosynthetic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of cholesterol transport	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of interleukin-12 production	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
response to muscle stretch	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of apoptotic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of inflammatory response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
B cell receptor signaling pathway	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of protein metabolic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
mammary gland involution	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription initiation by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to mechanical stimulus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to nicotine	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-1	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-6	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to tumor necrosis factor	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to dsRNA	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-17	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to virus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
antibacterial innate immune response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of hyaluronan biosynthetic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to angiotensin	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of miRNA metabolic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to stress	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
innate immune response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
response to cytokine	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
follicular dendritic cell differentiation	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
germinal center formation	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
regulation of DNA-templated transcription	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
extracellular matrix organization	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
response to lipopolysaccharide	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
rhythmic process	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
spleen development	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cellular response to stress	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
innate immune response	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
response to cytokine	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
inflammatory response	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-6 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-8 production	Transcription factor p65	Homo sapiens (human)
positive regulation of amyloid-beta formation	Transcription factor p65	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Transcription factor p65	Homo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
liver development	Transcription factor p65	Homo sapiens (human)
hair follicle development	Transcription factor p65	Homo sapiens (human)
defense response to tumor cell	Transcription factor p65	Homo sapiens (human)
response to ischemia	Transcription factor p65	Homo sapiens (human)
acetaldehyde metabolic process	Transcription factor p65	Homo sapiens (human)
chromatin organization	Transcription factor p65	Homo sapiens (human)
DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
inflammatory response	Transcription factor p65	Homo sapiens (human)
cellular defense response	Transcription factor p65	Homo sapiens (human)
neuropeptide signaling pathway	Transcription factor p65	Homo sapiens (human)
canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
positive regulation of cell population proliferation	Transcription factor p65	Homo sapiens (human)
response to xenobiotic stimulus	Transcription factor p65	Homo sapiens (human)
animal organ morphogenesis	Transcription factor p65	Homo sapiens (human)
response to UV-B	Transcription factor p65	Homo sapiens (human)
positive regulation of vascular endothelial growth factor production	Transcription factor p65	Homo sapiens (human)
positive regulation of gene expression	Transcription factor p65	Homo sapiens (human)
positive regulation of Schwann cell differentiation	Transcription factor p65	Homo sapiens (human)
negative regulation of angiogenesis	Transcription factor p65	Homo sapiens (human)
cytokine-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
protein catabolic process	Transcription factor p65	Homo sapiens (human)
response to muramyl dipeptide	Transcription factor p65	Homo sapiens (human)
response to progesterone	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-12 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-6 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-8 production	Transcription factor p65	Homo sapiens (human)
response to insulin	Transcription factor p65	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of protein sumoylation	Transcription factor p65	Homo sapiens (human)
response to cobalamin	Transcription factor p65	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Transcription factor p65	Homo sapiens (human)
intracellular signal transduction	Transcription factor p65	Homo sapiens (human)
cellular response to hepatocyte growth factor stimulus	Transcription factor p65	Homo sapiens (human)
response to muscle stretch	Transcription factor p65	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Transcription factor p65	Homo sapiens (human)
prolactin signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of protein catabolic process	Transcription factor p65	Homo sapiens (human)
negative regulation of apoptotic process	Transcription factor p65	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
response to amino acid	Transcription factor p65	Homo sapiens (human)
negative regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Transcription factor p65	Homo sapiens (human)
regulation of inflammatory response	Transcription factor p65	Homo sapiens (human)
positive regulation of T cell receptor signaling pathway	Transcription factor p65	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Transcription factor p65	Homo sapiens (human)
response to cAMP	Transcription factor p65	Homo sapiens (human)
defense response to virus	Transcription factor p65	Homo sapiens (human)
cellular response to hydrogen peroxide	Transcription factor p65	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
response to interleukin-1	Transcription factor p65	Homo sapiens (human)
cellular response to lipopolysaccharide	Transcription factor p65	Homo sapiens (human)
cellular response to lipoteichoic acid	Transcription factor p65	Homo sapiens (human)
cellular response to peptidoglycan	Transcription factor p65	Homo sapiens (human)
cellular response to nicotine	Transcription factor p65	Homo sapiens (human)
cellular response to interleukin-1	Transcription factor p65	Homo sapiens (human)
cellular response to interleukin-6	Transcription factor p65	Homo sapiens (human)
cellular response to tumor necrosis factor	Transcription factor p65	Homo sapiens (human)
postsynapse to nucleus signaling pathway	Transcription factor p65	Homo sapiens (human)
antiviral innate immune response	Transcription factor p65	Homo sapiens (human)
negative regulation of non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
negative regulation of miRNA transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of miRNA transcription	Transcription factor p65	Homo sapiens (human)
cellular response to angiotensin	Transcription factor p65	Homo sapiens (human)
positive regulation of leukocyte adhesion to vascular endothelial cell	Transcription factor p65	Homo sapiens (human)
positive regulation of miRNA metabolic process	Transcription factor p65	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway	Transcription factor p65	Homo sapiens (human)
cellular response to stress	Transcription factor p65	Homo sapiens (human)
response to cytokine	Transcription factor p65	Homo sapiens (human)
innate immune response	Transcription factor p65	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
transcription cis-regulatory region binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
chromatin binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription coregulator activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
protein binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
identical protein binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
actinin binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
protein binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
transcription cis-regulatory region binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II core promoter sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
transcription coactivator binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
DNA binding	Transcription factor p65	Homo sapiens (human)
chromatin binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor activity	Transcription factor p65	Homo sapiens (human)
protein binding	Transcription factor p65	Homo sapiens (human)
enzyme binding	Transcription factor p65	Homo sapiens (human)
protein kinase binding	Transcription factor p65	Homo sapiens (human)
chromatin DNA binding	Transcription factor p65	Homo sapiens (human)
ubiquitin protein ligase binding	Transcription factor p65	Homo sapiens (human)
peptide binding	Transcription factor p65	Homo sapiens (human)
phosphate ion binding	Transcription factor p65	Homo sapiens (human)
identical protein binding	Transcription factor p65	Homo sapiens (human)
protein homodimerization activity	Transcription factor p65	Homo sapiens (human)
actinin binding	Transcription factor p65	Homo sapiens (human)
histone deacetylase binding	Transcription factor p65	Homo sapiens (human)
NF-kappaB binding	Transcription factor p65	Homo sapiens (human)
ankyrin repeat binding	Transcription factor p65	Homo sapiens (human)
general transcription initiation factor binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor binding	Transcription factor p65	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
mitochondrion	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytosol	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
secretory granule lumen	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
specific granule lumen	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
chromatin	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription regulator complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
I-kappaB/NF-kappaB complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
NF-kappaB p50/p65 complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytosol	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
chromatin	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
Bcl3/NF-kappaB2 complex	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleolus	Transcription factor p65	Homo sapiens (human)
nucleus	Transcription factor p65	Homo sapiens (human)
glutamatergic synapse	Transcription factor p65	Homo sapiens (human)
nucleus	Transcription factor p65	Homo sapiens (human)
nucleoplasm	Transcription factor p65	Homo sapiens (human)
cytoplasm	Transcription factor p65	Homo sapiens (human)
cytosol	Transcription factor p65	Homo sapiens (human)
NF-kappaB p50/p65 complex	Transcription factor p65	Homo sapiens (human)
NF-kappaB complex	Transcription factor p65	Homo sapiens (human)
chromatin	Transcription factor p65	Homo sapiens (human)
transcription regulator complex	Transcription factor p65	Homo sapiens (human)
cytoplasm	Transcription factor p65	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (65)

Assay ID	Title	Year	Journal	Article
AID753467	Antimigratory activity against human A549 cells treated at 25 uM after scratching measured at 6 hrs interval over 120 hrs by scratch-wound assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753480	Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase after 16 hrs by flow cytometry relative to untreated control	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423614	Inhibition of recombinant PLK1	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID753471	Inhibition of TNFalpha-induced NF-kappa-B transcriptional activity in human K562 cells pretreated with compound for 2 hrs measured 6 hrs post TNFalpha challenge by luciferase reporter gene assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753472	Induction of apoptosis in human K562 cells assessed as reduction in Bcl-xL expression after 16 to 72 hrs by Western blot analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423600	Inhibition of recombinant CDK4/CycD1	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID1666597	Induction of DNA damage in human SU8686 cells assessed as increase in gammaH2AX phosphorylation at ser193 at cytotoxic IC50 in presence of 0.3 uM doxorubicin by fluorometry method	2020	Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4	Targeting the DNA damage response (DDR) by natural compounds.
AID423610	Inhibition of recombinant FLT3	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423602	Inhibition of recombinant EGFR	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID1188354	Antimicrobial activity against Staphylococcus aureus ATCC 6538 by broth dilution assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID753478	Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase at 4 uM after 72 hrs by flow cytometry relative to untreated control	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423615	Inhibition of recombinant CK2alpha1	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID753473	Induction of apoptosis in human K562 cells assessed as reduction in XIAP expression after 16 to 72 hrs by Western blot analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753476	Induction of apoptosis in human K562 cells assessed as cleavage of caspase-3 after 16 to 24 hrs by Western blot analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423601	Inhibition of recombinant COT	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423618	Cytotoxicity against mouse L5178Y cells at 10 ug/mL by MTT assay	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID1666596	Induction of DNA damage in human SU8686 cells assessed as increase in gammaH2AX phosphorylation at ser193 at cytotoxic IC50 in presence of 5 uM cisplatin by fluorometry method	2020	Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4	Targeting the DNA damage response (DDR) by natural compounds.
AID1188351	Antimicrobial activity against Escherichia coli ATCC 25922 by broth dilution assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID423613	Inhibition of recombinant PDGFRbeta	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID1072979	Antimicrobial activity against Staphylococcus aureus	2014	Journal of natural products, Mar-28, Volume: 77, Issue:3	Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening.
AID423609	Inhibition of recombinant VEGFR3	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID335502	Antimicrobial activity against Fusarium verticillioides NRRL 25457 at 250 ug/disk by standard agar diffusion assay	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium.
AID1188355	Antimicrobial activity against Kocuria rhizophila ATCC 9341 by broth dilution assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID753474	Induction of apoptosis in human K562 cells assessed as cleavage of caspase-9 after 16 to 24 hrs by Western blot analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423594	Inhibition of recombinant AKT1	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID753469	Antiproliferative activity against human K562 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753485	Cytotoxicity against human PBMCs after 24 hrs by trypan blue exclusion test	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID1188348	Cytotoxic activity against human A549 cells by MTT assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID753486	Effect on metabolism of human PBMCs after 24 hrs by CellTiter-Glo luminescent cell viability assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753484	Cytotoxicity against human A549 cells after 24 hrs by XTT assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753468	Antiproliferative activity against human A549 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753481	Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase after 24 hrs by flow cytometry relative to untreated control	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID1142307	Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay	2014	Bioorganic & medicinal chemistry, Jun-01, Volume: 22, Issue:11	Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.
AID423603	Inhibition of recombinant EPHB4	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID753482	Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase after 16 to 72 hrs by flow cytometry	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID753488	Cytotoxicity against human K562 cells after 24 hrs by trypan blue exclusion test	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423606	Inhibition of recombinant IGF1R	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423619	Inhibition of recombinant TIE2	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID335505	Antimicrobial activity against Bacillus subtilis ATCC 6051 at 200 ug/disk by standard agar diffusion assay	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium.
AID1188350	Antimicrobial activity against Micrococcus tetragenus ATCC 13623 by broth dilution assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID423604	Inhibition of recombinant ERBB2	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423598	Inhibition of recombinant B-RAF-V600E mutant	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID753489	Cytotoxicity against human K562 cells at 0.5 to 100 uM after 8 to 72 hrs by trypan blue exclusion test	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423599	Inhibition of recombinant CDK2/CycA	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID1188347	Cytotoxic activity against mouse B16F10 cells by MTT assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID423616	Inhibition of recombinant SAK	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID1072978	Antimicrobial activity against Pseudomonas aeruginosa	2014	Journal of natural products, Mar-28, Volume: 77, Issue:3	Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening.
AID753483	Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase at 0.2 to 10 uM by flow cytometry	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID1188356	Antimicrobial activity against Bacillus subtilis ATCC 6633 by broth dilution assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1188352	Antimicrobial activity against Staphylococcus albus ATCC 8799 by broth dilution assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID423611	Inhibition of recombinant INSR	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID753479	Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase at 4 uM after 48 hrs by flow cytometry relative to untreated control	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423612	Inhibition of recombinant MET	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423607	Inhibition of recombinant SRC	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423608	Inhibition of recombinant VEGFR2	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID1188353	Antimicrobial activity against Bacillus cereus ATCC 14579 by broth dilution assay	2014	Journal of natural products, Sep-26, Volume: 77, Issue:9	Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID753487	Cytotoxicity against human K562 cells after 48 hrs by trypan blue exclusion test	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID423605	Inhibition of recombinant FAK	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID335503	Antimicrobial activity against Staphylococcus aureus ATCC 29213 at 200 ug/disk by standard agar diffusion assay	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium.
AID753475	Induction of apoptosis in human K562 cells assessed as reduction in Mcl-1 expression after 16 to 72 hrs by Western blot analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
AID335504	Antimicrobial activity against Aspergillus flavus NRRL 6541 at 250 ug/disk by standard agar diffusion assay	2002	Journal of natural products, Jun, Volume: 65, Issue:6	Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium.
AID423595	Inhibition of recombinant ARK5	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423597	Inhibition of recombinant Aurora B	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID423596	Inhibition of recombinant Aurora A	2009	Journal of natural products, Apr, Volume: 72, Issue:4	Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
AID753477	Induction of apoptosis in human K562 cells after 16 to 72 hrs using annexin V-propidium iodide staining by FACS analysis	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (7.14)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (14.29)	29.6817
2010's	9 (64.29)	24.3611
2020's	2 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.1	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	2.05	1	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
kojic acid [no description available]	2.25	1	4-pyranones; enol; primary alcohol	Aspergillus metabolite; EC 1.10.3.1 (catechol oxidase) inhibitor; EC 1.10.3.2 (laccase) inhibitor; EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; EC 1.4.3.3 (D-amino-acid oxidase) inhibitor; NF-kappaB inhibitor; skin lightening agent
beta-lapachone beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.	2.1	1	benzochromenone; orthoquinones	anti-inflammatory agent; antineoplastic agent; plant metabolite
phloretin [no description available]	2.1	1	dihydrochalcones	antineoplastic agent; plant metabolite
sanguinarine benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.	2.1	1	alkaloid antibiotic; benzophenanthridine alkaloid; botanical anti-fungal agent
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.1	1	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
aloe emodin aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.	2.25	1	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite
caproamide [no description available]	2.25	1	primary carboxamide; primary fatty amide
viridicatin viridicatin: structure. viridicatin : A hydroxyquinolone that is 3-hydroxyuinolin-2(1H)-one which is substituted at position 4 by a phenyl groups. Isolated from the mycelium of several Penicillium species, it exhibits strong antibiotic activity against M. tuberculosis and also against B. subtilis, S. aureus and S. cerevisiae.	2.25	1	hydroxyquinoline	antibacterial agent; Aspergillus metabolite; marine metabolite; Penicillium metabolite
pinocembrin pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.	2.25	1	(2S)-flavan-4-one; dihydroxyflavanone	antineoplastic agent; antioxidant; metabolite; neuroprotective agent; vasodilator agent
avarol avarol: RN given refers to parent cpd; extract from Dysidea avara(sea sponge)	2.25	1
avarone avarone: antileukemic agent; isolated from Dysidea avara	2.25	1
skyrin skyrin: main pigment of toxin rice fungus Penicillium islandicum; RN given refers to parent cpd; structure	2.25	1	biaryl; trihydroxyanthraquinone
xanthorrhizol xanthorrhizol: structure in first source	2.25	1	sesquiterpenoid
aeroplysinin i aeroplysinin I: isolated from sponge Aplysina sp.; RN refers to (1S-trans)-isomer; structure given in second source	2.25	1	tertiary alcohol
matairesinol matairesinol: lignan that is a central precursor in plants in the biosynthesis of numerous lignans (coordinate with specific); RN refers to (3R-trans)-isomer. (-)-matairesinol : A lignan that is gamma-butyrolactone in which the 3 and 4 positions are substituted by 4-hydroxy-3-methoxybenzyl groups (the 3R,4R-diastereomer).	2.25	1	gamma-lactone; lignan; polyphenol	angiogenesis inhibitor; anti-asthmatic agent; phytoestrogen; plant metabolite
macrosporin macrosporin: isolated from fermentation product of fungus Alternaria porri (Ellis) Ciferri; structure given in first source	8.29	6
dactylarin dactylarin: isolated from Dactylaria lutea (Deuteromycetes); structure	2.5	2
dactylariol dactylariol: structure	2.5	2
isoliquiritigenin [no description available]	2.1	1	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
beauvericin [no description available]	2.25	1	cyclodepsipeptide	antibiotic insecticide; antifungal agent; antineoplastic agent; apoptosis inhibitor; fungal metabolite; ionophore; mycotoxin; P450 inhibitor
3-deoxyisoochracinic acid 3-deoxyisoochracinic acid: structure in first source	2.01	1
8-hydroxymanzamine a 8-hydroxymanzamine A: active against HIV-II; isolated from the sponge Pachypellina; structure in first source. 8-hydroxymanzamine A : An alkaloid that is manzamine A with a hydroxy substituent at position 8. Isolated from Pachypellina and Acanthostrongylophora, it exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).	2.25	1	alkaloid; beta-carbolines; isoquinolines	anti-HSV-2 agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; metabolite
butein [no description available]	2.1	1	chalcones; polyphenol	antineoplastic agent; antioxidant; EC 1.1.1.21 (aldehyde reductase) inhibitor; geroprotector; hypoglycemic agent; plant metabolite; radiosensitizing agent; tyrosine kinase inhibitor
4-hydroxychalcone 4-hydroxychalcone: structure in first source. 4-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4.	2.1	1	chalcones; phenols	antihypertensive agent; plant metabolite
neobavaisoflavone neobavaisoflavone: isolated from Psoralea corylifolia; structure in first source. neobavaisoflavone : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with an additonal hydroxy group at position 4' and a prenyl group at position 3'. Isolated from seeds of Psoralea corylifolia, it exhibits inhibitory activity against DNA polymerase and platelet aggregation.	2.25	1	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; plant metabolite; platelet aggregation inhibitor
alternariol monomethyl ether djalonensone : A benzochromenone that is alternariol in which the hydroxy group at position 9 has been converted into the corresponding methyl ether. A natural product found in Chaetomium globosum as well as being one of the two most important compounds belonging to the group of Altenaria mycotoxins.	2.25	1	aromatic ether; benzochromenone	antifungal agent; fungal metabolite; mycotoxin
luffariellolide luffariellolide: structure given in first source; a partially reversible phospholipase A2 inhibitor; a major metabolite of the sponge Luffariella; do not confuse with luffolide, a minor metabolite of the same species	2.25	1	diterpene lactone
bakuchiol bakuchiol: chief component of Psoralea corylifolia Linn; structure	2.25	1
flavokawain C flavokawain C: antineoplastic from roots of Kava (Piper methysticum Forst); structure in first source	2.1	1	chalcones
3-o-methylbutein 3-O-methylbutein: RN given refers to (E)-isomer; structure given in first source	2.1	1	chalcones
goniothalamin goniothalamin: has antineoplastic activity; structure given in first source	2.1	1
bavachalcone bavachalcone: structure in first source	2.25	1	chalcones
aerothionin [no description available]	2.25	1	isoxazoles	metabolite
roquefortine [no description available]	2.25	1	pyrroloindole
kahalalide f kahalalide F: a cyclodepsipeptide toxin; isolated from a mollusk, Elysia rubefescens; exhibits antitumoral activity against cell lines of colon cancer and prostatic cancer; structure given in first source	2.05	1
4-hydroxycoumarin 2-hydroxychromone: structure	2.1	1	hydroxycoumarin

Condition	Relationship Strength	Studies
Cancer of Lung [description not available]	2.08	1
Granulocytic Leukemia, Chronic [description not available]	2.08	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.08	1
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.	2.08	1
Benign Neoplasms [description not available]	2.11	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.11	1

altersolanol a

Description

Cross-References

Synonyms (26)

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (107)

Molecular Functions (28)

Ceullar Components (16)

Bioassays (65)

Research

Studies (14)

Market Indicators

Research Demand Index: 12.43

Study Types

altersolanol a

Description

Cross-References

Synonyms (26)

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (107)

Molecular Functions (28)

Ceullar Components (16)

Bioassays (65)

Research

Studies (14)

Market Indicators

Research Demand Index: 12.43

Study Types

Related Drugs (38)

Related Conditions (6)