cumambrin B: RN given for (3aR-(3aalpha,4alpha,6alpha,6aalpha,9aalpha,9bbeta))-isomer; isolated from Chrysanthemum boreale; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Chrysanthemum | genus | A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.[MeSH] | Asteraceae | A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 9992975 |
| CHEMBL ID | 191331 |
| MeSH ID | M0300455 |
| Synonym |
|---|
| cumambrin b |
| CHEMBL191331 |
| (3ar,4s,6r,6ar,9ar,9br)-4,6-dihydroxy-6,9-dimethyl-3-methylidene-4,5,6a,7,9a,9b-hexahydro-3ah-azuleno[4,5-b]furan-2-one |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC100 (µMol) | 100.0000 | 10.0000 | 10.0000 | 10.0000 | AID242927 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC100 (µMol) | 100.0000 | 10.0000 | 10.0000 | 10.0000 | AID242927 |
| Transcription factor p65 | Homo sapiens (human) | IC100 (µMol) | 100.0000 | 5.0000 | 9.0000 | 10.0000 | AID242927; AID262798 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID243231 | Concentration required for complete inhibition of Nuclear factor kappa B DNA binding | 2004 | Journal of medicinal chemistry, Nov-18, Volume: 47, Issue:24 | Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. |
| AID262798 | Inhibition of NF-kappaB DNA binding by EMSA | 2006 | Journal of medicinal chemistry, Apr-06, Volume: 49, Issue:7 | Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. |
| AID1525095 | Cytotoxicity against mouse HT22 cells assessed as reduction in cell viability at 40 uM measured after 24 hrs by MTT assay | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5 | Eudesmane Glycosides from Ambrosia artemisiifolia (Common Ragweed) as Potential Neuroprotective Agents. |
| AID242927 | Concentration required for complete inhibition of Nuclear factor kappa B DNA binding | 2004 | Journal of medicinal chemistry, Nov-18, Volume: 47, Issue:24 | Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||