| Assay ID | Title | Year | Journal | Article |
|---|
| AID315695 | Antimicrobial activity against Enterobacter cloacae GC 1477 expressing AmpC beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID43916 | Inhibitory activity against serine beta-lactamase, PC1 (class A) derived from Staphylococcus aureus | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors. |
| AID113524 | In vivo inhibitory activity against Serratia marcescens in mice | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I. |
| AID50704 | Inhibition of Class C beta-lactamase from Enterobacter cloacae strain P99 | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. |
| AID315697 | Antimicrobial activity against Enterobacter cloacae GC 6991 expressing AmpC beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282064 | Antimicrobial activity against Escherichia coli GC 2920 expressing IRT2 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID315700 | Antimicrobial activity against Pseudomonas aeruginosa GC 1764 expressing AmpC beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID44069 | Inhibitory activity against AmpC (class C) beta-lactamase | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II. |
| AID91391 | Synergic activity against IMP-1 beta lactamase produced by Escherichia coli was determined in presence of Piperacillin | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID43575 | The concentration of compound to inhibit Beta-lactamase was measured on Escherichia coli WC3310 | 1995 | Journal of medicinal chemistry, Mar-17, Volume: 38, Issue:6
| Synthesis and biological activity of 7-alkylidenecephems. |
| AID315690 | Antimicrobial activity against Escherichia coli GC 2905 expressing P99 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID203143 | In vitro inhibitory activity against Serratia marcescens | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I. |
| AID200369 | Beta-Lactamase inhibitory activity against represent active class C (P99) serine enzyme | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID315696 | Antimicrobial activity against Enterobacter cloacae GC 4142 expressing AmpC beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID50710 | The compound was evaluated for inhibition against the GC1 extended spectrum Class C beta-lactamase | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. |
| AID200363 | Beta-Lactamase inhibitory activity against representative class A (TEM-1) serine enzyme from Escherichia coli ATCC 35218 in presence of Piperacillin | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID282066 | Antimicrobial activity against Escherichia coli GC 2805 expressing CcrA in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID200987 | Synergistic activity against SPM-1 beta lactamase produced by Escherichia coli in presence of Piperacillin | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID113523 | In vivo inhibitory activity against Escherichia coli in mice | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I. |
| AID315705 | Antibacterial efficacy against Escherichia coli LSU 80-8 infected ip dosed CD1 mouse model | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID50693 | Inhibition of class A TEM-1 beta-lactamase derived from Enterobacter cloacae | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. |
| AID205372 | In vivo inhibitory activity against Serratia marcescens in mice | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II. |
| AID315703 | Antimicrobial activity against Escherichia coli GC 2203 after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID44224 | Inhibitory activity against serine Beta-lactamase TEM derived from Staphylococcus aureus | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors. |
| AID68693 | In vitro inhibitory activity against Escherichia coli | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II. |
| AID217203 | Synergistic activity against VIM-1 beta lactamase produced by Escherichia coli in presence of Piperacillin; R = Resistant | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID21250 | The partition coefficient value of the compound | 1995 | Journal of medicinal chemistry, Mar-17, Volume: 38, Issue:6
| Synthesis and biological activity of 7-alkylidenecephems. |
| AID315693 | Antimicrobial activity against Escherichia coli GC 2805 expressing CcrA beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282059 | Inhibition of Escherichia coli TEM1 | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID107428 | Beta-Lactamase Inhibition of metallo-beta-lactamase representative class B (L1) enzyme | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID44068 | Inhibitory activity against AmpC (class C) beta-lactamase | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I. |
| AID315699 | Antimicrobial activity against Serratia marcescens GC 1781 expressing Sme1 and AmpC beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID44225 | The compound was evaluated for inhibition against Beta-lactamase TEM derived from Staphylococcus aureus | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. |
| AID282069 | Antimicrobial activity against Enterobacter cloacae GC 2071 expressing Imi1 and AmpC in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID315698 | Antimicrobial activity against Enterobacter cloacae GC 1475 expressing P99 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282070 | Antimicrobial activity against Enterobacter cloacae GC 1475 expressing P99 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID315682 | Inhibition of TEM1 beta-lactamase | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282065 | Antimicrobial activity against Escherichia coli GC 2804 expressing Imp in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID315683 | Inhibition of Imi1 beta lactamase | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID43914 | Inhibitory activity against serine Beta-lactamase derived from Staphylococcus aureus | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors. |
| AID25760 | The pseudo second order rate constant of inhibition (k3'') was measured by using Kitz and Wilson method | 1995 | Journal of medicinal chemistry, Mar-17, Volume: 38, Issue:6
| Synthesis and biological activity of 7-alkylidenecephems. |
| AID217326 | Synergistic activity against VIM-7 beta lactamase produced by Escherichia coli in presence of Piperacillin; R = Resistant | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID315685 | Antimicrobial activity against Escherichia coli GC 2844 after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID91385 | Synergic activity against IMP-1 beta lactamase produced by Escherichia coli was determined in presence of Piperacillin; R = Resistant | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID315689 | Antimicrobial activity against Escherichia coli GC 2894 expressing AmpC beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID315687 | Antimicrobial activity against Escherichia coli GC 2920 expressing IRT2 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID315684 | Inhibition of AmpC beta-lactamase | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282068 | Antimicrobial activity against Enterobacter cloacae GC 1477 expressing AmpC in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID50705 | The compound was evaluated for inhibition against Class C beta-lactamase derived from Enterobacter cloacae P99 | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. |
| AID282062 | Antimicrobial activity against Escherichia coli GC 2844 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID315704 | Antimicrobial activity against Staphylococcus aureus GC 2216 after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282067 | Antimicrobial activity against Escherichia coli GC 2252 expressing IRT2 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID43282 | The concentration of compound to inhibit Beta-lactamase was measured on Enterobacter cloacae P99 | 1995 | Journal of medicinal chemistry, Mar-17, Volume: 38, Issue:6
| Synthesis and biological activity of 7-alkylidenecephems. |
| AID70724 | In vitro inhibitory activity against Escherichia coli | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I. |
| AID43405 | The concentration of compound to inhibit Beta-lactamase was measured on Enterobacter cloacae SC 12368 | 1995 | Journal of medicinal chemistry, Mar-17, Volume: 38, Issue:6
| Synthesis and biological activity of 7-alkylidenecephems. |
| AID315688 | Antimicrobial activity against Escherichia coli GC 2883 expressing OXA10 and PSE2 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID207422 | Antibacterial activity was determined against the Staphylococcus aureus ATCC 29213 in presence of Piperacillin | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID107427 | Inhibition of class B (BCII) metallo-beta-lactamase representative enzyme | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID315702 | Antimicrobial activity against Serratia marcescens GC 4132 expressing AmpC beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID44071 | Inhibitory activity against TEM-1 (class A) beta-lactamase | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II. |
| AID200367 | Beta-Lactamase inhibitory activity against representative class A (TEM-1) serine enzyme | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID282063 | Antimicrobial activity against Escherichia coli GC 2847 expressing TEM1 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID43919 | The compound was evaluated for inhibition against Beta-lactamase derived from Staphylococcus aureus | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. |
| AID200982 | Synergistic activity against SPM-1 beta lactamase produced by Escherichia coli in presence of Piperacillin; R = Resistant | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID217320 | Synergistic activity against VIM-1 beta lactamase produced by Escherichia coli in presence of Piperacillin | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID282073 | Antimicrobial activity against Pseudomonas aeruginosa GC 1764 expressing AmpC in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID282076 | Antimicrobial activity against Staphylococcus aureus GC 2216 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID44070 | Inhibitory activity against TEM-1 (class A) beta-lactamase | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I. |
| AID200365 | Beta-Lactamase inhibitory activity against representative class C (AmpC) serine enzyme from Escherichia coli P99 in presence of Piperacillin | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID50699 | Inhibition of class A beta-lactamase derived from Staphylococcus aureus strain PC1 | 2000 | Bioorganic & medicinal chemistry letters, May-01, Volume: 10, Issue:9
| The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. |
| AID217330 | Synergistic activity against VIM-7 beta lactamase produced by Escherichia coli in presence of Piperacillin | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. |
| AID315686 | Antimicrobial activity against Escherichia coli GC 2847 expressing TEM1 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID68828 | In vivo inhibitory activity against Escherichia coli in mice | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II. |
| AID315694 | Antimicrobial activity against Escherichia coli GC 2253 expressing IRT2 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282072 | Antimicrobial activity against Serratia marcescens GC 1781 expressing Sme1 and AmpC in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID315701 | Antimicrobial activity against Stenotrophomonas maltophilia GC 1721 expressing L1 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282074 | Antimicrobial activity against Serratia marcescens GC 4142 expressing AmpC in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID282061 | Inhibition of Bacteroides fragilis CcrA | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID282071 | Antimicrobial activity against Klebsiella pneumoniae GC 2825 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID203144 | In vitro inhibitory activity against Serratia marcescens | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| 6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II. |
| AID315692 | Antimicrobial activity against Escherichia coli GC 2804 expressing imp beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID315691 | Antimicrobial activity against Escherichia coli GC 2906 expressing Imi1 beta-lactamase after 18 to 24 hrs by broth microdilution method | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. |
| AID282060 | Inhibition of Enterobacter cloacae AmpC | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID282075 | Antimicrobial activity against Escherichia coli GC 2203 in presence of 4 ug/mL piperacillin | 2004 | Journal of medicinal chemistry, Dec-16, Volume: 47, Issue:26
| Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |