Assay ID | Title | Year | Journal | Article |
AID711227 | Inhibition of HSP90 binding to HIF1alpha in human H1299 cells at 12.5 uM after 30 mins by immunoprecipitation and immunoblotting analysis | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID711225 | Antiangiogenic activity in transgenic zebrafish embryos at 50% epiboly after 5.3 hrs | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID711226 | Inhibition of HSP90 binding to HIF1alpha in human H1299 cells at 12.5 uM after 30 mins by immunoprecipitation and immunoblotting analysis in presence of ATP | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID1261571 | Inhibition of HIF-1alpha in human H1299 cells at 100 nM after 72 hrs subsequently incubated for 12 hrs under hypoxic conditions by Western blot assay relative to control | 2015 | European journal of medicinal chemistry, Nov-02, Volume: 104 | Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors. |
AID711222 | Toxicity in transgenic zebrafish embryos assessed as developmental deffect at 50 nM to 1.25 uM after 24 hrs | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID711218 | Toxicity in transgenic zebrafish embryos assessed as effect on growth at 50 nM to 1.25 uM after 74 hrs | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID711223 | Toxicity in transgenic zebrafish embryos assessed as developmental deffect at 10 uM after 24 hrs | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID711215 | Toxicity in transgenic zebrafish embryos assessed as effect on viability at 50 nM to 1.25 uM after 74 hrs | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID1387506 | Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assay | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20
| Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy. |
AID1543584 | Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth at 10 uM after 72 hrs by MTT assay relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. |
AID708845 | Cytotoxicity against human H1299 cells after 3 days by MTS assay | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID1387519 | Suppression of hypoxia-mediated retinal neovascularization in mouse model of oxygen-induced retinopathy assessed as reduction in retinal neovascular tufts at 1 uM dosed via intravitreal route | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20
| Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy. |
AID1543583 | Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth at 1 uM after 72 hrs by MTT assay relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. |
AID1543586 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. |
AID1255084 | Inhibition of STAT3 phosphorylation in human MCF10A cells transformed with H-ras at 10 uM after 24 hrs by Western blot analysis | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action. |
AID1543588 | Inhibition of FITC-geldanamycin binding to recombinant human full-length C-terminal His-tagged HSP90alpha N-terminal domain (1 to 732 residues) expressed in Escherichia coli after 1 hr by fluorescence polarization assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. |
AID708843 | Inhibition of HSP90 in human H1299 cells assessed as reduction of HIF1alpha level treated for 72 hrs followed by incubated for 12 hrs under hypoxia condition by Western blot analysis | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
AID1255082 | Inhibition of STAT3 transcriptional activity in human oncostatin M-stimulated HeLa cells at 10 uM after 24 hrs by luciferase reporter gene assay | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action. |
AID1604461 | Antiproliferative activity against human NCI-H1299 cells incubated for 2 days followed by medium replacement by MTT assay | 2020 | Journal of medicinal chemistry, 03-12, Volume: 63, Issue:5
| Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions. |
AID1322390 | Inhibition of HSP90 in human H1299 cells assessed as suppression of HIF-1alpha at 100 nM preincubated for 72 hrs followed by incubation under hypoxic condition for 12 hrs by Western blot method relative to control | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors. |
AID1543587 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. |
AID1543585 | Antiproliferative activity against human NCI-H1299 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. |
AID1543582 | Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth at 0.1 uM after 72 hrs by MTT assay relative to control | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. |
AID1387518 | Suppression of hypoxia-mediated retinal neovascularization in mouse model of oxygen-induced retinopathy assessed as reduction in retinal neovascular tufts at 100 nM dosed via intravitreal route | 2018 | Journal of medicinal chemistry, 10-25, Volume: 61, Issue:20
| Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy. |
AID711217 | Antiangiogenic activity in transgenic zebrafish assessed as depletion of subintestinal veins after 72 hrs | 2012 | Journal of medicinal chemistry, Dec-27, Volume: 55, Issue:24
| Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |