| Assay ID | Title | Year | Journal | Article |
|---|
| AID389982 | Mean terminal half life in Beagle dog at 0.8 mg/kg, iv after 24 hrs | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389975 | Antagonist activity against human androgen receptor expressed in human MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced effect by luciferase receptor gene assay | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389980 | Plasma clearance in Beagle dog at 0.8 mg/kg, iv after 24 hrs | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID1885021 | Binding affinity to human Androgen receptor | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Therapeutic Strategies to Target the Androgen Receptor. |
| AID389985 | Phototoxicity in mouse 3T3 cells by neutral red uptake phototoxicity | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389978 | Metabolic stability assessed as half life in rat liver microsomes at 5 uM | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389979 | Metabolic stability assessed as intrinsic clearance per mg of protein in rat liver microsomes at 5 uM | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389984 | Reduction of sebum ester production in golden syrian hamster ear topically dosed twice daily 5 days per week for two weeks | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389974 | Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389976 | Inhibition of progesterone receptor | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID1885097 | In vivo antagonist activity at Androgen receptor assessed as reduction in wax ester in golden hamster ear model | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Therapeutic Strategies to Target the Androgen Receptor. |
| AID389981 | Apparent volume of distribution in Beagle dog at 0.8 mg/kg, iv after 24 hrs | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID1885096 | Antagonist activity at Androgen receptor in human MDA-kb2 cells | 2022 | Journal of medicinal chemistry, 07-14, Volume: 65, Issue:13
| Therapeutic Strategies to Target the Androgen Receptor. |
| AID389977 | Reduction of sebum ester production in golden syrian hamster ear topically dosed at 3% twice daily 5 days per week for two weeks | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID389983 | Activation of hair growth in C3H/HeN mouse hair growth model topically dosed twice daily 5 days per week for 4 weeks | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346888 | Human Androgen receptor (3C. 3-Ketosteroid receptors) | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| AID1798552 | Androgen Receptor Binding Assay from Article 10.1021/jm8009316: \\Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for de | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |