n-butyl gallate profile

n-Butyl gallate (nBG) is an organic compound that is an ester of gallic acid and n-butanol. It is a white, crystalline solid that is soluble in organic solvents but insoluble in water. It is a common food additive used as an antioxidant to prevent oxidation of fats and oils. nBG is produced by the esterification of gallic acid with n-butanol. It has been shown to have several biological activities, including antioxidant, anti-inflammatory, and anticancer properties. nBG is also used in cosmetics as a preservative and in pharmaceuticals as an antioxidant. Studies on nBG have focused on its potential applications in food, cosmetics, and pharmaceuticals. It is being investigated for its use as a natural antioxidant alternative to synthetic antioxidants, and for its potential therapeutic effects. It is also being studied for its potential use in preventing oxidative stress and inflammation.'

ID Source	ID
PubMed CID	14128
CHEMBL ID	494005
SCHEMBL ID	35913
MeSH ID	M0064039

Synonym
HMS1577L19
benzoic acid, 3,4,5-trihydroxy-, butyl ester
butyl 3,4,5-trihydroxybenzoate
n-butyl gallate
butyl gallate
1083-41-6
gallic acid, butyl ester
nsc33956
benzoic acid,4,5-trihydroxy-, butyl ester
nsc-33956
progallin butyl
butylester kyseliny gallove [czech]
brn 3032709
nsc 33956
einecs 214-107-7
CBDIVE_013159
bdbm50280382
gallic acid butyl ester
G0186
CHEMBL494005
A801860
butyl 3,4,5-tris(oxidanyl)benzoate
3,4,5-trihydroxybenzoic acid butyl ester
unii-67hz41u710
67hz41u710 ,
butylester kyseliny gallove
4-10-00-02004 (beilstein handbook reference)
FT-0626597
AKOS015914064
SCHEMBL35913
gallic acid n-butyl ester
DTXSID40148490
mfcd00016432
CCG-305745
Q27264133
D90725
gallicacidn-butylester

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Estrogen receptor	Homo sapiens (human)	IC50 (µMol)	8.9700	0.0000	0.7237	32.7000	AID1505260
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
positive regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
antral ovarian follicle growth	Estrogen receptor	Homo sapiens (human)
epithelial cell development	Estrogen receptor	Homo sapiens (human)
chromatin remodeling	Estrogen receptor	Homo sapiens (human)
regulation of DNA-templated transcription	Estrogen receptor	Homo sapiens (human)
signal transduction	Estrogen receptor	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Estrogen receptor	Homo sapiens (human)
androgen metabolic process	Estrogen receptor	Homo sapiens (human)
male gonad development	Estrogen receptor	Homo sapiens (human)
negative regulation of gene expression	Estrogen receptor	Homo sapiens (human)
positive regulation of phospholipase C activity	Estrogen receptor	Homo sapiens (human)
intracellular steroid hormone receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
intracellular estrogen receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
response to estradiol	Estrogen receptor	Homo sapiens (human)
regulation of toll-like receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
negative regulation of smooth muscle cell apoptotic process	Estrogen receptor	Homo sapiens (human)
negative regulation of canonical NF-kappaB signal transduction	Estrogen receptor	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Estrogen receptor	Homo sapiens (human)
response to estrogen	Estrogen receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Estrogen receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
fibroblast proliferation	Estrogen receptor	Homo sapiens (human)
positive regulation of fibroblast proliferation	Estrogen receptor	Homo sapiens (human)
stem cell differentiation	Estrogen receptor	Homo sapiens (human)
regulation of inflammatory response	Estrogen receptor	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Estrogen receptor	Homo sapiens (human)
RNA polymerase II preinitiation complex assembly	Estrogen receptor	Homo sapiens (human)
uterus development	Estrogen receptor	Homo sapiens (human)
vagina development	Estrogen receptor	Homo sapiens (human)
prostate epithelial cord elongation	Estrogen receptor	Homo sapiens (human)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	Estrogen receptor	Homo sapiens (human)
regulation of branching involved in prostate gland morphogenesis	Estrogen receptor	Homo sapiens (human)
mammary gland branching involved in pregnancy	Estrogen receptor	Homo sapiens (human)
mammary gland alveolus development	Estrogen receptor	Homo sapiens (human)
epithelial cell proliferation involved in mammary gland duct elongation	Estrogen receptor	Homo sapiens (human)
protein localization to chromatin	Estrogen receptor	Homo sapiens (human)
cellular response to estradiol stimulus	Estrogen receptor	Homo sapiens (human)
negative regulation of miRNA transcription	Estrogen receptor	Homo sapiens (human)
regulation of epithelial cell apoptotic process	Estrogen receptor	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
cellular response to estrogen stimulus	Estrogen receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Estrogen receptor	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Estrogen receptor	Homo sapiens (human)
TFIIB-class transcription factor binding	Estrogen receptor	Homo sapiens (human)
transcription coregulator binding	Estrogen receptor	Homo sapiens (human)
transcription corepressor binding	Estrogen receptor	Homo sapiens (human)
transcription coactivator binding	Estrogen receptor	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Estrogen receptor	Homo sapiens (human)
chromatin binding	Estrogen receptor	Homo sapiens (human)
DNA-binding transcription factor activity	Estrogen receptor	Homo sapiens (human)
nuclear receptor activity	Estrogen receptor	Homo sapiens (human)
steroid binding	Estrogen receptor	Homo sapiens (human)
protein binding	Estrogen receptor	Homo sapiens (human)
calmodulin binding	Estrogen receptor	Homo sapiens (human)
beta-catenin binding	Estrogen receptor	Homo sapiens (human)
zinc ion binding	Estrogen receptor	Homo sapiens (human)
TBP-class protein binding	Estrogen receptor	Homo sapiens (human)
enzyme binding	Estrogen receptor	Homo sapiens (human)
protein kinase binding	Estrogen receptor	Homo sapiens (human)
nitric-oxide synthase regulator activity	Estrogen receptor	Homo sapiens (human)
nuclear estrogen receptor activity	Estrogen receptor	Homo sapiens (human)
nuclear estrogen receptor binding	Estrogen receptor	Homo sapiens (human)
estrogen response element binding	Estrogen receptor	Homo sapiens (human)
identical protein binding	Estrogen receptor	Homo sapiens (human)
ATPase binding	Estrogen receptor	Homo sapiens (human)
14-3-3 protein binding	Estrogen receptor	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Estrogen receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Estrogen receptor	Homo sapiens (human)
nucleoplasm	Estrogen receptor	Homo sapiens (human)
transcription regulator complex	Estrogen receptor	Homo sapiens (human)
cytoplasm	Estrogen receptor	Homo sapiens (human)
Golgi apparatus	Estrogen receptor	Homo sapiens (human)
cytosol	Estrogen receptor	Homo sapiens (human)
plasma membrane	Estrogen receptor	Homo sapiens (human)
membrane	Estrogen receptor	Homo sapiens (human)
chromatin	Estrogen receptor	Homo sapiens (human)
euchromatin	Estrogen receptor	Homo sapiens (human)
protein-containing complex	Estrogen receptor	Homo sapiens (human)
nucleus	Estrogen receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (34)

Assay ID	Title	Year	Journal	Article
AID417968	Antimicrobial activity against Trichophyton rubrum after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID417967	Antimicrobial activity against Epidermophyton floccosum after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197648	Antiviral activity against feline herpesvirus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197623	Antiviral activity against HCV genotype 1b I389luc-ubi-neo/NS3-3'/5.1 replicons infected in human Huh5-2 HCV subgenomic replicon-containing cells assessed as reduction in virus replication after 3 days by luciferase reporter gene assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417962	Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID417963	Antimicrobial activity against Aspergillus fumigatus after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID417960	Antifungal activity against Candida tropicalis after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1505260	Displacement of Fluor.ES2 Green from human ERalpha by TR-FRET competitive binding assay	2018	ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1	Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution.
AID1505259	Xenoestrogen activity in human MCF7 cells assessed as stimulation of estrogen production at 0.125 to 128 ug/ml incubated for 24 hrs by ELISA	2018	ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1	Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution.
AID1505254	Antibacterial activity against Staphylococcus aureus 155554A incubated for 16 hrs by microdilution assay	2018	ACS medicinal chemistry letters, Jan-11, Volume: 9, Issue:1	Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution.
AID417965	Antimicrobial activity against Aspergillus niger after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197621	Antiviral activity against HIV2 ROD infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197649	Antiviral activity against chikungunya virus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197638	Antiviral activity against vesicular stomatitis virus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197642	Antiviral activity against reovirus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417964	Antimicrobial activity against Aspergillus flavus after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197647	Antiviral activity against feline coronavirus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197620	Antiviral activity against HIV1 3B infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197639	Antiviral activity against human coxsackievirus B4	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417961	Antifungal activity against Saccharomyces cerevisiae after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197640	Antiviral activity against RSV	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417966	Antimicrobial activity against Microsporum gypseum after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID417969	Antimicrobial activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197622	Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197646	Antiviral activity against punta toro virus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197637	Antiviral activity against vaccinia virus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197643	Antiviral activity against sindbis virus	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417959	Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique	2009	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6	Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197624	Cytotoxicity against human Huh5-2 cells after 72 hrs by MTS assay	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197645	Antiviral activity against influenza A virus (H1N1)	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197644	Antiviral activity against influenza A virus H3N2	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197641	Antiviral activity against human parainfluenza virus 3	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (10.00)	18.7374
1990's	1 (10.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	3.41	7	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
pyrogallol benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.	2.05	1	benzenetriol; phenolic donor	plant metabolite
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	1.95	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.05	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
propyl gallate Propyl Gallate: Antioxidant for foods, fats, oils, ethers, emulsions, waxes, and transformer oils.	2.71	3	trihydroxybenzoic acid
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.17	1	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.15	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
butylparaben [no description available]	2.17	1	organic molecular entity
methyl gallate methyl gallate: has both immunosuppressive and phytogenic antineoplastic activities; isolated from Acer saccharinum. methyl 3,4,5-trihydroxybenzoate : A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.	2.05	1	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite
3,4,5-trimethoxybenzoic acid 3,4,5-trimethoxybenzoic acid: RN given refers to parent cpd; structure. 3,4,5-trimethoxybenzoic acid : A benzoic acid derivative carrying 3-, 4- and 5-methoxy substituents.	2.05	1	benzoic acids; methoxybenzenes	human urinary metabolite; human xenobiotic metabolite; plant metabolite
ethyl-p-hydroxybenzoate ethyl-p-hydroxybenzoate: structure	2.17	1	ethyl ester; paraben	antifungal agent; antimicrobial food preservative; phytoestrogen; plant metabolite
ethyl gallate ethyl gallate: used with osmium in procedure for mapping neuronal pathways. ethyl gallate : A gallate ester obtained by the formal condensation of gallic acid with ethanol.	2.48	2	gallate ester	plant metabolite
lauryl gallate [no description available]	2.48	2	gallate ester
octyl gallate [no description available]	2.79	3	gallate ester	food antioxidant; hypoglycemic agent; plant metabolite
nonyl gallate [no description available]	2.05	1
tenofovir tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.	2.11	1	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor
pentyl gallate pentyl gallate: food and pharmaceutical antioxidant with ability of electron-donating; structure in first source	2.73	3
terbinafine [no description available]	2.05	1	acetylenic compound; allylamine antifungal drug; enyne; naphthalenes; tertiary amine	EC 1.14.13.132 (squalene monooxygenase) inhibitor; P450 inhibitor; sterol biosynthesis inhibitor
telaprevir [no description available]	2.11	1	cyclopentapyrrole; cyclopropanes; oligopeptide; pyrazines	antiviral drug; hepatitis C protease inhibitor; peptidomimetic
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.05	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
pradimicin a pradimicin A: from actinomycete strain No. P157-2; has inhibitory effect against HIV in vitro; structure given in first source. pradimicin A : A member of the class of pradimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557).	2.11	1	aromatic ether; carboxylic acid; disaccharide derivative; L-alanine derivative; p-quinones; polyphenol; pradimicin; secondary alcohol

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
HIV Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.	2.11	1

n-butyl gallate

Cross-References

Synonyms (37)

Protein Targets (1)

Inhibition Measurements

Biological Processes (42)

Molecular Functions (26)

Ceullar Components (11)

Bioassays (34)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.43

Study Types

n-butyl gallate

Cross-References

Synonyms (37)

Protein Targets (1)

Inhibition Measurements

Biological Processes (42)

Molecular Functions (26)

Ceullar Components (11)

Bioassays (34)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.43

Study Types

Related Drugs (21)

Related Conditions (3)