Compounds > 2,2'-methylenebis(ethyl-6-tert-butylphenol)
Page last updated: 2024-11-05

2,2'-methylenebis(ethyl-6-tert-butylphenol)

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2,2'-Methylenebis(ethyl-6-tert-butylphenol), also known as MBP, is a synthetic antioxidant commonly used in a variety of industrial applications. It is typically synthesized through the reaction of ethyl-6-tert-butylphenol with formaldehyde under acidic conditions. MBP exhibits strong antioxidant properties, effectively scavenging free radicals and inhibiting oxidation processes, making it crucial in preventing degradation of materials exposed to oxidative stress. It is commonly incorporated into polymers, plastics, rubber, and lubricants, to extend their shelf life and enhance their performance. The compound has been studied extensively for its potential health effects, particularly its role in endocrine disruption. Some studies have shown that MBP may interfere with hormone signaling pathways, raising concerns about its potential to disrupt reproductive development. However, further research is needed to fully understand the specific mechanisms and health implications of MBP exposure.'

Cross-References

ID SourceID
PubMed CID6928
CHEMBL ID3182523
SCHEMBL ID27533
MeSH IDM0096607

Synonyms (80)

Synonym
AKOS015839099
usaf cy-6
plastanox 425
2,2'-methylenebis(4-ethyl-6-tert-butylphenol)
chemanox 22
phenol,2'-methylenebis[6-tert-butyl-4-ethyl-
88-24-4
antioxidant 425
plastanox 425 antioxidant
ao 425
wln: 1x1&1&r bq f2 c1r bq d2 cx1&1&1
2,2'-methylenebis(6-tert-butyl-4-ethylphenol)
bis(2-hydroxy-3-tert-butyl-5-ethylphenyl)methane
nsc7782
phenol,2'-methylenebis[6-(1,1-dimethylethyl)-4-ethyl-
nsc-7782
phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-ethyl-
phenol, 2,2'-methylenebis[6-tert-butyl-4-ethyl-
2,2'-methylenebis(ethyl-6-tert-butylphenol)
agidol 7
nsc 7782
phenol, 2,2'-methylenebis(6-tert-butyl-4-ethyl-
cyanox 425
2,2-methylenebis(4-ethyl-6-t-butylphenol)
einecs 201-814-0
ccris 7788
hsdb 5257
ai3-25275
yoshinox 425
brn 2016207
antage w 500
6,6'-di-tert-butyl-4,4'-diethyl-2,2'-methylenediphenol
nocrac ns 5
phenol, 2,2'-methylenebis(6-(1,1-dimethylethyl)-4-ethyl-
2,2'-methylenebis(6-(1,1-dimethylethyl)-4-ethylphenol)
bis(3-tert-butyl-5-ethyl-2-hydroxyphenyl)methane
c25h36o2
2,2'-methylenebis(6-t-butyl-4-ethylphenol)
2,2'-methanediylbis(6-tert-butyl-4-ethylphenol)
2-tert-butyl-6-[(3-tert-butyl-5-ethyl-2-hydroxyphenyl)methyl]-4-ethylphenol
3,3'-di-tert-butyl-5,5'-diethyl-2,2'-dihydroxydiphenylmethane
M0215
2-tert-butyl-4-ethyl-6-[(2-hydroxyphenyl)methyl]phenol
A842508
2,2-methylenebis(4-ethyl-6-tert-butylphenol)
NCGC00257360-01
dtxsid7038864 ,
cas-88-24-4
tox21_303358
dtxcid5018864
rzw97f6cts ,
4-06-00-06806 (beilstein handbook reference)
unii-rzw97f6cts
2,2'-methylenebis(6-(tert-butyl)-4-ethylphenol)
FT-0609308
2,2'-methylene-bis-(4-ethyl-6-tert.butylphenol)
2,2'-methylene-bis(4-ethyl-6-tert-butyl phenol)
2,2'-methylenebis (6-tert-butyl-4-ethylphenol)
2,2'-methylene-bis(4-ethyl-6-tertiarybutyl phenol)
6,6'-methylenebis(2-(tert-butyl)-4-ethylphenol)
SCHEMBL27533
methylenebis(4-ethyl-6-tert-butylphenol), 2-2'-
2,2'-methylenebis(6-t-butyl-4-ethylphenol) [hsdb]
2,2'-methylenebis[6-(tert-butyl)-4-ethylphenol]
2,2'-methylenebis(4-ethyl-6-t-butylphenol)
W-100409
2,2'-methylene-bis-(4-ethyl-6-tert-butylphenol)
2,2'-methylenebis(6-tert-butyl-4-ethylphenol), certified reference material, tracecert(r)
CHEMBL3182523 ,
2,2'-methylene-bis(4-ethyl-6-t-butyl) phenol
phenol, 2,2'-methylenebis[4-ethyl-6(1,1-dimethylethyl)]-
mfcd00026296
DS-13037
D71074
Q27288370
2,2'-methylene-bis(4-ethyl-6-tert-butylphenol) 100 microg/ml in acetonitrile
bdbm50522652
2,2'-methylene-bis(4-ethyl-6-tert-butylphenol)
2,2/'-methylene bis(6-tert-butyl-4-ethylphenol)
CS-0152543

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In acute toxicity test, the LD50 values were estimated to be greater than 10 g/kg BW by oral and intraperitoneal administration in each sex."( Toxicity studies of a synthetic antioxidant, 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rats. 1. Acute and subchronic toxicity.
Aida, Y; Hasegawa, R; Kurokawa, Y; Momma, J; Naitoh, K; Suzuki, S; Takada, K; Takagi, A; Tobe, M, 1992)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (37)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency12.12313.189029.884159.4836AID1224846; AID1224894
RAR-related orphan receptor gammaMus musculus (house mouse)Potency18.61710.006038.004119,952.5996AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency48.97220.173734.304761.8120AID1346924
SMAD family member 3Homo sapiens (human)Potency48.97220.173734.304761.8120AID1346924
GLI family zinc finger 3Homo sapiens (human)Potency31.18610.000714.592883.7951AID1259368; AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency31.94230.000221.22318,912.5098AID1259243; AID1259247; AID743035; AID743036; AID743042; AID743053; AID743063
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency68.58960.013326.981070.7614AID1346978
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency29.52730.000657.913322,387.1992AID1259377; AID1259378; AID1259394
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency30.37360.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency44.21830.000417.946075.1148AID1346784; AID1346795
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency15.71090.000214.376460.0339AID720691; AID720692; AID720719
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency26.31620.003041.611522,387.1992AID1159552; AID1159553; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency34.89970.000817.505159.3239AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency31.53870.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency26.09300.375827.485161.6524AID743217; AID743220; AID743239
pregnane X nuclear receptorHomo sapiens (human)Potency0.68590.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency30.17020.000229.305416,493.5996AID1259244; AID1259248; AID1259383; AID743069; AID743075; AID743077; AID743078; AID743079; AID743080; AID743091
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency22.15480.001024.504861.6448AID743212; AID743215; AID743227
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency28.02000.001019.414170.9645AID743094; AID743140; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency17.45290.023723.228263.5986AID743222; AID743223; AID743241
caspase-3Homo sapiens (human)Potency68.58960.013326.981070.7614AID1346978
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency30.63790.001723.839378.1014AID743083
activating transcription factor 6Homo sapiens (human)Potency30.63410.143427.612159.8106AID1159516; AID1159519
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency25.053219.739145.978464.9432AID1159509; AID1159518
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency14.50960.057821.109761.2679AID1159526; AID1159528
Histone H2A.xCricetulus griseus (Chinese hamster)Potency49.52690.039147.5451146.8240AID1224845; AID1224896
Caspase-7Cricetulus griseus (Chinese hamster)Potency54.48270.006723.496068.5896AID1346980
caspase-3Cricetulus griseus (Chinese hamster)Potency54.48270.006723.496068.5896AID1346980
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency6.35690.000323.4451159.6830AID743065; AID743067
heat shock protein beta-1Homo sapiens (human)Potency17.29180.042027.378961.6448AID743210; AID743228
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency23.45150.000627.21521,122.0200AID743202; AID743219
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency30.63790.001557.789015,848.9004AID1259244
Cellular tumor antigen p53Homo sapiens (human)Potency19.75160.002319.595674.0614AID651631; AID720552
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency30.63790.001551.739315,848.9004AID1259244
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency27.84010.011917.942071.5630AID651632; AID720516
Ataxin-2Homo sapiens (human)Potency27.30600.011912.222168.7989AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Endoplasmic reticulum chaperone BiPHomo sapiens (human)IC50 (µMol)100.00000.80007.02509.1000AID1590351
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (161)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
ER overload responseEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cerebellum structural organizationEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cerebellar Purkinje cell layer developmentEndoplasmic reticulum chaperone BiPHomo sapiens (human)
substantia nigra developmentEndoplasmic reticulum chaperone BiPHomo sapiens (human)
positive regulation of cell migrationEndoplasmic reticulum chaperone BiPHomo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayEndoplasmic reticulum chaperone BiPHomo sapiens (human)
endoplasmic reticulum unfolded protein responseEndoplasmic reticulum chaperone BiPHomo sapiens (human)
post-translational protein targeting to membrane, translocationEndoplasmic reticulum chaperone BiPHomo sapiens (human)
negative regulation of protein-containing complex assemblyEndoplasmic reticulum chaperone BiPHomo sapiens (human)
positive regulation of protein ubiquitinationEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein folding in endoplasmic reticulumEndoplasmic reticulum chaperone BiPHomo sapiens (human)
response to endoplasmic reticulum stressEndoplasmic reticulum chaperone BiPHomo sapiens (human)
maintenance of protein localization in endoplasmic reticulumEndoplasmic reticulum chaperone BiPHomo sapiens (human)
ERAD pathwayEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cellular response to glucose starvationEndoplasmic reticulum chaperone BiPHomo sapiens (human)
negative regulation of apoptotic processEndoplasmic reticulum chaperone BiPHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIEndoplasmic reticulum chaperone BiPHomo sapiens (human)
regulation of protein folding in endoplasmic reticulumEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cellular response to interleukin-4Endoplasmic reticulum chaperone BiPHomo sapiens (human)
regulation of ATF6-mediated unfolded protein responseEndoplasmic reticulum chaperone BiPHomo sapiens (human)
regulation of IRE1-mediated unfolded protein responseEndoplasmic reticulum chaperone BiPHomo sapiens (human)
negative regulation of IRE1-mediated unfolded protein responseEndoplasmic reticulum chaperone BiPHomo sapiens (human)
regulation of PERK-mediated unfolded protein responseEndoplasmic reticulum chaperone BiPHomo sapiens (human)
chaperone cofactor-dependent protein refoldingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein refoldingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (49)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
calcium ion bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
ATP bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
ATP hydrolysis activityEndoplasmic reticulum chaperone BiPHomo sapiens (human)
enzyme bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein domain specific bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
ubiquitin protein ligase bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
ribosome bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cadherin bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
unfolded protein bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein-folding chaperone bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
misfolded protein bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
ATP-dependent protein folding chaperoneEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein folding chaperoneEndoplasmic reticulum chaperone BiPHomo sapiens (human)
heat shock protein bindingEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (38)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
COP9 signalosomeEndoplasmic reticulum chaperone BiPHomo sapiens (human)
nucleusEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cytoplasmEndoplasmic reticulum chaperone BiPHomo sapiens (human)
mitochondrionEndoplasmic reticulum chaperone BiPHomo sapiens (human)
endoplasmic reticulumEndoplasmic reticulum chaperone BiPHomo sapiens (human)
endoplasmic reticulum lumenEndoplasmic reticulum chaperone BiPHomo sapiens (human)
endoplasmic reticulum membraneEndoplasmic reticulum chaperone BiPHomo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cytosolEndoplasmic reticulum chaperone BiPHomo sapiens (human)
plasma membraneEndoplasmic reticulum chaperone BiPHomo sapiens (human)
focal adhesionEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cell surfaceEndoplasmic reticulum chaperone BiPHomo sapiens (human)
membraneEndoplasmic reticulum chaperone BiPHomo sapiens (human)
midbodyEndoplasmic reticulum chaperone BiPHomo sapiens (human)
melanosomeEndoplasmic reticulum chaperone BiPHomo sapiens (human)
intracellular membrane-bounded organelleEndoplasmic reticulum chaperone BiPHomo sapiens (human)
extracellular exosomeEndoplasmic reticulum chaperone BiPHomo sapiens (human)
protein-containing complexEndoplasmic reticulum chaperone BiPHomo sapiens (human)
endoplasmic reticulum chaperone complexEndoplasmic reticulum chaperone BiPHomo sapiens (human)
endoplasmic reticulum lumenEndoplasmic reticulum chaperone BiPHomo sapiens (human)
cytoplasmEndoplasmic reticulum chaperone BiPHomo sapiens (human)
nucleusEndoplasmic reticulum chaperone BiPHomo sapiens (human)
membraneEndoplasmic reticulum chaperone BiPHomo sapiens (human)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1590351Inhibition of GRP78 (26 to 636 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 cells pre-incubated for 10 mins before FITC-NRLLLTG fluorescent peptide addition in presence of 20 uM ADP followed by further incubation for 2 hrs by fluoresc2019Bioorganic & medicinal chemistry letters, 07-15, Volume: 29, Issue:14
A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (50.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.36 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (11.11%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bithionol
Bithionol: Halogenated anti-infective agent that is used against trematode and cestode infestations.. bithionol : An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.		2.2110aryl sulfide;
bridged diphenyl antifungal drug;
bridged diphenyl fungicide;
dichlorobenzene;
organochlorine pesticide;
polyphenol		antifungal agrochemical;
antiplatyhelmintic drug
dichlorophen
Dichlorophen: Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.)		2.2110bridged diphenyl fungicide;
diarylmethane
hexachlorophene
Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797). hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.		2.2110bridged diphenyl fungicide;
polyphenol;
trichlorobenzene		acaricide;
antibacterial agent;
antifungal agrochemical;
antiseptic drug
triclosan
[no description available]		2.2110aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
santowhite powder
4,4'-butylidenebis(6-tert-butyl-m-cresol): putatively both an androgen and estrogen antagonist; structure in first source		1.9610
2,2'-methylenebis(4-methyl-6-tert-butylphenol)
[no description available]		2.4120diarylmethane
oxyclozanide
Oxyclozanide: Anthelmintic used in grazing animals for fasciola and cestode infestations.		2.2110
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.2110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
2,2'-bisphenol f
2,2'-bisphenol F: contact allergen; structure given in first source		2.2110diarylmethane
isobornyl acrylate
isobornyl acrylate: causes contact dermatitis in some individuals; structure in first source		2.3110
ver 155008
VER 155008: structure in first source		2.2110purine nucleoside
ConditionIndicatedRelationship StrengthStudiesTrials
Allergic Contact Dermatitis
[description not available]		02.3110
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.		02.3110
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.3110
Liver Steatosis
[description not available]		01.9610
Fatty Liver
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.		01.9610
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.6630
Atrophy
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.		01.9810
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		01.9710
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9710