Page last updated: 2024-12-10
mammeisin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5281419 |
| CHEMBL ID | 194485 |
| CHEBI ID | 69990 |
| SCHEMBL ID | 6913744 |
| MeSH ID | M0042270 |
Synonyms (22)
| Synonym |
|---|
| 2h-1-benzopyran-2-one, 5,7-dihydroxy-8-(3-methyl-2-butenyl)-6-(3-methyl-1-oxobutyl)-4-phenyl- |
| 5,7-dihydroxy-6-(3-methylbutanoyl)-8-(3-methylbut-2-enyl)-4-phenyl-chromen-2-one |
| C09275 |
| mammeisin |
| 18483-64-2 |
| LMPK12100002 |
| chebi:69990 , |
| CHEMBL194485 |
| 5,7-dihydroxy-6-(3-methylbutanoyl)-8-(3-methylbut-2-enyl)-4-phenylchromen-2-one |
| SCHEMBL6913744 |
| 5,7-dihydroxy-8-(3-methyl-2-butenyl)-6-(3-methyl-1-oxobutyl)-4-phenyl-2h-1-benzopyran-2-one |
| mammea a/aa |
| DTXSID20171665 |
| bdbm50483571 |
| 5,7-dihydroxy-8-(3-methyl-2-butenyl)-6-(3-methyl-1-oxobutyl)-4-phenyl-2h-1-benzopyran-2-one, 9ci |
| 5,7-dihydroxy-8-(3-methyl-2-butenyl)-6-(3-methylbutyryl)-4-phenylcoumarin |
| 5,7-dihydroxy-8-isopentenyl-6-isovaleroyl-4-phenylcoumarin |
| Q27138334 |
| nsc-781046 |
| nsc781046 |
| 4-phenyl-5,7-dihydroxy-6-(3-methylbutanoyl)-8-(3-methyl-2-butenyl)-2h-1-benzopyran-2-one |
| AKOS040752922 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (1)
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (1)
| Class | Description |
|---|---|
| neoflavonoid | Any 1-benzopyran with an aryl substituent at position 4. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Protein Targets (2)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 (µMol) | 4.0750 | 0.0007 | 2.4652 | 9.2100 | AID587080; AID587081 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | IC50 (µMol) | 4.0750 | 0.0030 | 2.6002 | 8.5100 | AID587080; AID587081 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (98)
Molecular Functions (23)
Ceullar Components (13)
Bioassays (14)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID256309 | Anti-HIV activity (at 50 uM) against Jurkat-derived 5.1 cell line stably transfected with HIV-LTR activated by TNF alpha | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | 4-Phenylcoumarins as HIV transcription inhibitors. |
| AID256342 | Anti-HIV activity (at 25 uM) against Jurkat-derived 5.1 cell line stably transfected with HIV-LTR activated by TNF alpha; NT= not tested | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | 4-Phenylcoumarins as HIV transcription inhibitors. |
| AID256333 | Anti-HIV activity (at 25 uM) against human HeLa-Tat-Luc cells transfected with HIV-1 LTR activated by Tat protein; NT= not tested | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | 4-Phenylcoumarins as HIV transcription inhibitors. |
| AID377462 | Cytotoxicity against human H460 cells | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata. |
| AID256243 | Toxicity of compound against human MT-2 cell line at the concentration of 50 uM | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | 4-Phenylcoumarins as HIV transcription inhibitors. |
| AID377461 | Cytotoxicity against human MCF7 cells | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata. |
| AID587179 | Antiproliferative activity against human PC3 cells after 48 hrs | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Natural and semisynthetic mammea-type isoprenylated dihydroxycoumarins uncouple cellular respiration. |
| AID587081 | Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Natural and semisynthetic mammea-type isoprenylated dihydroxycoumarins uncouple cellular respiration. |
| AID587080 | Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Natural and semisynthetic mammea-type isoprenylated dihydroxycoumarins uncouple cellular respiration. |
| AID256287 | Anti-HIV activity (at 50 uM) against human HeLa cells through a HeLa-Tet-ON assay; U= unspecific | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | 4-Phenylcoumarins as HIV transcription inhibitors. |
| AID254982 | Inhibitory concentration against recombinant human immunodeficiency virus 1 reverse transcriptase; NT= not tested | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | 4-Phenylcoumarins as HIV transcription inhibitors. |
| AID377463 | Cytotoxicity against human SF268 cells | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata. |
| AID587178 | Antiproliferative activity against human T47D cells after 48 hrs | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Natural and semisynthetic mammea-type isoprenylated dihydroxycoumarins uncouple cellular respiration. |
| AID256298 | Anti-HIV activity (at 50 uM) against human HeLa-Tat-Luc cells transfected with HIV-1 LTR activated by Tat protein | 2005 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 15, Issue:20 | 4-Phenylcoumarins as HIV transcription inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.52
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.52) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||