AGN 194204: a retinoid X receptor ligand; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 9863342 |
| CHEMBL ID | 69091 |
| SCHEMBL ID | 5860163 |
| MeSH ID | M0393565 |
| Synonym |
|---|
| (2e,4e)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6, 7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid |
| gtpl2811 |
| agn 194204 |
| CHEMBL69091 , |
| (e)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid |
| 3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid |
| bdbm50101444 |
| SCHEMBL5860163 |
| (2e,4e)-5-[2-methyl-2-(1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene-6-yl)cyclopropyl]-3-methyl-2,4-pentadienoic acid |
| (2e,4e)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid |
| Q27074352 |
| nrx194204-nrx4204|vtp194204|agn194204|agn4204 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor alpha | Homo sapiens (human) | Kd | 9.5000 | 0.0002 | 0.5268 | 9.5000 | AID166204 |
| Retinoic acid receptor beta | Homo sapiens (human) | Kd | 20.5000 | 0.0002 | 0.2876 | 2.3000 | AID166208 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Kd | 15.9000 | 0.0002 | 0.4245 | 3.8240 | AID166212 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | Kd | 0.0015 | 0.0004 | 0.5838 | 8.8000 | AID167583 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | Kd | 0.0025 | 0.0025 | 0.0140 | 0.0350 | AID167593 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | Kd | 0.0018 | 0.0018 | 0.0616 | 0.3060 | AID167595 |
| Type-2 angiotensin II receptor | Homo sapiens (human) | Kd | 0.0025 | 0.0025 | 0.0254 | 0.0500 | AID167593 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID166208 | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-beta | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| AID166204 | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| AID167583 | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alpha | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| AID166212 | Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-gamma | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| AID167595 | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-gamma | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| AID167593 | Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| AID1346794 | Mouse Retinoid X receptor-beta (2B. Retinoid X receptors) | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| AID1346768 | Human Retinoid X receptor-alpha (2B. Retinoid X receptors) | 2001 | Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (88.89) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.29) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||