agn 194204

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Description

AGN 194204: a retinoid X receptor ligand; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9863342
CHEMBL ID	69091
SCHEMBL ID	5860163
MeSH ID	M0393565

Synonyms (12)

Synonym
(2e,4e)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6, 7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
gtpl2811
agn 194204
CHEMBL69091 ,
(e)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
bdbm50101444
SCHEMBL5860163
(2e,4e)-5-[2-methyl-2-(1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene-6-yl)cyclopropyl]-3-methyl-2,4-pentadienoic acid
(2e,4e)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
Q27074352
nrx194204-nrx4204\|vtp194204\|agn194204\|agn4204

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (7)

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Retinoic acid receptor alpha	Homo sapiens (human)	Kd	9.5000	0.0002	0.5268	9.5000	AID166204
Retinoic acid receptor beta	Homo sapiens (human)	Kd	20.5000	0.0002	0.2876	2.3000	AID166208
Retinoic acid receptor gamma	Homo sapiens (human)	Kd	15.9000	0.0002	0.4245	3.8240	AID166212
Retinoic acid receptor RXR-alpha	Homo sapiens (human)	Kd	0.0015	0.0004	0.5838	8.8000	AID167583
Retinoic acid receptor RXR-beta	Homo sapiens (human)	Kd	0.0025	0.0025	0.0140	0.0350	AID167593
Retinoic acid receptor RXR-gamma	Homo sapiens (human)	Kd	0.0018	0.0018	0.0616	0.3060	AID167595
Type-2 angiotensin II receptor	Homo sapiens (human)	Kd	0.0025	0.0025	0.0254	0.0500	AID167593
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (108)

Process	via Protein(s)	Taxonomy
ureteric bud development	Retinoic acid receptor alpha	Homo sapiens (human)
neural tube closure	Retinoic acid receptor alpha	Homo sapiens (human)
liver development	Retinoic acid receptor alpha	Homo sapiens (human)
glandular epithelial cell development	Retinoic acid receptor alpha	Homo sapiens (human)
growth plate cartilage development	Retinoic acid receptor alpha	Homo sapiens (human)
protein phosphorylation	Retinoic acid receptor alpha	Homo sapiens (human)
germ cell development	Retinoic acid receptor alpha	Homo sapiens (human)
female pregnancy	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of cell population proliferation	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of cell population proliferation	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of translation	Retinoic acid receptor alpha	Homo sapiens (human)
hippocampus development	Retinoic acid receptor alpha	Homo sapiens (human)
prostate gland development	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of granulocyte differentiation	Retinoic acid receptor alpha	Homo sapiens (human)
embryonic camera-type eye development	Retinoic acid receptor alpha	Homo sapiens (human)
regulation of myelination	Retinoic acid receptor alpha	Homo sapiens (human)
response to estradiol	Retinoic acid receptor alpha	Homo sapiens (human)
response to retinoic acid	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of type II interferon production	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of tumor necrosis factor production	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of interleukin-13 production	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of interleukin-4 production	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of interleukin-5 production	Retinoic acid receptor alpha	Homo sapiens (human)
response to vitamin A	Retinoic acid receptor alpha	Homo sapiens (human)
response to cytokine	Retinoic acid receptor alpha	Homo sapiens (human)
multicellular organism growth	Retinoic acid receptor alpha	Homo sapiens (human)
mRNA transcription by RNA polymerase II	Retinoic acid receptor alpha	Homo sapiens (human)
regulation of apoptotic process	Retinoic acid receptor alpha	Homo sapiens (human)
apoptotic cell clearance	Retinoic acid receptor alpha	Homo sapiens (human)
response to ethanol	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of T-helper 2 cell differentiation	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of neuron differentiation	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of cell cycle	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of DNA-templated transcription	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of DNA-templated transcription	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Retinoic acid receptor alpha	Homo sapiens (human)
regulation of synaptic plasticity	Retinoic acid receptor alpha	Homo sapiens (human)
retinoic acid receptor signaling pathway	Retinoic acid receptor alpha	Homo sapiens (human)
positive regulation of binding	Retinoic acid receptor alpha	Homo sapiens (human)
ventricular cardiac muscle cell differentiation	Retinoic acid receptor alpha	Homo sapiens (human)
Sertoli cell fate commitment	Retinoic acid receptor alpha	Homo sapiens (human)
limb development	Retinoic acid receptor alpha	Homo sapiens (human)
face development	Retinoic acid receptor alpha	Homo sapiens (human)
trachea cartilage development	Retinoic acid receptor alpha	Homo sapiens (human)
chondroblast differentiation	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of cartilage development	Retinoic acid receptor alpha	Homo sapiens (human)
cellular response to lipopolysaccharide	Retinoic acid receptor alpha	Homo sapiens (human)
cellular response to retinoic acid	Retinoic acid receptor alpha	Homo sapiens (human)
cellular response to estrogen stimulus	Retinoic acid receptor alpha	Homo sapiens (human)
regulation of hematopoietic progenitor cell differentiation	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of miRNA transcription	Retinoic acid receptor alpha	Homo sapiens (human)
cell differentiation	Retinoic acid receptor alpha	Homo sapiens (human)
hormone-mediated signaling pathway	Retinoic acid receptor alpha	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Retinoic acid receptor alpha	Homo sapiens (human)
ureteric bud development	Retinoic acid receptor beta	Homo sapiens (human)
glandular epithelial cell development	Retinoic acid receptor beta	Homo sapiens (human)
growth plate cartilage development	Retinoic acid receptor beta	Homo sapiens (human)
apoptotic process	Retinoic acid receptor beta	Homo sapiens (human)
signal transduction	Retinoic acid receptor beta	Homo sapiens (human)
striatum development	Retinoic acid receptor beta	Homo sapiens (human)
neurogenesis	Retinoic acid receptor beta	Homo sapiens (human)
regulation of myelination	Retinoic acid receptor beta	Homo sapiens (human)
negative regulation of chondrocyte differentiation	Retinoic acid receptor beta	Homo sapiens (human)
embryonic hindlimb morphogenesis	Retinoic acid receptor beta	Homo sapiens (human)
multicellular organism growth	Retinoic acid receptor beta	Homo sapiens (human)
positive regulation of apoptotic process	Retinoic acid receptor beta	Homo sapiens (human)
embryonic eye morphogenesis	Retinoic acid receptor beta	Homo sapiens (human)
embryonic digestive tract development	Retinoic acid receptor beta	Homo sapiens (human)
ventricular cardiac muscle cell differentiation	Retinoic acid receptor beta	Homo sapiens (human)
neural precursor cell proliferation	Retinoic acid receptor beta	Homo sapiens (human)
stem cell proliferation	Retinoic acid receptor beta	Homo sapiens (human)
negative regulation of stem cell proliferation	Retinoic acid receptor beta	Homo sapiens (human)
retinoic acid receptor signaling pathway	Retinoic acid receptor beta	Homo sapiens (human)
hormone-mediated signaling pathway	Retinoic acid receptor beta	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Retinoic acid receptor beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Retinoic acid receptor beta	Homo sapiens (human)
cell differentiation	Retinoic acid receptor beta	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Retinoic acid receptor gamma	Homo sapiens (human)
neural tube closure	Retinoic acid receptor gamma	Homo sapiens (human)
glandular epithelial cell development	Retinoic acid receptor gamma	Homo sapiens (human)
growth plate cartilage chondrocyte growth	Retinoic acid receptor gamma	Homo sapiens (human)
apoptotic process	Retinoic acid receptor gamma	Homo sapiens (human)
positive regulation of cell population proliferation	Retinoic acid receptor gamma	Homo sapiens (human)
negative regulation of cell population proliferation	Retinoic acid receptor gamma	Homo sapiens (human)
regulation of cell size	Retinoic acid receptor gamma	Homo sapiens (human)
anterior/posterior pattern specification	Retinoic acid receptor gamma	Homo sapiens (human)
positive regulation of gene expression	Retinoic acid receptor gamma	Homo sapiens (human)
embryonic camera-type eye development	Retinoic acid receptor gamma	Homo sapiens (human)
regulation of myelination	Retinoic acid receptor gamma	Homo sapiens (human)
negative regulation of chondrocyte differentiation	Retinoic acid receptor gamma	Homo sapiens (human)
response to retinoic acid	Retinoic acid receptor gamma	Homo sapiens (human)
embryonic hindlimb morphogenesis	Retinoic acid receptor gamma	Homo sapiens (human)
multicellular organism growth	Retinoic acid receptor gamma	Homo sapiens (human)
positive regulation of apoptotic process	Retinoic acid receptor gamma	Homo sapiens (human)
positive regulation of programmed cell death	Retinoic acid receptor gamma	Homo sapiens (human)
regulation of myeloid cell differentiation	Retinoic acid receptor gamma	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Retinoic acid receptor gamma	Homo sapiens (human)
embryonic eye morphogenesis	Retinoic acid receptor gamma	Homo sapiens (human)
retinoic acid receptor signaling pathway	Retinoic acid receptor gamma	Homo sapiens (human)
canonical Wnt signaling pathway	Retinoic acid receptor gamma	Homo sapiens (human)
face development	Retinoic acid receptor gamma	Homo sapiens (human)
trachea cartilage development	Retinoic acid receptor gamma	Homo sapiens (human)
prostate gland epithelium morphogenesis	Retinoic acid receptor gamma	Homo sapiens (human)
Harderian gland development	Retinoic acid receptor gamma	Homo sapiens (human)
cellular response to retinoic acid	Retinoic acid receptor gamma	Homo sapiens (human)
stem cell proliferation	Retinoic acid receptor gamma	Homo sapiens (human)
cellular response to leukemia inhibitory factor	Retinoic acid receptor gamma	Homo sapiens (human)
negative regulation of stem cell proliferation	Retinoic acid receptor gamma	Homo sapiens (human)
cell differentiation	Retinoic acid receptor gamma	Homo sapiens (human)
hormone-mediated signaling pathway	Retinoic acid receptor gamma	Homo sapiens (human)
positive regulation of cholesterol efflux	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
positive regulation of thyroid hormone mediated signaling pathway	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
hormone-mediated signaling pathway	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
positive regulation of bone mineralization	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
positive regulation of transporter activity	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
response to retinoic acid	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
peroxisome proliferator activated receptor signaling pathway	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
mRNA transcription by RNA polymerase II	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
steroid hormone mediated signaling pathway	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
positive regulation of DNA-templated transcription	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
retinoic acid receptor signaling pathway	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
positive regulation of vitamin D receptor signaling pathway	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
cell differentiation	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
anatomical structure development	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
hormone-mediated signaling pathway	Retinoic acid receptor RXR-beta	Homo sapiens (human)
positive regulation of bone mineralization	Retinoic acid receptor RXR-beta	Homo sapiens (human)
mRNA transcription by RNA polymerase II	Retinoic acid receptor RXR-beta	Homo sapiens (human)
steroid hormone mediated signaling pathway	Retinoic acid receptor RXR-beta	Homo sapiens (human)
positive regulation of DNA-templated transcription	Retinoic acid receptor RXR-beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Retinoic acid receptor RXR-beta	Homo sapiens (human)
positive regulation of vitamin D receptor signaling pathway	Retinoic acid receptor RXR-beta	Homo sapiens (human)
anatomical structure development	Retinoic acid receptor RXR-beta	Homo sapiens (human)
cell differentiation	Retinoic acid receptor RXR-beta	Homo sapiens (human)
retinoic acid receptor signaling pathway	Retinoic acid receptor RXR-beta	Homo sapiens (human)
response to retinoic acid	Retinoic acid receptor RXR-beta	Homo sapiens (human)
steroid hormone mediated signaling pathway	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
retinoic acid receptor signaling pathway	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
anatomical structure development	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
response to retinoic acid	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
cell differentiation	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
blood vessel remodeling	Type-2 angiotensin II receptor	Homo sapiens (human)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin	Type-2 angiotensin II receptor	Homo sapiens (human)
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	Type-2 angiotensin II receptor	Homo sapiens (human)
brain renin-angiotensin system	Type-2 angiotensin II receptor	Homo sapiens (human)
cell surface receptor signaling pathway	Type-2 angiotensin II receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Type-2 angiotensin II receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	Type-2 angiotensin II receptor	Homo sapiens (human)
brain development	Type-2 angiotensin II receptor	Homo sapiens (human)
regulation of blood pressure	Type-2 angiotensin II receptor	Homo sapiens (human)
negative regulation of heart rate	Type-2 angiotensin II receptor	Homo sapiens (human)
negative regulation of cell growth	Type-2 angiotensin II receptor	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Type-2 angiotensin II receptor	Homo sapiens (human)
regulation of metanephros size	Type-2 angiotensin II receptor	Homo sapiens (human)
exploration behavior	Type-2 angiotensin II receptor	Homo sapiens (human)
nitric oxide-cGMP-mediated signaling	Type-2 angiotensin II receptor	Homo sapiens (human)
angiotensin-activated signaling pathway	Type-2 angiotensin II receptor	Homo sapiens (human)
vasodilation	Type-2 angiotensin II receptor	Homo sapiens (human)
negative regulation of blood vessel endothelial cell migration	Type-2 angiotensin II receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Type-2 angiotensin II receptor	Homo sapiens (human)
negative regulation of neurotrophin TRK receptor signaling pathway	Type-2 angiotensin II receptor	Homo sapiens (human)
neuron apoptotic process	Type-2 angiotensin II receptor	Homo sapiens (human)
positive regulation of metanephric glomerulus development	Type-2 angiotensin II receptor	Homo sapiens (human)
positive regulation of branching involved in ureteric bud morphogenesis	Type-2 angiotensin II receptor	Homo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathway	Type-2 angiotensin II receptor	Homo sapiens (human)
inflammatory response	Type-2 angiotensin II receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (42)

Process	via Protein(s)	Taxonomy
mRNA regulatory element binding translation repressor activity	Retinoic acid receptor alpha	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Retinoic acid receptor alpha	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Retinoic acid receptor alpha	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Retinoic acid receptor alpha	Homo sapiens (human)
DNA-binding transcription repressor activity	Retinoic acid receptor alpha	Homo sapiens (human)
transcription coactivator binding	Retinoic acid receptor alpha	Homo sapiens (human)
retinoic acid binding	Retinoic acid receptor alpha	Homo sapiens (human)
chromatin binding	Retinoic acid receptor alpha	Homo sapiens (human)
DNA-binding transcription factor activity	Retinoic acid receptor alpha	Homo sapiens (human)
nuclear receptor activity	Retinoic acid receptor alpha	Homo sapiens (human)
signaling receptor binding	Retinoic acid receptor alpha	Homo sapiens (human)
protein binding	Retinoic acid receptor alpha	Homo sapiens (human)
zinc ion binding	Retinoic acid receptor alpha	Homo sapiens (human)
enzyme binding	Retinoic acid receptor alpha	Homo sapiens (human)
protein domain specific binding	Retinoic acid receptor alpha	Homo sapiens (human)
chromatin DNA binding	Retinoic acid receptor alpha	Homo sapiens (human)
histone deacetylase binding	Retinoic acid receptor alpha	Homo sapiens (human)
protein kinase B binding	Retinoic acid receptor alpha	Homo sapiens (human)
retinoic acid-responsive element binding	Retinoic acid receptor alpha	Homo sapiens (human)
mRNA 5'-UTR binding	Retinoic acid receptor alpha	Homo sapiens (human)
protein kinase A binding	Retinoic acid receptor alpha	Homo sapiens (human)
alpha-actinin binding	Retinoic acid receptor alpha	Homo sapiens (human)
heterocyclic compound binding	Retinoic acid receptor alpha	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Retinoic acid receptor alpha	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Retinoic acid receptor beta	Homo sapiens (human)
DNA binding	Retinoic acid receptor beta	Homo sapiens (human)
zinc ion binding	Retinoic acid receptor beta	Homo sapiens (human)
protein-containing complex binding	Retinoic acid receptor beta	Homo sapiens (human)
nuclear retinoid X receptor binding	Retinoic acid receptor beta	Homo sapiens (human)
heterocyclic compound binding	Retinoic acid receptor beta	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Retinoic acid receptor beta	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Retinoic acid receptor beta	Homo sapiens (human)
nuclear receptor activity	Retinoic acid receptor beta	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Retinoic acid receptor gamma	Homo sapiens (human)
DNA binding	Retinoic acid receptor gamma	Homo sapiens (human)
chromatin binding	Retinoic acid receptor gamma	Homo sapiens (human)
DNA-binding transcription factor activity	Retinoic acid receptor gamma	Homo sapiens (human)
protein binding	Retinoic acid receptor gamma	Homo sapiens (human)
zinc ion binding	Retinoic acid receptor gamma	Homo sapiens (human)
nuclear retinoid X receptor binding	Retinoic acid receptor gamma	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Retinoic acid receptor gamma	Homo sapiens (human)
nuclear receptor activity	Retinoic acid receptor gamma	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Retinoic acid receptor gamma	Homo sapiens (human)
vitamin D response element binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
transcription cis-regulatory region binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
transcription coregulator binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
retinoic acid binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
double-stranded DNA binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
DNA-binding transcription factor activity	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
nuclear steroid receptor activity	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
nuclear receptor activity	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
protein binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
zinc ion binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
enzyme binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
peptide binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
identical protein binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
nuclear vitamin D receptor binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
sequence-specific DNA binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
retinoic acid-responsive element binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
DNA binding domain binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
LBD domain binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Retinoic acid receptor RXR-beta	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Retinoic acid receptor RXR-beta	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Retinoic acid receptor RXR-beta	Homo sapiens (human)
nuclear steroid receptor activity	Retinoic acid receptor RXR-beta	Homo sapiens (human)
nuclear receptor activity	Retinoic acid receptor RXR-beta	Homo sapiens (human)
protein binding	Retinoic acid receptor RXR-beta	Homo sapiens (human)
zinc ion binding	Retinoic acid receptor RXR-beta	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Retinoic acid receptor RXR-beta	Homo sapiens (human)
retinoic acid-responsive element binding	Retinoic acid receptor RXR-beta	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
nuclear steroid receptor activity	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
protein binding	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
zinc ion binding	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
molecular condensate scaffold activity	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
nuclear receptor activity	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
retinoic acid-responsive element binding	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
angiotensin type II receptor activity	Type-2 angiotensin II receptor	Homo sapiens (human)
protein binding	Type-2 angiotensin II receptor	Homo sapiens (human)
receptor antagonist activity	Type-2 angiotensin II receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (16)

Process	via Protein(s)	Taxonomy
nucleus	Retinoic acid receptor alpha	Homo sapiens (human)
nucleoplasm	Retinoic acid receptor alpha	Homo sapiens (human)
transcription regulator complex	Retinoic acid receptor alpha	Homo sapiens (human)
nucleolus	Retinoic acid receptor alpha	Homo sapiens (human)
cytoplasm	Retinoic acid receptor alpha	Homo sapiens (human)
cytosol	Retinoic acid receptor alpha	Homo sapiens (human)
plasma membrane	Retinoic acid receptor alpha	Homo sapiens (human)
actin cytoskeleton	Retinoic acid receptor alpha	Homo sapiens (human)
dendrite	Retinoic acid receptor alpha	Homo sapiens (human)
perinuclear region of cytoplasm	Retinoic acid receptor alpha	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Retinoic acid receptor alpha	Homo sapiens (human)
chromatin	Retinoic acid receptor alpha	Homo sapiens (human)
protein-containing complex	Retinoic acid receptor alpha	Homo sapiens (human)
nucleus	Retinoic acid receptor alpha	Homo sapiens (human)
nucleus	Retinoic acid receptor beta	Homo sapiens (human)
nucleoplasm	Retinoic acid receptor beta	Homo sapiens (human)
cytoplasm	Retinoic acid receptor beta	Homo sapiens (human)
chromatin	Retinoic acid receptor beta	Homo sapiens (human)
nucleus	Retinoic acid receptor beta	Homo sapiens (human)
nucleus	Retinoic acid receptor gamma	Homo sapiens (human)
nucleoplasm	Retinoic acid receptor gamma	Homo sapiens (human)
cytoplasm	Retinoic acid receptor gamma	Homo sapiens (human)
membrane	Retinoic acid receptor gamma	Homo sapiens (human)
chromatin	Retinoic acid receptor gamma	Homo sapiens (human)
transcription regulator complex	Retinoic acid receptor gamma	Homo sapiens (human)
nucleus	Retinoic acid receptor gamma	Homo sapiens (human)
nucleus	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
nucleoplasm	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
transcription regulator complex	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
mitochondrion	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
cytosol	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
chromatin	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
receptor complex	Retinoic acid receptor RXR-alpha	Homo sapiens (human)
nucleus	Retinoic acid receptor RXR-beta	Homo sapiens (human)
nucleoplasm	Retinoic acid receptor RXR-beta	Homo sapiens (human)
nucleolus	Retinoic acid receptor RXR-beta	Homo sapiens (human)
cytosol	Retinoic acid receptor RXR-beta	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Retinoic acid receptor RXR-beta	Homo sapiens (human)
chromatin	Retinoic acid receptor RXR-beta	Homo sapiens (human)
nucleoplasm	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
cytoplasm	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
chromatin	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Retinoic acid receptor RXR-gamma	Homo sapiens (human)
plasma membrane	Type-2 angiotensin II receptor	Homo sapiens (human)
plasma membrane	Type-2 angiotensin II receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID166208	Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-beta	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
AID166204	Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
AID167583	Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alpha	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
AID166212	Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-gamma	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
AID167595	Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-gamma	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
AID167593	Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
AID1346794	Mouse Retinoid X receptor-beta (2B. Retinoid X receptors)	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
AID1346768	Human Retinoid X receptor-alpha (2B. Retinoid X receptors)	2001	Journal of medicinal chemistry, Jul-05, Volume: 44, Issue:14	Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	16 (88.89)	29.6817
2010's	2 (11.11)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.29 (24.57)
Research Supply Index	2.94 (2.92)
Research Growth Index	4.23 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.29)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ciglitazone ciglitazone: structure given in second source; PPAR agonist used for type II diabetes. ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.	2.05	1	aromatic ether; thiazolidinone	antineoplastic agent; insulin-sensitizing drug
clofibrate angiokapsul: contains clofibrate & insoitolnicotinate	2.05	1	aromatic ether; ethyl ester; monochlorobenzenes	anticholesteremic drug; antilipemic drug; geroprotector; PPARalpha agonist
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.02	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
lg 100268 LG 100268: a retinoid X receptor (RXR) selective compound; structure given in first source	2.05	1
troglitazone Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.	2.02	1	chromanes; thiazolidinone	anticoagulant; anticonvulsant; antineoplastic agent; antioxidant; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; hypoglycemic agent; platelet aggregation inhibitor; vasodilator agent
urethane [no description available]	2.05	1	carbamate ester	fungal metabolite; mutagen
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	2.01	1	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
oleanolic acid [no description available]	2.05	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
deoxycytidine [no description available]	2.02	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
vinyl carbamate vinyl carbamate: promutagen & more carcinogenic analog of ethyl carbamate (urethane); structure	2.05	1	carbamate ester
gemcitabine gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.	2.02	1	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic
agn 193109 AGN 193109: structure given in first source	2	1
bardoxolone methyl methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate: structure in first source	2.05	1	cyclohexenones
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	3.4	7	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
retinol Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.. vitamin A : Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.. all-trans-retinol : A retinol in which all four exocyclic double bonds have E- (trans-) geometry.. retinol : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).	2.01	1	retinol; vitamin A	human metabolite; mouse metabolite; plant metabolite
alitretinoin Alitretinoin: A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.	3.4	7	retinoic acid	antineoplastic agent; keratolytic drug; metabolite; retinoid X receptor agonist
calcitriol dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes	2.02	1	D3 vitamins; hydroxycalciol; triol	antineoplastic agent; antipsoriatic; bone density conservation agent; calcium channel agonist; calcium channel modulator; hormone; human metabolite; immunomodulator; metabolite; mouse metabolite; nutraceutical
gamma-linolenic acid gamma-Linolenic Acid: An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed). gamma-linolenic acid : A C18, omega-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.	2.02	1	linolenic acid; omega-6 fatty acid	human metabolite; mouse metabolite; plant metabolite
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid: RN refers to (E)-isomer; structure given in first source. arotinoid acid : A retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR).	2.7	3	benzoic acids; naphthalenes; retinoid	antineoplastic agent; retinoic acid receptor agonist; teratogenic agent
agn 191659 AGN 191659: a retinoid x receptor pan-agonist; structure in first source	2	1
agn 190121 [no description available]	2	1
nrx 194204 IRX4204: retinoid X receptor (RXR) agonist; structure in first source	2	1
agn 193836 AGN 193836: structure in first source	2	1
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide: synthetic potential anticarcinogenic	2.05	1
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.02	1

Condition	Relationship Strength	Studies
Herpes Simplex Virus Infection [description not available]	2.1	1
Stomatitis, Vesicular [description not available]	2.1	1
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	2.1	1
Adenocarcinoma, Basal Cell [description not available]	2.05	1
Cancer of Lung [description not available]	2.44	2
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.05	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.44	2
Experimental Mammary Neoplasms [description not available]	2.05	1
Invasiveness, Neoplasm [description not available]	2.05	1
Central Hypothyroidism [description not available]	2.01	1
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	2.01	1
Hypothyroidism A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.	2.01	1
Chronic Illness [description not available]	2.02	1
Chronic Kidney Failure [description not available]	2.02	1
DDD MPGNII [description not available]	2.02	1
Albuminuria The presence of albumin in the urine, an indicator of KIDNEY DISEASES.	2.02	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.02	1
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	2.02	1
Glomerulonephritis, Membranoproliferative Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.	2.02	1
Cirrhosis, Liver [description not available]	2.02	1
Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.	2.02	1
Cancer of Pancreas [description not available]	2.02	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.02	1
Granulocytic Leukemia [description not available]	2.02	1
Leukemia, Myeloid Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.	2.02	1
Breast Cancer [description not available]	2.43	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.43	2
Alloxan Diabetes [description not available]	2.02	1
Hepatocellular Carcinoma [description not available]	2	1
Cancer of Liver [description not available]	2	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2	1
Liver Neoplasms Tumors or cancer of the LIVER.	2	1
Hypertriglyceridemia A condition of elevated levels of TRIGLYCERIDES in the blood.	2	1

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