Compounds > calotropin
Page last updated: 2024-12-05

calotropin

Description

calotropin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16142
CHEMBL ID495949
CHEBI ID3329
SCHEMBL ID868547
MeSH IDM0542745

Synonyms (16)

Synonym
card-20(22)-enolide, 14-hydroxy-19-oxo-3,2-((tetrahydro-3,4-dihydroxy-6-methyl-2h-pyran-2,3-diyl)bis(oxy))-, (2alpha(2s,4s,6r),3beta,5alpha)-
calotropin
C08855
1986-70-5
chebi:3329 ,
CHEMBL495949
3xk21u1bzs ,
unii-3xk21u1bzs
calotropin [mi]
(2.alpha.,3.beta.,5.alpha.)-14-hydroxy-19-oxo-2,3-(((2s,3s,4s,6r)-tetrahydro-3,4-dihydroxy-6-methyl-2h-pyran-3,2-diyl)bis(oxy))card-20(22)-enolide
card-20(22)-enolide, 14-hydroxy-19-oxo-2,3-(((2s,3s,4s,6r)-tetrahydro-3,4-dihydroxy-6-methyl-2h-pyran-3,2-diyl)bis(oxy))-, (2.alpha.,3.beta.,5.alpha.)-
SCHEMBL868547
DTXSID10173613
Q27106025
bdbm50277173
(1s,3r,5s,7r,9s,10s,12r,14r,15s,18r,19r,22s,23r)-9,10,22-trihydroxy-7,18-dimethyl-19-(5-oxo-2h-furan-3-yl)-4,6,11-trioxahexacyclo[12.11.0.03,12.05,10.015,23.018,22]pentacosane-14-carbaldehyde

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"This study revealed the ATP binding mode of KATNAL1 and identified calotropin as a potential lead molecule against it showing high binding efficiency with good bioavailability and no mutagenicity."( Molecular Modeling and Dynamics Simulation Analysis of KATNAL1 for Identification of Novel Inhibitor of Sperm Maturation.
Bora, SS; Das, R; Das, S; Deb, B; Dehury, B; Dohutia, C; Modi, MK; Nath, S; Parida, P; Roychoudhury, S; Sarma, K, 2017)		0.69
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
cardenolide glycosideAny member of the class of cardenolides with glycosyl residues attached to position 3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neurogenic locus notch homolog protein 1Homo sapiens (human)IC50 (µMol)0.80000.80000.80000.8000AID1500975
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (159)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IINeurogenic locus notch homolog protein 1Homo sapiens (human)
luteolysisNeurogenic locus notch homolog protein 1Homo sapiens (human)
in utero embryonic developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
epithelial to mesenchymal transitionNeurogenic locus notch homolog protein 1Homo sapiens (human)
liver developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
heart loopingNeurogenic locus notch homolog protein 1Homo sapiens (human)
sprouting angiogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of neuroblast proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
inhibition of neuroepithelial cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
inflammatory response to antigenic stimulusNeurogenic locus notch homolog protein 1Homo sapiens (human)
outflow tract morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
endocardium developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
endocardium morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
atrioventricular node developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
coronary vein morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
aortic valve morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
atrioventricular valve morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
coronary sinus valve morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
pulmonary valve morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
mitral valve formationNeurogenic locus notch homolog protein 1Homo sapiens (human)
epithelial to mesenchymal transition involved in endocardial cushion formationNeurogenic locus notch homolog protein 1Homo sapiens (human)
endocardial cushion morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac chamber formationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac ventricle morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac atrium morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac right atrium morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac left ventricle morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac right ventricle formationNeurogenic locus notch homolog protein 1Homo sapiens (human)
ventricular trabecula myocardium morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
growth involved in heart morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cell proliferation involved in heart valve morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cell migration involved in endocardial cushion formationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of extracellular matrix constituent secretionNeurogenic locus notch homolog protein 1Homo sapiens (human)
pericardium morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
regulation of DNA-templated transcriptionNeurogenic locus notch homolog protein 1Homo sapiens (human)
regulation of transcription by RNA polymerase IINeurogenic locus notch homolog protein 1Homo sapiens (human)
transcription by RNA polymerase IINeurogenic locus notch homolog protein 1Homo sapiens (human)
protein import into nucleusNeurogenic locus notch homolog protein 1Homo sapiens (human)
immune responseNeurogenic locus notch homolog protein 1Homo sapiens (human)
humoral immune responseNeurogenic locus notch homolog protein 1Homo sapiens (human)
Notch signaling pathwayNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of transcription of Notch receptor targetNeurogenic locus notch homolog protein 1Homo sapiens (human)
spermatogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
determination of left/right symmetryNeurogenic locus notch homolog protein 1Homo sapiens (human)
compartment pattern specificationNeurogenic locus notch homolog protein 1Homo sapiens (human)
foregut morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
endoderm developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
heart developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of cell population proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cell population proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
auditory receptor cell fate commitmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
epidermal cell fate specificationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cardiac muscle hypertrophyNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of gene expressionNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of gene expressionNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cell-substrate adhesionNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of myotube differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
mesenchymal cell developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
regulation of somitogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
calcium-ion regulated exocytosisNeurogenic locus notch homolog protein 1Homo sapiens (human)
cell differentiation in spinal cordNeurogenic locus notch homolog protein 1Homo sapiens (human)
neural tube developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
protein catabolic processNeurogenic locus notch homolog protein 1Homo sapiens (human)
keratinocyte differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of ossificationNeurogenic locus notch homolog protein 1Homo sapiens (human)
lung developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of cell migrationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of BMP signaling pathwayNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of BMP signaling pathwayNeurogenic locus notch homolog protein 1Homo sapiens (human)
forebrain developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
hair follicle morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
animal organ regenerationNeurogenic locus notch homolog protein 1Homo sapiens (human)
response to muramyl dipeptideNeurogenic locus notch homolog protein 1Homo sapiens (human)
response to lipopolysaccharideNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of collagen biosynthetic processNeurogenic locus notch homolog protein 1Homo sapiens (human)
embryonic hindlimb morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
tube formationNeurogenic locus notch homolog protein 1Homo sapiens (human)
skeletal muscle cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulusNeurogenic locus notch homolog protein 1Homo sapiens (human)
tissue regenerationNeurogenic locus notch homolog protein 1Homo sapiens (human)
retinal cone cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of catalytic activityNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of viral genome replicationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of endothelial cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of inner ear auditory receptor cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of keratinocyte differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of myoblast differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of osteoblast differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of Notch signaling pathwayNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of DNA-templated transcriptionNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of DNA-templated transcriptionNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IINeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of calcium ion-dependent exocytosisNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STATNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of photoreceptor cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of Ras protein signal transductionNeurogenic locus notch homolog protein 1Homo sapiens (human)
somatic stem cell divisionNeurogenic locus notch homolog protein 1Homo sapiens (human)
astrocyte differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
oligodendrocyte differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of astrocyte differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of oligodendrocyte differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
branching morphogenesis of an epithelial tubeNeurogenic locus notch homolog protein 1Homo sapiens (human)
homeostasis of number of cells within a tissueNeurogenic locus notch homolog protein 1Homo sapiens (human)
epithelial cell proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of epithelial cell proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of epithelial cell proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of neurogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of smooth muscle cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac muscle tissue morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac muscle cell proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of cardiac muscle cell proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of glial cell proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cilium assemblyNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac epithelial to mesenchymal transitionNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cell adhesion molecule productionNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac muscle cell myoblast differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac septum morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
ventricular septum morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
prostate gland epithelium morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
regulation of epithelial cell proliferation involved in prostate gland developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
arterial endothelial cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
venous endothelial cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cardiac vascular smooth muscle cell developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
endocardial cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
vasculogenesis involved in coronary vascular morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
coronary artery morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
neuroendocrine cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
regulation of cell adhesion involved in heart morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
heart trabecula morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of cardiac epithelial to mesenchymal transitionNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of biomineral tissue developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeNeurogenic locus notch homolog protein 1Homo sapiens (human)
left/right axis specificationNeurogenic locus notch homolog protein 1Homo sapiens (human)
cellular response to tumor cellNeurogenic locus notch homolog protein 1Homo sapiens (human)
cellular response to follicle-stimulating hormone stimulusNeurogenic locus notch homolog protein 1Homo sapiens (human)
cellular response to hypoxiaNeurogenic locus notch homolog protein 1Homo sapiens (human)
distal tubule developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
collecting duct developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
regulation of stem cell proliferationNeurogenic locus notch homolog protein 1Homo sapiens (human)
glomerular mesangial cell developmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
epithelial cell fate commitmentNeurogenic locus notch homolog protein 1Homo sapiens (human)
T-helper 17 type immune responseNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cell migration involved in sprouting angiogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of canonical Wnt signaling pathwayNeurogenic locus notch homolog protein 1Homo sapiens (human)
neuronal stem cell population maintenanceNeurogenic locus notch homolog protein 1Homo sapiens (human)
interleukin-17-mediated signaling pathwayNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
regulation of extracellular matrix assemblyNeurogenic locus notch homolog protein 1Homo sapiens (human)
apoptotic process involved in embryonic digit morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of apoptotic process involved in morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
positive regulation of aorta morphogenesisNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of cell-cell adhesion mediated by cadherinNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of stem cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of anoikisNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of pro-B cell differentiationNeurogenic locus notch homolog protein 1Homo sapiens (human)
negative regulation of endothelial cell chemotaxisNeurogenic locus notch homolog protein 1Homo sapiens (human)
axon guidanceNeurogenic locus notch homolog protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Processvia Protein(s)Taxonomy
cis-regulatory region sequence-specific DNA bindingNeurogenic locus notch homolog protein 1Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificNeurogenic locus notch homolog protein 1Homo sapiens (human)
transcription coactivator activityNeurogenic locus notch homolog protein 1Homo sapiens (human)
enzyme inhibitor activityNeurogenic locus notch homolog protein 1Homo sapiens (human)
transmembrane signaling receptor activityNeurogenic locus notch homolog protein 1Homo sapiens (human)
Notch bindingNeurogenic locus notch homolog protein 1Homo sapiens (human)
calcium ion bindingNeurogenic locus notch homolog protein 1Homo sapiens (human)
protein bindingNeurogenic locus notch homolog protein 1Homo sapiens (human)
enzyme bindingNeurogenic locus notch homolog protein 1Homo sapiens (human)
chromatin DNA bindingNeurogenic locus notch homolog protein 1Homo sapiens (human)
identical protein bindingNeurogenic locus notch homolog protein 1Homo sapiens (human)
transcription regulator activator activityNeurogenic locus notch homolog protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
Golgi membraneNeurogenic locus notch homolog protein 1Homo sapiens (human)
acrosomal vesicleNeurogenic locus notch homolog protein 1Homo sapiens (human)
extracellular regionNeurogenic locus notch homolog protein 1Homo sapiens (human)
nucleusNeurogenic locus notch homolog protein 1Homo sapiens (human)
nucleoplasmNeurogenic locus notch homolog protein 1Homo sapiens (human)
endoplasmic reticulum membraneNeurogenic locus notch homolog protein 1Homo sapiens (human)
cytosolNeurogenic locus notch homolog protein 1Homo sapiens (human)
plasma membraneNeurogenic locus notch homolog protein 1Homo sapiens (human)
adherens junctionNeurogenic locus notch homolog protein 1Homo sapiens (human)
endosome membraneNeurogenic locus notch homolog protein 1Homo sapiens (human)
apical plasma membraneNeurogenic locus notch homolog protein 1Homo sapiens (human)
MAML1-RBP-Jkappa- ICN1 complexNeurogenic locus notch homolog protein 1Homo sapiens (human)
receptor complexNeurogenic locus notch homolog protein 1Homo sapiens (human)
cell surfaceNeurogenic locus notch homolog protein 1Homo sapiens (human)
plasma membraneNeurogenic locus notch homolog protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID403697Cytotoxicity against human MCF7 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID1674393Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay
AID1674397Inhibition of porcine cerebral cortex Na+/K+-ATPase after 15 mins by ADP-Glo reagent based assay
AID1674396Selectivity index, ratio of IC50 for human MDA-MB-231 cells to IC50 for human BT-549 cells
AID403695Cytotoxicity against human A549 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID403698Cytotoxicity against human HepG2 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID1557488Antiproliferative activity against human DU145 cells assessed as reduction in viability after 48 hrs by MTTS assay2019Journal of natural products, 03-22, Volume: 82, Issue:3
Potential Anticancer Agents Characterized from Selected Tropical Plants.
AID1674399Induction of intracellular Ca2+ concentration in human BT-549 cells at 150 nM after 2 hrs by Cal520-AM dye-based fluorescence assay relative to control
AID1674400Induction of intracellular Ca2+ concentration in human MDA-MB-231 cells at 150 nM after 2 hrs by Cal520-AM dye-based fluorescence assay
AID1674386Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
AID1654143Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by WST-8 assay
AID1500975Inhibition of recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) expressed in human LS174T cells assessed as reduction in doxycycline-induced NICD expression after 12 hrs by Bright-Glo luciferase reporter gene assay2017Journal of natural products, 09-22, Volume: 80, Issue:9
Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells.
AID1674398Induction of intracellular Ca2+ concentration in human BT-549 cells at 150 to 500 nM after 3 hrs by Cal520-AM dye-based fluorescence assay
AID403696Cytotoxicity against human MDA-MB-231 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID403699Cytotoxicity against human KB cells2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID418024Cytotoxicity against human Raji cells by MTT assay2009Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.
AID1674387Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay
AID378431Cytotoxicity against human KB cells by SRB assay2006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
AID378432Cytotoxicity against human BC cells by SRB assay2006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
AID1500979Effect on gamma-secretase activity in human LS174T cells harboring mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) after 12 hrs by Western blot analysis2017Journal of natural products, 09-22, Volume: 80, Issue:9
Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells.
AID378437Antimalarial activity after 48 hrs against multidrug-resistant Plasmodium falciparum K12006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
AID418023Cytotoxicity against human HepG2 cells by MTT assay2009Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.
AID1654142Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay
AID378433Cytotoxicity against human NCI-H187 cells by SRB assay2006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.26)18.7374
1990's0 (0.00)18.2507
2000's4 (21.05)29.6817
2010's10 (52.63)24.3611
2020's4 (21.05)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.54 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.75 (4.65)
Search Engine Demand Index47.56 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0310indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
parthenolide
[no description available]		3.3110germacranolide
cannogenol-3-o-beta-d-allomethyloside
cannogenol-3-O-beta-D-allomethyloside: cardenolide from Convallaria majalis L.; structure in first source		2.1310
justicidin a
justicidins: from Justica procumbens		3.3110lignan
sitosterol, (3beta)-isomer
Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.		3.31103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol		anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor
digitoxin
Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.		3.3110cardenolide glycosideEC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
Calactin
[no description available]		2.4320cardenolide glycoside
digitoxigenin
Digitoxigenin: 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. A cardenolide which is the aglycon of digitoxin. Synonyms: Cerberigenin; Echujetin; Evonogenin; Thevetigenin.. digitoxigenin : A 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22).		2.743014beta-hydroxy steroid;
3beta-hydroxy steroid
amentoflavone
[no description available]		3.3110biflavonoid;
hydroxyflavone;
ring assembly		angiogenesis inhibitor;
antiviral agent;
cathepsin B inhibitor;
P450 inhibitor;
plant metabolite
chrysosplenetin b
chrysosplenetin B: constituent of the root of Berneuxia thibetica Decne. chrysosplenetin : A tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin.		3.3110dihydroxyflavone;
tetramethoxyflavone		antiviral agent;
plant metabolite
euxanthone
euxanthone : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense.		3.3110phenols;
xanthones		metabolite;
plant metabolite
mangostin
mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.		3.3110aromatic ether;
phenols;
xanthones		antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester
DAPT : A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor.		2.1510carboxylic ester;
difluorobenzene;
dipeptide;
tert-butyl ester		EC 3.4.23.46 (memapsin 2) inhibitor
furanoheliangolide
furanoheliangolide: structure in first source		3.3110
artonin e
artonin E: structure given in first source; isolated from the bark of Artocarpus communis Forst.		3.3110
gambogic acid
gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer		3.3110pyranoxanthonesmetabolite
morelloflavone
morelloflavone: also inhibits cruzain; RN given for (2S-trans)-isomer; structure in first source. (+)-morelloflavone : A biflavonoid found in Rheedia edulis and Garcinia livingstonei.		3.3110biflavonoid;
hydroxyflavanone;
hydroxyflavone		plant metabolite
15-deoxygoyazensolide
15-deoxygoyazensolide: an NSAID with schistossomicidal and trypanosomicidal activities; structure in first source		3.3110
lychnopholide
lychnopholide: isolated from Vanillosmopsis erythropappa; structure in first source		3.3110
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma, Non-Small Cell Lung
[description not available]		02.1710
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1710
Cancer of Lung
[description not available]		02.1710
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.1710
Lung Neoplasms
Tumors or cancer of the LUNG.		02.1710
Cancer of Colon
[description not available]		02.110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.110
Cancer of Prostate
[description not available]		02.110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.110
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