Compounds > di-allate
Page last updated: 2024-11-10

di-allate

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Description

di-allate: RN given refers to cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5284376
CHEMBL ID2252931
CHEBI ID82216
SCHEMBL ID116715
MeSH IDM0045904

Synonyms (81)

Synonym
carbamothioic acid, bis(1-methylethyl)-, s-(2,3-dichloro-2-propenyl) ester
diallate
2303-16-4
hsdb 3431
carbamic acid, diisopropylthio-, s-(2,3-dichloroallyl) ester, (z)-
carbamic acid, diisopropylthio-, s-(2,3-dichloroallyl)ester, (z)-
cis-diallate
carbamothioic acid, bis(1-methylethyl)-, s-(2,3-dichloro-2-propenyl) ester, (z)-
diallaat [dutch]
s-2,3-dichloroallyl n,n-diisopropylthiolcarbamate
2,3-dichloro-2-propene-1-thiol, diisopropylcarbamate
2,3-dcdt
di-allate [bsi:iso]
rcra waste number u062
dichloroallyl diisopropylthiocarbamate
hsdb 1566
2,3-dichlorallyl-n,n-(diisopropyl)-thiocarbamat [german]
ccris 198
einecs 218-961-1
pyradex
rcra waste no. u062
brn 2210954
carbamic acid, diisopropylthio-, s-(2,3-dichloroallyl) ester
2,3-dichloroallyl n,n-diisopropylthiolcarbamate
s-(2,3-dichloro-2-propenyl) bis(1-methylethyl)carbamothioate
diisopropylthiocarbamic acid, s-(2,3-dichloroallyl) ester
avadex
diallate [iso-french]
bis(1-methylethyl)carbamothioic acid, s-(2,3-dichloro-2-propenyl) ester
s-(2,3-dichloro-allil)-n,n-diisopropil-monotiocarbammato [italian]
diallat [german]
epa pesticide chemical code 078801
di-isopropylthiolocarbamate de s-(2,3-dichloro allyle) [french]
s-(2,3-dichlor-allyl)-n,n-diisopropyl-monothiocarbamaat [dutch]
s-2,3-dichloroallyl diisopropylthiocarbamate
cp 15,336
di-allate
2-propene-1-thiol, 2,3-dichloro-, diisopropylcarbamate
caswell no. 299
bis(1-methylethyl) carbamothioic acid, s-(2,3-dichloro-2-propenyl)ester
NCGC00248775-01
C19094
diallat
carbamothioic acid, bis(1-methylethyl)-, s-((2z)-2,3-dichloro-2-propenyl) ester
0r9v496q48 ,
17708-57-5
unii-0r9v496q48
s-(2,3-dichlor-allyl)-n,n-diisopropyl-monothiocarbamaat
77003ki5vj ,
diallaat
di-isopropylthiolocarbamate de s-(2,3-dichloro allyle)
s-(2,3-dichloro-allil)-n,n-diisopropil-monotiocarbammato
unii-77003ki5vj
2,3-dichlorallyl-n,n-(diisopropyl)-thiocarbamat
dtxsid2020391 ,
tox21_200642
cas-2303-16-4
dtxcid40391
NCGC00258196-01
AKOS015898747
chebi:82216 ,
CHEMBL2252931
cis-diallate [hsdb]
diallate, z-
datc, z-
diallate, (z)-
2,3-dichloro-2-propene-1-thiol, z-
2,3-dichloro-2z-propene-1-thiol
SCHEMBL116715
s-(2,3-dichloroallyl) diisopropylthiocarbamate
DTXSID8058326
SPANOECCGNXGNR-UHFFFAOYSA-N
diallate i
2,3-dichlorallyl-n,n-(diisopropyl)-thiocarbamate
s-[2,3-dichloro-2-propenyl] diisopropylthiocarbamate #
cp 15336
SPANOECCGNXGNR-UITAMQMPSA-N
bdbm50487033
(z)-diallate
Q1208433
carbamothioic acid, n,n-bis(1-methylethyl)-, s-(2,3-dichloro-2-propen-1-yl) ester

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"Two allylthiocarbamate herbicides, diallate and triallate, were evaluated for neurotoxicity by oral and topical dosing studies with mature white leghorn hens."( Neurotoxicity of diallate and triallate when administered orally or topically to hens.
Francis, BM; Hansen, LG; Metcalf, RL; Reinders, JH, 1985)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
tertiary amineA compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (15)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency9.74770.006038.004119,952.5996AID1159521
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency77.42860.001022.650876.6163AID1224838
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency61.50380.003041.611522,387.1992AID1159552
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency27.47270.001530.607315,848.9004AID1224848; AID1224849
pregnane X nuclear receptorHomo sapiens (human)Potency21.82240.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency49.30190.000229.305416,493.5996AID743069; AID743075
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency9.74770.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency16.10080.001628.015177.1139AID1224843; AID1224895
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency39.161919.739145.978464.9432AID1159509
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency49.30190.057821.109761.2679AID1159528
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency43.58810.000323.4451159.6830AID743065; AID743067
Cellular tumor antigen p53Homo sapiens (human)Potency24.48510.002319.595674.0614AID651631
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency34.58610.011917.942071.5630AID651632
Ataxin-2Homo sapiens (human)Potency34.58610.011912.222168.7989AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Photosystem II protein D1Spinacia oleracea (spinach)IC50 (µMol)87.50000.06500.48491.9000AID1090450; AID1090458
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (141)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (26)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID1090460Inhibition of Spinacia oleracea (spinach) photosystem I assessed as electron flow from ascorbate/DAD to methylviologen at >200 uM after 1 hr by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090449Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated PMS-induced cyclic phosphorylation by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090421Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated rate of oxygen evolution per mg of chloroplast at 125 uM preincubated with DTT in dark condition for 5 min presence of 0.31 mM DTT1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090446Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated PMS-induced cyclic phosphorylation at 50 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090441Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated DAD-induced cyclic phosphorylation at 50 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090439Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated DAD-induced cyclic phosphorylation at 200 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090455Inhibition of Spinacia oleracea (spinach) photosystem II assessed as light-induced re-reduction of Cyt-f at 100 uM added prior to illumination by dual wavelength spectrophotometer analysis1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090430Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated light-induced ATP-Pi exchange assessed as inorganic phosphate release at 200 uM treated during incubation stage1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090442Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated DAD-induced cyclic phosphorylation at 25 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090447Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated PMS-induced cyclic phosphorylation at 25 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090428Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated sulfhydryl-induced ATP-Pi exchange assessed as inorganic phosphate release at 200 uM treated during incubation stage1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090432Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated sulfhydryl-induced ATP-Pi exchange assessed as inorganic phosphate release at 200 uM1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090445Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated PMS-induced cyclic phosphorylation at 100 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090431Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated light-induced ATP-Pi exchange assessed as inorganic phosphate release at 200 uM treated during activation stage1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090450Inhibition of Spinacia oleracea (spinach) photosystem II mediated noncyclic photophosphorylation assessed as 32P-orthophosphate incorporation into ATP by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090463Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain assessed as electron flow from water to ferricyanide by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090422Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated rate of oxygen evolution per mg of chloroplast at 125 uM1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090435Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated light-induced ATP-Pi exchange assessed as inorganic phosphate release1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090458Inhibition of Spinacia oleracea (spinach) photosystem II assessed as electron flow from H20 to PDOX after 1 hr by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090443Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated DAD-induced cyclic phosphorylation at 10 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090448Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated PMS-induced cyclic phosphorylation at 10 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090429Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated Mg2+-ATPase activity assessed as inorganic phosphate release1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090434Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated sulfhydryl-induced ATP-Pi exchange assessed as inorganic phosphate release1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090453Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated noncyclic photophosphorylation assessed as 32P-orthophosphate incorporation into ATP by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090425Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated rate of oxygen evolution per mg of chloroplast at 62.5 uM1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090426Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated rate of oxygen evolution per mg of chloroplast at 62.5 uM in presence of 0.31 mM DTT1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090459Inhibition of Spinacia oleracea (spinach) photosystem II assessed as electron flow from H20 to PDOX at 300 uM after 1 hr by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090454Inhibition of Spinacia oleracea (spinach) photosystem I assessed as light-induced oxidation of Cyt-f at 100 uM added prior to illumination by dual wavelength spectrophotometer analysis1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090440Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated DAD-induced cyclic phosphorylation at 100 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090427Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated sulfhydryl-induced ATP-Pi exchange assessed as inorganic phosphate release at 200 uM treated during activation stage1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090444Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated PMS-induced cyclic phosphorylation at 200 uM by polarographically1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090423Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated rate of oxygen evolution per mg of chloroplast at 125 uM in presence of 0.31 mM DTT1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
AID1090433Inhibition of Spinacia oleracea (spinach) chloroplast electron transport chain-mediated light-induced ATP-Pi exchange assessed as inorganic phosphate release at 200 uM1977Plant physiology, Dec, Volume: 60, Issue:6
Inhibition of chloroplast electron transport reactions by trifluralin and diallate.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (78.57)18.7374
1990's2 (14.29)18.2507
2000's0 (0.00)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.33 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorpyrifos
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.		1.9510chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
ether
Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.		1.9610ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant
methyl methanesulfonate
[no description available]		1.9610methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
triallate
Triallate: A pre-emergence, selective herbicide for the control of wild oats in various crops.		3.2160tertiary amine
trifluralin
Trifluralin: A microtubule-disrupting pre-emergence herbicide.. trifluralin : A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.		6.9510(trifluoromethyl)benzenes;
C-nitro compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
2-acetylaminofluorene
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.		1.96102-acetamidofluorenesantimitotic;
carcinogenic agent;
epitope;
mutagen
propane
Propane: A three carbon alkane with the formula H3CCH2CH3.		1.9610alkane;
gas molecular entity		food propellant
propyleneimine
[no description available]		1.9610aziridines
cdec
CDEC: structure		1.9610thiocarbonyl compound
alpha-chlorohydrin
alpha-Chlorohydrin: A chlorinated PROPANEDIOL with antifertility activity in males used as a chemosterilant in rodents.. 3-chloropropane-1,2-diol : A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.		1.9610chloropropane-1,2-diol
ethylene carbonate
[no description available]		1.9610carbonate ester
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		1.9610mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
bis(2-chloroethyl)ether
bis(2-chloroethyl)ether: structure		1.9610ether
ditiocarb
Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.		1.9610dithiocarbamic acidschelator;
copper chelator
vinylene carbonate
[no description available]		1.9610
1,3-propane sultone
1,3-propane sultone: sultone is usually defined as a derivative of 1,8-naphtholsulfonic acid; structure		1.9610sultone
sodium bisulfide
sodium bisulfide: RN given refers to sodium sulfide (Na(SH)); see also record for sodium sulfide (Na2S)		1.9610
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		1.9610inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		1.9610pseudohalide anionmitochondrial respiratory-chain inhibitor
ethylenethiourea
Ethylenethiourea: A degradation product of ethylenebis(dithiocarbamate) fungicides. It has been found to be carcinogenic and to cause THYROID hyperplasia.		1.9610imidazolidines
thiosemicarbazide
thiosemicarbazide: glutamate decarboxylase antagonist; structure given in first source. hydrazinecarbothioamide : A member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group.		1.9610hydrazines;
thiocarboxamide;
thioureas
nadp
[no description available]		1.9610
rubeanic acid
rubeanic acid: indicator for copper, cobalt, & nickel; structure		1.9610
methylnitronitrosoguanidine
Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position		1.9610nitroso compoundalkylating agent
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L5178
An experimental lymphocytic leukemia of mice.		01.9610
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		01.9610
Abnormalities, Autosome
[description not available]		01.9610
Arrhythmia
[description not available]		02.910
Hepatitis B Virus Infection
[description not available]		02.910
Arrhythmias, Cardiac
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.		02.910
Hepatitis B
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		02.910
Cancer of Lung
[description not available]		01.9910
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9910
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9610
Ataxia
Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.		01.9610
Nervous System Disorders
[description not available]		01.9610
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.		01.9610