Compounds > haliclonadiamine
Page last updated: 2024-11-12

haliclonadiamine

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Description

haliclonadiamine: from an Indonesian sponge Haliclona sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10316977
CHEMBL ID2177349
MeSH IDM0590421

Synonyms (4)

Synonym
haliclonadiamine
chembl2177349 ,
bdbm50398326
(1s,2e,4e,6s,7r,12s,14s,20r,22s,27r)-15,19-diazapentacyclo[18.7.0.06,14.07,12.022,27]heptacosa-2,4-diene
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Endothelial PAS domain-containing protein 1Homo sapiens (human)EC50 (µMol)14.80000.02000.93303.3000AID707849
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Processvia Protein(s)Taxonomy
response to hypoxiaEndothelial PAS domain-containing protein 1Homo sapiens (human)
angiogenesisEndothelial PAS domain-containing protein 1Homo sapiens (human)
embryonic placenta developmentEndothelial PAS domain-containing protein 1Homo sapiens (human)
blood vessel remodelingEndothelial PAS domain-containing protein 1Homo sapiens (human)
regulation of heart rateEndothelial PAS domain-containing protein 1Homo sapiens (human)
epithelial cell maturationEndothelial PAS domain-containing protein 1Homo sapiens (human)
response to oxidative stressEndothelial PAS domain-containing protein 1Homo sapiens (human)
mitochondrion organizationEndothelial PAS domain-containing protein 1Homo sapiens (human)
signal transductionEndothelial PAS domain-containing protein 1Homo sapiens (human)
visual perceptionEndothelial PAS domain-containing protein 1Homo sapiens (human)
erythrocyte differentiationEndothelial PAS domain-containing protein 1Homo sapiens (human)
lung developmentEndothelial PAS domain-containing protein 1Homo sapiens (human)
norepinephrine metabolic processEndothelial PAS domain-containing protein 1Homo sapiens (human)
mRNA transcription by RNA polymerase IIEndothelial PAS domain-containing protein 1Homo sapiens (human)
surfactant homeostasisEndothelial PAS domain-containing protein 1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IIEndothelial PAS domain-containing protein 1Homo sapiens (human)
myoblast fate commitmentEndothelial PAS domain-containing protein 1Homo sapiens (human)
multicellular organismal-level iron ion homeostasisEndothelial PAS domain-containing protein 1Homo sapiens (human)
cellular response to hypoxiaEndothelial PAS domain-containing protein 1Homo sapiens (human)
positive regulation of cold-induced thermogenesisEndothelial PAS domain-containing protein 1Homo sapiens (human)
regulation of protein neddylationEndothelial PAS domain-containing protein 1Homo sapiens (human)
regulation of transcription by RNA polymerase IIEndothelial PAS domain-containing protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Processvia Protein(s)Taxonomy
sequence-specific DNA bindingEndothelial PAS domain-containing protein 1Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingEndothelial PAS domain-containing protein 1Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificEndothelial PAS domain-containing protein 1Homo sapiens (human)
transcription coactivator bindingEndothelial PAS domain-containing protein 1Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificEndothelial PAS domain-containing protein 1Homo sapiens (human)
protein bindingEndothelial PAS domain-containing protein 1Homo sapiens (human)
protein heterodimerization activityEndothelial PAS domain-containing protein 1Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingEndothelial PAS domain-containing protein 1Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA bindingEndothelial PAS domain-containing protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
nucleoplasmEndothelial PAS domain-containing protein 1Homo sapiens (human)
cytosolEndothelial PAS domain-containing protein 1Homo sapiens (human)
nuclear speckEndothelial PAS domain-containing protein 1Homo sapiens (human)
chromatinEndothelial PAS domain-containing protein 1Homo sapiens (human)
transcription regulator complexEndothelial PAS domain-containing protein 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (35)

Assay IDTitleYearJournalArticle
AID707682Cytotoxicity against human SK-RC-28 cells expressing HIF1alpha after 2 days by XTT assay2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707415Downregulation of HIF1alpha mRNA expression in human 786-0 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707400Downregulation of TGFalpha mRNA expression in human SK-RC-28 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707407Downregulation of HIF1alpha mRNA expression in human RCC4 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707408Inhibition of HIF1alpha/2alpha in human RCC4 cells assessed as reduction in VEGFA mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID1225345Cytotoxicity against human UO31 cells after 48 hrs by XTT assay2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua.
AID707845Inhibition of total protein expression in serum deprived human 786-0 cells at 20 uM after 48 hrs relative to control2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707405Downregulation of HIF2alpha mRNA expression in human RCC4 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707395Downregulation of actin mRNA expression in human 786-0 cells expressing HIF1alpha at 21 uM after 48 hrs by RT-PCr analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707849Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707417Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in CCND1 mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707410Inhibition of HIF2alpha in human RCC4 cells coexpressing HIF1alpha assessed as reduction in GLUT1 mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707396Downregulation of HIF2alpha mRNA expression in human SK-RC-28 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707391Downregulation of actin mRNA expression in human SK-RC-28 cells expressing HIF2alpha at 21 uM after 48 hrs by RT-PCr analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707401Inhibition of HIF1alpha in human SK-RC-28 cells assessed as reduction in VEGFA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707409Inhibition of HIF2alpha in human RCC4 cells coexpressing HIF1alpha assessed as reduction in CCND1 mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707847Inhibition of HIF-mediated VEGFA protein expression in serum deprived human 786-0 cells at 21 uM after 48 hrs relative to control2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID1225347Cytotoxicity against human SF295 cells after 48 hrs by XTT assay2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua.
AID1635082Antimycobacterial activity against Mycobacterium smegmatis NBRC 3207 at 10 ug/disc after 2 days by paper disc method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island.
AID1635084Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by WST-1 assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island.
AID707416Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in VEGFA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707393Downregulation of actin mRNA expression in human RCC4 cells expressing HIF1alpha and HIF2alpha at 21 uM after 48 hrs by RT-PCr analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707397Downregulation of HIF1alpha mRNA expression in human SK-RC-28 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707403Inhibition of HIF1alpha in human SK-RC-28 cells assessed as reduction in carbonic anhydrase 9 expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID1225346Cytotoxicity against human A498 cells after 48 hrs by XTT assay2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua.
AID707411Inhibition of HIF2alpha in human RCC4 cells coexpressing HIF1alpha assessed as reduction in TGFalpha mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707418Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in GLUT1 mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707414Downregulation of HIF2alpha mRNA expression in human 786-0 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707841Cytotoxicity against human RCC4 cells expressing HIF2alpha and HIF1alpha after 2 days by XTT assay2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707399Downregulation of GLUT1 mRNA expression in human SK-RC-28 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707398Downregulation of CCND1 mRNA expression in human SK-RC-28 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707842Cytotoxicity against human 786-0 cells expressing HIF2alpha after 2 days by XTT assay2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707420Downregulation of carbonic anhydrase 9 expression in human 786-0 cells at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707413Inhibition of HIF1alpha in human RCC4 cells coexpressing HIF2alpha assessed as decrease in carbonic anhydrase 9 mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707419Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in TGFalpha mRNA expression at 21 uM after 48 hrs by RT-PCR analysis2012Journal of natural products, Sep-28, Volume: 75, Issue:9
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
guanidine
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.		2.1310carboxamidine;
guanidines;
one-carbon compound
puupehenone
[no description available]		2.0710
aaptamine
aaptamine: natural product from sea sponge Aaptos aaptos; structure given in first source; RN from CA Index Guide 1984		2.0710
xestoquinone
xestoquinone: structure given in first source; RN given refers to the (S)-isomer; RN for cpd without isomeric designation not available 5/91; isolated from the sea sponge Xestospongia sapra		2.0710
variolin b
variolin B: from Antartic sponge, Kirkpatrickia variolosa; structure in first source		2.0710
papuamine
papuamine: antineoplastic from an Indonesian sponge Haliclona sp.; structure in first source		7.830
monanchorin
monanchorin: a bicyclic alkaloid from the sponge Monanchora ungiculata; structure in first source		7.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Kidney
[description not available]		02.0710
Kidney Neoplasms
Tumors or cancers of the KIDNEY.		02.0710
Hepatocellular Carcinoma
[description not available]		02.1310
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.1310