cholenic acid dimethylamide profile

cholenic acid dimethylamide: binds LXRalpha receptor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	24768125
CHEMBL ID	352837
SCHEMBL ID	13366259
MeSH ID	M0385353

Synonym
cholenic acid dimethylamide
(4r)-4-[(1s,2r,5s,10s,11s,14r,15r)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadec-7-en-14-yl]-n,n-dimethylpentanamide
bdbm20186
CHEMBL352837
SCHEMBL13366259
dmhca
MS-26842
(3.beta.)-3-hydroxy-n,n-dimethyl-chol-5-en-24-amide
HY-129098
CS-0103576
(4r)-4-[(3s,8s,9s,10r,13r,14s,17r)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl]-n,n-dimethylpentanamide
(3beta)-3-hydroxy-n,n-dimethyl-chol-5-en-24-amide
AKOS040758351

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Delta(24)-sterol reductase	Homo sapiens (human)	IC50 (µMol)	0.0007	0.0007	0.0007	0.0007	AID1502695
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Oxysterols receptor LXR-alpha	Homo sapiens (human)	EC50 (µMol)	0.2540	0.0001	0.6302	6.7100	AID101835; AID1414113; AID1797959
Oxysterols receptor LXR-beta	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.1240	0.0300	0.0770	0.1240	AID1542682
NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)	EC50 (µMol)	3.1000	1.7000	3.5250	8.7000	AID1179742
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Delta(24)-sterol reductase	Homo sapiens (human)	INH	1.0000	1.0000	1.0000	1.0000	AID1502693
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of transcription by RNA polymerase II	Oxysterols receptor LXR-alpha	Homo sapiens (human)
hormone-mediated signaling pathway	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of macrophage derived foam cell differentiation	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of triglyceride biosynthetic process	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of cholesterol efflux	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of cholesterol storage	Oxysterols receptor LXR-alpha	Homo sapiens (human)
intracellular receptor signaling pathway	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of lipid transport	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of cholesterol transport	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of transporter activity	Oxysterols receptor LXR-alpha	Homo sapiens (human)
response to progesterone	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of toll-like receptor 4 signaling pathway	Oxysterols receptor LXR-alpha	Homo sapiens (human)
phosphatidylcholine acyl-chain remodeling	Oxysterols receptor LXR-alpha	Homo sapiens (human)
cholesterol homeostasis	Oxysterols receptor LXR-alpha	Homo sapiens (human)
regulation of circadian rhythm	Oxysterols receptor LXR-alpha	Homo sapiens (human)
mRNA transcription by RNA polymerase II	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of macrophage activation	Oxysterols receptor LXR-alpha	Homo sapiens (human)
apoptotic cell clearance	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of fatty acid biosynthetic process	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of proteolysis	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of DNA-templated transcription	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of lipid biosynthetic process	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of pinocytosis	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of inflammatory response	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of lipoprotein lipase activity	Oxysterols receptor LXR-alpha	Homo sapiens (human)
positive regulation of protein metabolic process	Oxysterols receptor LXR-alpha	Homo sapiens (human)
lipid homeostasis	Oxysterols receptor LXR-alpha	Homo sapiens (human)
sterol homeostasis	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of type II interferon-mediated signaling pathway	Oxysterols receptor LXR-alpha	Homo sapiens (human)
triglyceride homeostasis	Oxysterols receptor LXR-alpha	Homo sapiens (human)
cellular response to lipopolysaccharide	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of pancreatic juice secretion	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of secretion of lysosomal enzymes	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Oxysterols receptor LXR-alpha	Homo sapiens (human)
negative regulation of response to endoplasmic reticulum stress	Oxysterols receptor LXR-alpha	Homo sapiens (human)
cell differentiation	Oxysterols receptor LXR-alpha	Homo sapiens (human)
cholesterol biosynthetic process	Delta(24)-sterol reductase	Homo sapiens (human)
cholesterol biosynthetic process	Delta(24)-sterol reductase	Homo sapiens (human)
Ras protein signal transduction	Delta(24)-sterol reductase	Homo sapiens (human)
protein localization	Delta(24)-sterol reductase	Homo sapiens (human)
negative regulation of cell population proliferation	Delta(24)-sterol reductase	Homo sapiens (human)
response to hormone	Delta(24)-sterol reductase	Homo sapiens (human)
tissue development	Delta(24)-sterol reductase	Homo sapiens (human)
male genitalia development	Delta(24)-sterol reductase	Homo sapiens (human)
plasminogen activation	Delta(24)-sterol reductase	Homo sapiens (human)
cholesterol biosynthetic process via desmosterol	Delta(24)-sterol reductase	Homo sapiens (human)
cholesterol biosynthetic process via lathosterol	Delta(24)-sterol reductase	Homo sapiens (human)
amyloid precursor protein catabolic process	Delta(24)-sterol reductase	Homo sapiens (human)
skin development	Delta(24)-sterol reductase	Homo sapiens (human)
membrane organization	Delta(24)-sterol reductase	Homo sapiens (human)
steroid metabolic process	Delta(24)-sterol reductase	Homo sapiens (human)
cholesterol biosynthetic process	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
intestinal cholesterol absorption	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
cholesterol transport	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
lipoprotein metabolic process	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
vitamin E metabolic process	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
vitamin transport	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
cellular response to sterol depletion	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
cholesterol homeostasis	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
transcription cis-regulatory region binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
transcription cis-regulatory region binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Oxysterols receptor LXR-alpha	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Oxysterols receptor LXR-alpha	Homo sapiens (human)
DNA binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
nuclear receptor activity	Oxysterols receptor LXR-alpha	Homo sapiens (human)
protein binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
zinc ion binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
cholesterol binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
chromatin DNA binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
sterol response element binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Oxysterols receptor LXR-alpha	Homo sapiens (human)
delta24(24-1) sterol reductase activity	Delta(24)-sterol reductase	Homo sapiens (human)
protein binding	Delta(24)-sterol reductase	Homo sapiens (human)
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Delta(24)-sterol reductase	Homo sapiens (human)
enzyme binding	Delta(24)-sterol reductase	Homo sapiens (human)
peptide antigen binding	Delta(24)-sterol reductase	Homo sapiens (human)
delta24-sterol reductase activity	Delta(24)-sterol reductase	Homo sapiens (human)
FAD binding	Delta(24)-sterol reductase	Homo sapiens (human)
protein binding	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
vitamin E binding	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
cholesterol binding	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
small GTPase binding	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
myosin V binding	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
protein homodimerization activity	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Oxysterols receptor LXR-alpha	Homo sapiens (human)
nucleoplasm	Oxysterols receptor LXR-alpha	Homo sapiens (human)
cytoplasm	Oxysterols receptor LXR-alpha	Homo sapiens (human)
cytosol	Oxysterols receptor LXR-alpha	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Oxysterols receptor LXR-alpha	Homo sapiens (human)
chromatin	Oxysterols receptor LXR-alpha	Homo sapiens (human)
receptor complex	Oxysterols receptor LXR-alpha	Homo sapiens (human)
nucleus	Oxysterols receptor LXR-alpha	Homo sapiens (human)
Golgi membrane	Delta(24)-sterol reductase	Homo sapiens (human)
nucleus	Delta(24)-sterol reductase	Homo sapiens (human)
endoplasmic reticulum	Delta(24)-sterol reductase	Homo sapiens (human)
endoplasmic reticulum membrane	Delta(24)-sterol reductase	Homo sapiens (human)
membrane	Delta(24)-sterol reductase	Homo sapiens (human)
cytoplasm	Delta(24)-sterol reductase	Homo sapiens (human)
plasma membrane	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
apical plasma membrane	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
cytoplasmic vesicle membrane	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
plasma membrane	NPC1-like intracellular cholesterol transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID1389142	Antagonist activity at human full length LXRbeta expressed in human BHK21 cells co-expressing human pSG5/RXRalpha assessed as inhibition of GW3965-induced receptor activation at 10 uM after 18 hrs by luciferase reporter gene assay	2018	Bioorganic & medicinal chemistry, 03-01, Volume: 26, Issue:5	Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors.
AID1502693	Inhibition of DHCR24 in human HL60 cells assessed as compound level causing induction of sterol accumulation incubated for 24 hrs by GC-MS analysis	2017	European journal of medicinal chemistry, Nov-10, Volume: 140	New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
AID1389140	Antagonist activity at human full length LXRalpha expressed in human BHK21 cells co-expressing human pSG5/RXRalpha assessed as inhibition of GW3965-induced receptor activation at 10 uM after 18 hrs by luciferase reporter gene assay	2018	Bioorganic & medicinal chemistry, 03-01, Volume: 26, Issue:5	Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors.
AID1502695	Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesized cholesterol after 24 hrs GC/MS analysis	2017	European journal of medicinal chemistry, Nov-10, Volume: 140	New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
AID1542682	Transactivation of rat LXRbeta expressed in HEK293FT cells measured after 14 to 18 hrs by dual-luciferase reporter gene assay	2019	Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11	Structural requirements of cholenamide derivatives as the LXR ligands.
AID1389139	Agonist activity at human full length LXRalpha expressed in human BHK21 cells co-expressing human pSG5/RXRalpha at 10 uM after 18 hrs by luciferase reporter gene assay relative to GW3965	2018	Bioorganic & medicinal chemistry, 03-01, Volume: 26, Issue:5	Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors.
AID1414114	Agonist activity at human LXRalpha expressed in HEK293 cells after 24 hrs by One-Glo luciferase reporter gene assay relative to TO901317	2018	Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24	Recent Advances in the Medicinal Chemistry of Liver X Receptors.
AID101835	Concentration required for half maximal activity was calculated in human nuclear oxysterol receptor liver X receptor-alpha in LiSA.	2001	Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6	Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.
AID1502681	Cytotoxicity in human HL60 cells by MTT assay	2017	European journal of medicinal chemistry, Nov-10, Volume: 140	New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
AID1179742	Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy	2014	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15	Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein.
AID1414113	Agonist activity at human LXRalpha expressed in HEK293 cells after 24 hrs by One-Glo luciferase reporter gene assay	2018	Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24	Recent Advances in the Medicinal Chemistry of Liver X Receptors.
AID101844	Tested for its ability to activate Liver X receptor-alpha expressed as Relative efficacy determined by maximal increase in relative fluorescence in LiSA	2001	Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6	Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.
AID1542683	Transactivation of rat LXRbeta expressed in HEK293FT cells measured after 14 to 18 hrs by dual-luciferase reporter gene assay relative to T0901317	2019	Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11	Structural requirements of cholenamide derivatives as the LXR ligands.
AID1542678	Transactivation of rat LXRbeta expressed in HEK293FT cells at 5 uM measured after 14 to 18 hrs by dual-luciferase reporter gene assay	2019	Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11	Structural requirements of cholenamide derivatives as the LXR ligands.
AID1502687	Induction of sterol accumulation in human HL60 cells assessed as desmosterol accumulation at 50 uM incubated for 24 hrs by GC-MS analysis	2017	European journal of medicinal chemistry, Nov-10, Volume: 140	New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
AID1502682	Induction of sterol accumulation in human HL60 cells assessed as desmosterol accumulation at 1 uM incubated for 24 hrs by GC-MS analysis	2017	European journal of medicinal chemistry, Nov-10, Volume: 140	New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
AID768322	Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane after 24 hrs by fluorescence microscopic analysis	2013	Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17	Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.
AID1542677	Transactivation of rat LXRalpha expressed in HEK293FT cells at 5 uM measured after 14 to 18 hrs by dual-luciferase reporter gene assay	2019	Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11	Structural requirements of cholenamide derivatives as the LXR ligands.
AID1389141	Agonist activity at human full length LXRbeta expressed in human BHK21 cells co-expressing human pSG5/RXRalpha at 10 uM after 18 hrs by luciferase reporter gene assay relative to GW3965	2018	Bioorganic & medicinal chemistry, 03-01, Volume: 26, Issue:5	Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors.
AID1797959	Cell-Free Ligand Sensing Assay (LiSA)-LXRalpha-SRC1 Assay from Article 10.1021/jm0004749: \\Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.\\	2001	Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6	Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (14.29)	29.6817
2010's	6 (85.71)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	2.49	2	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	2	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
triparanol Triparanol: Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.	2.15	1	stilbenoid	anticoronaviral agent
androstenediol Androstenediol: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).. androst-5-ene-3beta,17beta-diol : A 3beta-hydroxy-Delta(5)-steroid that is 3beta-hydroxyandrost-5-ene carrying an additional hydroxy group at position 17beta.	2.1	1	17beta-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid	androgen; human metabolite; mouse metabolite; radiation protective agent
25-hydroxycholesterol [no description available]	2.74	3	25-hydroxy steroid; oxysterol	human metabolite
lathosterol lathosterol: RN given refers to (3beta,5alpha)-isomer. 5alpha-cholest-7-en-3beta-ol : A cholestanoid that is (5alpha)-cholest-7-ene substituted by a beta-hydroxy group at position 3.	2.15	1	3beta-sterol; C27-steroid; cholestanoid; Delta(7)-sterol	human metabolite; mouse metabolite
trifluoperazine hydrochloride [no description available]	2.15	1	hydrochloride
7-ketocholesterol 7-ketocholesterol: inhibits uptake of cholesterol in rabbit aorta. 7-ketocholesterol : A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.	2.49	2	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; 7-oxo steroid; cholestanoid	neuroprotective agent
cholestane-3,5,6-triol, (3beta, 5alpha, 6beta)-isomer [no description available]	2.49	2	3beta-hydroxy steroid; 5alpha-hydroxy steroid; 6beta-hydroxy steroid
zymosterol [no description available]	2.15	1	3beta-sterol; cholestanoid	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
3 beta-hydroxy-delta 5-cholenic acid [no description available]	2.74	3	steroid
5-pregnene-3,20-diol 5-pregnene-3,20-diol: RN given refers to (3 beta,20 alpha)-isomer	2.15	1	corticosteroid hormone
6-ketocholestanol [no description available]	2.49	2
22-hydroxycholesterol [no description available]	2	1	cholanoid
(20s)-20-hydroxycholesterol 20-hydroxycholesterol: RN given refers to (20S)-isomer. 20-hydroxycholesterol : An oxysterol that is cholesterol substituted by a hydroxy group at position 20.	2.74	3	20-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid; oxysterol	human metabolite; mouse metabolite
24-hydroxycholesterol (24S)-24-hydroxycholesterol : A 24-hydroxycholesterol that has S configuration at position 24. It is the major metabolic breakdown product of cholesterol in the brain.	2	1	24-hydroxycholesterol	biomarker; human blood serum metabolite; mouse metabolite
27-hydroxycholesterol (25R)-cholest-5-ene-3beta,26-diol : A 26-hydroxycholesterol in which the 25-position has R-configuration.	2	1	26-hydroxycholesterol	apoptosis inducer; human metabolite; mouse metabolite; neuroprotective agent
ezetimibe Ezetimibe: An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.. ezetimibe : A beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer).	2.08	1	azetidines; beta-lactam; organofluorine compound	anticholesteremic drug; antilipemic drug; antimetabolite
ys 64 cholestan-6-oxo-3,5-diol: metabolite of 5,6-epoxycholesterol; structure in first source	2.1	1	cholestanoid
(22r)-22-hydroxycholesterol (22R)-22-hydroxycholesterol : An oxysterol that is the 22R-hydroxy derivative of cholesterol.	2.74	3	22-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid; oxysterol
22s-hydroxycholesterol (22S)-22-hydroxycholesterol : An oxysterol that is the 22S-hydroxy derivative of cholesterol.	2.74	3	22-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid; oxysterol
t0901317 T0901317: an LXRalpha and LXRbeta agonist	2.21	1
cholest-5-en-3 beta,7 alpha-diol, (3beta,7beta)-isomer [no description available]	2.49	2	7beta-hydroxy steroid; oxysterol
24,25-epoxycholesterol 24,25-epoxycholesterol: Rn given refers to (3alpha,5beta)-isomer; structure given in first source. 24(S),25-epoxycholesterol : A 3beta-hydroxy-Delta(5)-steroid that is desmosterol in which the double bond at position 24-25 has been oxidised to the corresponding epoxide (the 24S diastereoisomer). It is an oxysterol agonist of the liver X receptor.	2	1	3beta-hydroxy-Delta(5)-steroid; cholestanoid; epoxy steroid	liver X receptor agonist
19-hydroxycholesterol 19-hydroxycholesterol: structure given in first source	2.49	2	cholestanoid
u 18666a 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one: inhibits cycloartenol synthase. 3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride : A hydrochloride obtained by reaction of 3beta-(2-diethylaminoethoxy)androst-5-en-17-one with one equivalent of hydrochloric acid. It is a cholesterol synthesis and transport inhibitor.	2.15	1	hydrochloride	antiviral agent; EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor; Hedgehog signaling pathway inhibitor; nicotinic antagonist; sterol biosynthesis inhibitor
sr9238 SR9238: liver-selective LXR inverse agonist that suppresses hepatic steatosis; structure in first source	3.27	1

Condition	Relationship Strength	Studies
Neurovisceral Storage Disease with Vertical Supranuclear Ophthalmoplegia [description not available]	2.1	1
Niemann-Pick Disease, Type C An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.	2.1	1
Atherogenesis [description not available]	3.09	1
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	3.09	1

cholenic acid dimethylamide

Description

Cross-References

Synonyms (13)

Protein Targets (4)

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (57)

Molecular Functions (21)

Ceullar Components (14)

Bioassays (20)

Research

Studies (7)

Market Indicators

Research Demand Index: 13.25

Study Types

cholenic acid dimethylamide

Description

Cross-References

Synonyms (13)

Protein Targets (4)

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (57)

Molecular Functions (21)

Ceullar Components (14)

Bioassays (20)

Research

Studies (7)

Market Indicators

Research Demand Index: 13.25

Study Types

Related Drugs (27)

Related Conditions (4)