Page last updated: 2024-11-13

oxytetracycline hydrochloride

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Cross-References

ID SourceID
PubMed CID54680782
CHEMBL ID1607480
CHEMBL ID4591469
CHEMBL ID4549546
CHEBI ID31953
SCHEMBL ID124996
MeSH IDM0329915

Synonyms (87)

Synonym
oxytetracycline.hcl
(4s,4ar,5s,5ar,6s,12as)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
terramycin hydrochloride
oxytetracycline hydrochloride
2058-46-0
NCGC00091268-01
tm 5 (van)
oxyject 100
hydroxytetrazyklinhydrochlorid
caswell no. 628
ccris 200
biosolvomycin
4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
oxytet
oxytetracyclini hydrochloridum
2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha))-
oxy ws
einecs 218-161-2
oxytetracycline hydrochloride (internal use)
epa pesticide chemical code 006308
2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4s,4ar,5s,5ar,6s,12as)-
ai3-50164
oxytetracycline hydrochloride, >=95% (hplc), crystalline
D01596
oxytetracycline hydrochloride (jp17/usp)
NCGC00164443-01
SPECTRUM1500457
oxytetracycline hcl
AC-11614
HMS1920F04
CHEMBL1607480
chebi:31953 ,
2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4s,4ar,5s,5ar,6s,12as)-
oxytetracycline hydrochloride [usp:jan]
oxatet
unii-4u7k4n52zm
neo-oxy 100/100 mr
4u7k4n52zm ,
(4s,5s,6s,12as,4ar,5ar)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl -1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide, chloride
NCGC00254367-01
tox21_300601
tox21_201850
NCGC00259399-01
pharmakon1600-01500457
nsc757262
tox21_111109
dtxsid5021097 ,
cas-2058-46-0
dtxcid601097
AKOS015950811
CCG-40206
oxytetracycline hydrochloride [green book]
oxytetracycline hydrochloride [vandf]
oxytetracyclini hydrochloridum [who-ip latin]
oxytetracycline hydrochloride [jan]
oxytetracycline hydrochloride [mi]
oxytetracycline hydrochloride [ep monograph]
terra-cortril component oxytetracycline hydrochloride
oxytetracycline hydrochloride [mart.]
oxytetracycline hydrochloride [who-ip]
oxytetracycline hydrochloride [usp-rs]
15000-39-2
oxytetracycline hydrochloride [usp monograph]
2-naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4s-(4.alpha.,4a.alpha.,5.alpha.,5a.alpha.,6.beta.,12a.alpha.))-
oxytetracycline hydrochloride [who-dd]
oxytetracycline hydrochloride [orange book]
oxytetracycline hydrochloride component of terra-cortril
S5199
SCHEMBL124996
NC00526
mfcd00135815
oxytetracycline hydrochloride, vetranal(tm), analytical standard
oxytetracycline hydrochloride, united states pharmacopeia (usp) reference standard
oxytetracycline hydrochloride, pharmaceutical secondary standard; certified reference material
oxytetracycline hydrochloride, european pharmacopoeia (ep) reference standard
Q27114732
oxytetracycline (hydrochloride)
HY-B0275A
oxytetracycline hydrochloride 100 microg/ml in acetonitrile
O0475
(4s,4ar,5s,5ar,6s,12ar)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
CS-0013151
CHEMBL4591469
CHEMBL4549546
oxytetracycline for system suitability
EN300-19651144
PD002932

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (35)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.89130.003245.467312,589.2998AID2517
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency0.31360.004023.8416100.0000AID485290; AID489007
Chain A, HADH2 proteinHomo sapiens (human)Potency3.55190.025120.237639.8107AID886; AID893
Chain B, HADH2 proteinHomo sapiens (human)Potency3.55190.025120.237639.8107AID886; AID893
interleukin 8Homo sapiens (human)Potency66.82420.047349.480674.9780AID651758
15-lipoxygenase, partialHomo sapiens (human)Potency0.39810.012610.691788.5700AID887
phosphopantetheinyl transferaseBacillus subtilisPotency44.66840.141337.9142100.0000AID1490
RAR-related orphan receptor gammaMus musculus (house mouse)Potency35.86200.006038.004119,952.5996AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency21.82690.173734.304761.8120AID1346924
GLS proteinHomo sapiens (human)Potency3.54810.35487.935539.8107AID624170
SMAD family member 3Homo sapiens (human)Potency21.82690.173734.304761.8120AID1346924
TDP1 proteinHomo sapiens (human)Potency22.72310.000811.382244.6684AID686978; AID686979
AR proteinHomo sapiens (human)Potency31.04180.000221.22318,912.5098AID743035; AID743036; AID743063
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency28.18380.011212.4002100.0000AID1030
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency68.45010.000657.913322,387.1992AID1259377
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency17.19390.003041.611522,387.1992AID1159552
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency34.30630.001530.607315,848.9004AID1224841
farnesoid X nuclear receptorHomo sapiens (human)Potency48.86440.375827.485161.6524AID743217
estrogen nuclear receptor alphaHomo sapiens (human)Potency31.43650.000229.305416,493.5996AID588514; AID743069; AID743075; AID743078
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency45.12580.001024.504861.6448AID588535; AID743212; AID743215
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency49.14720.001019.414170.9645AID588537; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency49.08290.023723.228263.5986AID588541; AID743222; AID743223; AID743241
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency4.46680.035520.977089.1251AID504332
activating transcription factor 6Homo sapiens (human)Potency54.82670.143427.612159.8106AID1159516
Histone H2A.xCricetulus griseus (Chinese hamster)Potency75.53200.039147.5451146.8240AID1224845
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency7.07950.001815.663839.8107AID894
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency50.11870.354828.065989.1251AID504847
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency12.58930.01789.637444.6684AID588834
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency41.01230.000627.21521,122.0200AID651741; AID743202; AID743219
DNA polymerase kappa isoform 1Homo sapiens (human)Potency3.35870.031622.3146100.0000AID588579
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency15.84890.251215.843239.8107AID504327
lamin isoform A-delta10Homo sapiens (human)Potency0.00080.891312.067628.1838AID1487
Cellular tumor antigen p53Homo sapiens (human)Potency30.00030.002319.595674.0614AID651631
Nuclear receptor ROR-gammaHomo sapiens (human)Potency6.68240.026622.448266.8242AID651802
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency24.90531.000010.475628.1838AID1457; AID901
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (134)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
xenobiotic metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of glucose metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of steroid metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
intracellular receptor signaling pathwayNuclear receptor ROR-gammaHomo sapiens (human)
circadian regulation of gene expressionNuclear receptor ROR-gammaHomo sapiens (human)
cellular response to sterolNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of circadian rhythmNuclear receptor ROR-gammaHomo sapiens (human)
regulation of fat cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of DNA-templated transcriptionNuclear receptor ROR-gammaHomo sapiens (human)
adipose tissue developmentNuclear receptor ROR-gammaHomo sapiens (human)
T-helper 17 cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (38)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingNuclear receptor ROR-gammaHomo sapiens (human)
oxysterol bindingNuclear receptor ROR-gammaHomo sapiens (human)
zinc ion bindingNuclear receptor ROR-gammaHomo sapiens (human)
ligand-activated transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
sequence-specific double-stranded DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
nuclear receptor activityNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (19)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
nucleoplasmNuclear receptor ROR-gammaHomo sapiens (human)
nuclear bodyNuclear receptor ROR-gammaHomo sapiens (human)
chromatinNuclear receptor ROR-gammaHomo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (59)

Assay IDTitleYearJournalArticle
AID667674Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 to 48 hrs by serial dilution technique2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum.
AID1070215Inhibition of Trichomonas vaginalis uridine nucleoside ribohydrolase using 5-fluorouridine as substrate at 0.04 to 200 uM after 40 mins by NMR spectrometric analysis2014Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4
Identification of proton-pump inhibitor drugs that inhibit Trichomonas vaginalis uridine nucleoside ribohydrolase.
AID1517186Antibacterial activity against Escherichia coli ATCC 25922 cultured in MHB medium assessed as no bacterial growth incubated at 37 degC for 24 hrs by microdilution susceptibility test
AID1139680Antimicrobial activity against Micrococcus luteus DSM 20030 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1783234Antibacterial activity against Chromobacterium violaceum DSM30191 assessed as inhibition of bacterial growth by broth microdilution method
AID1517187Antibacterial activity against Pseudomonas aeruginosa PA01 DSM 19880 (ATCC 15692) cultured in MHB medium assessed as no bacterial growth incubated at 37 degC for 24 hrs by microdilution susceptibility test
AID1139684Antimicrobial activity against Escherichia coli DSM 1116 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID667676Antimicrobial activity against Nocardia flava after 24 to 48 hrs by serial dilution technique2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum.
AID1055483Antibacterial activity against Chromobacterium violaceum DSM 30191 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1783236Antibacterial activity against Kocuria rhizophila DSM1790 assessed as inhibition of bacterial growth by broth microdilution method
AID1139683Antimicrobial activity against Chromobacterium violaceum DSM 30191 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1517190Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 4 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
AID1139675Antimicrobial activity against Bacillus subtilis DSM 10 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1139677Antimicrobial activity against Nocardia sp. DSM 43069 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1171193Antimicrobial activity against Nocardia sp. 43069 after 24 to 48 hrs by serial dilution method2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
AID1055480Antibacterial activity against Mycobacterium diernhoferi DSM 43524 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1055479Antibacterial activity against Nocardia sp. DSM 43069 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1055478Antibacterial activity against Nocardioides simplex DSM 20130 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1228183Antimicrobial activity against Bacillus subtilis DSM10 assessed as inhibition of microbial growth incubated for 24 to 48 hrs by serial dilution assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471.
AID667675Antimicrobial activity against Escherichia coli after 24 to 48 hrs by serial dilution technique2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum.
AID1139678Antimicrobial activity against Staphylococcus aureus DSM 346 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1783235Antibacterial activity against Escherichia coli DSM1116 assessed as inhibition of bacterial growth by broth microdilution method
AID667673Antimicrobial activity against Micrococcus luteus after 24 to 48 hrs by serial dilution technique2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum.
AID1783233Antibacterial activity against Bacillus subtilis DSM10 assessed as inhibition of bacterial growth by broth microdilution method
AID1139676Antimicrobial activity against Nocardioides simplex DSM 20130 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1171198Antimicrobial activity against Chromobacterium violaceum 30191 after 24 to 48 hrs by serial dilution method2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
AID1139679Antimicrobial activity against Mycobacterium diernhoferi DSM 43524 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1055475Antibacterial activity against Staphylococcus aureus DSM 346 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1055481Antibacterial activity against Escherichia coli DSM 1116 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1171195Antimicrobial activity against Mycobacterium diernhoferi 43542 after 24 to 48 hrs by serial dilution method2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
AID1517188Hemolytic activity against human RBC incubated for 1 hr
AID1055482Antibacterial activity against Micrococcus luteus DSM 20030 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1066580Antibacterial activity against Paenibacillus polymyxa DSM 36 assessed as growth inhibition after 24 to 48 hrs2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Pyrronazols, metabolites from the myxobacteria Nannocystis pusilla and N. exedens, are unusual chlorinated pyrone-oxazole-pyrroles.
AID1228185Antimicrobial activity against Micrococcus luteus DSM1790 assessed as inhibition of microbial growth incubated for 24 to 48 hrs by serial dilution assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471.
AID1517189Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 4 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
AID1171196Antimicrobial activity against Paenibacillus polymyxa 36 after 24 to 48 hrs by serial dilution method2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
AID1139681Antimicrobial activity against Paenibacillus polymyxa DSM 36 by serial dilution method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Indothiazinone, an indolyl thiazolyl ketone from a novel myxobacterium belonging to the Sorangiineae.
AID1228188Antimicrobial activity against Escherichia coli DSM1116 assessed as inhibition of microbial growth incubated for 24 to 48 hrs by serial dilution assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471.
AID1171194Antimicrobial activity against Staphylococcus aureus 346 after 24 to 48 hrs by serial dilution method2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
AID1783225Antibacterial activity against Staphylococcus aureus DSM346 assessed as inhibition of bacterial growth by broth microdilution method
AID667677Antimicrobial activity against Chromobacterium violaceum after 24 to 48 hrs by serial dilution technique2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum.
AID1517185Antibacterial activity against Corynebacterium glutamicum ATCC 13032 cultured in MHB medium assessed as no bacterial growth incubated at 20 degC for 24 hrs by microdilution susceptibility test
AID1055477Antibacterial activity against Paenibacillus polymyxa DSM 36 assessed as growth inhibition2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Gymnopalynes A and B, chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.
AID1228187Antimicrobial activity against Chromobacterium violaceum DSM30191 assessed as inhibition of microbial growth incubated for 24 to 48 hrs by serial dilution assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471.
AID1517184Antibacterial activity against Staphylococcus aureus ATCC 9144 cultured in MHB medium assessed as no bacterial growth incubated at 37 degC for 24 hrs by microdilution susceptibility test
AID1228184Antimicrobial activity against Staphylococcus aureus DSM346 assessed as inhibition of microbial growth incubated for 24 to 48 hrs by serial dilution assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471.
AID1171197Antimicrobial activity against Escherichia coli 1116 after 24 to 48 hrs by serial dilution method2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1616905Antibacterial activity against Escherichia coli DSM 1116 incubated for 24 hrs by broth microdilution method
AID1616909Antibacterial activity against Staphylococcus aureus DSM 346 incubated for 24 hrs by broth microdilution method
AID1616906Antibacterial activity against Micrococcus luteus DSM 1790 incubated for 24 hrs by broth microdilution method
AID1616904Antibacterial activity against Chromobacterium violaceum DSM 30191 incubated for 24 hrs by broth microdilution method
AID1616903Antibacterial activity against Bacillus subtilis DSM 10 incubated for 24 hrs by broth microdilution method
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's14 (87.50)24.3611
2020's2 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 66.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index66.81 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.84 (4.65)
Search Engine Demand Index106.45 (26.88)
Search Engine Supply Index2.01 (0.95)

This Compound (66.81)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]