| Assay ID | Title | Year | Journal | Article |
|---|
| AID240398 | Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay; not calculated as plateau not reached at doses tested | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID499581 | Activation of RXR/LXR heterodimer in mouse RAW264.7 cells assessed as induction of ABCA1 mRNA expression by RT-PCR | 2010 | Journal of natural products, Aug-27, Volume: 73, Issue:8
| Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. |
| AID328046 | Inhibition of Saccharomyces sp. alpha-glucosidase | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID243328 | Maximal induction of liver X receptor-alpha receptor in transactivation assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID758940 | Agonist activity at human LXRalpha-LBD assessed as recruitment of co-activator peptide after 2 hrs by TR-FRET assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14
| Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes. |
| AID101844 | Tested for its ability to activate Liver X receptor-alpha expressed as Relative efficacy determined by maximal increase in relative fluorescence in LiSA | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. |
| AID328049 | Agonist activity at LXR | 2008 | Bioorganic & medicinal chemistry, Apr-15, Volume: 16, Issue:8
| Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
| AID768317 | Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane at 10 uM after 24 hrs by fluorescence microscopic analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect. |
| AID1458206 | Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID243323 | Maximal induction of liver X receptor-beta receptor in transactivation assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID403096 | Displacement of [3H2]F3-methyl AA from human recombinant LXRalpha expressed in Escherichia coli BL21 cells at 100 uM | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID243990 | Percent inhibition of [3H2]-F3-methyl AA (1) binding to liver X receptor-alpha at 100 uM | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID1505268 | Agonist activity at 6xHis tagged human RORgammat LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as biotinylated SRC1-2 peptide coactivator recruitment by AlphaScreen assay | 2018 | Journal of medicinal chemistry, Jul-26, Volume: 61, Issue:14
| Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy. |
| AID240397 | Effective concentration against liver X receptor-beta in HEK293 transactivation assay; not calculated as no plateau obtained at doses tested | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID1458213 | Agonist activity at LXR in human HepG2 cells assessed as upregulation of FASN mRNA levels at 10 uM after 6 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID240210 | Effective concentration for cofactor association with recombinant liver X receptor-beta | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID403364 | Activity of human recombinant LXRbeta ligand binding domain-mediated transcriptional activity in human HEK293 cells with Gal4 reporter plasmid by luciferase reporter assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID1458222 | Agonist activity at LXR in human U937 cells assessed as downregulation of LPS-induced TNFalpha mRNA expression at 10 uM after 6 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID101835 | Concentration required for half maximal activity was calculated in human nuclear oxysterol receptor liver X receptor-alpha in LiSA. | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. |
| AID1458219 | Agonist activity at LXR in human U937 cells assessed as upregulation of FASN mRNA levels at 10 uM after 6 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID1480585 | Agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells at 10 to 20 uM in presence of RXR-antagonist HX531 measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay | 2017 | Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
| DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators. |
| AID695017 | Agonist activity at Hh receptor in mouse C3H10T1/2 cells assessed as fold increase in Gli1 expression at 5 uM by RT-PCR analysis relative to control | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. |
| AID403098 | Displacement of [3H2]F3-methyl AA from human recombinant LXRbeta expressed in Escherichia coli BL21 cells at 100 uM | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID240218 | Effective concentration for cofactor association with recombinant liver X receptor-alpha | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID1173425 | Displacement of [3H]25-hydroxycholesterol from human RORc-LBD expressed in bacterial expression system after 3 hrs by scintillation counting analysis | 2014 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 24, Issue:24
| A reversed sulfonamide series of selective RORc inverse agonists. |
| AID695018 | Agonist activity at LXR in mouse C3H10T1/2 cells assessed as fold increase in ABCA1 expression at 5 uM by RT-PCR analysis relative to control | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. |
| AID1458214 | Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1c mRNA levels at 10 uM after 6 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID403100 | Agonist activity at human recombinant LXRbeta expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRbeta ligand binding domain by HTRF assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID403360 | Activity of human recombinant LXRalpha ligand binding domain-mediated transcriptional activity in human HEK293 cells with Gal4 reporter plasmid by luciferase reporter assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID1458220 | Agonist activity at LXR in human U937 cells assessed as upregulation of ABCA1 mRNA levels at 10 uM after 6 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID1458216 | Agonist activity at LXR in human U937 cells assessed as upregulation of FASN mRNA levels at 10 uM after 16 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID499586 | Agonist activity at RXRalpha in mouse peritoneal macrophages assessed as ApoAI-mediated cholesterol efflux after 24 hrs by Western blotting | 2010 | Journal of natural products, Aug-27, Volume: 73, Issue:8
| Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. |
| AID1458223 | Agonist activity at LXR in human HepG2 cells assessed as upregulation of SCD1 mRNA levels at 10 uM after 6 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID243986 | Percent inhibition of [3H2]-F3-methyl AA (1) binding to liver X receptor-beta at 100 uM | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID1458218 | Agonist activity at LXR in human U937 cells assessed as upregulation of SREBP1c mRNA levels at 10 uM after 6 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID1458205 | Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID1458215 | Agonist activity at LXR in human U937 cells assessed as upregulation of SCD1 mRNA levels at 10 uM after 16 hrs by qPCR analysis | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID403099 | Agonist activity at human recombinant LXRalpha expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRalpha ligand binding domain by HTRF assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID1458217 | Agonist activity at LXR in human U937 cells assessed as upregulation of SCD1 mRNA levels at 10 uM after 6 hrs by qPCR analysis relative to control | 2017 | Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
| Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. |
| AID1179741 | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization at 10 uM after 24 hrs by fluorescence microscopy | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein. |
| AID1797959 | Cell-Free Ligand Sensing Assay (LiSA)-LXRalpha-SRC1 Assay from Article 10.1021/jm0004749: \\Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.\\ | 2001 | Journal of medicinal chemistry, Mar-15, Volume: 44, Issue:6
| Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. |
| AID1346993 | Human Liver X receptor-beta (1H. Liver X receptor-like receptors) | 1996 | Nature, Oct-24, Volume: 383, Issue:6602
| An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. |
| AID1346755 | Human Liver X receptor-alpha (1H. Liver X receptor-like receptors) | 1996 | Nature, Oct-24, Volume: 383, Issue:6602
| An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. |
| AID1346766 | Human Farnesoid X receptor (1H. Liver X receptor-like receptors) | 2006 | The Journal of pharmacology and experimental therapeutics, Apr, Volume: 317, Issue:1
| Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |