| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID159443 | Antimalarial activity as change in MST against drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 160 mg/kg subcutaneous dose after 72 hr | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides. |
| AID1143977 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as disease cure from parasite infection at 60 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID124999 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 10 mg/kg. | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| AID124562 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) after subcutaneous administration dose of 160 mg/kg; 5 survival after 60 days | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID1143951 | Toxicity in Plasmodium berghei infected mouse assessed as mortality at 320 mg/kg, sc administered 72 hrs after infection measured after 2 to 5 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1134794 | Antiplasmodial activity against drug-sensitive Plasmodium berghei infected in mouse assessed as change in mean survival time at 40 mg/kg, sc administered as single dose 72 hrs post infection | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines. |
| AID1134972 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in chick assessed as mean survival time at 120 mg/kg, sc single dose (Rvb = 3.6 days) | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID125022 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 320 mg/kg; 2 toxic death and 3 survived occurred on days 2-5 after injection | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| AID449706 | NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1143939 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as increase in mean survival days of host at 10 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID117293 | Parenteral antimalarial effect against Plasmodium berghei in mice (Mus musculus) at a dose of 80 mg/kg subcutaneously | 1981 | Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
| Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines. |
| AID1143967 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as disease cure from parasite infection at 160 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143978 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as increase in mean survival days of host at 30 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1134787 | Toxicity in drug-sensitive Plasmodium berghei infected mouse at 640 mg/kg, sc administered as single dose 72 hrs post infection measured 60 days postinfection | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines. |
| AID1134795 | Antiplasmodial activity against drug-sensitive Plasmodium berghei infected in mouse assessed as change in mean survival time at 20 mg/kg, sc administered as single dose 72 hrs post infection | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines. |
| AID1143996 | Antimalarial activity against sporozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as increase in mean survival days of host at 60 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1134956 | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 80 mg/kg, sc single dose after 72 hrs of infection | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID159449 | Antimalarial activity as change in MST against drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 20 mg/kg subcutaneous dose after 72 hr | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides. |
| AID1143994 | Toxicity in sporozoite-induced Plasmodium gallinaceum infected white leghorn chicken assessed as mortality at 120 mg/kg, sc administered 72 hrs after infection measured up to 6 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1134997 | Antimalarial activity against sporozoite-induced Plasmodium gallinaceum infected in chick assessed as change in cured at 60 mg/kg, sc single dose | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID1143944 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as disease cure from parasite infection at 320 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1144006 | Antimalarial activity against sporozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as increase in mean survival days of host at 15 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143974 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as disease cure from parasite infection at 120 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID449703 | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID122518 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 640 mg/kg; 5 toxic death occurred on days 2-5 after injection | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| AID1134793 | Antiplasmodial activity against drug-sensitive Plasmodium berghei infected in mouse assessed as change in mean survival time at 80 mg/kg, sc administered as single dose 72 hrs post infection | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines. |
| AID1134999 | Antimalarial activity against sporozoite-induced Plasmodium gallinaceum infected in chick assessed as change in cured at 15 mg/kg, sc single dose | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID602119 | NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration | 2011 | Science (New York, N.Y.), Dec-09, Volume: 334, Issue:6061
| Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. |
| AID1143937 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as increase in mean survival days of host at 40 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1367779 | Inhibition of Plasmodium falciparum DHFR | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
| Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely. |
| AID1143982 | Toxicity in sporozoite-induced Plasmodium gallinaceum infected white leghorn chicken assessed as mortality at 480 mg/kg, sc administered 72 hrs after infection measured up to 6 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143954 | Ratio of quinine hydrochloride SD90 to compound SD90 for trophozoite-induced Plasmodium berghei infected in mouse assessed as daily dose required to suppression of 90% parasite infection administered with diet for 6 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143936 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as increase in mean survival days of host at 80 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143976 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as increase in mean survival days of host at 60 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143947 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as disease cure from parasite infection at 40 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID117288 | Parenteral antimalarial effect against Plasmodium berghei in mice (Mus musculus) at a dose of 640 subcutaneously mg/kg | 1981 | Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
| Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines. |
| AID124828 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) after subcutaneous administration dose of 640 mg/kg; 5 toxic deaths | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID1144000 | Toxicity in sporozoite-induced Plasmodium gallinaceum infected white leghorn chicken assessed as mortality at 60 mg/kg, sc administered 72 hrs after infection measured up to 6 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID159588 | Antimalarial activity as change in MST for drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 640 mg/kg subcutaneous dose over 72 hr | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides. |
| AID1143952 | Toxicity in Plasmodium berghei infected mouse assessed as mortality at 640 mg/kg, sc administered 72 hrs after infection measured after 2 to 5 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143988 | Toxicity in sporozoite-induced Plasmodium gallinaceum infected white leghorn chicken assessed as mortality at 240 mg/kg, sc administered 72 hrs after infection measured up to 6 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID449704 | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID602118 | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | 2011 | Science (New York, N.Y.), Dec-09, Volume: 334, Issue:6061
| Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. |
| AID1144001 | Antimalarial activity against sporozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as increase in mean survival days of host at 30 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1134790 | Toxicity in drug-sensitive Plasmodium berghei infected mouse at 320 mg/kg, sc administered as single dose 72 hrs post infection measured 2 to 5 days postinfection | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines. |
| AID122520 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 80 mg/kg; 2 survived occurred on days 2-5 after injection | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| AID1144016 | Antimalarial activity against DDS-resistant Plasmodium berghei assessed as drug resistance relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID124556 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) after subcutaneous dose of 10 mg/kg | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID117133 | Parenteral antimalarial effect against Plasmodium berghei in mice (Mus musculus) at a dose of 160 subcutaneously mg/kg | 1981 | Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
| Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines. |
| AID1134994 | Toxicity in trophozoite-induced Plasmodium gallinaceum infected in chick assessed as death at 30 mg/kg, sc single dose measured within 48 hrs | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID124679 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) at 20 mg/kg subcutaneous dose | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID1134959 | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 10 mg/kg, sc single dose after 72 hrs of infection | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID159574 | Antimalarial activity as change in MST for drug-sensitive Plasmodium berghei infected mice (Mus musculus) after 72 hrs at 320 mg/kg subcutaneous dose | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides. |
| AID1134973 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in chick assessed as mean survival time at 60 mg/kg, sc single dose (Rvb = 3.6 days) | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID449705 | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1143953 | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as daily dose required to suppression of 90% parasite infection administered with diet for 6 days | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID122504 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 40 mg/kg; 1 survived occurred on days 2-5 after injection | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| AID125020 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 20 mg/kg. | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| AID1143938 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as increase in mean survival days of host at 20 mg/kg, sc administered 72 hrs after infection relative to control | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID117272 | Parenteral antimalarial effect against Plasmodium berghei in mice (Mus musculus) at a dose of 320 subcutaneous mg/kg | 1981 | Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
| Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines. |
| AID1134958 | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 20 mg/kg, sc single dose after 72 hrs of infection | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID1143975 | Toxicity in trophozoite-induced Plasmodium gallinaceum infected white leghorn chicken assessed as mortality at 120 mg/kg, sc administered 72 hrs after infection measured after 48 hrs | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID117268 | Parenteral antimalarial effect against Plasmodium berghei in mice (Mus musculus) at a dose of 20sc mg/kg | 1981 | Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
| Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines. |
| AID1143946 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as disease cure from parasite infection at 80 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID159582 | Antimalarial activity as change in MST for drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 40 mg/kg subcutaneous dose over 72 hr | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides. |
| AID1134974 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in chick assessed as mean survival time at 30 mg/kg, sc single dose (Rvb = 3.6 days) | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID122521 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 80 mg/kg; 2 survived occurred on days 2-5 after injection. | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| AID124699 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) after subcutaneous administration dose of 40 mg/kg; 1 survival after 60 days | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID1134957 | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 40 mg/kg, sc single dose after 72 hrs of infection | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID159709 | Antimalarial activity as change in MST for drug-sensitive Plasmodium berghei infected mice (Mus musculus) at 80 mg/kg subcutaneous dose over 72 hr | 1984 | Journal of medicinal chemistry, Dec, Volume: 27, Issue:12
| Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides. |
| AID1143979 | Antimalarial activity against trophozoite-induced Plasmodium gallinaceum infected in white leghorn chicken assessed as disease cure from parasite infection at 30 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID1143945 | Antimalarial activity against Plasmodium berghei infected in mouse assessed as disease cure from parasite infection at 160 mg/kg, sc administered 72 hrs after infection | 1978 | Journal of medicinal chemistry, Oct, Volume: 21, Issue:10
| Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. |
| AID124833 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) after subcutaneous after 60 days | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID124690 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) after subcutaneous administration dose of 320 mg/kg; 3 survived after 2-5 days of injection | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID1134791 | Antiplasmodial activity against drug-sensitive Plasmodium berghei infected in mouse assessed as cure from infection at 160 mg/kg, sc administered as single dose 72 hrs post infection measured 60 days postinfection | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines. |
| AID117280 | Parenteral antimalarial effect against Plasmodium berghei in mice (Mus musculus) at a dose of 40 mg/kg subcutaneously | 1981 | Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
| Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines. |
| AID124689 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice (Mus musculus) after subcutaneous administration dose of 320 mg/kg; 2 toxic deaths after 2-5 days of injection | 1983 | Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
| Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines. |
| AID1134998 | Antimalarial activity against sporozoite-induced Plasmodium gallinaceum infected in chick assessed as change in cured at 30 mg/kg, sc single dose | 1979 | Journal of medicinal chemistry, Oct, Volume: 22, Issue:10
| Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
| AID125002 | Mean survival time against trophozoite induced Plasmodium berghei in mice minus control was evaluated at a dose 160 mg/kg; 5 survived occurred on days 2-5 after injection | 1985 | Journal of medicinal chemistry, Feb, Volume: 28, Issue:2
| Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |