Compounds > epitiostanol
Page last updated: 2024-09-27

epitiostanol

Description

epitiostanol: used in therapy of advanced breast cancer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID443935
CHEMBL ID2106161
CHEBI ID31546
SCHEMBL ID8995
MeSH IDM0043853

Synonyms (35)

Synonym
nsc-194684
10275-s
nsc 194684
androstan-17-ol, 2,3-epithio-, (2alpha,3alpha,5alpha,17beta)-
epitiostanol [inn:jan]
2alpha,3alpha-epithio-5alpha-androstan-17beta-ol
2alpha,3alpha-epithio-5alpha-androstan-17beta-o1
5alpha-androstan-17beta-ol, 2alpha,3alpha-epithio-
epitiostanolum [inn-latin]
2-alpha,3-alpha-epithio-5-alpha-androstan-17-beta-ol
NCGC00016609-01
cas-2363-58-8
2363-58-8
epitiostanol
epitiostanol (jan/inn)
D01265
unii-ye7586973l
ye7586973l ,
epitiostanolum
dtxsid2045367 ,
dtxcid0025367
tox21_110520
epithioandrostanol
CHEMBL2106161
epitiostanol [mi]
epitiostanol [mart.]
epitiostanol [inn]
epitiostanol [who-dd]
epitiostanol [jan]
CCG-221006
SCHEMBL8995
CHEBI:31546
2alpha,3alpha-epithio-5alpha-androstane-17beta-ol
(1s,2s,4r,6s,8s,11r,12s,15s,16s)-2,16-dimethyl-5-thiapentacyclo[9.7.0.0,.0,.0,octadecan-15-ol
(1s,2s,4r,6s,8s,11r,12s,15s,16s)-2,16-dimethyl-5-thiapentacyclo[9.7.0.02,8.04,6.012,16]octadecan-15-ol

Drug Classes (1)

ClassDescription
organic molecular entityAny molecular entity that contains carbon.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency0.07660.000221.22318,912.5098AID743035; AID743036; AID743040; AID743053; AID743054; AID743063
estrogen nuclear receptor alphaHomo sapiens (human)Potency1.18370.000229.305416,493.5996AID743069; AID743075; AID743077; AID743078; AID743079
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency2.54290.001723.839378.1014AID743083
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency7.07950.01789.637444.6684AID588834
Cellular tumor antigen p53Homo sapiens (human)Potency9.02260.002319.595674.0614AID651631
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (124)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (34)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (19)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (47.37)18.7374
1990's5 (26.32)18.2507
2000's0 (0.00)29.6817
2010's3 (15.79)24.3611
2020's2 (10.53)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (5.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (10.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (85.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
mepitiostane[no description available]medium50organic molecular entity
mepitiostane[no description available]medium51organic molecular entity
mifepristone[no description available]medium103-oxo-Delta(4) steroid;
acetylenic compound;
tertiary amino compound		abortifacient;
contraceptive drug;
hormone antagonist;
synthetic oral contraceptive
chlormadinone acetate[no description available]medium10corticosteroid hormone
fluoxymesterone[no description available]medium3111beta-hydroxy steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
anabolic androgenic steroid;
fluorinated steroid		anabolic agent;
antineoplastic agent
diethylstilbestrol[no description available]medium11olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
tamoxifen[no description available]medium51stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
oleic acid[no description available]medium10octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
promegestone[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid		antineoplastic agent;
progesterone receptor agonist;
progestin
Acetylpheneturide[no description available]low00organic molecular entity
afloqualone[no description available]low00organic molecular entity
aranidipine[no description available]low00organic molecular entity
bromazepam[no description available]low00organic molecular entity
seratrodast[no description available]low00organic molecular entity
brotizolam[no description available]low00organic molecular entity
cadralazine[no description available]low00organic molecular entity
carbazilquinone[no description available]low00organic molecular entity
clinofibrate[no description available]low00organic molecular entity
clotiazepam[no description available]low00organic molecular entity
cyclofenil[no description available]low00organic molecular entity
ebastine[no description available]low00organic molecular entity
emorfazone[no description available]low00organic molecular entity
ethenzamide[no description available]low00organic molecular entity
ethyl loflazepate[no description available]low00organic molecular entity
etizolam[no description available]low00organic molecular entity
amidoline[no description available]low00organic molecular entity
floctafenine[no description available]low00organic molecular entity
flopropione[no description available]low00organic molecular entity
fp 83[no description available]low00organic molecular entity
flutazolam[no description available]low00hemiaminal ether;
organic molecular entity
flutoprazepam[no description available]low00organic molecular entity
glybuzole[no description available]low00organic molecular entity
haloxazolam[no description available]low00organic molecular entity
ibuprofen piconol[no description available]low00organic molecular entity
iothalamic acid[no description available]low00organic molecular entity
iotrolan[no description available]low00organic molecular entity
iotroxic acid[no description available]low00organic molecular entity
mazindol[no description available]low00organic molecular entity
medazepam[no description available]low00organic molecular entity
mefruside[no description available]low00organic molecular entity
meprobamate[no description available]low00organic molecular entity
metharbital[no description available]low00organic molecular entity
methyprylon[no description available]low00organic molecular entity
myristicin[no description available]low00organic molecular entitymetabolite
niceritrol[no description available]low00organic molecular entity
osalmide[no description available]low00organic molecular entity
oxazolam[no description available]low00hemiaminal ether;
organic molecular entity
oxypertine[no description available]low00organic molecular entity
pirenoxine[no description available]low00organic molecular entity
propyliodone[no description available]low00organic molecular entity
repirinast[no description available]low00organic molecular entity
simfibrate[no description available]low00organic molecular entity
sobuzoxane[no description available]low00organic molecular entity
sulthiame[no description available]low00organic molecular entity
tazanolast[no description available]low00organic molecular entity
tofisopam[no description available]low00organic molecular entity
3-(2',4',5'-triethoxybenzoyl)propionic acid[no description available]low00organic molecular entity
vesnarinone[no description available]low00organic molecular entity
cn 100[no description available]low00organic molecular entity
procaine hydrochloride[no description available]low00organic molecular entity
lysine[no description available]low00aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
Mebutamate[no description available]low00organic molecular entity
methandrostenolone[no description available]low00organic molecular entity
tetramethylammonium chloride[no description available]low00organic molecular entity
methsuximide[no description available]low00organic molecular entity
1-phenylpropanol[no description available]low00organic molecular entity
butylparaben[no description available]low00organic molecular entity
efloxate[no description available]low00organic molecular entity
sulfan blue[no description available]low00organic molecular entity
1,2-dihydroxybenzene-3,5-disulfonic acid disodium salt[no description available]low00organic molecular entity
cycloguanil hydrochloride[no description available]low00hydrochloride;
organic molecular entity
nicarbazin[no description available]low00organic molecular entity
fluocinonide[no description available]low00organic molecular entity
copper gluconate[no description available]low00organic molecular entity
naphazoline hydrochloride[no description available]low00organic molecular entity
doxylamine succinate[no description available]low00organic molecular entity
carbamylhydrazine monohydrochloride[no description available]low00organic molecular entity
Berberine chloride (TN)[no description available]low00organic molecular entity
isosorbide[no description available]low00organic molecular entity
bucetin[no description available]low00organic molecular entity
tetradecyltrimethylammonium bromide[no description available]low00organic molecular entity
rimantadine hydrochloride[no description available]low00organic molecular entity
nitrofen[no description available]low00organic molecular entityEC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
perlapine[no description available]low00organic molecular entity
clorexolone[no description available]low00organic molecular entity
stavudine[no description available]low00dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
iobenzamic acid[no description available]low00organic molecular entity
sulfamethomidine[no description available]low00organic molecular entity
Brilliant Blue[no description available]low00organic molecular entity
pyrodifenium bromide[no description available]low00organic molecular entity
didecyldimethylammonium chloride[no description available]low00organic molecular entity
iocarmic acid[no description available]low00organic molecular entity
bisoxatin acetate[no description available]low00organic molecular entity
levamisole hydrochloride[no description available]low00organic molecular entity
halazepam[no description available]low00organic molecular entity
nicomol[no description available]low00organic molecular entity
feprazone[no description available]low00organic molecular entity
b 10610[no description available]low00organic molecular entity
haloperidol decanoate[no description available]low00organic molecular entity
pinacidil[no description available]low00organic molecular entity
loxiglumide[no description available]low00organic molecular entity
saquinavir monomethanesulfonate[no description available]low00organic molecular entity
Pronetalol hydrochloride[no description available]low00organic molecular entity
phenelzine sulfate[no description available]low00organic molecular entity
magnesium peroxide[no description available]low00organic molecular entity
dexamethasone 21-palmitate[no description available]low00organic molecular entity
rotenolone[no description available]low00organic molecular entitymetabolite
nilverm[no description available]low00organic molecular entity
diumide[no description available]low00organic molecular entity
docarpamine[no description available]low00organic molecular entity
clobetasone butyrate[no description available]low00organic molecular entity
enocitabine[no description available]low00organic molecular entity
ranimustine[no description available]low00organic molecular entity
protizinic acid[no description available]low00organic molecular entity
nipradilol[no description available]low00organic molecular entity
panipenem[no description available]low00organic molecular entity
p-Aminobenzamidine dihydrochloride[no description available]low00organic molecular entity
aucubin[no description available]low00organic molecular entitymetabolite
catalpol[no description available]low00organic molecular entitymetabolite
halopredone acetate[no description available]low00organic molecular entity
3-acetyllupeol[no description available]low00organic molecular entitymetabolite
phenmetrazine hydrochloride[no description available]low00organic molecular entity
isometamidium chloride[no description available]low00organic molecular entity
melanotan-ii[no description available]low00organic molecular entity
anecortave acetate[no description available]low00organic molecular entity
aluminum phthalocyanine[no description available]low00organic molecular entity
olprinone[no description available]low00organic molecular entity
clidanac[no description available]low00organic molecular entity
enkephalin-met, arg(6)-phe(7)-[no description available]low00organic molecular entity
angiotensin ii, des-asp(1)-des-arg(2)-ile(5)-[no description available]low00organic molecular entity
ramatroban[no description available]low00organic molecular entity
3-acetylpyridine adenine dinucleotide[no description available]low00organic molecular entity
iguratimod[no description available]low00organic molecular entity
blonanserin[no description available]low00organic molecular entity
fudosteine[no description available]low00organic molecular entity
perlolyrine[no description available]low00organic molecular entitymetabolite
timepidium bromide[no description available]low00organic molecular entity
2-(2-hydroxy-4-methylphenyl)aminothiazole[no description available]low00organic molecular entity
cupric hydroxide[no description available]low00organic molecular entity
beta-mercaptolactate cysteine disulfide[no description available]low00organic molecular entity
s 8308[no description available]low00organic molecular entity
farrerol[no description available]low00organic molecular entitymetabolite
hydroxylamine hydrochloride[no description available]low00organic molecular entity
cyclo(l-phe-l-pro)[no description available]low00organic molecular entitymetabolite
gestonorone caproate[no description available]low00organic molecular entity
halcinonide[no description available]low00organic molecular entitySMO receptor agonist
oxendolone[no description available]low00organic molecular entity
dironyl[no description available]low00organic molecular entity
ao 128[no description available]low00organic molecular entity
ditiocarb sodium[no description available]low00organic molecular entity
aceglatone[no description available]low00organic molecular entity
opc-2009[no description available]low00organic molecular entity
bucillamine[no description available]low00organic molecular entity
cefsulodin sodium[no description available]low00organic molecular entity
n-(3,4-dimethoxyphenyl)-n-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-4-nitrobenzamide hydrochloride[no description available]low00organic molecular entity
4E2RCat[no description available]low00organic molecular entity
potassium oxonate[no description available]low00organic molecular entity
p-aminosalicylic acid monosodium salt[no description available]low00organic molecular entity
1-deoxyfructose[no description available]low00organic molecular entity
ungeremine[no description available]low00organic molecular entitymetabolite
ethyl 4-(3-oxo-2,3-dihydroisothiazol-2-yl)benzoate[no description available]low00organic molecular entity
pyrantel pamoate[no description available]low00organic molecular entity
chlorpheniramine maleate[no description available]low00organic molecular entity
dexchlorpheniramine maleate[no description available]low00organic molecular entity
gsh-prostaglandin a1[no description available]low00organic molecular entity
lafutidine[no description available]low00organic molecular entity
pheniramine maleate[no description available]low00organic molecular entity
sf 837[no description available]low00organic molecular entity
gefarnate[no description available]low00organic molecular entity
sorivudine[no description available]low00organic molecular entity
ornoprostil[no description available]low00organic molecular entity
cd 3400[no description available]low00organic molecular entity
rokitamycin[no description available]low00organic molecular entity
prednisolone farnesylate[no description available]low00organic molecular entity
dinoprost tromethamine[no description available]low00organic molecular entity
phenoxybenzamine hydrochloride[no description available]low00organic molecular entity
proscillaridin[no description available]low00organic molecular entity
goserelin[no description available]low00organic molecular entity
azodicarbonamide[no description available]low00organic molecular entity
tulobuterol hydrochloride[no description available]low00organic molecular entity
maxacalcitol[no description available]low00organic molecular entity
longiborneol[no description available]low00organic molecular entity
falcarindiol[no description available]low00organic molecular entitymetabolite
ozagrel, monohydrochloride, (e)-isomer[no description available]low00organic molecular entity
microcystin rr[no description available]low00microcystin;
organic molecular entity		bacterial metabolite;
environmental contaminant;
xenobiotic
lankacidins[no description available]low00organic molecular entity
romurtide[no description available]low00organic molecular entity
ciclesonide[no description available]low00organic molecular entity
fursultiamin monohydrochloride[no description available]low00organic molecular entity
pentagastrin[no description available]low00organic molecular entity
calcium sulfide[no description available]low00organic molecular entity
barettin[no description available]low00organic molecular entity
8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, (r)-isomer,[no description available]low00organic molecular entity
nociceptin[no description available]low00organic molecular entity;
polypeptide		human metabolite;
rat metabolite
sodium salicylate[no description available]low00organic molecular entity
n-(2-methylbenzyl)linoleamide[no description available]low00organic molecular entity
halisulfate 1[no description available]low00organic molecular entitymetabolite
novobiocin sodium[no description available]low00organic molecular entity
cefoperazone sodium[no description available]low00organic molecular entity
osteum[no description available]low00organic molecular entity
cefoxitin sodium[no description available]low00organic molecular entity
dexon (fungicide), sodium salt[no description available]low00organic molecular entity
zinacef[no description available]low00organic molecular entity
sodium iodate[no description available]low00organic molecular entity
pyrithiobac sodium[no description available]low00organic molecular entity
cortisol succinate, sodium salt[no description available]low00organic molecular entity
sodium 2,6-dichloroindophenol[no description available]low00organic molecular entity
quinupristin-dalfopristin[no description available]low00organic molecular entity
gyy 4137[no description available]low00organic molecular entity
monanchocidin[no description available]low00organic molecular entitymetabolite
spinetoram[no description available]low00organic molecular entity
gimeracil[no description available]low00organic molecular entity
suvanine[no description available]low00organic molecular entitymetabolite
vt-1161[no description available]low00organic molecular entity
3-hydroxykynurenine glucoside[no description available]low00organic molecular entity
dBET6[no description available]low00organic molecular entity
MZ1[no description available]low00organic molecular entity
staphylopine(1-)[no description available]low00organic molecular entity
pseudopaline(2-)[no description available]low00organic molecular entity
valtrex[no description available]low00organic molecular entity
hlo 7[no description available]low00organic molecular entity
7-deazaguanine[no description available]low00organic molecular entity
7,8-dihydropterin[no description available]low00organic molecular entity;
pterins
pteroylpentaglutamic acid[no description available]low00organic molecular entity
amicoumacin a[no description available]low00organic molecular entity
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight0low10
Breast Cancer0medium41
Breast Carcinoma0medium41
Breast Neoplasms0medium41
Breast Tumors0medium41
Cancer of Breast0medium41
Cancer of the Breast0medium41
Carcinoma0low10
Carcinoma, Anaplastic0low10
Carcinoma, Spindle-Cell0low10
Carcinoma, Undifferentiated0low10
Carcinomatosis0low10
Complications, Pregnancy0low10
Dysembryoma0low20
Epithelial Neoplasms, Malignant0low10
Epithelial Tumors, Malignant0low10
Epithelioma0low10
Experimental Mammary Neoplasms0low40
Experimental Neoplasms0low10
Human Mammary Carcinoma0medium41
Local Neoplasm Recurrence0low20
Local Neoplasm Recurrences0low20
Locoregional Neoplasm Recurrence0low20
Lymph Node Metastasis0medium11
Lymphatic Metastasis0medium11
Malignant Epithelial Neoplasms0low10
Malignant Neoplasm of Breast0medium41
Malignant Tumor of Breast0medium41
Mammary Cancer0medium41
Mammary Carcinoma, Human0medium41
Mammary Neoplasm, Human0medium41
Mammary Neoplasms, Experimental0low40
Mammary Neoplasms, Human0medium41
Menopause0medium11
Metastase0low10
Metastases, Neoplasm0low10
Metastasis0low10
Metastasis, Neoplasm0low10
Neoplasm Metastases0low10
Neoplasm Metastasis0low10
Neoplasm Recurrence, Local0low20
Neoplasm Recurrence, Locoregional0low20
Neoplasm Recurrences, Local0low20
Neoplasms, Breast0medium41
Neoplasms, Experimental0low10
Neoplasms, Experimental Mammary0low40
Neoplasms, Malignant Epithelial0low10
Pregnancy0low20
Pregnancy Complications0low10
Recurrence, Local Neoplasm0low20
Recurrence, Locoregional Neoplasm0low20
Recurrences, Local Neoplasm0low20
Teratoid Tumor0low20
Teratoma0low20
Teratoma, Benign0low20
Teratoma, Cystic0low20
Teratoma, Immature0low20
Teratoma, Malignant0low20
Teratoma, Mature0low20
Tumors, Breast0medium41

Research Highlights

Long-term Use (1)

ArticleYear
[Internal endocrine therapy of breast cancer].
Gan to kagaku ryoho. Cancer & chemotherapy, Volume: 11, Issue: 5		1984
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]