1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) is a **chlorine-containing compound** commonly used as a **disinfectant and bleaching agent**.
Here's why it's important for research:
**1. Antimicrobial properties:**
* DCDMH exhibits strong **bactericidal, fungicidal, and virucidal activity**, making it useful for a wide range of applications, including:
* **Water purification:** DCDMH is effective in killing harmful bacteria and viruses in water, contributing to public health and safety.
* **Food preservation:** It can extend the shelf life of foods by preventing microbial growth.
* **Medical disinfection:** DCDMH is used to disinfect medical equipment and surfaces, minimizing the spread of infections.
* **Research on antimicrobial mechanisms:** DCDMH's mode of action involves the **release of chlorine**, which disrupts microbial cell function. Studying its interaction with microorganisms provides insights into antimicrobial mechanisms and potential development of new disinfectants.
**2. Chemical synthesis and reactions:**
* DCDMH is a versatile starting material in **organic synthesis**. Its reactivity allows for the production of various chlorine-containing compounds with diverse applications.
* **Research on chlorination reactions:** DCDMH's ability to transfer chlorine atoms facilitates the study of chlorination reactions, which are essential in organic chemistry and have applications in drug discovery and materials science.
**3. Environmental applications:**
* **Pool disinfection:** DCDMH is a popular disinfectant for swimming pools, offering long-lasting effectiveness and reduced odor compared to traditional chlorine.
* **Wastewater treatment:** DCDMH can be used to disinfect wastewater, reducing the risk of pathogens being released into the environment.
* **Environmental remediation:** Research is ongoing into the potential use of DCDMH for the removal of pollutants and contaminants from soil and water.
**4. Safety and toxicity:**
* **Safety considerations:** DCDMH is a strong oxidizer and should be handled with caution.
* **Toxicity research:** Studies on DCDMH's toxicity are crucial to assess its potential risks to human health and the environment. Research focuses on its effects on different organisms, its bioaccumulation potential, and its impact on ecosystems.
Overall, 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) is a significant compound with diverse applications in various fields, including disinfection, chemical synthesis, and environmental remediation. Its importance for research lies in understanding its antimicrobial properties, its role in chemical reactions, and its potential environmental impact.
sulfochloranthine: combination of dichlorodimethylhydantoin, dimethylhydantoin, sodium polyphosphate, sulfanol [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 8360 |
CHEMBL ID | 1899986 |
SCHEMBL ID | 123299 |
MeSH ID | M0106418 |
Synonym |
---|
AC-1604 |
c5h6cl2n2o2 |
nsc-38630 |
nsc38630 |
nsc-33307 |
hydantoin,3-dichloro-5,5-dimethyl- |
daktin |
2, 1,3-dichloro-5,5-dimethyl- |
dactin |
nci-c03054 |
dichlorantin |
hydan |
dantoin |
halane |
wln: t5nvnv ehj ag cg e1 e1 |
hydantoin, dichlorodimethyl- |
1,5-dimethyl hydantoin |
omchlor |
nsc33307 |
118-52-5 |
1,5-dimethylhydantoin |
1,3-dichloro-5,5-dimethyl-imidazolidine-2,4-dione |
hydantoin, 1,3-dichloro-5,5-dimethyl- (8ci) |
DDH , |
1,3-dichloro-5,5-dimethylhydantoin, available chlorine 68 % |
NCGC00164351-01 |
1,3-dichloro-5,5-dimethyl-2,4-imidazolidinedione |
hydantoin, 1,3-dichloro-5,5-dimethyl- |
caswell no. 306 |
ai3-23669 |
1,3-dwuchloro-5,5-dwumetylohydantoina [polish] |
dwuchlorantyny [polish] |
epa pesticide chemical code 028501 |
nsc 33307 |
1,3-dichloro-5,5-dimethyl hydantoin |
nsc 38630 |
sulfochloranthine |
ccris 5900 |
1,3-dichloro-5,5'-methylhydantoin |
hydan (antiseptic) |
brn 0146013 |
hsdb 4373 |
einecs 204-258-7 |
1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione |
2,4-imidazolidinedione, 1,3-dichloro-5,5-dimethyl- |
1,3-dichloro-5,5-dimethylhydantoin |
D1783 |
STK802311 |
AKOS000120004 |
NCGC00164351-03 |
NCGC00164351-02 |
dwuchlorantyny |
1,3-dwuchloro-5,5-dwumetylohydantoina |
unii-70h8b2wwtu |
sulfochlorantine |
5-24-05-00373 (beilstein handbook reference) |
70h8b2wwtu , |
tox21_202384 |
tox21_300184 |
dtxcid604985 |
NCGC00254084-01 |
NCGC00259933-01 |
dtxsid4024985 , |
cas-118-52-5 |
BBL011089 |
FT-0606647 |
dichloro-5,5-dimethylhydantoin, 1,3- |
1,3-dichloro-5,5-dimethylhydantoin [hsdb] |
j5.299j , |
1,3-dichloro-5,5-dimethylhydantoin [mi] |
1 ,3-dichloro-5,5-dimethylhydantoin |
1,3-dichloro-5,5-dimethyl-hydantoin |
dichlorodimethylhydantoin |
SCHEMBL123299 |
dantochlor rw |
dcdmh |
1,3-dichloro-5,5-dimethylhydantoine |
CHEMBL1899986 |
W-108540 |
mfcd00003190 |
F0001-0296 |
chlorantine |
CS-W018514 |
VS-02831 |
Q20963665 |
chlorosulfonicacid |
EN300-19870 |
D77848 |
1,3-dichloro-dimethylhydantoin |
2,4-imidazolidinedione, 1,3-dichloro-5,5-dimethyl-; n,n'-dichlorodimethylhydantoin; 1,3-dichloro-5,5-dimethylhydantoin; 1,3-dichloro-5,5-dimethyl-imidazolidine-2,4-dione |
Excerpt | Relevance | Reference |
---|---|---|
" Animals were dosed topically with 'test article'--neat HD, 10% agent/chloroform solutions or product solutions (waste-streams) from neutralized CAIS--and evaluated for skin-damaging effects (gross and microscopic)." | ( Evaluation of neutralized chemical agent identification sets (CAIS) for skin injury with an overview of the vesicant potential of agent degradation products. Hayes, TL; MacIver, B; Menton, RG; Miller, TL; Olajos, EJ; Olson, CT; Rosso, T; Salem, H; Singer, AW, ) | 0.13 |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
AR protein | Homo sapiens (human) | Potency | 61.7353 | 0.0002 | 21.2231 | 8,912.5098 | AID743036 |
glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0028 | 0.0002 | 14.3764 | 60.0339 | AID588532 |
retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 6.9626 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531 |
estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 27.9005 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1259401 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.3554 | 0.0002 | 29.3054 | 16,493.5996 | AID743069; AID743075; AID743077; AID743079 |
aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 68.6594 | 0.0007 | 23.0674 | 1,258.9301 | AID743085 |
Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 1.3699 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 3 (75.00) | 18.7374 |
1990's | 1 (25.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (34.80) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 1 (11.11%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 8 (88.89%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |