Page last updated: 2024-12-11

variolin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

variolin B: from Antartic sponge, Kirkpatrickia variolosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9817550
CHEMBL ID	380500
SCHEMBL ID	13175404
MeSH ID	M0450818

Synonyms (8)

Synonym
variolin b
DB08694
CHEMBL380500
bdbm50398327
9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol
SCHEMBL13175404
13-amino-8-(2-aminopyrimidin-4-yl)-1,3,12-triazatricyclo[7.4.0.02,7]trideca-2(7),4,8,10,12-pentaen-6-one
Q27097881

Research Excerpts

Overview

Variolin B (VAR-B) is a natural product isolated from the sponge Kirkpatrickia variolosa, found in Antarctica. It showed promising anti-cancer activity soon after its isolation.

Excerpt	Reference	Relevance
"Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. "	( Intercalative DNA binding of the marine anticancer drug variolin B. Albericio, F; Álvarez, M; Arribas-Bosacoma, R; Aymamí, J; Canals, A; Coll, M, 2017)	2.14
"Variolin B (VAR-B) is a natural product isolated from the sponge Kirkpatrickia variolosa, found in Antarctica. "	( Variolin B and its derivate deoxy-variolin B: new marine natural compounds with cyclin-dependent kinase inhibitor activity. Bailly, C; Cuevas, C; D'Incalci, M; Damia, G; Di Francesco, AM; Erba, E; Fernandez Sousa-Faro, JM; Riccardi, R; Simone, M; Vikhanskaya, F, 2005)	3.21

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Endothelial PAS domain-containing protein 1	Homo sapiens (human)	EC50 (µMol)	0.7000	0.0200	0.9330	3.3000	AID707849
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Process	via Protein(s)	Taxonomy
response to hypoxia	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
angiogenesis	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
embryonic placenta development	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
blood vessel remodeling	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
regulation of heart rate	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
epithelial cell maturation	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
response to oxidative stress	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
mitochondrion organization	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
signal transduction	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
visual perception	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
erythrocyte differentiation	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
lung development	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
norepinephrine metabolic process	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
mRNA transcription by RNA polymerase II	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
surfactant homeostasis	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
myoblast fate commitment	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
multicellular organismal-level iron ion homeostasis	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
cellular response to hypoxia	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
regulation of protein neddylation	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Process	via Protein(s)	Taxonomy
sequence-specific DNA binding	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
transcription coactivator binding	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
protein binding	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
protein heterodimerization activity	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Process	via Protein(s)	Taxonomy
nucleoplasm	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
cytosol	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
nuclear speck	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
chromatin	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
transcription regulator complex	Endothelial PAS domain-containing protein 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (42)

Assay ID	Title	Year	Journal	Article
AID707624	Inhibition of HIF2alpha in human RCC4 cells coexpressing HIF1alpha assessed as reduction in GLUT1 mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260403	Inhibition of growth against DU145 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID707640	Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in TGFalpha mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260415	Inhibition of growth against LoVo cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID707423	Downregulation of HIF2alpha mRNA expression in human SK-RC-28 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707431	Downregulation of TGFalpha mRNA expression in human SK-RC-28 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707437	Downregulation of HIF2alpha mRNA expression in human RCC4 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707637	Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in GLUT1 mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707635	Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in CCND1 mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707439	Downregulation of HIF1alpha mRNA expression in human RCC4 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260406	Inhibition of growth against IGROV cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID707682	Cytotoxicity against human SK-RC-28 cells expressing HIF1alpha after 2 days by XTT assay	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707627	Inhibition of HIF1alpha in human RCC4 cells coexpressing HIF2alpha assessed as decrease in carbonic anhydrase 9 mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707849	Inhibition of HIF2alpha in human 786-0 cells expressing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter gene assay	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707630	Downregulation of HIF2alpha mRNA expression in human 786-0 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707436	Inhibition of HIF1alpha in human SK-RC-28 cells assessed as reduction in carbonic anhydrase 9 expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707428	Downregulation of GLUT1 mRNA expression in human SK-RC-28 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707441	Inhibition of HIF1alpha/2alpha in human RCC4 cells assessed as reduction in VEGFA mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707631	Downregulation of HIF1alpha mRNA expression in human 786-0 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260416	Inhibition of growth against LoVo-Dox cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID707621	Inhibition of HIF2alpha in human RCC4 cells coexpressing HIF1alpha assessed as reduction in CCND1 mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260409	Inhibition of growth against MEL28 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260405	Inhibition of growth against SKOV3 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260412	Inhibition of growth against K562 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID707625	Inhibition of HIF2alpha in human RCC4 cells coexpressing HIF1alpha assessed as reduction in TGFalpha mRNA expression at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707848	Inhibition of HIF-mediated VEGFA protein expression in serum deprived human 786-0 cells at 1 uM after 48 hrs relative to control	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260411	Inhibition of growth against A549 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260407	Inhibition of growth against IGROV-ET cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260417	Inhibition of growth against HeLa cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID707841	Cytotoxicity against human RCC4 cells expressing HIF2alpha and HIF1alpha after 2 days by XTT assay	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707641	Down regulation of carbonic anhydrase 9 expression in human 786-0 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707425	Downregulation of HIF1alpha mRNA expression in human SK-RC-28 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707842	Cytotoxicity against human 786-0 cells expressing HIF2alpha after 2 days by XTT assay	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707427	Downregulation of CCND1 mRNA expression in human SK-RC-28 cells at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID707634	Inhibition of HIF2alpha in human 786-0 cells assessed as reduction in VEGFA at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260414	Inhibition of growth against HT29 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260408	Inhibition of growth against SKBR3 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260410	Inhibition of growth against HMEC1 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID707433	Inhibition of HIF1alpha in human SK-RC-28 cells assessed as reduction in VEGFA at 1 uM after 48 hrs by RT-PCR analysis	2012	Journal of natural products, Sep-28, Volume: 75, Issue:9	Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
AID260418	Inhibition of growth against HeLa-Apl cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260413	Inhibition of growth against PANC1 cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
AID260404	Inhibition of growth against LnCAP cells after 72 hrs exposure	2006	Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3	Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (66.67)	29.6817
2010's	4 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.44 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.37 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.44)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.08	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
trifluoroacetic acid Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.	2.02	1	fluoroalkanoic acid	human xenobiotic metabolite; NMR chemical shift reference compound; reagent
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.01	1	metal allergen; nickel group element atom; platinum group metal atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.08	1	copper group element atom; elemental gold
trifluoromethanesulfonic acid trifluoromethanesulfonic acid: deblocking reagent for peptide synthesis; RN given refers to parent cpd. triflic acid : A one-carbon compound that is methanesulfonic acid in which the hydrogens attached to the methyl carbon have been replaced by fluorines.	2.01	1	one-carbon compound; perfluoroalkanesulfonic acid
puupehenone [no description available]	2.07	1
fascaplysine fascaplysine: from tropic sea sponges	3.18	1
aaptamine aaptamine: natural product from sea sponge Aaptos aaptos; structure given in first source; RN from CA Index Guide 1984	3.58	2
xestoquinone xestoquinone: structure given in first source; RN given refers to the (S)-isomer; RN for cpd without isomeric designation not available 5/91; isolated from the sea sponge Xestospongia sapra	2.07	1
lestaurtinib [no description available]	3.18	1	indolocarbazole
carbodiimides Carbodiimides: Compounds with the general formula RN=C=NR, where R is a hydrocarbyl group.. methanediimine : A carbodiimide in which both nitrogens are unsubstituted.	2.01	1	carbodiimide
enzastaurin [no description available]	3.18	1	indoles; maleimides
staurosporine staurosporinium : Conjugate acid of staurosporine.	3.18	1	ammonium ion derivative
plitidepsin plitidepsin: a cyclodepsipeptide isolated from Aplidium albicans; has a pyruvoyl-proline residue instead of the lactyl-proline residue found in the linear peptide moiety of didemnin B. plitidepsin : A didemnin that is didemin B in which the hydroxy group of the 1-(2-hydroxypropanoyl)-L-prolinamide moiety has been oxidised to the corresponding ketone. It was originally isolated from the Mediterranean tunicate Aplidium albicans.	3.18	1	didemnin	anticoronaviral agent; antineoplastic agent; marine metabolite
midostaurin midostaurin : An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.	3.18	1	benzamides; gamma-lactam; indolocarbazole; organic heterooctacyclic compound	antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor
haliclonadiamine haliclonadiamine: from an Indonesian sponge Haliclona sp.; structure in first source	2.07	1
liphagal liphagal: selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga; structure in first source. liphagal : A meroterpenoid isolated from the marine sponge Aka coralliphaga and has been shown to exhibit inhibitory activity against phosphatidylinositol-3-OH kinase.	3.18	1	aldehyde; cyclic ether; meroterpenoid; organic heterotetracyclic compound; polyphenol	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; metabolite
sphingosine kinase [no description available]	3.18	1
meriolin 3 meriolin 3: a cell death-inducing kinase inhibitor; structure in first source	2.03	1
kahalalide f kahalalide F: a cyclodepsipeptide toxin; isolated from a mollusk, Elysia rubefescens; exhibits antitumoral activity against cell lines of colon cancer and prostatic cancer; structure given in first source	3.18	1
pyrimidinones Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	2.08	1

Condition	Relationship Strength	Studies
Cancer of Kidney [description not available]	2.07	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2.07	1
Adenocarcinoma, Basal Cell [description not available]	2.02	1
Cancer of Colon [description not available]	2.02	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.02	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.02	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1

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