| Assay ID | Title | Year | Journal | Article |
|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1676109 | Antagonist activity at ER-alpha in human MCF-7:WS8 cells transfected with an estrogen response element assessed as suppression of estrogen-induced response incubated for 18 hrs by luciferase reporter gene assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID295031 | Antitumor activity against HL60 cells at 5 uM after 6 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. |
| AID1676124 | Selectivity index, ratio of CC50 for human A549 cells to IC50 for antiviral activity against pseudotyped Marburgvirus-Musoke infected in human A549 cells | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID295033 | Antitumor activity against HL60 cells at 10 uM after 6 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. |
| AID1676114 | Binding affinity to glycoprotein P187E mutant in pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells at 0.12 to 250 uM assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay relative to wild type | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1676126 | Antiviral activity against pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID295036 | Antitumor activity against HL60 cells after 3 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. |
| AID1676127 | Antiviral activity against pseudotyped Marburgvirus-Musoke infected in human A549 cells assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1676108 | Agonist activity at ER-alpha in human MCF-7:WS8 cells transfected with an estrogen response element incubated for 18 hrs by luciferase reporter gene assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1676110 | Binding affinity to glycoprotein T502S mutant in pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells at 0.12 to 250 uM assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay relative to wild type | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1676112 | Binding affinity to glycoprotein V66M mutant in pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells at 0.12 to 250 uM assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay relative to wild type | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1676117 | Binding affinity to glycoprotein Y517S mutant in pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells at 0.12 to 250 uM assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID295035 | Antitumor activity against HL60 cells at 5 ug/ml after 4 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. |
| AID1676122 | Selectivity index, ratio of CC50 for human A549 cells to IC50 for antiviral activity against pseudotyped Ebola virus - Zaire (1995) Kikwit infected in human A549 cells | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1061233 | Inhibition of trypsin-like activity of human 20S proteasome beta 2 subunit assessed as hydrolysis of Boc-LRR-AMC fluorogenic substrate measured for 1 hr by fluorometric analysis | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor. |
| AID1676121 | Antiviral activity against pseudotyped Marburgvirus-Angola infected in human A549 cells assessed as reduction in viral infection incubated for 24 hrs by Hoechst staining based fluorescence assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID295037 | Induction of apoptosis in HL60 cells assessed as DNA fragmentation at 9 uM by agarose gel electrophoresis | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. |
| AID1061232 | Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr by fluorometric analysis | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor. |
| AID1676120 | Selectivity index, ratio of CC50 for human A549 cells to IC50 for antiviral activity against pseudotyped Marburgvirus-Angola infected in human A549 cells | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1061234 | Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as hydrolysis of succinyl-LLVY-AMC fluorogenic substrate measured for 1 hr by fluorometric analysis | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor. |
| AID1676118 | Binding affinity to glycoprotein I627V mutant in pseudotyped Marburgvirus-Musoke infected in human A549 cells at 0.12 to 250 uM assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay relative to wild type | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1676113 | Binding affinity to glycoprotein R64K mutant in pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells at 0.12 to 250 uM assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay relative to wild type | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1061239 | Inhibition of calpain (unknown origin) at >10 uM | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor. |
| AID1676119 | Cytotoxicity in human A549 cells assessed as reduction in cell viability by cellTiter-Glo luminescent cell viability assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID1676123 | Antiviral activity against pseudotyped Ebola virus - Zaire (1995) Kikwit infected in human A549 cells assessed as reduction in viral infection incubated for 24 hrs by Hoechst staining based fluorescence assay | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID295032 | Antitumor activity against HL60 cells at 7.5 uM after 6 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. |
| AID1061240 | Inhibition of cathepsin (unknown origin) at >10 uM | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor. |
| AID1676111 | Binding affinity to glycoprotein E100D mutant in pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells at 0.12 to 250 uM assessed as reduction in viral infection incubated for 48 hrs by luciferase reporter gene assay relative to wild type | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| AID295034 | Antitumor activity against HL60 cells after 6 hrs by MTT assay | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity. |
| AID1676125 | Selectivity index, ratio of CC50 for human A549 cells to IC50 for antiviral activity against pseudotyped Ebola virus - Mayinga, Zaire infected in human A549 cells | 2020 | Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19
| Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |