Compounds > 5,15-diphenylporphine
Page last updated: 2024-11-12

5,15-diphenylporphine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5,15-diphenylporphine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10895852
CHEMBL ID207155
SCHEMBL ID2563180
MeSH IDM0497820

Synonyms (30)

Synonym
AKOS015840533
5,15-diphenylporphine
22112-89-6
5,15-diphenylporphyrin
D2860
5,15-diphenyl-21h,23h-porphine
CHEMBL207155 ,
bdbm50396176
FT-0682574
AB44847
FNNOEKVUXXVPAI-UHFFFAOYSA-N
SCHEMBL2563180
21h,23h-porphine, 5,15-diphenyl-
DTXSID60447492
5, 15-dpp
mfcd08276335
AKOS025394541
10,20-diphenyl-21,22-dihydroporphyrin
stat3 inhibitor viii, 5,15-dpp
J-014513
BCP18710
10.14272/FNNOEKVUXXVPAI-DUVOQLPESA-N.1
doi:10.14272/fnnoekvuxxvpai-duvoqlpesa-n.1
5,15-dpp
D90121
A878709
XAA11289
HY-W035137
PD046442
515-dpp
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Signal transducer and activator of transcription 3Homo sapiens (human)IC50 (µMol)0.28000.02304.13789.9800AID702253
Signal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)IC50 (µMol)10.00007.90009.000010.0000AID702252
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (111)

Processvia Protein(s)Taxonomy
positive regulation of vascular endothelial growth factor productionSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 3Homo sapiens (human)
temperature homeostasisSignal transducer and activator of transcription 3Homo sapiens (human)
eye photoreceptor cell differentiationSignal transducer and activator of transcription 3Homo sapiens (human)
regulation of DNA-templated transcriptionSignal transducer and activator of transcription 3Homo sapiens (human)
regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 3Homo sapiens (human)
protein import into nucleusSignal transducer and activator of transcription 3Homo sapiens (human)
inflammatory responseSignal transducer and activator of transcription 3Homo sapiens (human)
signal transductionSignal transducer and activator of transcription 3Homo sapiens (human)
transforming growth factor beta receptor signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STATSignal transducer and activator of transcription 3Homo sapiens (human)
nervous system developmentSignal transducer and activator of transcription 3Homo sapiens (human)
cell population proliferationSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of cell population proliferationSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of autophagySignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of gene expressionSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of gene expressionSignal transducer and activator of transcription 3Homo sapiens (human)
phosphorylationSignal transducer and activator of transcription 3Homo sapiens (human)
cytokine-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
sexual reproductionSignal transducer and activator of transcription 3Homo sapiens (human)
cell differentiationSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of cell migrationSignal transducer and activator of transcription 3Homo sapiens (human)
intracellular receptor signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
response to estradiolSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of interleukin-1 beta productionSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of interleukin-10 productionSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of interleukin-6 productionSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of interleukin-8 productionSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of tumor necrosis factor productionSignal transducer and activator of transcription 3Homo sapiens (human)
cellular response to hormone stimulusSignal transducer and activator of transcription 3Homo sapiens (human)
leptin-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
somatic stem cell population maintenanceSignal transducer and activator of transcription 3Homo sapiens (human)
interleukin-15-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
interleukin-2-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
interleukin-9-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
interleukin-11-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
regulation of multicellular organism growthSignal transducer and activator of transcription 3Homo sapiens (human)
glucose homeostasisSignal transducer and activator of transcription 3Homo sapiens (human)
eating behaviorSignal transducer and activator of transcription 3Homo sapiens (human)
mRNA transcription by RNA polymerase IISignal transducer and activator of transcription 3Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transductionSignal transducer and activator of transcription 3Homo sapiens (human)
cellular response to leptin stimulusSignal transducer and activator of transcription 3Homo sapiens (human)
response to leptinSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of erythrocyte differentiationSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of Notch signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of angiogenesisSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of glycolytic processSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of DNA-templated transcriptionSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 3Homo sapiens (human)
astrocyte differentiationSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of inflammatory responseSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activitySignal transducer and activator of transcription 3Homo sapiens (human)
regulation of cell cycleSignal transducer and activator of transcription 3Homo sapiens (human)
radial glial cell differentiationSignal transducer and activator of transcription 3Homo sapiens (human)
retinal rod cell differentiationSignal transducer and activator of transcription 3Homo sapiens (human)
regulation of feeding behaviorSignal transducer and activator of transcription 3Homo sapiens (human)
growth hormone receptor signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATSignal transducer and activator of transcription 3Homo sapiens (human)
interleukin-6-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
T-helper 17 type immune responseSignal transducer and activator of transcription 3Homo sapiens (human)
T-helper 17 cell lineage commitmentSignal transducer and activator of transcription 3Homo sapiens (human)
energy homeostasisSignal transducer and activator of transcription 3Homo sapiens (human)
cellular response to interleukin-17Signal transducer and activator of transcription 3Homo sapiens (human)
cell surface receptor signaling pathway via STATSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of inflammatory response to woundingSignal transducer and activator of transcription 3Homo sapiens (human)
interleukin-10-mediated signaling pathwaySignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of cytokine production involved in inflammatory responseSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of miRNA transcriptionSignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of metalloendopeptidase activitySignal transducer and activator of transcription 3Homo sapiens (human)
positive regulation of vascular endothelial cell proliferationSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of primary miRNA processingSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of stem cell differentiationSignal transducer and activator of transcription 3Homo sapiens (human)
negative regulation of neuron migrationSignal transducer and activator of transcription 3Homo sapiens (human)
regulation of cell population proliferationSignal transducer and activator of transcription 3Homo sapiens (human)
response to peptide hormoneSignal transducer and activator of transcription 3Homo sapiens (human)
defense responseSignal transducer and activator of transcription 3Homo sapiens (human)
endothelial cell migrationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of endothelial cell proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of mesenchymal cell proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of defense response to virus by hostSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to nutrientSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
blood circulationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to xenobiotic stimulusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to mechanical stimulusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
macrophage derived foam cell differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of angiogenesisSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of interferon-alpha productionSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to insulin stimulusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
tumor necrosis factor-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to cytokineSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to type II interferonSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to interferon-betaSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to interferon-betaSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
interleukin-9-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to hydrogen peroxideSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
regulation of apoptotic processSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of canonical NF-kappaB signal transductionSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to peptide hormoneSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of erythrocyte differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of DNA-templated transcriptionSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IISignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation by virus of viral protein levels in host cellSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of smooth muscle cell proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
response to cAMPSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
defense response to virusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic processSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
type II interferon-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
type I interferon-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
renal tubule developmentSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
interleukin-27-mediated signaling pathwaySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to type II interferonSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cellular response to organic cyclic compoundSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
metanephric mesenchymal cell proliferation involved in metanephros developmentSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
metanephric mesenchymal cell differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
negative regulation of metanephric nephron tubule epithelial cell differentiationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
regulation of cell population proliferationSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
defense responseSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (36)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingSignal transducer and activator of transcription 3Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingSignal transducer and activator of transcription 3Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificSignal transducer and activator of transcription 3Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificSignal transducer and activator of transcription 3Homo sapiens (human)
DNA bindingSignal transducer and activator of transcription 3Homo sapiens (human)
DNA-binding transcription factor activitySignal transducer and activator of transcription 3Homo sapiens (human)
nuclear receptor activitySignal transducer and activator of transcription 3Homo sapiens (human)
signaling receptor bindingSignal transducer and activator of transcription 3Homo sapiens (human)
protein bindingSignal transducer and activator of transcription 3Homo sapiens (human)
protein kinase bindingSignal transducer and activator of transcription 3Homo sapiens (human)
protein phosphatase bindingSignal transducer and activator of transcription 3Homo sapiens (human)
chromatin DNA bindingSignal transducer and activator of transcription 3Homo sapiens (human)
signaling adaptor activitySignal transducer and activator of transcription 3Homo sapiens (human)
identical protein bindingSignal transducer and activator of transcription 3Homo sapiens (human)
protein homodimerization activitySignal transducer and activator of transcription 3Homo sapiens (human)
protein dimerization activitySignal transducer and activator of transcription 3Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingSignal transducer and activator of transcription 3Homo sapiens (human)
primary miRNA bindingSignal transducer and activator of transcription 3Homo sapiens (human)
lncRNA bindingSignal transducer and activator of transcription 3Homo sapiens (human)
DNA-binding transcription factor bindingSignal transducer and activator of transcription 3Homo sapiens (human)
RNA sequestering activitySignal transducer and activator of transcription 3Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
RNA polymerase II core promoter sequence-specific DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
transcription corepressor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
transcription coactivator bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
double-stranded DNA bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
DNA-binding transcription factor activitySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
tumor necrosis factor receptor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nuclear receptor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
enzyme bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
CCR5 chemokine receptor bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
histone acetyltransferase bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
histone bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
identical protein bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein homodimerization activitySignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
ubiquitin-like protein ligase bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cadherin bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein phosphatase 2A bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
promoter-specific chromatin bindingSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
nucleusSignal transducer and activator of transcription 3Homo sapiens (human)
nucleusSignal transducer and activator of transcription 3Homo sapiens (human)
nucleoplasmSignal transducer and activator of transcription 3Homo sapiens (human)
cytoplasmSignal transducer and activator of transcription 3Homo sapiens (human)
cytosolSignal transducer and activator of transcription 3Homo sapiens (human)
plasma membraneSignal transducer and activator of transcription 3Homo sapiens (human)
RNA polymerase II transcription regulator complexSignal transducer and activator of transcription 3Homo sapiens (human)
chromatinSignal transducer and activator of transcription 3Homo sapiens (human)
transcription regulator complexSignal transducer and activator of transcription 3Homo sapiens (human)
cytoplasmSignal transducer and activator of transcription 3Homo sapiens (human)
nucleusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
nucleolusSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cytoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cytosolSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
axonSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
dendriteSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
perinuclear region of cytoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
ISGF3 complexSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
RNA polymerase II transcription regulator complexSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
chromatinSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
protein-containing complexSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
cytoplasmSignal transducer and activator of transcription 1-alpha/betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID393315Phototoxicity against human HCT116 cells after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs by MTT assay2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID265678Cytotoxicity against human HCT116 cell line2006Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
Comparison between 5,10,15,20-tetraaryl- and 5,15-diarylporphyrins as photosensitizers: synthesis, photodynamic activity, and quantitative structure-activity relationship modeling.
AID768739Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes assessed as reduction of parasite growth after 24 to 44 hrs by Giemsa staining2013European journal of medicinal chemistry, Sep, Volume: 67Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.
AID393319Cell cycle arrest in human HCT116 cells assessed as accumulation at G1 phase at IC50 after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs by flow cytometry2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID393321Cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at IC50 after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs by flow cytometry2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID768743Antileishmanial activity against promastigote forms of Leishmania donovani MHOM/ET/67/HU3 after 3 days by MTT assay2013European journal of medicinal chemistry, Sep, Volume: 67Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.
AID702253Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction by AlphaScreen assay2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
AID393320Cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at IC50 after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs by flow cytometry2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID768741Trypanocidal activity against Trypanosoma brucei brucei by drug incubation infectivity test2013European journal of medicinal chemistry, Sep, Volume: 67Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.
AID393317Induction of apoptosis in human HCT116 cells assessed as decrease in survivin protein expression at IC50 after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs using annexin V-FITC stainin2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID768742Antileishmanial activity against amastigotes forms of Leishmania donovani MHOM/ET/67/HU3 infected in Swiss mouse peritoneal macrophages at 20 uM after 5 days2013European journal of medicinal chemistry, Sep, Volume: 67Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.
AID393420Induction of apoptosis in human HCT116 cells at IC50 after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs using annexin V-FITC staining by FACS2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID393318Induction of apoptosis in human HCT116 cells assessed as increase in Bax protein expression at IC50 after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs using annexin V-FITC staining by 2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID393316Induction of apoptosis in human HCT116 cells assessed as decrease in Bcl2 protein expression at IC50 after 24 hrs irradiated with tungsten-halogen white light for 2 hrs followed by incubation in drug free medium for 24 hrs using annexin V-FITC staining by2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Photodynamic effects of novel 5,15-diaryl-tetrapyrrole derivatives on human colon carcinoma cells.
AID768740Cytotoxicity against Swiss mouse peritoneal macrophages at 20 uM after 5 days by MTT assay2013European journal of medicinal chemistry, Sep, Volume: 67Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives.
AID702252Inhibition of STAT1 SH2 domain assessed as inhibition of STAT1 SH2-phosphotyrosine interaction by AlphaScreen assay2012Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's6 (60.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0810aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.0810phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0810aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
pyrrolidonecarboxylic acid
Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.		2.08105-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
porphine
porphine: structure given in first source		7.0210
singlet oxygen
Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.		2.0510chalcogen;
monoatomic oxygen;
nonmetal atom		macronutrient
cryptotanshinone
cryptotanshinone: from Salvia miltiorrhiza		3.1710abietane diterpenoidanticoronaviral agent
nsc 74859
NSC 74859: inhibits Stat3 binding activity; structure in first source. S3I-201 : An amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid.		3.1710amidobenzoic acid;
monohydroxybenzoic acid;
tosylate ester		STAT3 inhibitor
stattic
[no description available]		3.17101-benzothiophenes;
C-nitro compound;
sulfone		antineoplastic agent;
radiosensitizing agent;
STAT3 inhibitor
nifuroxazide
nifuroxazide: structure		3.1710benzoic acids
ochromycinone
ochromycinone: structure in first source		3.1710
temoporfin
[no description available]		2.4420
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma, Anaplastic
[description not available]		02.0510
Cancer of Colon
[description not available]		02.0510
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0510
Benign Neoplasms
[description not available]		02.9910
Palmoplantaris Pustulosis
[description not available]		02.9910
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.9910
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.		02.9910
Age-Related Macular Degeneration
[description not available]		02.1110
Angiogenesis, Pathologic
[description not available]		02.1110
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.1110
Macular Degeneration
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.		02.1110