fluorouracil has been researched along with Cholesteatoma in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cholesteatoma: A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of applied 5-Fluorouracil is effective in the treatment of cholesteatoma." | 7.67 | [A new medical therapeutic approach to cholesteatoma. 5-fluorouracil in local treatment]. ( Boniver, R; Hutten, R, 1987) |
| "5-Fluorouracil was introduced in the early 1960s as a topical chemotherapeutic agent and has become increasingly accepted because of its efficacy, economy, and relative absence of side effects in treating many pre-cancerous conditions, certain benign and malignant tumors, and dermatoses." | 5.27 | The topical use of 5-fluorouracil in the ear in the management of cholesteatoma and excessive mucous secretion. ( Smith, MF, 1985) |
| "The use of applied 5-Fluorouracil is effective in the treatment of cholesteatoma." | 3.67 | [A new medical therapeutic approach to cholesteatoma. 5-fluorouracil in local treatment]. ( Boniver, R; Hutten, R, 1987) |
| "5-Fluorouracil was introduced in the early 1960s as a topical chemotherapeutic agent and has become increasingly accepted because of its efficacy, economy, and relative absence of side effects in treating many pre-cancerous conditions, certain benign and malignant tumors, and dermatoses." | 1.27 | The topical use of 5-fluorouracil in the ear in the management of cholesteatoma and excessive mucous secretion. ( Smith, MF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takahashi, H | 1 |
| Funabiki, K | 1 |
| Hasebe, S | 1 |
| Fukuda-Yamamoto, T | 1 |
| Kaieda, S | 1 |
| Iwanaga, T | 1 |
| Kumagami, H | 1 |
| Takasaki, K | 1 |
| Sala, DT | 1 |
| Hutten, R | 1 |
| Boniver, R | 1 |
| Smith, MF | 1 |
4 other studies available for fluorouracil and Cholesteatoma
| Article | Year |
|---|---|
Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic | 2005 |
Topical applications of 5-fluorouracil in the medical treatment of cholesteatoma of the middle ear.
Topics: Administration, Topical; Cholesteatoma; Ear Diseases; Ear, Middle; Fluorouracil; Humans | 1994 |
[A new medical therapeutic approach to cholesteatoma. 5-fluorouracil in local treatment].
Topics: Cholesteatoma; Ear Diseases; Fluorouracil; Humans | 1987 |
The topical use of 5-fluorouracil in the ear in the management of cholesteatoma and excessive mucous secretion.
Topics: Adolescent; Adult; Aged; Child; Cholesteatoma; Ear Diseases; Ear, Middle; Fluorouracil; Humans; Midd | 1985 |