ganglioside--gd1a has been researched along with Gangliosidoses* in 2 studies
2 other study(ies) available for ganglioside--gd1a and Gangliosidoses
| Article | Year |
|---|---|
Ganglioside complexes as new target antigens in Guillain-Barré syndrome.
Antibodies specific for a complex of gangliosides GD1a and GD1b (GD1a/GD1b) were found in sera from eight of 100 patients with Guillain-Barre syndrome (GBS) by the use of enzyme-linked immunosorbent assay and thin-layer chromatogram immunostaining. Those sera also had antibody activities to such ganglioside complexes as GD1a/GM1, GD1b/GT1b, and GM1/GT1b but had little or no reactivity to the each isolated antigen. Clustered epitopes of the ganglioside complex in the plasma membrane may be targeted by such an antibody, and interaction between the antibody and ganglioside complex may induce the neuropathy. Topics: Adult; Aged; Antibodies; Chromatography, Thin Layer; Enzyme-Linked Immunosorbent Assay; Female; Gangliosides; Gangliosidoses; Guillain-Barre Syndrome; Humans; Immunoblotting; Male; Middle Aged | 2004 |
Internalization of exogenous gangliosides in cultured skin fibroblasts for the diagnosis of mucolipidosis IV.
The internalization of exogenous mixed brain gangliosides in ML IV cultured skin fibroblasts indicated an impairment of ganglioside catabolism in these cells. Incubation of ML IV, normal and various other lysosomal storage disorders cell lines for five days with exogenous tritium labelled GM3, GD1a or GT1 gangliosides allowed accurate quantitation of the retained gangliosides. This in vitro approach provides a reliable method for the diagnosis of ML IV. Topics: Cells, Cultured; Child; Child, Preschool; Fibroblasts; G(M2) Ganglioside; G(M3) Ganglioside; Gangliosides; Gangliosidoses; Humans; Infant; Mucolipidoses | 1986 |